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1. 发明申请

US20070026009A1 Systems and methods for identifying replikin scaffolds and uses of said replikin scaffolds 有权
标题翻译：用于鉴定复制素支架的系统和方法以及所述复制素支架的用途
公开(公告)号：US20070026009A1
公开(公告)日：2007-02-01
申请号：US11355120
申请日：2006-02-16
申请人： Samuel Bogoch , Elenore Bogoch , Samuel Bogoch , Anne-Elenore Borsanyi
发明人： Samuel Bogoch , Elenore Bogoch , Samuel Bogoch , Anne-Elenore Borsanyi
IPC分类号： A61K39/12 , A61K39/145 , C12Q1/70 , G06F19/00 , C12N7/00 , C07K14/11
CPC分类号： A61K39/015 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/215 , A61K2039/505 , A61K2039/53 , A61K2039/6081 , C07K14/005 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234 , C12N2770/20034 , G01N33/56983 , G01N2333/11 , G01N2469/10 , G06F19/22 , Y02A90/26
摘要： The present invention provides a new class of peptides related to rapid replication and high human mortality, and their use in diagnosing, preventing and treating disease including vaccines and therapeutics for emerging viral diseases and methods of identifying the new class of peptides and related structures.
摘要翻译：本发明提供了与快速复制和高人死亡率相关的新一类肽，以及它们在诊断，预防和治疗疾病中的用途，包括用于新出现的病毒疾病的疫苗和治疗剂以及鉴定新类型肽和相关结构的方法。

2. 发明授权

US09233148B2 Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza 有权
标题翻译：用于预防和治疗流感的基于复制素的化合物和分化流感中的感染性和致死性的方法
公开(公告)号：US09233148B2
公开(公告)日：2016-01-12
申请号：US12581112
申请日：2009-10-16
申请人： Samuel Bogoch , Elenore S. Bogoch , Anne Elenore Borsanyi , Samuel Winston Bogoch
发明人： Samuel Bogoch , Elenore S. Bogoch , Anne Elenore Borsanyi , Samuel Winston Bogoch
IPC分类号： A61K39/145 , C07K14/00 , C07H21/00 , A61K39/00 , C07K14/005 , C07K14/44 , C07K14/72
CPC分类号： C07K16/1018 , A61K39/00 , A61K39/0011 , A61K2039/542 , A61K2039/552 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/11 , C07K14/44 , C07K14/72 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2770/24122 , C12N2770/32022
摘要： The present invention provides methods of differentiating the infectivity and lethality of isolates of influenza virus and provides compounds for diagnosing, preventing, and treating outbreaks of influenza virus including compounds for diagnosing, preventing, and treating across different strains of influenza virus.
摘要翻译：本发明提供了区分流感病毒分离物的感染性和致死性的方法，并提供用于诊断，预防和治疗流感病毒爆发的化合物，包括用于诊断，预防和治疗不同流感病毒株的化合物。

3. 发明申请

US20140105904A1 ANTHRAX AND SMALL POX REPLIKINS AND METHODS OF USE 审中-公开
标题翻译： ANTHRAX和小POX REPLIKINS和使用方法
公开(公告)号：US20140105904A1
公开(公告)日：2014-04-17
申请号：US14026567
申请日：2013-09-13
申请人： Samuel Bogoch , Elenore S. Bogoch
发明人： Samuel Bogoch , Elenore S. Bogoch
IPC分类号： C07K16/08
CPC分类号： C07K16/081 , A61K39/00 , C07K14/005 , C12N2710/24122
摘要： Isolated peptides of the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.
摘要翻译：炭疽芽孢杆菌炭疽毒素致死致死因子蛋白质pX01-107的分离肽，肽特异性抗体和刺激受试者的免疫应答的方法以产生针对炭疽芽孢杆菌炭疽杆菌毒素致死因子蛋白质pX01-107的抗体。还公开了小型痘病毒表面抗原S前体蛋白质的分离肽，对肽有特异性的抗体以及刺激受试者的免疫应答以产生针对小痘病毒表面抗原S前体蛋白的抗体的方法。

4. 发明申请

US20130084303A1 PEPTIDES SHARED AMONG LETHAL CANCERS AND THERAPEUTIC COMPOSITIONS COMPRISING SAID PEPTIDES 审中-公开
标题翻译：肝癌组合物和包含上皮细胞的治疗组合物
公开(公告)号：US20130084303A1
公开(公告)日：2013-04-04
申请号：US13553137
申请日：2012-07-19
申请人： Samuel Bogoch , Elenore S. Bogoch , Anne Elenore Borsanyi , Samuel Winston Bogoch
发明人： Samuel Bogoch , Elenore S. Bogoch , Anne Elenore Borsanyi , Samuel Winston Bogoch
IPC分类号： A61K39/00 , C07K7/08 , C07K7/06
CPC分类号： A61K39/0011 , C07K7/06 , C07K7/08 , C07K14/4748 , C07K16/30
摘要： The present invention provides cancer peptides related to rapid replication and shared among different histological cancer types. The peptides are provided in compositions for interfering with replication in cancer, in preventive and therapeutic vaccines, and in diagnostic applications. The compositions for interfering with replication in cancer are useful for preventing and treating different histological types of cancer including ectodermic, endodermic, and mesodermic cancers as well as cancers arising in association with HIV.
摘要翻译：本发明提供了与快速复制相关的癌症肽，并且在不同的组织学癌症类型之间共享。在用于干扰癌症，预防和治疗疫苗以及诊断应用中的复制的组合物中提供了肽。用于干扰癌症复制的组合物可用于预防和治疗不同组织学类型的癌症，包括外胚层，内胚层和中胚层癌以及与HIV相关的癌症。

5. 发明授权

US07758863B2 Replikin peptides in rapid replication of glioma cells and in influenza epidemics 失效
标题翻译：复制素肽在胶质瘤细胞和流行性感冒流行中的快速复制
公开(公告)号：US07758863B2
公开(公告)日：2010-07-20
申请号：US12412888
申请日：2009-03-27
申请人： Samuel Bogoch , Elenore S. Bogoch
发明人： Samuel Bogoch , Elenore S. Bogoch
IPC分类号： A61K39/145 , C07K4/00 , C07K14/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , Y02A50/412
摘要： Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus.
摘要翻译：公开了流感病毒血凝素蛋白和恶性疟原虫疟疾抗原肽，肽特异性抗体，流感疫苗，疟疾疫苗和刺激受试者的免疫应答以产生抗流感病毒或疟疾的方法。还公开了用于制定用于流感病毒的疫苗的方法。

6. 发明申请

US20090137778A1 REPLIKIN PEPTIDES AND ANTIBODIES THEREFORE 审中-公开
标题翻译： REPLIKIN肽及其抗体
公开(公告)号：US20090137778A1
公开(公告)日：2009-05-28
申请号：US12252028
申请日：2008-10-15
申请人： Samuel BOGOCH , Elenore S. BOGOCH
发明人： Samuel BOGOCH , Elenore S. BOGOCH
IPC分类号： C07K14/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , Y02A50/412
摘要： The present invention provides a new class of peptides related to rapid replication and their use in diagnosing, preventing and treating disease.
摘要翻译：本发明提供了与快速复制相关的新一类肽及其在诊断，预防和治疗疾病中的用途。

7. 发明申请

US20060024669A1 System and method for identifying complex patterns of amino acids 有权
公开(公告)号：US20060024669A1
公开(公告)日：2006-02-02
申请号：US11116203
申请日：2005-04-28
申请人： Samuel Bogoch , Elenore Bogoch
发明人： Samuel Bogoch , Elenore Bogoch
IPC分类号： C12Q1/70 , G01N33/48 , C07H21/04 , G06F19/00 , G01N33/50 , C12N15/86
CPC分类号： G06F19/16 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , C40B30/02 , G06F19/22
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file or database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.

8. 发明授权

US5866690A Detection of malignant tumor cells 失效
标题翻译：检测恶性肿瘤细胞
公开(公告)号：US5866690A
公开(公告)日：1999-02-02
申请号：US487345
申请日：1995-06-07
申请人： Samuel Bogoch
发明人： Samuel Bogoch
IPC分类号： G01N33/574 , A61K38/00 , A61K39/395 , A61P35/00 , C07K1/22 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C12N5/08 , C12N5/10 , C12N15/09 , C12P21/00 , C12R1/91 , G01N33/577
CPC分类号： C07K16/30 , A61K38/00
摘要： Described herein is the production of two products which are distinct species of human anti-malignin antibody, and the production of a cell line which has the distinguishing characteristic of manufacturing both species of anti-malignin antibody at different times. These anti-malignin products are useful to detect the presence of cancerous or malignant tumor cells. Additionally, these anti-malignin products preferentially attach to cancerous or malignant tumor cells in cell collections in vitro or in vivo and thus can be detected by any visible or other signal emitter attached to said anti-malignin product. This preferential attachment to malignant tumor cells also makes these products useful for metabolic and therapeutic purposes with or without an attached cytotoxic agent.
摘要翻译：本文描述了两种不同种类的人类抗恶性肿瘤抗体的产品的生产，以及具有在不同时间制造两种抗恶性肿瘤抗体的区别特征的细胞系的生产。这些抗恶性肿瘤产品可用于检测癌细胞或恶性肿瘤细胞的存在。此外，这些抗恶性肿瘤产品在体外或体内优先附着于细胞集合中的癌细胞或恶性肿瘤细胞，因此可通过附着于所述抗恶性肿瘤产品的任何可见或其他信号发射体来检测。恶性肿瘤细胞的这种优先依附也使得这些产品在有或没有附着的细胞毒性剂的情况下可用于代谢和治疗目的。

9. 发明授权

US4624931A Recognins and their chemoreciprocals 失效
标题翻译：识别及其化学相互作用
公开(公告)号：US4624931A
公开(公告)日：1986-11-25
申请号：US519598
申请日：1983-10-03
申请人： Samuel Bogoch
发明人： Samuel Bogoch
IPC分类号： C07K14/47 , C07K16/18 , G01N33/574 , G01N33/544 , A61K39/00 , G01N33/53
CPC分类号： C07K14/4731 , C07K16/18 , G01N33/57488 , G01N2333/473 , Y10S435/961
摘要： The process for producing polypeptide products which are useful in tests for malignant cells is disclosed. The polypeptide products produced by this process are also disclosed. The process employs the steps of extraction of acidic fractionation and formation of a precipitate in the quantitative precipitin test and the Ouchterlony gel diffusion test. The product is characterized by being soluble in acidic solution, insoluble in basic solution, having a particular spectrophotometric absorption and an amino acid residue composition of high proportions of glutamic and aspartic acids and high ratios of glutamic and aspartic acids to histidine.
摘要翻译：公开了可用于恶性细胞试验的产生多肽产物的方法。还公开了通过该方法生产的多肽产物。该方法采用在定量沉淀试验和Ouchterlony凝胶扩散试验中提取酸性分馏和形成沉淀物的步骤。该产品的特征在于可溶于酸性溶液，不溶于碱性溶液，具有特定的分光光度吸收和高比例的谷氨酸和天冬氨酸和高比例的谷氨酸和天冬氨酸与组氨酸的氨基酸残基组合物。

10. 发明授权

US4486538A Detection of malignant tumor cells 失效
标题翻译：检测恶性肿瘤细胞
公开(公告)号：US4486538A
公开(公告)日：1984-12-04
申请号：US271645
申请日：1981-06-08
申请人： Samuel Bogoch
发明人： Samuel Bogoch
IPC分类号： G01N33/574 , A61K38/00 , A61K39/00 , A61K39/395 , C07K14/00 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/18 , C07K16/30 , C12N5/10 , C12N15/00 , C12N15/02 , C12P1/00 , C12P21/00 , C12P21/08 , C12Q1/04 , C12R1/19 , C12R1/91 , G01N33/577 , G01N33/54 , G01N33/56
CPC分类号： C07K16/30 , C07K14/4731 , C07K16/18 , C12N15/00 , C12P1/00 , G01N33/57488 , G01N33/577 , A61K38/00 , G01N2333/473 , Y10S436/804 , Y10S436/813 , Y10S436/815 , Y10S514/908 , Y10S530/809 , Y10S530/828
摘要： Described herein is the production of two products which are distinct species of anti-malignin antibody, and the production of three artificially produced species of cell each of which has the distinguishing characteristic of manufacturing either one or both species of anti-malignin antibody. These anti-malignin products are useful to detect the presence of cancerous or malignant tumor cells. These anti-malignin products attach preferentially to cancerous or malignant tumor cells in cell collections in vitro or in vivo and thus can be detected by any attached visible or other signal emitter. This preferential attachment to malignant tumor cells also makes these products useful for metabolic and therapeutic purposes.
摘要翻译：这里描述的是产生两种不同种类的抗恶性肿瘤抗体的产品，以及三种人工产生的细胞种类的生产，每种产品具有制造一种或两种抗恶性抗体的特征。这些抗恶性肿瘤产品可用于检测癌细胞或恶性肿瘤细胞的存在。这些抗恶性肿瘤产品在体外或体内在细胞集合中优先附着于癌细胞或恶性肿瘤细胞，因此可以通过任何附着的可见或其它信号发射体检测。恶性肿瘤细胞的优先依附也使得这些产品可用于代谢和治疗目的。

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