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1. 发明授权

US08735413B2 Compound 有权
标题翻译：复合
公开(公告)号：US08735413B2
公开(公告)日：2014-05-27
申请号：US13546444
申请日：2012-07-11
申请人： Stephen Connolly , Mark Richard Ebden , Iain Alastair Stewart Walters , Thomas Langer , Alan Robert Steven , Craig Robert Stewart , Paula Margaret Tomlin , Andrew John Williams
发明人： Stephen Connolly , Mark Richard Ebden , Iain Alastair Stewart Walters , Thomas Langer , Alan Robert Steven , Craig Robert Stewart , Paula Margaret Tomlin , Andrew John Williams
IPC分类号： A01N43/54 , A61K31/505 , A61K31/506 , C07D239/56
CPC分类号： C07D403/12 , A61K31/506 , C07C65/21 , C07C69/78 , C07C69/92 , C07D205/04 , C07D239/56 , C07D307/12 , C07D317/18 , C07D317/20 , C07D317/24 , C07D317/26
摘要： There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.
摘要翻译：提供了化合物，其为（a）式（I）或（b）的嘧啶磺酰胺或其药学上可接受的盐，化合物的结晶形式，获得化合物的方法，用于制备化合物的药物中间体，和含有该化合物的药物组合物。该化合物可用于治疗调节趋化因子受体活性有益的疾病/病症。

2. 发明申请

US20100209436A1 METHOD FOR TREATING DISEASES RELATED TO MITOCHONDRIAL DYSFUNCTION 审中-公开
标题翻译：用于治疗与麻醉性功能障碍有关的疾病的方法
公开(公告)号：US20100209436A1
公开(公告)日：2010-08-19
申请号：US12667329
申请日：2008-07-02
申请人： Andreas Reichert , Stéphane Duvezin-Caubet , Johannes Wagener , Michael Zick , Thomas Langer , Mirko Koppen , Walter Neupert
发明人： Andreas Reichert , Stéphane Duvezin-Caubet , Johannes Wagener , Michael Zick , Thomas Langer , Mirko Koppen , Walter Neupert
IPC分类号： A61K39/395 , G01N33/53 , A61K31/7088 , A61K38/16 , C07H21/04 , C07K16/00 , C07K14/00 , A61P43/00
CPC分类号： C12Q1/42 , C12Q1/37 , G01N2500/04
摘要： The present invention relates to means and methods for therapeutic intervention of mitochondrial disorders or diseases, in particular to a method for the treatment, prevention and/or amelioration of a disorder or disease correlated with mitochondrial dysfunction, a mitochondrial disorder or disease or a disorder or disease characterized by an altered OPA1 processing. Thereby, a pharmaceutically active amount of a compound capable of modulating the activity of an oligomeric complex comprising Afg3I1 and/or Afg3I2 or (a) variant(s) thereof is administered to a patient in need of medical intervention. The present invention also relates to the use of an oligomeric complex comprising Afg3I1 and/or Afg3I2 or (a) variant(s) thereof for the preparation of a pharmaceutical composition for the mentioned therapeutic intervention. The present invention further relates to a method of screening for a compound capable of modulating the activity of an oligomeric complex comprising Afg3I1 and/or Afg3I2 or (a) variant(s) thereof comprising the use of OPA1.
摘要翻译：本发明涉及线粒体疾病或疾病的治疗性干预的方法和方法，特别是涉及治疗，预防和/或改善与线粒体功能障碍，线粒体疾病或疾病或病症相关的病症或疾病的方法，或以改变的OPA1处理为特征的疾病。由此，将药物活性量的能够调节包含Afg3I1和/或Afg3I2的寡聚化复合物或（a）其变体的活性的化合物给予需要医疗干预的患者。本发明还涉及包含Afg3I1和/或Afg3I2或（a）其变体的寡聚复合物在制备用于所述治疗干预的药物组合物中的用途。本发明还涉及一种筛选能够调节包含Afg3I1和/或Afg3I2的寡聚化复合物的活性的化合物或（a）包含使用OPA1的变体的化合物的方法。

3. 发明授权

US06993284B2 Interactive access to supplementary material related to a program being broadcast 有权
公开(公告)号：US06993284B2
公开(公告)日：2006-01-31
申请号：US10092045
申请日：2002-03-05
申请人： Lee S. Weinblatt , Thomas Langer
发明人： Lee S. Weinblatt , Thomas Langer
IPC分类号： H04H1/00
CPC分类号： H04H20/93 , H04H20/30 , H04H60/37 , H04H60/80 , H04H2201/40 , H04N7/17318 , H04N21/4117 , H04N21/4126 , H04N21/435 , H04N21/441 , H04N21/44222 , H04N21/4722 , H04N21/4784 , H04N21/6582 , H04N21/812
摘要： A method and apparatus for, interactively with a broadcast program that is being performed, enabling access to supplementary materials related to the program from a broadcast signal that is a combination of a programming signal and a supplementary materials signal. The broadcast output signal is received at a location of an audience. The programming signal of the received output signal is performed for the audience, with reproduction equipment. A signal related to the supplementary material signal is extracted from the received broadcast signal. Access to the supplementary material corresponding to the supplementary material signal is enabled in response to an interactive control signal actuated by a member of the audience tuned to the programming signal being performed, and based on the extracted signal.

4. 发明授权

US4719946A Method of producing a tubular woven fabric and a circular loom for carrying out the method 失效
标题翻译：生产用于实施该方法的管状织物和圆形织机的方法
公开(公告)号：US4719946A
公开(公告)日：1988-01-19
申请号：US048461
申请日：1987-05-11
申请人： Johann Buchinger , Bruno Mistlberger , Rudolf Wolf , Johann Schonberger , Thomas Langer , Johann Bloo , Kurt Vilsecker , Bruno Haider
发明人： Johann Buchinger , Bruno Mistlberger , Rudolf Wolf , Johann Schonberger , Thomas Langer , Johann Bloo , Kurt Vilsecker , Bruno Haider
IPC分类号： D03D37/00
CPC分类号： D03D37/00
摘要： For the production of a tubular woven fabric having a floats-including weave, by using a circular loom, at least two shuttles are moved through sheds formed by warp threads. The warp threads are guided through thread eyes of thread guiding organs and are lifted and lowered by the thread guiding organs to form the shed. In order to be able to produce tubular woven fabrics of different types of floats-including weaves, free warp threads, i.e., warp threads that are loosely guided through between thread guiding organs carrying neighboring warp threads, additionally run between warp threads guided by the thread guiding organs. These loose warp threads cross the opened shed approximately in the middle thereof and are lifted by a guide means arranged on at least one shuttle and, as the method proceeds, are lowered by a guide means arranged on at least one shuttle.
摘要翻译：为了生产具有包括浮体的织造的管状织物，通过使用圆形织机，至少两个梭子通过由经线形成的梭口移动。经线被导纱器的线眼引导，并被引线器官升降，形成梭口。为了能够生产不同类型的浮体（包括编织物）的管状织物，自由经线，即松散地引导通过承载相邻经线的导纱器之间的经线，另外在由螺纹引导的经线之间延伸指导器官这些松散的经线大致在其中间穿过敞开的梭口，并且通过布置在至少一个梭上的引导装置提升，并且随着该方法的进行，通过布置在至少一个梭上的引导装置降低。

5. 发明申请

US20140073563A1 FUSION PROTEINS FOR TREATING A METABOLIC SYNDROME 审中-公开
标题翻译：用于治疗代谢综合征的融合蛋白
公开(公告)号：US20140073563A1
公开(公告)日：2014-03-13
申请号：US14019735
申请日：2013-09-06
申请人： Oliver BOSCHEINEN , Matthias DREYER , Paul HABERMANN , Hans-Ludwig SCHAEFER , Mark SOMMERFELD , Thomas LANGER
发明人： Oliver BOSCHEINEN , Matthias DREYER , Paul HABERMANN , Hans-Ludwig SCHAEFER , Mark SOMMERFELD , Thomas LANGER
IPC分类号： C07K14/50 , C07K14/605
CPC分类号： C07K14/605 , A61K38/1825 , A61K38/26 , A61K47/60 , A61K2300/00 , C07K14/50 , C07K14/575 , C07K14/57563 , C07K2319/00 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/50 , C07K2319/90
摘要： The invention is directed to a fusion protein comprising at least one FGF-21 (fibroblast growth factor-21) compound and at least one GLP-1R (glucagon-like peptide-1 receptor) agonist as well as to pharmaceutical compositions, medical uses and methods of treatment involving the fusion protein, particularly in the field of diabetes, dyslipidemia, obesity and/or adipositas.
摘要翻译：本发明涉及包含至少一种FGF-21（成纤维细胞生长因子-21）化合物和至少一种GLP-1R（胰高血糖素样肽-1受体）激动剂以及药物组合物，医学用途和涉及融合蛋白的治疗方法，特别是在糖尿病，血脂异常，肥胖和/或脂肪酸领域。

6. 发明申请

US20120244152A1 NOVEL ANTAGONIST ANTIBODIES AND THEIR FAB FRAGMENTS AGAINST GPVI AND USES THEREOF 有权
标题翻译：新型拮抗剂抗体及其抗GPVI及其用途的FAB片段
公开(公告)号：US20120244152A1
公开(公告)日：2012-09-27
申请号：US13515650
申请日：2010-12-17
申请人： Nicolas Baurin , Francis Blanche , Beatrice Cameron , Carsten Corvey , Tarik Dabdoubi , Christian Engel , Peter Florian , Ingo Focken , Katja Kroll , Jochen Kruip , Christian Lange , Thomas Langer , Martin Lorenz , Vincent Mikol , Ercole Rao , Peter Wonerow
发明人： Nicolas Baurin , Francis Blanche , Beatrice Cameron , Carsten Corvey , Tarik Dabdoubi , Christian Engel , Peter Florian , Ingo Focken , Katja Kroll , Jochen Kruip , Christian Lange , Thomas Langer , Martin Lorenz , Vincent Mikol , Ercole Rao , Peter Wonerow
IPC分类号： A61K39/395 , C07K16/28 , A61P9/00 , C12P21/02 , A61P7/02 , C07K1/00 , C12N15/13
CPC分类号： C07K16/28 , A61K2039/505 , C07K1/1075 , C07K16/2803 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention discloses novel antibodies that specifically bind to the human platelet membrane protein Glycoprotein VI (GPVI) and their monovalent fragments or derivatives. The antibodies of the invention are antibodies from hybridoma clone 390 and fragment antibodies thereof able to induce a GPVI depletion pheno-type. These antibodies and Fab fragments are able to block collagen binding and thus preventing platelet activation by collagen. The invention also relates to hybridoma clones and expression plasmids for the production of disclosed antibodies and Fab fragments. The present invention further refers to the uses of monovalent antibody fragments to manufacture research, diagnostic and immunotherapeutic agents for the treatment of thrombosis and other vascular diseases. The invention also concerns a Fab bearing a molecule at the C-terminal extremity, as well as method for prevention of recognition of Fab by antibodies using such modified Fab. The invention concerns a method for prevention of platelet activation when an anti-GP VI Fab is used.
摘要翻译：本发明公开了特异性结合人血小板膜蛋白Glycoprotein VI（GPVI）及其一价片段或衍生物的新型抗体。本发明的抗体是来自杂交瘤克隆390的抗体及其能诱导GPVI消耗物质型的片段抗体。这些抗体和Fab片段能够阻断胶原结合，从而阻止胶原的血小板活化。本发明还涉及用于产生所公开的抗体和Fab片段的杂交瘤克隆和表达质粒。本发明还涉及一价抗体片段用于制备用于治疗血栓形成和其它血管疾病的研究，诊断和免疫治疗剂的用途。本发明还涉及在C-末端具有分子的Fab，以及使用这种修饰的Fab预防用抗体识别Fab的方法。本发明涉及当使用抗GP VI Fab时预防血小板活化的方法。

7. 发明授权

US07950031B2 Interactive reward associated with a broadcast 有权
标题翻译：与广播相关的互动奖励
公开(公告)号：US07950031B2
公开(公告)日：2011-05-24
申请号：US12275346
申请日：2008-11-21
申请人： Lee S. Weinblatt , Thomas Langer
发明人： Lee S. Weinblatt , Thomas Langer
IPC分类号： H04N7/16 , H04N7/10 , H04N7/025
CPC分类号： H04H20/28 , G06Q30/02 , H04H60/33 , H04H60/63 , H04N7/08 , H04N21/235 , H04N21/435 , H04N21/4784
摘要： An interactive technique for generating a supplementary, program-related output. A programming signal and a supplementary, program-related data signal are combined into a broadcast signal which is then broadcast from a program signal source. The broadcast signal is received, and the programming signal of the received broadcast signal is performed with reproduction equipment for an audience. The supplementary, program-related data signal of the received broadcast signal is stored, and retrieval of the stored supplementary, program-related data signal is enabled interactively with the programming signal being performed. In response to a control signal being actuated by a member of the audience tuned to the programming signal being performed, the stored supplementary, program-related data signal is retrieved and used to generate the supplementary, program-related output. The supplementary, program-related data signal can be used, for example, to print a reward, such as a discount coupon for purchasing a product advertised as part of the programming signal.
摘要翻译：一种用于生成辅助程序相关输出的交互技术。编程信号和辅助的与节目有关的数据信号被组合成广播信号，然后从节目信号源广播。广播信号被接收，接收到的广播信号的编程信号用观众的再现设备进行。存储所接收的广播信号的补充的与节目有关的数据信号，并且所存储的补充的与节目有关的数据信号的检索与正在执行的编程信号交互地使能。响应于由被调谐到正在执行的编程信号的受众的成员启动的控制信号，检索所存储的辅助程序相关数据信号并用于产生辅助的与程序有关的输出。补充的与程序相关的数据信号可以用于例如打印奖励，例如用于购买作为编程信号的一部分通告的产品的折扣券。

8. 发明申请

US20090077593A1 Interactive Reward Associated With A Broadcast 有权
标题翻译：与广播相关的互动奖励
公开(公告)号：US20090077593A1
公开(公告)日：2009-03-19
申请号：US12275346
申请日：2008-11-21
申请人： Lee S. Weinblatt , Thomas Langer
发明人： Lee S. Weinblatt , Thomas Langer
IPC分类号： H04N7/20
CPC分类号： H04H20/28 , G06Q30/02 , H04H60/33 , H04H60/63 , H04N7/08 , H04N21/235 , H04N21/435 , H04N21/4784
摘要： An interactive technique for generating a supplementary, program-related output. A programming signal and a supplementary, program-related data signal are combined into a broadcast signal which is then broadcast from a program signal source. The broadcast signal is received, and the programming signal of the received broadcast signal is performed with reproduction equipment for an audience. The supplementary, program-related data signal of the received broadcast signal is stored, and retrieval of the stored supplementary, program-related data signal is enabled interactively with the programming signal being performed. In response to a control signal being actuated by a member of the audience tuned to the programming signal being performed, the stored supplementary, program-related data signal is retrieved and used to generate the supplementary, program-related output. The supplementary, program-related data signal can be used, for example, to print a reward, such as a discount coupon for purchasing a product advertised as part of the programming signal.
摘要翻译：一种用于生成辅助程序相关输出的交互技术。编程信号和辅助的与节目有关的数据信号被组合成广播信号，然后从节目信号源广播。广播信号被接收，接收到的广播信号的编程信号用观众的再现设备进行。存储所接收的广播信号的补充的与节目有关的数据信号，并且所存储的补充的与节目有关的数据信号的检索与正在执行的编程信号交互地使能。响应于由被调谐到正在执行的编程信号的受众的成员启动的控制信号，检索所存储的辅助程序相关数据信号并用于产生辅助的与程序有关的输出。补充的与程序相关的数据信号可以用于例如打印奖励，例如用于购买作为编程信号的一部分通告的产品的折扣券。

9. 发明申请

US20060170903A1 Rangefinder 审中-公开
标题翻译：测距仪
公开(公告)号：US20060170903A1
公开(公告)日：2006-08-03
申请号：US11337535
申请日：2006-01-24
申请人： Shimon Aburmad , Ehud Chishinski , Thomas Langer
发明人： Shimon Aburmad , Ehud Chishinski , Thomas Langer
IPC分类号： G01C3/08
CPC分类号： G01S17/10 , G01S7/497 , G01S17/105
摘要： A range finder system for determining a range of an object. The system includes a source of laser radiation configured for transmitting a plurality of pulses, a first detector, a second detector, an optical arrangement configured for directing the pulses along an outgoing path and receiving the pulses reflected by the object along a return path. The first detector is deployed to be responsive to the pulses traveling along the outgoing path and the second detector insensitive to the reflections of the pulses from less that the minimum range. The system further includes a controller configured for shorting a connection within the second detector to make the second detector insensitive to the reflections of the pulses from less than a minimum range, and for determining the range of the object based upon a time-of-flight of one or more of the pulses based upon output signals of the first detector and the second detector.
摘要翻译：用于确定物体的范围的测距仪系统。该系统包括配置用于发送多个脉冲的激光辐射源，第一检测器，第二检测器，配置成沿着输出路径引导脉冲的光学装置，以及沿着返回路径接收被物体反射的脉冲。第一检测器被布置成响应于沿着输出路径行进的脉冲，而第二检测器响应于从小于最小范围的脉冲反射不敏感。该系统还包括控制器，该控制器被配置为使第二检测器内的连接短路，以使得第二检测器对于从小于最小范围的脉冲反射不敏感，并且用于基于飞行时间确定对象的范围基于第一检测器和第二检测器的输出信号的一个或多个脉冲。

10. 发明申请

US20060020963A1 Technique for making rewards available for an audience tuned to a broadcast 审中-公开
标题翻译：为受众广播的观众提供奖励的技术
公开(公告)号：US20060020963A1
公开(公告)日：2006-01-26
申请号：US11177112
申请日：2005-07-08
申请人： Lee Weinblatt , Thomas Langer
发明人： Lee Weinblatt , Thomas Langer
IPC分类号： H04N7/16 , H04N7/10 , H04N7/025
CPC分类号： H04H20/28 , H04H20/30 , H04H20/38 , H04H20/93 , H04H60/40 , H04H60/82 , H04N7/163 , H04N21/235 , H04N21/4117 , H04N21/435 , H04N21/4722 , H04N21/4784 , H04N21/6581 , H04N21/812 , H04N21/8352
摘要： A technique for enabling access to supplementary materials related to a program that is broadcast to a plurality of audience members. A programming signal is obtained to be used for performing the program. A supplementary material ID signal is obtained that uniquely identifies particular program-related supplementary material from among a plurality of available program-related supplementary materials, but which does not include sufficient data for printing and/or displaying such particular program-related supplementary material. The programming signal and the supplementary material ID signal are combined into an output signal that is broadcast from a broadcast signal source. At a location of each audience member, the broadcast output signal is received, the programming signal and the supplementary material ID signal are separated from the received broadcast output signal, the program is performed with the separated programming signal on reproduction equipment, the separated supplementary material ID signals received at the location during an interval of time are stored, and a control signal is generated, related to the stored supplementary material ID signals, upon actuation by the audience member at such location. At a location remote from each of the audience members, a database is provided that stores data for printing and/or displaying information related to the plurality of available program-related supplementary materials, the control signal is received and, in response thereto, stored data is retrieved from the database for printing and/or displaying information related to the stored program-related supplementary material respectively corresponding to the supplementary material ID signals, and the retrieved data is transmitted to the location from which the control signal was sent.
摘要翻译：一种用于使得能够访问与向多个观众成员广播的节目相关的辅助材料的技术。获得用于执行程序的编程信号。获得补充材料ID信号，其从多个可用的程序相关补充材料中唯一地识别特定程序相关补充材料，但是不包括用于打印和/或显示这些特定程序相关补充材料的足够数据。编程信号和辅助材料ID信号被组合成从广播信号源广播的输出信号。在每个观众成员的位置，广播输出信号被接收，编程信号和辅助材料ID信号与接收到的广播输出信号分离，在再现设备上利用分离的节目信号执行节目，分离的辅助材料存储在时间间隔期间在该位置处接收到的ID信号，并且在该位置处的受众成员启动时产生与所存储的辅助材料ID信号相关的控制信号。在远离每个观众成员的位置，提供数据库，其存储用于打印的数据和/或显示与多个可用节目相关补充材料相关的信息，接收控制信号，并响应于此存储数据从数据库检索用于打印和/或显示与分别对应于辅助材料ID信号的所存储的节目相关补充材料相关的信息，并且将检索到的数据发送到从其发送控制信号的位置。

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