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1. 发明申请

US20170121421A1 ANTIBODY CONJUGATES COMPRISING TOLL-LIKE RECEPTOR AGONIST 审中-公开
公开(公告)号：US20170121421A1
公开(公告)日：2017-05-04
申请号：US15333285
申请日：2016-10-25
申请人： Alex CORTEZ , Bernhard Hubert GEIERSTANGER , Timothy Z. HOFFMAN , Shailaja KASIBHATLA , Tetsuo UNO , Xing WANG , Tom Yao-Hsiang WU
发明人： Alex CORTEZ , Bernhard Hubert GEIERSTANGER , Timothy Z. HOFFMAN , Shailaja KASIBHATLA , Tetsuo UNO , Xing WANG , Tom Yao-Hsiang WU
IPC分类号： C07K16/32 , C07K16/28 , C07H15/26 , A61K47/48 , C07D487/04
摘要： Provided herein are antibody conjugates comprising toll-like receptor agonists and the use of such conjugates for the treatment of cancer. In some embodiments, the conjugates comprise anti-HER2 antibodies.

2. 发明授权

US08927281B2 Method for expanding hematopoietic stem cells 有权
标题翻译：扩大造血干细胞的方法
公开(公告)号：US08927281B2
公开(公告)日：2015-01-06
申请号：US12608946
申请日：2009-10-29
申请人： Anthony E. Boitano , Michael Cooke , Shifeng Pan , Peter G. Schultz , John Tellew , Yongqin Wan , Xing Wang
发明人： Anthony E. Boitano , Michael Cooke , Shifeng Pan , Peter G. Schultz , John Tellew , Yongqin Wan , Xing Wang
IPC分类号： C12N5/00 , C12N5/0789 , C07D487/04 , C07D473/34 , C07D473/16 , A61K38/00 , C07D495/04
CPC分类号： A61K35/28 , A61K9/0019 , A61K31/52 , A61K38/00 , A61K2035/124 , C07D473/16 , C07D473/34 , C07D487/04 , C07D495/04 , C12N5/0647 , C12N2501/38 , C12N2501/60
摘要： The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
摘要翻译：本发明涉及用于扩增用于移植的CD34 +细胞数量的化合物和组合物。本发明还涉及包含扩大的造血干细胞（HSCs）的细胞群及其在自体或同种异体移植中用于治疗遗传性免疫缺陷和自身免疫性疾病和多种造血障碍的患者的细胞群，以重建造血细胞谱系和免疫系统防御。

3. 发明申请

US20130143899A1 COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS 有权
标题翻译：作为蛋白激酶抑制剂的化合物和组合物
公开(公告)号：US20130143899A1
公开(公告)日：2013-06-06
申请号：US13577209
申请日：2011-02-04
申请人： Shifeng Pan , John E. Tellew , Yongqin Wan , Yongping Xie , Xing Wang , Xia Wang , Shenlin Huang , Zuosheng Liu , Qiong Zhang
发明人： Shifeng Pan , John E. Tellew , Yongqin Wan , Yongping Xie , Xing Wang , Xia Wang , Shenlin Huang , Zuosheng Liu , Qiong Zhang
IPC分类号： C07D471/04 , A61K45/06 , A61K31/444 , A61K31/519 , C07D401/14 , A61K31/506
CPC分类号： C07D471/04 , A61K31/444 , A61K31/506 , A61K31/519 , A61K45/06 , C07D401/14
摘要： The invention provides a novel class of compounds of Formula (I) (wherein A, Y, R2, R3, R4 and R5 are defined in the summary of the invention), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译：本发明提供了一类新颖的式（I）化合物（其中A，Y，R 2，R 3，R 4和R 5在本发明概述中定义），包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症，特别是涉及B-Raf异常活化的疾病或病症。

4. 发明申请

US20120053143A1 TRIACETYL-3-HYDROXYPHENYLADENOSINE AND ITS USE FOR REGULATING BLOOD FAT 有权
标题翻译：三硝基-3-羟基苯基腺苷及其用于调节血液脂肪
公开(公告)号：US20120053143A1
公开(公告)日：2012-03-01
申请号：US13255153
申请日：2009-03-10
申请人： Haibo Zhu , Song Wu , Linghua Hao , Kai Qu , Ping Zhu , Xing Wang , Wei Li
发明人： Haibo Zhu , Song Wu , Linghua Hao , Kai Qu , Ping Zhu , Xing Wang , Wei Li
IPC分类号： A61K31/7076 , C07H1/00 , A61P3/06 , C07H19/167
CPC分类号： A61K31/7076 , C07H19/167
摘要： The invention discloses triacetyl-3-hydroxyphenyladenosine represented by formula (I), the preparation, the pharmaceutical composition and the use thereof. Specially, the invention discloses a new compound of 2′,3′,5′-tri-O-acetyl-N6-(3-hydroxyphenyl)adenosine. Using hypoxanthine nucleoside as starting material, the compound is prepared by acetylating with acetic anhydride, chlorinating with thionyl chloride, and being substituted with 3-hydroxy aniline. The invention also discloses the pharmaceutical composition comprising triacetyl-3-hydroxyphenyladenosine. The dosage forms of the said pharmaceutical composition include tablet, capsule, pill, injection, sustained release preparation, controlled release preparation or particulate delivery system. The medicament for treatment or precaution of hyperlipemia prepared by the compound of the invention has the advantages of significant hypolipidemic activity, less toxicity and adverse effect as well as slow metabolism in vivo.
摘要翻译：本发明公开了由式（I）表示的三乙酰基-3-羟基苯基腺苷，其制备方法，药物组合物及其用途。特别地，本发明公开了一种新的2'，3'，5'-三-O-乙酰基-N6-（3-羟基苯基）腺苷化合物。使用次黄嘌呤核苷作为起始原料，该化合物通过用乙酸酐乙酰化制备，用亚硫酰氯氯化，并被3-羟基苯胺取代。本发明还公开了包含三乙酰基-3-羟基苯基腺苷的药物组合物。所述药物组合物的剂型包括片剂，胶囊，丸剂，注射剂，缓释制剂，控制释放制剂或颗粒递送系统。用于治疗或预防本发明化合物制备的高脂血症的药物具有明显的降血脂活性，较低毒性和不良反应以及体内代谢缓慢的优点。

5. 发明申请

US20110076694A1 METHOD OF ASSESSING MAMMALIAN EMBRYO QUALITY 审中-公开
标题翻译：评估MAMMALIAN EMBRYO质量的方法
公开(公告)号：US20110076694A1
公开(公告)日：2011-03-31
申请号：US12920670
申请日：2009-03-05
申请人： Gerald M. Kidder , Hong-Xing Wang , Dan Tong , Francis R. Tekpetey
发明人： Gerald M. Kidder , Hong-Xing Wang , Dan Tong , Francis R. Tekpetey
IPC分类号： G01N33/53 , C12Q1/02
CPC分类号： G01N33/56966 , G01N33/5091 , G01N2333/705
摘要： A method of assessing the health of each oocyte or embryo of a mammal from a plurality of oocytes/embryos of the mammal is provided. The method comprises the steps of: measuring gap junctional coupling strength or connexin43 expression of follicular cells associated with each oocyte; and identifying the gap junctional coupling strength/connexin43 expression of follicular cells associated with each oocyte, wherein the greater the coupling strength/connexin43 expression of follicular cells associated with an oocyte relative to the coupling strength/connexin43 expression of follicular cells associated with each other oocyte, the healthier the oocyte and the embryo resulting from that oocyte. Kits for conducting these methods are also provided.
摘要翻译：提供了一种从哺乳动物的多个卵母细胞/胚胎评估哺乳动物的每个卵母细胞或胚胎的健康状况的方法。该方法包括以下步骤：测量与每个卵母细胞相关的滤泡细胞的间隙连接耦合强度或连接蛋白43表达; 并鉴定与每个卵母细胞相关的滤泡细胞的间隙连接耦合强度/连接蛋白43表达，其中与卵母细胞相关的滤泡细胞的耦合强度/连接蛋白43表达相对于与彼此卵母细胞相关的滤泡细胞的偶联强度/连接蛋白43表达越大，由卵母细胞产生的卵母细胞和胚胎更健康。还提供了用于进行这些方法的套件。

6. 发明申请

US20110037375A1 CARBON FILM HAVING SHAPE SUITABLE FOR FIELD EMISSION 有权
标题翻译：具有适用于场发射的形状的碳膜
公开(公告)号：US20110037375A1
公开(公告)日：2011-02-17
申请号：US12912303
申请日：2010-10-26
申请人： Masanori HABA , Nan Jiang , Hong-Xing Wang , Akio Hiraki
发明人： Masanori HABA , Nan Jiang , Hong-Xing Wang , Akio Hiraki
IPC分类号： H01J1/304
CPC分类号： H01J1/304 , H01J2329/00
摘要： A carbon film of the present invention has an elongated needle shape whose radius decreases toward a tip. The shape is, preferably, a shape in which a field concentration coefficient β in the Fowler-Nordheim equation is expressed by h/r where r denotes the radius in an arbitrary position and h denotes height from the arbitrary position to the tip.
摘要翻译：本发明的碳膜具有朝向尖端的半径减小的细长针状。形状优选为场浓度系数＆bgr; 在Fowler-Nordheim方程中用h / r表示，其中r表示任意位置的半径，h表示从任意位置到尖端的高度。

7. 发明申请

US20110029147A1 Multi-interval dispatch method for enabling dispatchers in power grid control centers to manage changes 有权
标题翻译：多间隔调度方式，使电网控制中心的调度员能够管理变更
公开(公告)号：US20110029147A1
公开(公告)日：2011-02-03
申请号：US12830019
申请日：2010-07-02
申请人： David Sun , Kwok Cheung , Xing Wang , But-Chung Chiu , Ying Xiao
发明人： David Sun , Kwok Cheung , Xing Wang , But-Chung Chiu , Ying Xiao
IPC分类号： G06F1/26
CPC分类号： H02J3/00 , G05B15/02 , G06Q10/06 , G06Q50/06 , Y04S10/54
摘要： A method is provided that enables dispatchers in power grid control centers to manage changes by applying multi-interval dispatch. A multi-stage resource scheduling engine and a comprehensive operating plan are used. Multiple system parameter scenarios are coordinated.
摘要翻译：提供了一种方法，使得电网控制中心的调度员能够通过应用多间隔调度来管理变更。使用多阶段资源调度引擎和综合运行计划。协调多个系统参数场景。

8. 发明申请

US20100304077A1 CARBON FILM AND CARBON FILM STRUCTURE 有权
标题翻译：碳膜和碳膜结构
公开(公告)号：US20100304077A1
公开(公告)日：2010-12-02
申请号：US12471496
申请日：2009-05-26
申请人： Hong-Xing Wang , Akio Hiraki , Masanori Haba
发明人： Hong-Xing Wang , Akio Hiraki , Masanori Haba
IPC分类号： C01B31/00 , B32B33/00
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/05 , C01B32/16 , Y10T428/23957 , Y10T428/30
摘要： The present invention provides a carbon film that is remarkably excellent in current voltage (IV) characteristics. This is achieved by way of a carbon film structure, two or more carbon film assembly units 12 are formed on a substrate 10. The carbon film assembly units 12 comprise: a stem-like carbon film 14 which is made into a film in the shape of a long and thin needle; and a branch-like carbon film cluster 16 which is made into a film so as to surround the stem-like carbon film 14 from the halfway to the lower part of this stem-like carbon film 14. The stem-like carbon film 14 has the shape of a long and thin needle having a configuration which has a spiral streak-like step part 18 towards the distal end at the circumference face of a near tip and in which the radius becomes small as going to the distal end.
摘要翻译：本发明提供一种在电流（IV）特性方面非常优异的碳膜。这通过碳膜结构实现，在基板10上形成两个或更多个碳膜组件单元12.碳膜组件单元12包括：杆状碳膜14，其制成形状为膜长针细针以及从该棒状碳膜14的中途到下部，将树脂状碳膜14从树脂状碳膜14包围而形成薄膜状的分支状碳膜簇16.该茎状碳膜14具有长而细的针的形状，其具有在近尖端的圆周面处朝向远端的螺旋条纹状台阶部18，并且其中半径变得小到进入远端的构造。

9. 发明申请

US20100234376A1 [4,5']Bipyrimidinyl-6,4'-Diamine Deriviatives as Protein Kinase Inhibitors 失效
标题翻译： [4,5']联吡啶基-6,4'-二胺衍生物作为蛋白激酶抑制剂
公开(公告)号：US20100234376A1
公开(公告)日：2010-09-16
申请号：US12373441
申请日：2007-07-10
申请人： Pamela A. Albaugh , Yun He , Songchun Jiang , Pingda Ren , Xia Wang , Xing Wang , Yongping Xie
发明人： Pamela A. Albaugh , Yun He , Songchun Jiang , Pingda Ren , Xia Wang , Xing Wang , Yongping Xie
IPC分类号： A61K31/5377 , C07D413/14 , C07D403/04 , A61K31/506 , A61K31/497 , A61P35/00
CPC分类号： C07D401/14 , C07D239/42 , C07D401/12
摘要： The invention provides a novel class of compounds of the Formula I: in which the symbols have the meanings given in the description and claims, to pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of FGFR3 kinase.
摘要翻译：本发明提供了一类新颖的式I化合物：其中符号具有在说明书和权利要求书中给出的含义，涉及包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常相关的疾病或病症的方法，失调的激酶活性，特别是涉及FGFR3激酶异常激活的疾病或病症。

10. 发明申请

US20090229014A1 Drought and High Salinity Stress Induced Rice Promoters 审中-公开
标题翻译：干旱和高盐胁迫诱导水稻启动子
公开(公告)号：US20090229014A1
公开(公告)日：2009-09-10
申请号：US11733102
申请日：2007-04-09
申请人： Xing Wang Deng
发明人： Xing Wang Deng
IPC分类号： A01H5/00 , C07H21/04
CPC分类号： C12N15/8237
摘要： Rice promoters described herein promote the expression of drought and high-salinity stress responsive genes of rice so as to enable young and adult rice plants to withstand drought and high salinity stresses.
摘要翻译：这里描述的水稻启动子促进水稻的干旱和高盐胁迫响应基因的表达，以使年轻和成年的水稻植株能够耐受干旱和高盐度胁迫。

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