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1. 发明申请

US20110184380A1 SYSTEM AND METHOD FOR PROVIDING CLOSED LOOP INFUSION FORMULATION DELIVERY 有权
标题翻译：用于提供封闭环路输注配方交付的系统和方法
公开(公告)号：US20110184380A1
公开(公告)日：2011-07-28
申请号：US13009531
申请日：2011-01-19
申请人： TIMOTHY J. STARKWEATHER , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： TIMOTHY J. STARKWEATHER , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.
摘要翻译：一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。该算法计算具有比例，导数和基础速率分量的传送量。可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。交付量的安全限制可能包含在算法中。该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。生物状态由感测装置感测到，该感测装置向控制器提供信号。所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。

2. 发明申请

US20110112506A1 SYSTEM AND METHOD FOR PROVIDING CLOSED LOOP INFUSION FORMULATION DELIVERY 有权
公开(公告)号：US20110112506A1
公开(公告)日：2011-05-12
申请号：US13009519
申请日：2011-01-19
申请人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

3. 发明授权

US06740072B2 System and method for providing closed loop infusion formulation delivery 有权
标题翻译：用于提供闭环输注制剂递送的系统和方法
公开(公告)号：US06740072B2
公开(公告)日：2004-05-25
申请号：US10033173
申请日：2001-12-26
申请人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M3100
CPC分类号： A61M5/14276 , A61M5/172 , A61M5/1723 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/50
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.
摘要翻译：一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。该算法计算具有比例，导数和基础速率分量的传送量。可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。交付量的安全限制可能包含在算法中。该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。生物状态由感测装置感测到，该感测装置向控制器提供信号。所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。

4. 发明授权

US08795224B2 System and method for providing closed loop infusion formulation delivery 有权
公开(公告)号：US08795224B2
公开(公告)日：2014-08-05
申请号：US13009531
申请日：2011-01-19
申请人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

5. 发明授权

US08777896B2 System and method for providing closed loop infusion formulation delivery 有权
标题翻译：用于提供闭环输注制剂递送的系统和方法
公开(公告)号：US08777896B2
公开(公告)日：2014-07-15
申请号：US13009519
申请日：2011-01-19
申请人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.
摘要翻译：一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。该算法计算具有比例，导数和基础速率分量的传送量。可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。交付量的安全限制可能包含在算法中。该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。生物状态由感测装置感测到，该感测装置向控制器提供信号。所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。

6. 发明申请

US20110112505A1 SYSTEM AND METHOD FOR PROVIDING CLOSED LOOP INFUSION FORMULATION DELIVERY 有权
公开(公告)号：US20110112505A1
公开(公告)日：2011-05-12
申请号：US13009508
申请日：2011-01-19
申请人： TIMOTHY J. STARKWEATHER , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： TIMOTHY J. STARKWEATHER , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

7. 发明授权

US08784369B2 System and method for providing closed loop infusion formulation delivery 有权
公开(公告)号：US08784369B2
公开(公告)日：2014-07-22
申请号：US13009508
申请日：2011-01-19
申请人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

8. 发明授权

US08152789B2 System and method for providing closed loop infusion formulation delivery 有权
标题翻译：用于提供闭环输注制剂递送的系统和方法
公开(公告)号：US08152789B2
公开(公告)日：2012-04-10
申请号：US10850637
申请日：2004-05-20
申请人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.
摘要翻译：一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。该算法计算具有比例，导数和基础速率分量的传送量。可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。交付量的安全限制可能包含在算法中。该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。生物状态由感测装置感测到，该感测装置向控制器提供信号。所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。

9. 发明申请

US20110270045A1 MICROPROCESSOR CONTROLLED AMBULATORY MEDICAL APPARATUS WITH HAND HELD COMMUNICATION DEVICE 审中-公开
标题翻译：微处理器控制医疗设备手持通信设备
公开(公告)号：US20110270045A1
公开(公告)日：2011-11-03
申请号：US12902038
申请日：2010-10-11
申请人： Ronald J. Lebel , Timothy J. Starkweather , Philip T. Weiss
发明人： Ronald J. Lebel , Timothy J. Starkweather , Philip T. Weiss
IPC分类号： A61M5/172 , A61M5/142 , B23P11/00 , A61B5/00
CPC分类号： A61M5/172 , A61B5/0002 , A61B5/14532 , A61B5/6847 , A61B2560/0209 , A61M5/14244 , A61M5/14276 , A61M5/168 , A61M5/16831 , A61M2005/14208 , A61M2205/18 , A61M2205/3507 , A61M2205/3523 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/6018 , A61M2205/8206 , A61M2207/00 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37258 , A61N1/37264 , A61N1/3727 , A61N1/37276 , A61N1/375 , G06F3/0619 , G06F3/065 , G06F3/0673 , G06F8/60 , G06F8/65 , G06F19/3468 , G06Q50/22 , G16H40/40 , Y02D10/42 , Y10S128/13 , Y10S128/903 , Y10T29/49117 , Y10T29/49826
摘要： An implantable infusion pump possesses operational functionality that is, at least in part, controlled by software operating in two processor ICs which are configured to perform some different and some duplicate functions. The pump exchanges messages with an external device via telemetry. Each processor controls a different part of the drug infusion mechanism such that both processors must agree on the appropriateness of drug delivery for infusion to occur. Delivery accumulators are incremented and decremented with delivery requests and with deliveries made. When accumulated amounts reach or exceed, quantized deliverable amounts, infusion is made to occur. The accumulators are capable of being incremented by two or more independent types of delivery requests. Operational modes of the infusion device are changed automatically in view of various system errors that are trapped, various system alarm conditions that are detected, and when excess periods of time lapse between pump and external device interactions.
摘要翻译：可植入输注泵具有至少部分地由两个处理器IC中的软件操作控制的操作功能，这两个处理器IC被配置为执行一些不同的和一些重复的功能。泵通过遥测与外部设备交换信息。每个处理器控制药物输注机制的不同部分，使得两个处理器必须就药物输送的合适性达成一致以进行输注。交货累加器随着交货请求和交货而递增递减。当累积量达到或超过量化的可交付量时，进行输液。累加器能够通过两种或多种独立类型的递送请求递增。考虑到被捕获的各种系统错误，检测到的各种系统报警条件以及泵和外部设备相互作用之间的超时间时间，输液装置的操作模式自动改变。

10. 发明授权

US06585644B2 Ambulatory medical apparatus and method using a telemetry system with predefined reception listening periods 有权
标题翻译：使用具有预定义的接收听觉周期的遥测系统的动态医疗装置和方法
公开(公告)号：US06585644B2
公开(公告)日：2003-07-01
申请号：US09768203
申请日：2001-01-22
申请人： Ronald J. Lebel , Varaz Shahmirian , Timothy J. Starkweather , Philip T. Weiss , Daniel H. Villegas , Robert C. Dennard , John T. Armstrong , John D. Richert
发明人： Ronald J. Lebel , Varaz Shahmirian , Timothy J. Starkweather , Philip T. Weiss , Daniel H. Villegas , Robert C. Dennard , John T. Armstrong , John D. Richert
IPC分类号： A61B500
CPC分类号： A61M5/172 , A61B5/0002 , A61B5/14532 , A61B5/6847 , A61B2560/0209 , A61M5/14244 , A61M5/14276 , A61M5/168 , A61M5/16831 , A61M2005/14208 , A61M2205/18 , A61M2205/3507 , A61M2205/3523 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/6018 , A61M2205/8206 , A61M2207/00 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37258 , A61N1/37264 , A61N1/3727 , A61N1/37276 , A61N1/375 , G06F3/0619 , G06F3/065 , G06F3/0673 , G06F8/60 , G06F8/65 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H40/40 , Y02D10/42 , Y10S128/13 , Y10S128/903 , Y10T29/49117 , Y10T29/49826
摘要： An implanted medical device (e.g. infusion pump) and an external device communicate with one another via telemetry messages that are receivable only during windows or listening periods. Each listening period is open for a prescribed period of time and is spaced from successive listening periods by an interval. The prescribed period of time is typically kept small to minimize power consumption. To increase likelihood of successful communication, the window may be forced to an open state, by use of an attention signal, in anticipation of an incoming message. To further minimize power consumption, it is desirable to minimize use of extended attention signals, which is accomplished by the transmitter maintaining an estimate of listening period start times and attempting to send messages only during listening periods. In the communication device, the estimate is updated as a result of information obtained with the reception of each message from the medical device.
摘要翻译：植入式医疗装置（例如输液泵）和外部装置通过仅在窗口或收听期间可接收的遥测信息相互通信。每个聆听期间开放一段规定的时间段，并且与连续的收听周期间隔一段间隔。规定的时间段通常保持较小以最小化功耗。为了增加成功通信的可能性，可以通过使用注意信号将窗口强制为打开状态，以预期传入的消息。为了进一步最小化功率消耗，期望最小化延长的注意信号的使用，其由发射机维持听觉周期开始时间的估计并且仅在听音周期期间尝试发送消息来实现。在通信装置中，作为来自医疗装置的每个消息的接收获得的信息的结果，更新估计。

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