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1. 发明授权

US08795224B2 System and method for providing closed loop infusion formulation delivery 有权
公开(公告)号：US08795224B2
公开(公告)日：2014-08-05
申请号：US13009531
申请日：2011-01-19
申请人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

2. 发明授权

US08777896B2 System and method for providing closed loop infusion formulation delivery 有权
标题翻译：用于提供闭环输注制剂递送的系统和方法
公开(公告)号：US08777896B2
公开(公告)日：2014-07-15
申请号：US13009519
申请日：2011-01-19
申请人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.
摘要翻译：一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。该算法计算具有比例，导数和基础速率分量的传送量。可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。交付量的安全限制可能包含在算法中。该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。生物状态由感测装置感测到，该感测装置向控制器提供信号。所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。

3. 发明申请

US20110112505A1 SYSTEM AND METHOD FOR PROVIDING CLOSED LOOP INFUSION FORMULATION DELIVERY 有权
公开(公告)号：US20110112505A1
公开(公告)日：2011-05-12
申请号：US13009508
申请日：2011-01-19
申请人： TIMOTHY J. STARKWEATHER , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： TIMOTHY J. STARKWEATHER , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

4. 发明授权

US07678071B2 Microprocessor controlled ambulatory medical apparatus with hand held communication device 有权
标题翻译：具有手持通讯装置的微处理器控制动态医疗器械
公开(公告)号：US07678071B2
公开(公告)日：2010-03-16
申请号：US10411424
申请日：2003-04-10
申请人： Ronald J. Lebel , Timothy J. Starkweather , Philip T. Weiss
发明人： Ronald J. Lebel , Timothy J. Starkweather , Philip T. Weiss
IPC分类号： A61M31/00 , A61B5/00
CPC分类号： A61M5/172 , A61B5/0002 , A61B5/14532 , A61B5/6847 , A61B2560/0209 , A61M5/14244 , A61M5/14276 , A61M5/168 , A61M5/16831 , A61M2005/14208 , A61M2205/18 , A61M2205/3507 , A61M2205/3523 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/6018 , A61M2205/8206 , A61M2207/00 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37258 , A61N1/37264 , A61N1/3727 , A61N1/37276 , A61N1/375 , G06F3/0619 , G06F3/065 , G06F3/0673 , G06F8/60 , G06F8/65 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H40/40 , Y02D10/42 , Y10S128/13 , Y10S128/903 , Y10T29/49117 , Y10T29/49826
摘要： An implantable infusion pump possesses operational functionality that is, at least in part, controlled by software operating in two processor ICs which are configured to perform some different and some duplicate functions. The pump exchanges messages with an external device via telemetry. Each processor controls a different part of the drug infusion mechanism such that both processors must agree on the appropriateness of drug delivery for infusion to occur. Delivery accumulators are incremented and decremented with delivery requests and with deliveries made. When accumulated amounts reach or exceed, quantized deliverable amounts, infusion is made to occur. The accumulators are capable of being incremented by two or more independent types of delivery requests. Operational modes of the infusion device are changed automatically in view of various system errors that are trapped, various system alarm conditions that are detected, and when excess periods of time lapse between pump and external device interactions.
摘要翻译：可植入输注泵具有至少部分地由两个处理器IC中的软件操作控制的操作功能，这两个处理器IC被配置为执行一些不同的和一些重复的功能。泵通过遥测与外部设备交换信息。每个处理器控制药物输注机制的不同部分，使得两个处理器必须就药物输送的合适性达成一致以进行输注。交货累加器随着交货请求和交货而递增递减。当累积量达到或超过量化的可交付量时，进行输液。累加器能够通过两种或多种独立类型的递送请求递增。考虑到被捕获的各种系统错误，检测到的各种系统报警条件以及泵和外部设备相互作用之间的超时间时间，输液装置的操作模式自动改变。

5. 发明授权

US06958705B2 Microprocessor controlled ambulatory medical apparatus with hand held communication device 有权
标题翻译：具有手持通讯装置的微处理器控制动态医疗器械
公开(公告)号：US06958705B2
公开(公告)日：2005-10-25
申请号：US09768193
申请日：2001-01-22
申请人： Ronald J. Lebel , Varaz Shahmirian , Sam W. Bowman, IV , Timothy J. Starkweather
发明人： Ronald J. Lebel , Varaz Shahmirian , Sam W. Bowman, IV , Timothy J. Starkweather
IPC分类号： A61K9/22 , A61M5/142 , A61M5/168 , A61M5/172 , A61N1/372 , A61N1/375 , G06F9/445 , G06F19/00 , G08C19/00
CPC分类号： A61M5/172 , A61B5/0002 , A61B5/14532 , A61B5/6847 , A61B2560/0209 , A61M5/14244 , A61M5/14276 , A61M5/168 , A61M5/16831 , A61M2005/14208 , A61M2205/18 , A61M2205/3507 , A61M2205/3523 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/6018 , A61M2205/8206 , A61M2207/00 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37258 , A61N1/37264 , A61N1/3727 , A61N1/37276 , A61N1/375 , G06F3/0619 , G06F3/065 , G06F3/0673 , G06F8/60 , G06F8/65 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H40/40 , Y02D10/42 , Y10S128/13 , Y10S128/903 , Y10T29/49117 , Y10T29/49826
摘要： An implantable infusion pump possesses operational functionality that is, at least in part, controlled by software operating in two processor ICs which are configured to perform some different and some duplicate functions. The pump exchanges messages with an external device via telemetry. Each processor controls a different part of the drug infusion mechanism such that both processors must agree on the appropriateness of drug delivery for infusion to occur. Delivery accumulators are incremented and decremented with delivery requests and with deliveries made. When accumulated amounts reach or exceed, quantized deliverable amounts, infusion is made to occur. The accumulators are capable of being incremented by two or more independent types of delivery requests. Operational modes of the infusion device are changed automatically in view of various system errors that are trapped, various system alarm conditions that are detected, and when excess periods of time lapse between pump and external device interactions.
摘要翻译：可植入输注泵具有至少部分地由两个处理器IC中的软件操作控制的操作功能，这两个处理器IC被配置为执行一些不同的和一些重复的功能。泵通过遥测与外部设备交换信息。每个处理器控制药物输注机制的不同部分，使得两个处理器必须就药物输送的合适性达成一致以进行输注。交货累加器随着交货请求和交货而递增递减。当累积量达到或超过量化的可交付量时，进行输液。累加器能够通过两种或多种独立类型的递送请求递增。考虑到被捕获的各种系统错误，检测到的各种系统报警条件以及泵和外部设备相互作用之间的超时间时间，输液装置的操作模式自动改变。

6. 发明授权

US06811534B2 Ambulatory medical apparatus and method using a telemetry system with predefined reception listening periods 有权
公开(公告)号：US06811534B2
公开(公告)日：2004-11-02
申请号：US09768205
申请日：2001-01-22
申请人： Sam W. Bowman, IV , Ronald J. Lebel , Varaz Shahmirian , Timothy J. Starkweather , Philip T. Weiss , Daniel H. Villegas , Robert C. Dennard , John T. Armstrong , John D. Richert
发明人： Sam W. Bowman, IV , Ronald J. Lebel , Varaz Shahmirian , Timothy J. Starkweather , Philip T. Weiss , Daniel H. Villegas , Robert C. Dennard , John T. Armstrong , John D. Richert
IPC分类号： A61B500
CPC分类号： A61M5/172 , A61B5/0002 , A61B5/14532 , A61B5/6847 , A61B2560/0209 , A61M5/14244 , A61M5/14276 , A61M5/168 , A61M5/16831 , A61M2005/14208 , A61M2205/18 , A61M2205/3507 , A61M2205/3523 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/6018 , A61M2205/8206 , A61M2207/00 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37258 , A61N1/37264 , A61N1/3727 , A61N1/37276 , A61N1/375 , G06F3/0619 , G06F3/065 , G06F3/0673 , G06F8/60 , G06F8/65 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H40/40 , Y02D10/42 , Y10S128/13 , Y10S128/903 , Y10T29/49117 , Y10T29/49826
摘要： An implanted medical device (e.g. infusion pump) and an external device communicate with one another via telemetry messages that are receivable only during windows or listening periods. Each listening period is open for a prescribed period of time and is spaced from successive listening periods by an interval. The prescribed period of time is typically kept small to minimize power consumption. To increase likelihood of successful communication, the window may be forced to an open state, by use of an attention signal, in anticipation of an incoming message. To further minimize power consumption, it is desirable to minimize use of extended attention signals, which is accomplished by the transmitter maintaining an estimate of listening period start times and attempting to send messages only during listening periods. In the communication device, the estimate is updated as a result of information obtained with the reception of each message from the medical device.

7. 发明授权

US06811533B2 Ambulatory medical apparatus and method using a robust communication protocol 有权
标题翻译：动态医疗设备和方法使用健壮的通信协议
公开(公告)号：US06811533B2
公开(公告)日：2004-11-02
申请号：US09768035
申请日：2001-01-22
申请人： Ronald J. Lebel , Varaz Shahmirian , Sam W. Bowman, IV , Timothy J. Starkweather , Philip T. Weiss , Robert C. Dennard , John T. Armstrong , John D. Richert
发明人： Ronald J. Lebel , Varaz Shahmirian , Sam W. Bowman, IV , Timothy J. Starkweather , Philip T. Weiss , Robert C. Dennard , John T. Armstrong , John D. Richert
IPC分类号： A61B500
CPC分类号： A61M5/172 , A61B5/0002 , A61B5/14532 , A61B5/6847 , A61B2560/0209 , A61M5/14244 , A61M5/14276 , A61M5/168 , A61M5/16831 , A61M2005/14208 , A61M2205/18 , A61M2205/3507 , A61M2205/3523 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/6018 , A61M2205/8206 , A61M2207/00 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37258 , A61N1/37264 , A61N1/3727 , A61N1/37276 , A61N1/375 , G06F3/0619 , G06F3/065 , G06F3/0673 , G06F8/60 , G06F8/65 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H40/40 , Y02D10/42 , Y10S128/13 , Y10S128/903 , Y10T29/49117 , Y10T29/49826
摘要： An implanted medical device (e.g. infusion pump) and external device communicate with one another via telemetry wherein messages are transmitted under a robust communication protocol. The communication protocol gives enhanced assurance concerning the integrity of messages that impact medical operations of the implantable device. Messages are transmitted using a multipart format that includes a preamble, a frame sync, a telemetry ID, data, and a validation code. The data portion of the message includes an op-code that dictates various other elements that form part of the message. The data portion may also include additional elements such as sequence numbers, bolus numbers, and duplicate data elements. A telemetry ID for the transmitting device may be implicitly embedded in the message as part of the validation code that is sent with the message and that must be pre-known by the receiver to confirm the integrity of the received message.
摘要翻译：植入式医疗设备（例如输液泵）和外部设备通过遥测来彼此通信，其中消息在鲁棒的通信协议下传输。通信协议增强了对影响可植入设备的医疗操作的消息的完整性的保证。使用包括前导码，帧同步，遥测ID，数据和验证码的多部分格式发送消息。消息的数据部分包括指示形成消息的一部分的各种其他元素的操作码。数据部分还可以包括附加元件，例如序列号，推注号和重复数据元素。用于发送设备的遥测ID可以隐式地嵌入消息中，作为与消息一起发送的确认代码的一部分，并且必须由接收者预先知道用于确认接收到的消息的完整性。

8. 发明授权

US06694191B2 Ambulatory medical apparatus and method having telemetry modifiable control software 有权
标题翻译：具有遥测可修改控制软件的动态医疗设备和方法
公开(公告)号：US06694191B2
公开(公告)日：2004-02-17
申请号：US09768201
申请日：2001-01-22
申请人： Timothy J. Starkweather , Ronald J. Lebel , Varaz Shahmirian , Philip T. Weiss , David J. Marsh
发明人： Timothy J. Starkweather , Ronald J. Lebel , Varaz Shahmirian , Philip T. Weiss , David J. Marsh
IPC分类号： A61N100
CPC分类号： A61M5/172 , A61B5/0002 , A61B5/14532 , A61B5/6847 , A61B2560/0209 , A61M5/14244 , A61M5/14276 , A61M5/168 , A61M5/16831 , A61M2005/14208 , A61M2205/18 , A61M2205/3507 , A61M2205/3523 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/6018 , A61M2205/8206 , A61M2207/00 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37258 , A61N1/37264 , A61N1/3727 , A61N1/37276 , A61N1/375 , G06F3/0619 , G06F3/065 , G06F3/0673 , G06F8/60 , G06F8/65 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H40/40 , Y02D10/42 , Y10S128/13 , Y10S128/903 , Y10T29/49117 , Y10T29/49826
摘要： An implanted medical device (e.g. infusion pump) and handheld communication device wherein the implantable device is capable of operating under control of different software programs, wherein a first program operates after resetting the implantable device and is not capable of providing significant medical functionality but is capable of selected telemetry operations including telemetry operations that allow replacement software to be downloaded, and wherein a second program may be caused to take control of the device and is capable of significant medical functionality and selected telemetry operations but is incapable of receiving replacement software. A software image may be received in multiple messages where each message is provided with its own validation code and wherein a validation code for the whole image is provided and wherein each provided validation code must compared to a derived validation code prior to accepting the validity of the replacement software.
摘要翻译：植入医疗装置（例如输液泵）和手持通信装置，其中可植入装置能够在不同软件程序的控制下操作，其中第一程序在复位可植入装置之后运行，并且不能提供重要的医疗功能，但是能够选择的遥测操作，包括允许下载替换软件的遥测操作，并且其中可以引起第二程序来控制该设备，并且能够进行重大的医疗功能和选择的遥测操作，但是不能接收替换软件。可以在多个消息中接收软件图像，其中每个消息被提供有其自己的验证码，并且其中提供整个图像的验证码，并且其中每个提供的验证码必须在接受所述验证码的有效性之前与导出的验证码进行比较更换软件。

9. 发明授权

US06687546B2 Ambulatory medical apparatus and method using a robust communication protocol 有权
公开(公告)号：US06687546B2
公开(公告)日：2004-02-03
申请号：US09768202
申请日：2001-01-22
申请人： Ronald J. Lebel , Varaz Shahmirian , Sam W. Bowman, IV , Timothy J. Starkweather , Philip T. Weiss , Robert C. Dennard , John T. Armstrong , John D. Richert
发明人： Ronald J. Lebel , Varaz Shahmirian , Sam W. Bowman, IV , Timothy J. Starkweather , Philip T. Weiss , Robert C. Dennard , John T. Armstrong , John D. Richert
IPC分类号： A61B500
CPC分类号： A61M5/172 , A61B5/0002 , A61B5/14532 , A61B5/6847 , A61B2560/0209 , A61M5/14244 , A61M5/14276 , A61M5/168 , A61M5/16831 , A61M2005/14208 , A61M2205/18 , A61M2205/3507 , A61M2205/3523 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/6018 , A61M2205/8206 , A61M2207/00 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37258 , A61N1/37264 , A61N1/3727 , A61N1/37276 , A61N1/375 , G06F3/0619 , G06F3/065 , G06F3/0673 , G06F8/60 , G06F8/65 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H40/40 , Y02D10/42 , Y10S128/13 , Y10S128/903 , Y10T29/49117 , Y10T29/49826
摘要： An implanted medical device (e.g. infusion pump) and external device communicate with one another via telemetry wherein messages are transmitted under a robust communication protocol. The communication protocol gives enhanced assurance concerning the integrity of messages that impact medical operations of the implantable device. Messages are transmitted using a multipart format that includes a preamble, a frame sync, a telemetry ID, data, and a validation code. The data portion of the message includes an op-code that dictates various other elements that form part of the message. The data portion may also include additional elements such as sequence numbers, bolus numbers, and duplicate data elements. A telemetry ID for the transmitting device may be implicitly embedded in the message as part of the validation code that is sent with the message and that must be pre-known by the receiver to confirm the integrity of the received message.

10. 发明授权

US6161043A Implantable cardiac device having event recording capability with compression 有权
标题翻译：具有压缩事件记录能力的可植入心脏装置
公开(公告)号：US6161043A
公开(公告)日：2000-12-12
申请号：US255140
申请日：1999-02-22
申请人： Kelly H. McClure , Gabriel Mouchawar , Timothy J. Starkweather , James D. Causey, III
发明人： Kelly H. McClure , Gabriel Mouchawar , Timothy J. Starkweather , James D. Causey, III
IPC分类号： A61B5/00 , A61N1/365 , A61N1/37 , A01B5/0452
CPC分类号： A61B5/0006 , A61B5/7232 , A61N1/36542 , A61N1/3702
摘要： An implantable cardiac device is disclosed having a converter that provides a digital electrocardiogram signal to a controller which is stored in memory or transmitted via the telemetry circuit in an improved compressed fashion. The improved compression scheme comprises sampling the electrogram signal, transmitting the starting value in an uncompressed format followed by a plurality of delta signals in a compressed format. The delta signals may be determined by subtracting successive signals or by subtracting a predicted value from the current value. In either case, the delta signal is then transmitted in a truncated number of bits, e.g., 2 or 4 bits. When the delta signal is too large to be represented in the compressed number of bits, the controller then provides an indicator signal followed by the delta signal in the uncompressed format. In addition, whenever successive delta signals are below a minimum threshold (e.g., zero), they may be compressed into a count.
摘要翻译：公开了一种可植入心脏装置，其具有向控制器提供数字心电图信号的转换器，该控制器存储在存储器中或者以经改进的压缩方式通过遥测电路传输。改进的压缩方案包括对电描记图信号进行采样，以未压缩格式发送起始值，然后以压缩格式传送多个delta信号。 Δ信号可以通过减去连续信号或从当前值减去预测值来确定。在任一种情况下，然后以截断的位数（例如2或4位）发送增量信号。当增量信号太大而不能在压缩位数中表示时，控制器随后以未压缩格式提供指示符信号，后跟增量信号。此外，每当连续的delta信号低于最小阈值（例如，零）时，它们可以被压缩成计数。

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