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1. 发明授权

US09117643B2 Alkali metal introduction apparatus and alkali metal introduction method 有权
标题翻译：碱金属引入装置和碱金属引入方法
公开(公告)号：US09117643B2
公开(公告)日：2015-08-25
申请号：US13580047
申请日：2011-01-25
申请人： Michisato Toyoda , Hirofumi Nagao , Shuichi Shimma , Shigeo Hayakawa
发明人： Michisato Toyoda , Hirofumi Nagao , Shuichi Shimma , Shigeo Hayakawa
IPC分类号： B65G65/00 , H01J49/04
CPC分类号： H01J49/0459
摘要： An alkali metal introduction apparatus (1) includes: a dedicated fracture chamber (10) and a vacuum chamber (20); vacuum pumps (60a) and (60b) for evacuating the insides of the dedicated fracture chamber (10) and the vacuum chamber (20); an ampul fracturing section for causing, in the dedicated fracture chamber (10), an alkali metal encapsulated in an ampul (16) to be exposed out of the ampul (16) by deforming the ampul (16); a collision cell (40) configured to allow the ampul (16) to be introduced therein, the collision room (40) being provided inside the vacuum chamber (20); and an ampul introducing section (12) for moving the ampul (16) between an exposure position where the alkali metal encapsulated in the ampul (16) is to be exposed out of the ampul (16) thus deformed and an introduction position where the ampul (16) is to be introduced into the collision cell (40).
摘要翻译：碱金属引入装置（1）包括：专用断裂室（10）和真空室（20）; 真空泵（60a）和（60b），用于抽空专用断裂室（10）和真空室（20）的内部; 用于在所述专用断裂室（10）中使通过使所述安瓿（16）变形而包封在安瓿（16）中的碱金属暴露于所述安瓿（16）之外的安瓿压裂部分; 碰撞室（40），其构造成允许安瓿（16）被引入其中，所述碰撞室（40）设置在所述真空室（20）内; 以及安瓿引导部分（12），用于在所述安瓿（16）中包封的碱金属将被暴露于由此变形的安瓿（16）之间的暴露位置和所述安瓿（16）的引入位置之间移动所述安瓿（16）（16）被引入到所述碰撞单元（40）中。

2. 发明申请

US20070194223A1 Method and apparatus for time-of-flight mass spectrometry 有权
标题翻译：飞行时间质谱法的方法和装置
公开(公告)号：US20070194223A1
公开(公告)日：2007-08-23
申请号：US10592299
申请日：2005-05-17
申请人： Takaya Sato , Michisato Toyoda , Morio Ishihara
发明人： Takaya Sato , Michisato Toyoda , Morio Ishihara
IPC分类号： H01J49/00
CPC分类号： H01J49/164 , H01J49/408
摘要： A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory.
摘要翻译：用于飞行时间（TOF）质谱的方法和装置。该装置改善了正交方向上的离子聚焦性能，并且允许与正交加速度离子源的连接以提高灵敏度。该装置包括用于以脉冲方式发射离子的离子源，用于实现螺旋轨迹的分析器和用于检测离子的检测器。分析仪由多层叠环形电场组成，实现螺旋轨迹。

3. 发明申请

US20050103992A1 Mass spectrometer and method of determining mass-to-charge ratio of ion 有权
标题翻译：质谱仪和离子质荷比的测定方法
公开(公告)号：US20050103992A1
公开(公告)日：2005-05-19
申请号：US10983571
申请日：2004-11-09
申请人： Shinichi Yamaguchi , Morio Ishihara , Michisato Toyoda
发明人： Shinichi Yamaguchi , Morio Ishihara , Michisato Toyoda
IPC分类号： G01N27/62 , B01D59/44 , H01J49/00 , H01J49/06 , H01J49/40
CPC分类号： H01J49/408 , H01J49/0027
摘要： The present invention provides a time of flight mass spectrometer having a spiral flight path, whose mass resolution can be appropriately changed with respect to the analysis object or other factor without any complicated alteration or addition of the mechanical construction. In a specific form of the invention, the mass spectrometer includes deflecting electrodes 20-23 located between semi-cylindrical electrodes 11 and 12 for making ions fly along a spiral path. The deflecting electrodes 20-23 generate deflecting electric fields for shifting the ions in the axial direction of the semi-cylindrical electrodes 11 and 12. The voltage applied to the deflecting electrodes 20-23 is changed according to the mass resolution required. The deflecting electric fields are generated or removed with the change of the voltage, which makes the ions fly either along a spiral path or in the same loop orbit. The flight distance of the ions can be controlled as desired by regulating the voltage so that the ions fly in the loop orbit an appropriate number of times. Thus, the mass resolution can be arbitrarily controlled.
摘要翻译：本发明提供了具有螺旋飞行路径的飞行时间质谱仪，其质量分辨率可以相对于分析对象或其他因素适当地改变，而没有任何复杂的改变或添加机械结构。在本发明的具体形式中，质谱仪包括位于半圆柱形电极11和12之间的偏转电极20-23，用于使离子沿着螺旋路线飞行。偏转电极20-23产生用于使离子沿半圆柱形电极11和12的轴向移动的偏转电场。施加到偏转电极20-23的电压根据所需的质量分辨率而改变。随着电压的变化产生或去除偏转电场，这使得离子沿着螺旋路径或相同的环轨道飞行。通过调节电压可以根据需要控制离子的飞行距离，使得离子在环轨道中飞行适当次数。因此，质量分辨率可以任意控制。

4. 发明授权

US09373474B2 Ion source, and mass spectroscope provided with same 有权
标题翻译：离子源和质谱仪提供相同的
公开(公告)号：US09373474B2
公开(公告)日：2016-06-21
申请号：US13259152
申请日：2010-03-26
申请人： Michisato Toyoda , Jun Aoki , Shinichi Miki
发明人： Michisato Toyoda , Jun Aoki , Shinichi Miki
IPC分类号： H01J27/02 , H01J49/40 , H01J49/14 , H01J37/05
CPC分类号： H01J27/024 , H01J37/05 , H01J49/14 , H01J49/147 , H01J49/401 , H01J49/403
摘要： An ion source is provided with a push-out electrode, a pull-out electrode, and a pull-in electrode all for ionizing a sample and accelerating generated ions in a pulsed manner, wherein the push-out electrode and/or the pull-in electrode has a curved surface shape having a depression curved in the direction opposite to the direction of travel of the ions. As a result, a compact ion source capable of temporally and spatially focusing ions and outputting the ions, and a compact time-of-flight mass spectroscope with good detection resolution and detection sensitivity which is provided with the compact ion source can be provided.
摘要翻译：离子源设置有推出电极，拉出电极和引入电极，其全部用于电离样品并以脉冲方式加速产生的离子，其中推出电极和/或拉出电极电极具有弯曲表面形状，其具有在与离子的行进方向相反的方向上弯曲的凹陷。结果，可以提供能够暂时和空间上聚焦离子并输出离子的紧凑型离子源，并且可以提供具有紧凑离子源的具有良好的检测分辨率和检测灵敏度的紧凑的飞行时间质谱仪。

5. 发明申请

US20120257219A1 Distance Measuring Apparatus, Distance Measuring Method, Distance Measurement Program And Computer Readable Recording Medium 失效
标题翻译：距离测量仪器，距离测量方法，距离测量程序和计算机可读记录介质
公开(公告)号：US20120257219A1
公开(公告)日：2012-10-11
申请号：US13081510
申请日：2011-04-07
申请人： Michisato TOYODA , Toshio Tashima
发明人： Michisato TOYODA , Toshio Tashima
IPC分类号： G01B11/14
CPC分类号： G01B11/026
摘要： A distance measuring apparatus comprises: an edge specifying part 101 for specifying the edge of a probe 6 in a secondary portrait appearing on the surface of a work 9 and an image of the probe 6; a straight line inserting part 102 for inserting a straight line along the outer edge of the secondary portrait onto an image, and an overlap determining part 103 for determining an overlap of the edge and the straight line, wherein one or more LED lamps 7, and calculating part for calculating the distance wherein the imaging device and the probe 6 are movably held integrally for the surface of the work 9.
摘要翻译：距离测量装置包括：边缘指定部分101，用于指定出现在工件9的表面上的次要肖像中的探针6的边缘;以及探针6的图像; 用于将沿着次级肖像的外边缘的直线插入到图像上的直线插入部分102和用于确定边缘和直线的重叠的重叠确定部分103，其中一个或多个LED灯7和用于计算距离的计算部分，其中成像装置和探针6一体地保持在工件9的表面上。

6. 发明授权

US08237112B2 Method and apparatus for time-of-flight mass spectrometry 有权
标题翻译：飞行时间质谱法的方法和装置
公开(公告)号：US08237112B2
公开(公告)日：2012-08-07
申请号：US13028481
申请日：2011-02-16
申请人： Takaya Sato , Michisato Toyoda , Morio Ishihara
发明人： Takaya Sato , Michisato Toyoda , Morio Ishihara
IPC分类号： H01J49/42 , H01J49/22
CPC分类号： H01J49/164 , H01J49/408
摘要： A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory.
摘要翻译：用于飞行时间（TOF）质谱的方法和装置。该装置改善了正交方向上的离子聚焦性能，并且允许与正交加速度离子源的连接以提高灵敏度。该装置包括用于以脉冲方式发射离子的离子源，用于实现螺旋轨迹的分析器和用于检测离子的检测器。分析仪由多层叠环形电场组成，实现螺旋轨迹。

7. 发明申请

US20090212208A1 Method and Apparatus for Time-of-Flight Mass Spectrometry 有权
标题翻译：飞行时间质谱法的方法和装置
公开(公告)号：US20090212208A1
公开(公告)日：2009-08-27
申请号：US12390710
申请日：2009-02-23
申请人： Takaya Sato , Michisato Toyoda , Morio Ishihara
发明人： Takaya Sato , Michisato Toyoda , Morio Ishihara
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/164 , H01J49/408
摘要： A method and apparatus for time-of-flight (TOF) mass spectrometry. The apparatus improves the ion focusing properties in an orthogonal direction and permits connection with an orthogonal-acceleration ion source for improvement of sensitivity. The apparatus comprises an ion source for emitting ions in a pulsed manner, an analyzer for realizing a helical trajectory, and a detector for detecting the ions. The analyzer is composed of plural laminated toroidal electric fields to realize the helical trajectory.
摘要翻译：用于飞行时间（TOF）质谱的方法和装置。该装置改善了正交方向上的离子聚焦性能，并且允许与正交加速度离子源的连接以提高灵敏度。该装置包括用于以脉冲方式发射离子的离子源，用于实现螺旋轨迹的分析器和用于检测离子的检测器。分析仪由多层叠环形电场组成，实现螺旋轨迹。

8. 发明申请

US20070045527A1 Laser irradiation mass spectrometer 有权
标题翻译：激光照射质谱仪
公开(公告)号：US20070045527A1
公开(公告)日：2007-03-01
申请号：US11362526
申请日：2006-02-27
申请人： Kiyoshi Ogawa , Yoshikazu Yoshida , Kozo Shimazu , Mitsutoshi Setou , Shuichi Shimma , Michisato Toyoda
发明人： Kiyoshi Ogawa , Yoshikazu Yoshida , Kozo Shimazu , Mitsutoshi Setou , Shuichi Shimma , Michisato Toyoda
IPC分类号： H01J49/26
CPC分类号： H01J49/40 , H01J49/0004 , H01J49/004 , H01J49/164 , H01J49/424
摘要： The present invention provides a laser irradiation mass spectrometer capable of analyzing components of living tissue or living cells with high accuracy. It includes a laser unit for irradiating a sample with a beam of laser light and controlling the irradiation spot of the laser beam on the sample; and a mass analyzer for performing a mass analysis of the ions generated at the irradiation spot, where the mass analyzer uses a frequency-driven ion trap and a time-of-flight mass spectrometer to carry out the mass analysis. The ion trap of this system assuredly traps ions having large mass to charge ratios, and enables the system to carry out analyses on samples of large molecules. Preferably, a digital driving method is used to drive the aforementioned frequency-driven ion trap. Also, a multi-turn time-of-flight mass spectrometer may preferably be used as the aforementioned time-of-flight mass spectrometer.
摘要翻译：本发明提供能够高精度地分析活体组织或活细胞的成分的激光照射质谱仪。它包括用激光束照射样品的激光单元，并将激光束的照射点控制在样品上; 以及质量分析器，用于对照射点产生的离子进行质量分析，质量分析仪使用频率驱动离子阱和飞行时间质谱仪进行质量分析。该系统的离子阱确实捕获具有大质量与电荷比的离子，并使系统能够对大分子样品进行分析。优选地，使用数字驱动方法来驱动上述频率驱动的离子阱。此外，可以优选使用多匝飞行时间质谱仪作为上述飞行时间质谱仪。

9. 发明申请

US20050194528A1 Time of flight mass spectrometer 有权
标题翻译：飞行时间质谱仪
公开(公告)号：US20050194528A1
公开(公告)日：2005-09-08
申请号：US10929768
申请日：2004-08-31
申请人： Shinichi Yamaguchi , Morio Ishihara , Michisato Toyoda , Daisuke Okumura
发明人： Shinichi Yamaguchi , Morio Ishihara , Michisato Toyoda , Daisuke Okumura
IPC分类号： G01N27/62 , G01N27/64 , H01J49/00 , H01J49/40
CPC分类号： H01J49/408 , H01J49/406
摘要： A time of flight type mass spectrometer (TOF-MS) of the present invention includes: a flight space containing a loop orbit on which ions fly once or more than once; a flight controller for making ions of a same mass to charge ratio fly the loop orbit at several values of number of turns; a flight time measurer for measuring a length of flight time of the ions; and a processor for determining the mass to charge ratio of the ions based on a relationship between the value of number of turns and the length of flight time of the ions. The speed of ions flying a loop orbit depends on their mass to charge ratios. For ions of the same mass to charge ratio, the difference between the lengths of flight time of the ions flying the loop orbit N turns and of the ions flying the loop orbit N+1 turns depends on the speed of the ions, so that the difference depends on the mass to charge ratio of the ions. The difference in the length of flight time is unrelated to the variation in the starting time (jitter), variation in the detection timing (jitter), etc, so that the value of the mass to charge ratio can be precisely determined free from errors caused by such disturbing factors.
摘要翻译：本发明的飞行时间型质谱仪（TOF-MS）包括：包含离子飞行一次或多次的循环轨道的飞行空间; 用于使相同质荷比的离子的飞行控制器以匝数的几个值飞行环路轨道; 用于测量离子的飞行时间长度的飞行时间测量器; 以及用于基于匝数与离子的飞行时间长度之间的关系来确定离子的质荷比的处理器。飞行环路轨道的离子速度取决于其质荷比。对于相同质荷比的离子，飞越环轨道N圈的离子的飞行时间长度和飞行环轨道N + 1圈的离子之间的差异取决于离子的速度，因此差异取决于离子的质荷比。飞行时间长度的差异与启动时间（抖动）的变化，检测定时（抖动）等的变化无关，从而可以精确地确定质荷比值，从而避免误差受到这样的扰乱因素。

10. 发明授权

US07501620B2 Laser irradiation mass spectrometer 有权
标题翻译：激光照射质谱仪
公开(公告)号：US07501620B2
公开(公告)日：2009-03-10
申请号：US11362526
申请日：2006-02-27
申请人： Kiyoshi Ogawa , Yoshikazu Yoshida , Kozo Shimazu , Mitsutoshi Setou , Shuichi Shimma , Michisato Toyoda
发明人： Kiyoshi Ogawa , Yoshikazu Yoshida , Kozo Shimazu , Mitsutoshi Setou , Shuichi Shimma , Michisato Toyoda
IPC分类号： H01J49/26 , H01J49/40
CPC分类号： H01J49/40 , H01J49/0004 , H01J49/004 , H01J49/164 , H01J49/424
摘要： The present invention provides a laser irradiation mass spectrometer capable of analyzing components of living tissue or living cells with high accuracy. It includes a laser unit for irradiating a sample with a beam of laser light and controlling the irradiation spot of the laser beam on the sample; and a mass analyzer for performing a mass analysis of the ions generated at the irradiation spot, where the mass analyzer uses a frequency-driven ion trap and a time-of-flight mass spectrometer to carry out the mass analysis. The ion trap of this system assuredly traps ions having large mass to charge ratios, and enables the system to carry out analyses on samples of large molecules. Preferably, a digital driving method is used to drive the aforementioned frequency-driven ion trap. Also, a multi-turn time-of-flight mass spectrometer may preferably be used as the aforementioned time-of-flight mass spectrometer.
摘要翻译：本发明提供能够高精度地分析活体组织或活细胞的成分的激光照射质谱仪。它包括用激光束照射样品的激光单元，并将激光束的照射点控制在样品上; 以及质量分析器，用于对照射点产生的离子进行质量分析，质量分析仪使用频率驱动离子阱和飞行时间质谱仪进行质量分析。该系统的离子阱确实捕获具有大质量与电荷比的离子，并使系统能够对大分子样品进行分析。优选地，使用数字驱动方法来驱动上述频率驱动的离子阱。此外，可以优选使用多匝飞行时间质谱仪作为上述飞行时间质谱仪。

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