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1. 发明申请

US20100136029A1 Use of Tri-Substituted Glycerol Compounds for the Treatment of Hematological Malignancies 审中-公开
标题翻译：使用三取代甘油化合物治疗血液恶性肿瘤
公开(公告)号：US20100136029A1
公开(公告)日：2010-06-03
申请号：US12520354
申请日：2007-11-09
申请人： Axel Rolf Zander , Francis Ayuk Ayuketang , Wolfgang Richter , Lutz Weber
发明人： Axel Rolf Zander , Francis Ayuk Ayuketang , Wolfgang Richter , Lutz Weber
IPC分类号： A61K31/661 , A61P35/00 , A61P35/02 , A61K33/24 , A61K31/704 , A61K39/395 , C12Q1/68
CPC分类号： A61K31/661 , A61K31/4965 , A61K31/513 , A61K31/52 , A61K31/685 , A61K31/7048 , A61K39/39533 , A61K45/06 , C07F9/091 , A61K2300/00
摘要： The present invention relates to the use of a tri-substituted glycerol compound for the manufacture of a medicament for the treatment of hematological malignancies. The invention also refers to a kit-of-parts comprising such a medicament. Finally, the invention also relates to a corresponding method for the treatment of such conditions as well as to an in vitro method for determining the susceptibility of such malignant cells to a medicament as defined in the invention.
摘要翻译：本发明涉及三取代甘油化合物在制备用于治疗血液恶性肿瘤的药物中的用途。本发明还涉及包含这种药物的成套工具。最后，本发明还涉及用于治疗这些病症的相应方法以及用于确定这样的恶性细胞对本发明所定义的药物敏感性的体外方法。

2. 发明授权

US4341527A Process and reagent for determination of the hemoglobin content of blood 失效
标题翻译：用于测定血液中血红蛋白含量的方法和试剂
公开(公告)号：US4341527A
公开(公告)日：1982-07-27
申请号：US170575
申请日：1980-07-21
申请人： Rolf Zander , Werner Lang , Hans U. Wolf
发明人： Rolf Zander , Werner Lang , Hans U. Wolf
IPC分类号： B01F20060101 , C11D20060101 , G01N20060101 , G01N33/72
CPC分类号： G01N33/721
摘要： A reagent for photometric determination of the hemoglobin content of blood, which produces a characteristic color upon addition of the blood sample, consisting of an aqueous alkaline solution comprising a water-soluble, non-ionic detergent, whereby all hemoglobin-derivatives occurring in the blood and hemederivatives are converted into a unitary end product having a distinct absorption maximum in the visible spectral range.
摘要翻译：用于光度测定血液中血红蛋白含量的试剂，其在加入血液样品时产生特征性颜色，其由包含水溶性非离子型洗涤剂的碱性水溶液组成，由此血液中存在所有血红蛋白衍生物并且将中间体转化为在可见光谱范围内具有明显吸收最大值的单一最终产物。

3. 发明授权

US06194138B1 Method for flushing blood cells using gelatin 失效
标题翻译：使用明胶冲洗血细胞的方法
公开(公告)号：US06194138B1
公开(公告)日：2001-02-27
申请号：US09134581
申请日：1998-08-14
申请人： Rolf Zander
发明人： Rolf Zander
IPC分类号： A01N102
CPC分类号： A01N1/021
摘要： An aqueous solution of gelatin used as a flushing liquid for blood cells, in particular erythrocytes, in order to give no changes in the blood cells or at most slight, quality-impairing changes.
摘要翻译：用作血细胞的冲洗液，特别是红细胞的明胶水溶液，以便不会改变血细胞或至少轻微的质量损害变化。

4. 发明申请

US20110112390A1 APPARATUS AND METHOD FOR BLOOD CLOTTING DIAGNOSTICS 审中-公开
标题翻译：用于血液分析诊断的装置和方法
公开(公告)号：US20110112390A1
公开(公告)日：2011-05-12
申请号：US12991388
申请日：2009-04-28
申请人： Rolf Zander
发明人： Rolf Zander
IPC分类号： A61B5/00
CPC分类号： G01N33/86 , G01N33/4905
摘要： In order to be able still more precisely to determine the blood clotting activity in a patient according to the invention there is provided a method of extracorporeal determination of the blood clotting activity of a blood sample of an individual, in which the clotting time which elapses until the blood sample reaches a given degree of clotting or the degree of clotting reached by the blood sample within a given time is measured or in which in a corresponding manner the fibrinolysis time or the degree of fibrinolysis of a blood sample which has previously clotted to a certain degree is measured, the method being characterised in that measurement of the clotting/fibrinolysis time or the degree of clotting/fibrinolysis is effected with the exclusion of air. In addition according to the invention there is proposed a corresponding apparatus for the extracorporeal determination of the blood clotting activity wherein the apparatus has a measurement chamber for measuring the clotting time, the degree of clotting, the fibrinolysis time or the degree of fibrinolysis of a blood sample, the apparatus being characterised in that the measurement chamber is of such a configuration that measurement of the clotting/fibrinolysis time or the degree of clotting/fibrinolysis is effected with the exclusion of air.
摘要翻译：为了能够更精确地确定根据本发明的患者的血液凝固活性，提供了体外测定个体血液样品的血液凝固活性的方法，其中经过的凝血时间直到血液样品达到给定的凝血程度或在给定时间内由血液样品达到的凝血程度被测量，或以相应的方式测量血液样品的纤维蛋白溶解时间或纤维蛋白溶解度，其先前已凝结于该方法的特征在于，排除空气来实现凝血/纤维蛋白溶解时间的测量或凝血/纤维蛋白溶解的程度。此外，根据本发明，提出了用于血液凝固活性的体外测定的相应装置，其中所述装置具有用于测量凝血时间，凝血程度，纤维蛋白溶解时间或血液纤维蛋白溶解程度的测量室该装置的特征在于，测量室具有如下结构，其中排除空气来测量凝血/纤维蛋白溶解时间或凝血/纤维蛋白溶解度。

5. 发明授权

US5596983A Apparatus for oxygenating a patient 失效
标题翻译：用于给患者充氧的装置
公开(公告)号：US5596983A
公开(公告)日：1997-01-28
申请号：US957740
申请日：1992-10-07
申请人： Rolf Zander , Friedrich Mertzlufft
发明人： Rolf Zander , Friedrich Mertzlufft
IPC分类号： A61M16/06 , A61M16/00
CPC分类号： A61M16/06 , A61M2230/432
摘要： An apparatus is provided for oxygenating a patient, comprising an oxygen supply means with an oxygen applicator for supplying oxygen via the nose, the oxygen applicator being a closed system, with the applicator affixable about the nose in a tightly-sealable manner so that it supplies pure oxygen solely via the nose in a directed flow, and additionally comprising a one-way valve which can be inserted in substantially sealing-tight manner into the mouth of the patient, the one-way valve opening only upon gas outflow out of the mouth, the closed system at all times having a pressure which is greater than the pressure necessary to open the one-way valve, such that respired air from the patient can escape only through the mouth and no air can escape through the nose.
摘要翻译：提供了一种用于使患者充氧的装置，其包括氧气供应装置，其具有用于经由鼻部供应氧气的氧气施加器，所述氧气施加器是封闭系统，其中所述施用器以可紧密密封的方式围绕鼻子固定，使得其供应纯氧通过鼻子在有向流中，并且还包括可以基本上密封地插入患者口中的单向阀，单向阀仅在气体从嘴中流出时开口，所述封闭系统始终具有大于打开单向阀所需的压力的压力，使得来自患者的呼吸空气仅能够通过嘴部逸出，并且没有空气可以通过鼻子逸出。

6. 发明授权

US5296242A Aqueous solution and the use thereof 失效
标题翻译：水溶液及其用途
公开(公告)号：US5296242A
公开(公告)日：1994-03-22
申请号：US922819
申请日：1992-07-31
申请人： Rolf Zander
发明人： Rolf Zander
IPC分类号： A61K31/19 , A61K33/00 , A61K33/10 , A61M1/14 , A61M1/16 , A61M1/28
CPC分类号： A61M1/1654 , A61K33/00
摘要： A sterilizable aqueous solution with substantially physiological values of the pH, bicarbonate concentration and CO.sub.2 partial pressure, as well as with metabolizable anions in the form of two separately stored single solutions, which are combined with one another prior to use and whereof one is a bicarbonate-free, acid solution and the other a bicarbonate-containing, alkaline solution, is characterized in that per liter of the finished solution obtained by combining the two single solutions, the acid single solution contains 7.3 mmole.+-.3% of at least one metabolizable, organic acid and the alkaline single solution 19.1 mmole.+-.3% of alkali bicarbonate and 6.1 mmole.+-.3% of alkali carbonate.
摘要翻译：具有基本生理pH值，碳酸氢盐浓度和CO2分压的可灭菌水溶液，以及两种单独存储的单一溶液形式的可代谢阴离子，它们在使用之前相互组合，并且其中一种是碳酸氢盐不含酸的溶液，另一种含碳酸氢盐的碱性溶液的特征在于每升通过组合两种单一溶液获得的成品溶液，酸性单一溶液含有7.3毫摩尔±3％的至少一种可代谢的，有机酸和碱性单溶液19.1毫摩尔碱+碳酸碱+ 3％碱金属碳酸盐和6.1毫摩尔+ 3％碱金属碳酸盐。

7. 发明授权

US4454229A Determination of the acid-base status of blood 失效
标题翻译：测定血液的酸碱状态
公开(公告)号：US4454229A
公开(公告)日：1984-06-12
申请号：US364665
申请日：1982-04-02
申请人： Rolf Zander , Hans U. Wolf
发明人： Rolf Zander , Hans U. Wolf
IPC分类号： G01N21/80 , G01N33/487 , G01N33/49 , G01N33/72 , G01N33/84
CPC分类号： G01N33/4925 , G01N33/84 , Y10T436/204998
摘要： In order to simplify the operation for determination of the acid-base status of blood, composed of the values for pH, pCO.sub.2 and the base excess BE, the base excess BE is determined through measurement of the pH-value at a pCO.sub.2 of about 0 mm Hg. The pH-values may be determined photometrically, in which case the indicator solution for measuring the actual blood-pH is an aqueous solution of 40 micromol/l bromthymol blue plus 0.2 g/l sodium dodecylsulfate plus 1% ethanol; and for measurement of the base excess BE is an aqueous solution of 65 micro mol/l naphtholphthalein plus 0.2 g/l sodium dodecylsulfate plus 15% dimethylsulfoxide, which are measured at a wavelength of 635 nm. If desired, one may use a single solution for measuring both actual blood-pH as well as the base excess BE, composed of 16 micromol/l bromthymol blue plus 34 micromol/l naphtholphthalein plus 0.15 g/l sodium dodecylsulfate, which is measured at 615 nm wavelength.
摘要翻译：为了简化用于测定pH值，pCO 2和碱过量BE的血液酸碱状态的操作，通过测定pCO 2的pH值约为0来测定碱过量BE mm Hg。 pH值可以光度测定，在这种情况下，用于测量实际血液pH值的指示剂溶液是40微摩尔/升溴百里酚蓝加0.2克/升十二烷基硫酸钠加1％乙醇的水溶液; 并且对于碱过量的测量，BE是在635nm波长下测量的65微摩尔/升萘并噻吩加0.2克/升十二烷基硫酸钠加上15％二甲基亚砜的水溶液。如果需要，可以使用单一溶液来测量实际的血液pH值以及由16微摩尔/升溴百里酚蓝加上34微摩尔/萘酚酞加0.15克/升十二烷基硫酸钠组成的碱过量的BE，其在 615 nm波长。

8. 发明申请

US20110195497A1 METHOD FOR PURIFYING MESENCHYMAL STEM CELLS 审中-公开
标题翻译：纯化细胞干细胞的方法
公开(公告)号：US20110195497A1
公开(公告)日：2011-08-11
申请号：US12946648
申请日：2010-11-15
申请人： Claudia Lange , Axel Rolf Zander
发明人： Claudia Lange , Axel Rolf Zander
IPC分类号： C12N5/0775
CPC分类号： C12N5/0663
摘要： The invention relates to a method for purifying mesenchymal stem cells, producing cells corresponding to prior art, the cells obtained being characterised by an increased proliferation capacity while maintaining the multipotency and typical antigen characteristics. To this end, mesenchymal stem cells that can be multiplied in a significantly improved manner compared to prior art are first provided and can also be differentiated, after a longer cultivation period, in three mesenchymal directions.
摘要翻译：本发明涉及一种用于纯化间充质干细胞的方法，产生与现有技术相对应的细胞，所获得的细胞的特征在于增加的增殖能力，同时保持多能性和典型的抗原特征。为此，首先提供可以与现有技术相比以显着改善的方式倍增的间充质干细胞，并且也可以在更长的培养期后，在三个间充质方向上进行区分。

9. 发明授权

US5041387A Determination of the acid-base status of blood 失效
标题翻译：测定血液的酸碱状态
公开(公告)号：US5041387A
公开(公告)日：1991-08-20
申请号：US882638
申请日：1986-07-07
申请人： Rolf Zander , Hans U. Wolf
发明人： Rolf Zander , Hans U. Wolf
IPC分类号： G01N21/80 , G01N33/487 , G01N33/49 , G01N33/72 , G01N33/84
CPC分类号： G01N33/4925 , G01N33/84 , Y10T436/204998
摘要： In order to simplify the operation for determination of the acid-base status of blood, composed of the values for pH, pCO.sub.2 and the base excess BE, the base excess BE is determined through measurement of the pH-value at a pCO.sub.2 of about 0 mn Hg. The pH-values may be determined photometrically, in which case the indicator solution for measuring the actual blood-pH is an aqueous solution of 40 micromol/l bromthymol blue plus 0.2 g/l sodium dodecylsulfate plus 1% ethanol; and for measurement of the base excess BE is an aqueous solution of 65 micro mol/l naphtholphthalein plus 0.2 g/l sodium dodecylsulfate plus 15% dimethylsulfoxide, which are measured at a wavelength of 635 nm. If desired, one may use a single solution for measuring both actual blood-pH as well as the base excess BE, composed of 16 micromol/l bromthymol blue plus 34 micromol/l naphtholphthalein plus 0.15 g/l sodium dodecylsulfate, which is measured at 615 nm wavelength.

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