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    • 5. 发明授权
    • Molecule mass detection via field emission of electrons from membranes
    • 通过电子从膜发射的分子质量检测
    • US08274059B2
    • 2012-09-25
    • US12489037
    • 2009-06-22
    • Robert H. Blick
    • Robert H. Blick
    • G01T1/00
    • G01N23/00H01J47/001H01J49/025
    • An active detector and methods for detecting molecules, including large molecules such as proteins and oligonucleotides, at or near room temperature based on the generation of electrons via field emission (FE) and/or secondary electron emission (SEE). The detector comprises a semiconductor membrane having an external surface that is contacted by one or more molecules, and an internal surface having a thin metallic layer or other type of electron emitting layer. The kinetic energy of molecules contacting the semiconductor membrane is transferred through the membrane and induces the emission of electrons from the emitting layer. An electron detector, which optionally includes means for electron amplification, is positioned to detect the emitted electrons.
    • 基于通过场发射(FE)和/或二次电子发射(SEE)产生电子,在室温或室温下检测分子(包括大分子如蛋白质和寡核苷酸)的主动检测器和方法。 检测器包括具有与一个或多个分子接触的外表面的半导体膜和具有薄金属层或其它类型的电子发射层的内表面。 接触半导体膜的分子的动能通过膜转移并诱导从发射层发射电子。 可选地包括用于电子放大的装置的电子检测器被定位成检测发射的电子。