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1. 发明授权

US08565480B2 Creating and viewing three dimensional virtual slides 有权
公开(公告)号：US08565480B2
公开(公告)日：2013-10-22
申请号：US12979996
申请日：2010-12-28
申请人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G06K9/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional digital slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. These two dimensional digital slide images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.

2. 发明授权

US07689024B2 Systems and methods for creating and viewing three dimensional virtual slides 有权
标题翻译：用于创建和查看三维虚拟幻灯片的系统和方法
公开(公告)号：US07689024B2
公开(公告)日：2010-03-30
申请号：US12330370
申请日：2008-12-08
申请人： Ole Eichhorn , Greg Crandall , Dirk Soenksen , Steven Hashagen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Dirk Soenksen , Steven Hashagen , Mark Wrenn
IPC分类号： G06K9/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维虚拟幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

3. 发明授权

US07463761B2 Systems and methods for creating and viewing three dimensional virtual slides 有权
标题翻译：用于创建和查看三维虚拟幻灯片的系统和方法
公开(公告)号：US07463761B2
公开(公告)日：2008-12-09
申请号：US11140265
申请日：2005-05-27
申请人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G06K9/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维虚拟幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

4. 发明申请

US20090116733A1 Systems and Methods for Creating and Viewing Three Dimensional Virtual Slides 有权
标题翻译：用于创建和查看三维虚拟幻灯片的系统和方法
公开(公告)号：US20090116733A1
公开(公告)日：2009-05-07
申请号：US12330370
申请日：2008-12-08
申请人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G06K9/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维虚拟幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

5. 发明申请

US20070274603A1 Systems and Methods for Image Pattern Recognition 有权
标题翻译：图像模式识别系统与方法
公开(公告)号：US20070274603A1
公开(公告)日：2007-11-29
申请号：US11836713
申请日：2007-08-09
申请人： Ole Eichhorn , Dirk Soenksen
发明人： Ole Eichhorn , Dirk Soenksen
IPC分类号： G06K9/36
CPC分类号： G06K9/6218 , G06K9/00147 , G06T9/008 , G06T9/40 , H04N19/94 , H04N19/96
摘要： Systems and methods for image pattern recognition comprise digital image capture and encoding using vector quantization (“VQ”) of the image. A vocabulary of vectors is built by segmenting images into kernels and creating vectors corresponding to each kernel. Images are encoded by creating a vector index file having indices that point to the vectors stored in the vocabulary. The vector index file can be used to reconstruct an image by looking up vectors stored in the vocabulary. Pattern recognition of candidate regions of images can be accomplished by correlating image vectors to a pre-trained vocabulary of vector sets comprising vectors that correlate with particular image characteristics. In virtual microscopy, the systems and methods are suitable for rare-event finding, such as detection of micrometastasis clusters, tissue identification, such as locating regions of analysis for immunohistochemical assays, and rapid screening of tissue samples, such as histology sections arranged as tissue microarrays (TMAs).
摘要翻译：用于图像模式识别的系统和方法包括使用图像的矢量量化（“VQ”）的数字图像捕获和编码。通过将图像分割为内核并创建与每个内核相对应的向量来构建向量的词汇表。通过创建具有指向存储在词汇表中的向量的索引的向量索引文件对图像进行编码。向量索引文件可用于通过查找存储在词汇表中的向量来重建图像。可以通过将图像向量与包括与特定图像特征相关的向量的预先训练的矢量集合词汇相关联来实现图像候选区域的模式识别。在虚拟显微镜中，系统和方法适用于罕见事件发现，例如检测微转移簇，组织鉴定，例如免疫组织化学测定的分析区域以及组织样品的快速筛选，例如排列成组织的组织切片微阵列（TMA）。

6. 发明申请

US20070036462A1 System and Method for Data Management in a Linear-Array-Based Microscope Slide Scanner 有权
标题翻译：基于线性阵列的显微镜幻灯片扫描仪中数据管理的系统与方法
公开(公告)号：US20070036462A1
公开(公告)日：2007-02-15
申请号：US11379648
申请日：2006-04-21
申请人： Greg Crandall , Ole Eichhorn , Allen Olson , Dirk Soenksen
发明人： Greg Crandall , Ole Eichhorn , Allen Olson , Dirk Soenksen
IPC分类号： G06K9/36 , G06K9/32 , G06K9/00
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： A data management system and method for processing, storing, and viewing the extremely large imagery data that is rapidly produced by a linear-array-based microscope slide scanner is provided. The system receives, processes, and stores imagery data produced by the linear-array-based microscope slide scanner at approximately 3 GB per minute. The data are received as a series of overlapping image stripes and combined into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The data management system enables imagery data compression while scanning and capturing new image stripes. This advantageously eliminates the overhead associated with storing uncompressed image stripes. The image compression also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The data management system efficiently converts image stripes into a high quality virtual slide that allows rapid panning and zooming by image viewing software in accordance with the individually addressed regions. The virtual slide also allows efficient processing by an algorithm framework. The data management system is costs effective and scaleable, employs standard image file formats and supports the use of virtual slides in desirable applications such as telemedicine, telepathology, microscopy education, and the analysis of high value specimens such as tissue arrays.
摘要翻译：提供了一种用于处理，存储和查看由基于线性阵列的显微镜幻灯片扫描仪快速产生的极大图像数据的数据管理系统和方法。系统以每分钟3 GB的速度接收，处理和存储由基于线性阵列的显微镜幻灯片扫描仪生成的图像数据。数据被接收为一系列重叠的图像条纹并组合成无缝和连续的基线图像。基线图像被逻辑地映射到单独寻址的多个区域中，以便于观察和操纵基线图像。数据管理系统在扫描和捕获新的图像条纹时可以进行图像数据压缩。这有利地消除了与存储未压缩图像条纹相关联的开销。图像压缩还创建中间级图像，从而将基线图像组织成称为虚拟幻灯片的可变级金字塔结构。数据管理系统有效地将图像条纹转换成高质量的虚拟幻灯片，其允许通过图像查看软件根据单独寻址的区域进行快速平移和缩放。虚拟幻灯片还允许通过算法框架进行有效的处理。数据管理系统具有成本效益和可扩展性，采用标准图像文件格式，并支持虚拟幻灯片在远程医疗，远程病理学，显微镜教育等理想应用中的应用，以及组织阵列等高价值标本的分析。

7. 发明申请

US20110090223A1 CREATING AND VIEWING THREE DIMENSIONAL VIRTUAL SLIDES 有权
标题翻译：创建和查看三维虚拟幻灯片
公开(公告)号：US20110090223A1
公开(公告)日：2011-04-21
申请号：US12979996
申请日：2010-12-28
申请人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G06T15/40
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional digital slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. These two dimensional digital slide images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维数字幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。这些二维数字幻灯片图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像，并且选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

8. 发明授权

US07860292B2 Creating and viewing three dimensional virtual slides 有权
标题翻译：创建和查看三维虚拟幻灯片
公开(公告)号：US07860292B2
公开(公告)日：2010-12-28
申请号：US12731083
申请日：2010-03-24
申请人： Ole Eichhorn , Greg Crandall , Dirk Soenksen , Steven Hashagen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Dirk Soenksen , Steven Hashagen , Mark Wrenn
IPC分类号： G06K9/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维虚拟幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

9. 发明申请

US20100177166A1 Creating and Viewing Three Dimensional Virtual Slides 有权
标题翻译：创建和查看三维虚拟幻灯片
公开(公告)号：US20100177166A1
公开(公告)日：2010-07-15
申请号：US12731083
申请日：2010-03-24
申请人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： H04N13/02 , H04N7/18
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维虚拟幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

10. 发明申请

US20060007533A1 Systems and methods for creating and viewing three dimensional virtual slides 有权
标题翻译：用于创建和查看三维虚拟幻灯片的系统和方法
公开(公告)号：US20060007533A1
公开(公告)日：2006-01-12
申请号：US11140265
申请日：2005-05-27
申请人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G02B21/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维虚拟幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

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