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    • 2. 发明授权
    • Oil-in-water emulsion composition and method for producing the same
    • 水包油乳液组合物及其制备方法
    • US09345651B2
    • 2016-05-24
    • US13981170
    • 2012-01-24
    • Tomomi KuromiyaDaisuke SuzukiMasayoshi Miyamoto
    • Tomomi KuromiyaDaisuke SuzukiMasayoshi Miyamoto
    • A61K8/44A61K8/06A61Q19/02
    • A61K8/44A61K8/062A61K2800/21A61Q19/02
    • Disclosed is an oil-in-water type emulsion composition containing a physiologically acceptable salt of a tranexamate ester and a method for producing the same. An oil-in-water type emulsion composition containing a physiologically acceptable salt of a tranexamate ester can be obtained by preparing an oil phase including: A) a physiologically acceptable salt of a tranexamate ester; B) an amphiphilic substance; C) an oily substance; and D) water, a water-soluble organic solvent or a mixture thereof wherein the weight ratio of the ingredients A:B is in the range of 1:0.5 to 1:2.5, the weight ratio of the ingredients A:C is in the range of 1:1 to 1:5.0, and the weight ratio of the ingredients A:D is 1:0.2 to 1:5.0, and adding the oil phase to a water phase including E) water, a water-soluble organic solvent or a mixture thereof.
    • 本发明公开了一种含有氨基甲酸酯酯的生理学上可接受的盐的水包油型乳剂组合物及其制造方法。 含有氨甲酯酯的生理学上可接受的盐的水包油型乳剂组合物可以通过制备油相得到,该油相包括:A)氨基甲酸酯的生理学上可接受的盐; B)两亲物质; C)油性物质; 和D)水,水溶性有机溶剂或其混合物,其中成分A:B的重量比在1:0.5至1:2.5的范围内,成分A:C的重量比在 范围为1:1至1:5.0,成分A:D的重量比为1:0.2至1:5.0,并将油相加入到包含E)水,水溶性有机溶剂或 它们的混合物。