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1. 发明申请

US20120130069A1 NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT 有权
标题翻译：新颖的吲哚衍生物或其药学上可接受的盐作为蛋白激酶抑制剂用于增殖性疾病治疗，以及含有作为活性成分的药物组合物
公开(公告)号：US20120130069A1
公开(公告)日：2012-05-24
申请号：US13132772
申请日：2009-12-04
申请人： Tae Bo Sim , Jung Beom Son , Hwan Kim , Dong Sik Park , Hwan Geun Choi , Young Jin Ham , Jung Mi Hah , Kyung Ho Yoo , Chang Hyun Oh , So Ha Lee , Jae Du Ha , Sung Yun Cho , Byoung Mog Kwon , Dong Cho Han
发明人： Tae Bo Sim , Jung Beom Son , Hwan Kim , Dong Sik Park , Hwan Geun Choi , Young Jin Ham , Jung Mi Hah , Kyung Ho Yoo , Chang Hyun Oh , So Ha Lee , Jae Du Ha , Sung Yun Cho , Byoung Mog Kwon , Dong Cho Han
IPC分类号： C07D413/14 , C07D409/12 , C07D403/12 , C07D405/12 , A61P17/06 , C07D401/12 , C07D417/12 , C07D417/14 , A61P35/00 , A61P35/02 , C07D231/56 , C07D413/12
CPC分类号： C07D413/14 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.
摘要翻译：公开了由以下化学式1表示的新型吲唑衍生物或其药学上可接受的盐，水合物或溶剂合物，以及用于预防或治疗增殖性疾病的药物组合物，其含有活性成分。具有对蛋白激酶（如b-raf，KDR，Fms，Tie2，SAPK2a和Ret）的有效抑制作用，诱导由异常细胞增殖引起的疾病，该新型吲唑衍生物可用于预防或治疗由异常细胞引起的疾病增殖。

2. 发明授权

US08754209B2 Indazole derivatives or pharmaceutically acceptable salts thereof as protein kinase inhibitors for proliferative diseases treatment, and a pharmaceutical composition containing the same as an active ingredient 有权
标题翻译：作为用于增殖性疾病治疗的蛋白激酶抑制剂的吲唑衍生物或其药学上可接受的盐，以及含有该活性成分的药物组合物
公开(公告)号：US08754209B2
公开(公告)日：2014-06-17
申请号：US13132772
申请日：2009-12-04
申请人： Tae Bo Sim , Jung Beom Son , Hwan Kim , Dong Sik Park , Hwan Geun Choi , Young Jin Ham , Jung Mi Hah , Kyung Ho Yoo , Chang Hyun Oh , So Ha Lee , Jae Du Ha , Sung Yun Cho , Byoung Mog Kwon , Dong Cho Han
发明人： Tae Bo Sim , Jung Beom Son , Hwan Kim , Dong Sik Park , Hwan Geun Choi , Young Jin Ham , Jung Mi Hah , Kyung Ho Yoo , Chang Hyun Oh , So Ha Lee , Jae Du Ha , Sung Yun Cho , Byoung Mog Kwon , Dong Cho Han
IPC分类号： C07D413/14 , C07D413/12 , C07D417/12 , C07D401/12 , C07D405/12 , C07D403/12 , C07D409/12 , C07D231/56
CPC分类号： C07D413/14 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/04 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.
摘要翻译：公开了由以下化学式1表示的新型吲唑衍生物或其药学上可接受的盐，水合物或溶剂合物，以及用于预防或治疗增殖性疾病的药物组合物，其含有活性成分。具有对蛋白激酶（如b-raf，KDR，Fms，Tie2，SAPK2a和Ret）的有效抑制作用，诱导由异常细胞增殖引起的疾病，该新型吲唑衍生物可用于预防或治疗由异常细胞引起的疾病增殖。

3. 发明授权

US5953004A Device and method for controlling video muting using a microcomputer 失效
标题翻译：使用微电脑控制视频静音的装置和方法
公开(公告)号：US5953004A
公开(公告)日：1999-09-14
申请号：US785973
申请日：1997-01-22
申请人： Sung-Yun Cho
发明人： Sung-Yun Cho
IPC分类号： H04N3/24 , G06G1/04
CPC分类号： H04N3/24
摘要： A video muting control device using a microcomputer, comprising a video mute key for generating a video mute command upon activation by a user; a microcomputer connected to the video mute key, the microcomputer generating a blanking control signal in response to an input of the video muting command, a preamplifier for receiving RGB video signals, the preamplifier generating an amplified video signal in response to a clamping signal and a contrast control signal, and a video mute circuit for muting a video display in response to the blanking control signal by grounding any one of the RGB video signals, the clamping signal and the contrast control signal.
摘要翻译：一种使用微型计算机的视频静噪控制装置，包括用于在用户激活时产生视频静音命令的视频静音键; 微型计算机，连接到视频静音键，微型计算机响应于视频静音命令的输入产生消隐控制信号，用于接收RGB视频信号的前置放大器，前置放大器响应于钳位信号产生放大的视频信号，以及对比度控制信号，以及视频静音电路，用于通过对RGB视频信号，钳位信号和对比度控制信号中的任何一个进行接地，来响应于消隐控制信号来静音视频显示。

4. 发明授权

US5914402A Process for preparing 1-aryl-4-oxopyrrolo �3,2-c! quinoline derivatives 失效
标题翻译： 1-芳基-4-氧代吡咯并[3,2-c]喹啉衍生物的制备方法
公开(公告)号：US5914402A
公开(公告)日：1999-06-22
申请号：US983388
申请日：1998-01-16
申请人： Joong Kwon Choi , Sung Soo Kim , Eul Kyun Yum , Sung Yun Cho , Seung Kyu Kang
发明人： Joong Kwon Choi , Sung Soo Kim , Eul Kyun Yum , Sung Yun Cho , Seung Kyu Kang
IPC分类号： A61K31/437 , A61K31/44 , A61P1/04 , C07D471/04 , C07D491/048
CPC分类号： C07D471/04
摘要： The present invention relates to a process for preparing 1-aryl-4-oxopyrrolo�3,2-c!quinoline derivatives through reaction of 4-oxofuro�3,2-c! quinoline compounds with aniline compounds under mild conditions in a single step, wherein 1-aryl-4-oxopyrrolo�3,2-c!quinoline derivatives having various substituents may be prepared in high yield, so that the 1-aryl-4-oxopyrrolo�3,2-c!quinoline derivatives may be utilized as an intermediate for producing a reversible inhibitor of gastric acid secretion.
摘要翻译： PCT No.PCT / KR97 / 00074 Sec。 371日期1998年1月16日 102（e）日期1998年1月16日PCT提交1997年5月2日PCT公布。第WO97 / 44342号PCT公告日期1997年11月27日本发明涉及通过4-氧代呋喃并[3,2-c]喹啉化合物与温和的苯胺化合物反应制备1-芳基-4-氧代吡咯并[3,2-c]喹啉衍生物的方法可以以高产率制备具有各种取代基的1-芳基-4-氧代吡咯并[3,2-c]喹啉衍生物，使得1-芳基-4-氧代吡咯并[3,2-c] 喹啉衍生物可用作产生胃酸分泌的可逆抑制剂的中间体。

5. 发明授权

US5815361A Magnetic field shielding device in display 失效
标题翻译：磁场屏蔽装置显示
公开(公告)号：US5815361A
公开(公告)日：1998-09-29
申请号：US835056
申请日：1997-04-03
申请人： Sung-Yun Cho
发明人： Sung-Yun Cho
IPC分类号： H01J29/00 , H04N9/29 , H01F13/00
CPC分类号： H01J29/003 , H04N9/29 , H01J2229/0023 , H01J2229/0053
摘要： A magnetic field shielding device of a CRT (cathode ray tube) display includes a degaussing coil for preventing a magnetic field, generated by a voltage supplied to a deflection coil of the display, from being emitted from the display. A tilt coil maybe disposed at the middle portion of the degaussing coil so as to surround an electron gun of the cathode ray tube. The top and bottom portions of the degaussing coil are arranged so as to be horizontal. Both sides of the middle portion of the degaussing coil are bent inward so as to approach to each other, and so as to have a predetermined distance therebetween. The shielding device prevents dark color purity from being generated at the lower portion of the display.
摘要翻译： CRT（阴极射线管）显示器的磁场屏蔽装置包括用于防止由提供给显示器的偏转线圈的电压产生的磁场的消磁线圈从显示器发射。倾斜线圈可以设置在消磁线圈的中间部分，以围绕阴极射线管的电子枪。消磁线圈的顶部和底部布置成水平。消磁线圈的中间部分的两侧向内弯曲以彼此接近，并且在它们之间具有预定的距离。屏蔽装置防止在显示器的下部产生深色纯度。

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