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1. 发明授权

US11603520B2 Method for integrating biological tissues with a vascular system 有权
公开(公告)号：US11603520B2
公开(公告)日：2023-03-14
申请号：US17345825
申请日：2021-06-11
申请人： Public University Corporation Yokohama City University
发明人： Takanori Takebe , Hideki Taniguchi , Yoshinobu Takahashi
IPC分类号： A01K67/027 , C12N5/00 , C12N5/071 , G01N33/50 , C07D499/21 , A61L27/38 , A61K35/28 , A61K35/44 , A61K49/00
摘要： The present invention provides a method of constituting a tissue construct in vitro using a tissue without depending on scaffold materials.
A method of integrating a biological tissue with a vascular system in vitro, comprising coculturing a biological tissue with vascular cells and mesenchymal cells. A biological tissue which has been integrated with a vascular system by the above-described method. A method of preparing a tissue or an organ, comprising transplanting the biological tissue described above into a non-human animal and differentiating the biological tissue into a tissue or an organ in which vascular networks have been constructed. A method of regeneration or function recovery of a tissue or an organ, comprising transplanting the biological tissue described above into a human or a non-human animal and differentiating the biological tissue into a tissue or an organ in which vascular networks have been constructed. A method of preparing a non-human chimeric animal, comprising transplanting the biological tissue described above into a non-human animal and differentiating the biological tissue into a tissue or organ in which vascular networks have been constructed. A method of evaluating a drug, comprising using at least one member selected from the group consisting of the biological tissue described above, the tissue or organ prepared by the method described above, and the non-human chimeric animal prepared by the method described above. A composition for regenerative medicine, comprising a biological tissue which has been integrated with a vascular system by the method described above.

2. 发明申请

US20230039816A1 METHOD FOR INDUCING HEPATOCYTE PLASTICITY 有权
公开(公告)号：US20230039816A1
公开(公告)日：2023-02-09
申请号：US17762908
申请日：2020-09-24
申请人： Public University Corporation Yokohama City University
发明人： Hideki Taniguchi , Yunzhong Nie , YunWen Zheng
IPC分类号： C12N5/071
摘要： The disclosure provides a method for producing hepatocytes or hepatic progenitor cells; a method for suppressing hepatocyte aging using a drug causing histone hyperacetylation; a hepatocyte anti-aging agent; a method for increasing hepatocyte plasticity; and a drug for increasing hepatocyte plasticity.

3. 发明授权

US11365279B2 Fluorescent resin composition, molded object and medical device, and method for producing fluorescent resin composition 有权
公开(公告)号：US11365279B2
公开(公告)日：2022-06-21
申请号：US16308148
申请日：2017-11-13
申请人： Public University Corporation Yokohama City University , TRS Co., Ltd.
发明人： Jiro Maegawa , Teruo Hashimoto , Koji Hirai
IPC分类号： C08G18/38 , A61L29/06 , A61L31/06 , A61M25/09 , C08G18/10 , C08L75/04 , C08G18/64 , C08K5/42 , C08L75/06 , C08G18/00 , C08G18/76 , C08G18/75 , C08G18/44 , C08K5/00 , C09B23/01
摘要： A fluorescent resin composition including a urethane resin which is a polymer having at least a polyol compound (A), a polyisocyanate compound (B) and a chain-extending compound (C) as structural units, and a fluorescent dye that emits fluorescence by undergoing irradiation with near infrared light within a wavelength region of 700 nm to 1300 nm, the polyol compound (A) being an aliphatic polycarbonate diol (A1). In addition, a molded object made of the above-described fluorescent resin composition, and also a medical device including the molded object. Examples of the medical device can include a wire for detecting the position of a lymph vessel that includes the molded object made of the fluorescent resin composition as a fluorescent marker.

4. 发明申请

US20220184271A1 COATING-SECURING AGENT 有权
公开(公告)号：US20220184271A1
公开(公告)日：2022-06-16
申请号：US17439938
申请日：2020-03-13
申请人： PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
发明人： Hideki TANIGUCHI , Soichiro MURATA
IPC分类号： A61L24/08 , C09D105/04
摘要： Provided is a coating-fixing agent for transplanting a cell or a tissue onto the surface of an organ, intestinal membrane, peritoneal membrane, etc. Provided are: a formulation for coating and fixing a graft, the formulation comprising alginate; a formulation kit for coating and fixing a graft, comprising a formulation containing alginate and a divalent or higher valent metal salt in combination; and a method for transplanting a graft, comprising: transplanting the graft to a transplant site of a human or a non-human animal, and coating the graft with alginate.

5. 发明授权

US11193936B2 Method and reagent for detecting ovarian clear cell adenocarcinoma 有权
公开(公告)号：US11193936B2
公开(公告)日：2021-12-07
申请号：US16272089
申请日：2019-02-11
申请人： PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY , TOSOH CORPORATION
发明人： Noriaki Arakawa , Hisashi Hirano , Etsuko Miyagi , Norihisa Ohtake
IPC分类号： G01N33/574 , C07K16/38 , C07K14/47 , C12N15/09 , G01N27/62 , C07K14/81
摘要： The present invention aims to provide a method for detecting, with high sensitivity and specificity, ovarian clear cell adenocarcinoma, which is highly malignant, among benign and malignant ovarian tumors having various tissue types, and a reagent that can be used for the method. The present invention provides NT-TFPI2, which is a novel processed tissue factor pathway inhibitor 2 polypeptide, as a new detection marker for ovarian clear cell adenocarcinoma. The detection of ovarian clear cell adenocarcinoma is carried out by measuring the amount of NT-TFPI2, or the total amount of NT-TFPI2 and intact TFPI2. The reagent for detecting ovarian clear cell adenocarcinoma contains an antibody that specifically recognizes NT-TFPI2 and intact TFPI2.

6. 发明授权

US11186810B2 Cell culture vessel 有权
公开(公告)号：US11186810B2
公开(公告)日：2021-11-30
申请号：US16084283
申请日：2016-03-16
申请人： Shimadzu Corporation , Yokohama City University , Osaka University , CORNING INCORPORATED
发明人： Tomoki Ohkubo , Masaki Kanai , Hirohisa Abe , Hideki Taniguchi , Masahiro Kinooka , Goro Kobayashi , Takanori Takebe
IPC分类号： C12M1/00 , C12M3/00 , C12M3/06 , C12M1/34
摘要： A cell culture container includes a storage container, a cell culture area, a culture solution supply unit, and a discharge unit. The cell culture area is a region for culturing cells, and is provided in the storage container. The culture solution supply unit supplies the culture solution into the cell culture area at a flow rate equal to or less than a predetermined flow rate. The discharge unit discharges the liquid in the cell culture area to the outside of the storage container. A rectification unit is a structure in which a plurality of outflow ports are uniformly arranged in a direction perpendicular to the flow direction of the culture solution from the culture solution supply unit to the discharge unit.

7. 发明授权

US11061034B2 Blood biomarker for use in evaluation of effect of drug therapy on kidney cancer 有权
公开(公告)号：US11061034B2
公开(公告)日：2021-07-13
申请号：US15768192
申请日：2016-10-11
申请人： PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
发明人： Noboru Nakaigawa , Daiki Ueno , Masahiro Yao
IPC分类号： G01N31/00 , G01N33/53 , G01N33/574 , G01N33/50 , A61K45/00
摘要： Disclosed are methods for determining the efficacy of a pharmacotherapy drug for kidney cancer using a blood test. The methods include the evaluation of the effect of a drug therapy for the treatment of kidney cancer by measuring the PARK7 level in a blood sample taken from a patient with kidney cancer who receives the drug therapy for the treatment of kidney cancer. An increased PARK7 level indicates that the drug therapy is not effective. Moreover, by using the blood PARK7 level as an indicator, the efficacy of a candidate substance for a therapeutic agent for kidney cancer can also be determined.

8. 发明申请

US20210095012A1 ANTI-SEMAPHORIN 3A ANTIBODY AND TREATMENT OF ALZHEIMER'S DISEASE AND INFLAMMATORY IMMUNE DISEASES USING SAME 有权
公开(公告)号：US20210095012A1
公开(公告)日：2021-04-01
申请号：US17065246
申请日：2020-10-07
申请人： Yokohama City University , Chiome Bioscience Inc.
发明人： Yoshio Goshima , Fumio Nakamura , Naoya Yamashita , Hidetaka Seo , Shuichi Hashimoto , Koji Murakami , Naoki Takahash , Yukie Sasakura
IPC分类号： C07K16/18
摘要： The present invention mainly addresses the problem of providing an antibody against semaphorin 3A protein, said antibody enabling effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome. An anti-Sema 3A antibody comprising CDRs having specific amino acid sequences (SEQ ID NOS: 1-6, 60-62, 64-66, 68-70, 72-74, 76-78, 80-82, 84-86 and 88-90) enables effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome and, therefore, remarkably ameliorates symptoms associated with such a disease.

9. 发明申请

US20200289605A1 COMPOSITION FOR IMPROVING OR PREVENTING NONALCOHOLIC FATTY LIVER 审中-公开
公开(公告)号：US20200289605A1
公开(公告)日：2020-09-17
申请号：US16889367
申请日：2020-06-01
申请人： KOHJIN LIFE SCIENCES CO., LTD. , PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY , KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION , SAGA UNIVERSITY
发明人： Takaomi KESSOKU , Atsushi NAKAJIMA , Yoshio SUMIDA , Yuichiro EGUCHI , Susumu SAITO , Yusuke SAUCHI
IPC分类号： A61K38/06 , A61K38/00 , A61P1/16
摘要： An object of the present invention is to provide a composition for preventing or improving fat deposition on the liver in spite of the alcohol intake history of a level that a liver disease is not caused. The inventors found that glutathione has an effect of preventing or improving fat deposition on the liver, which is not caused by alcohol, and completed the present invention. Among nonalcoholic fat diseases, the present invention is particularly effective in an early stage of the treatment or in a case where treatment for another disease is not performed.

10. 发明授权

US10752879B2 Culture method and cell cluster 有权
公开(公告)号：US10752879B2
公开(公告)日：2020-08-25
申请号：US15314653
申请日：2015-05-29
申请人： Corning Incorporated , Public University Corporation Yokohama City University
发明人： Yoko Ejiri , Hideki Taniguchi , Takanori Takebe
IPC分类号： C12N5/00 , C12N5/077 , C12N5/071 , C12N5/10 , C12N1/00
摘要： The present invention provides a culture method for culturing, in recesses (10), a population including two or more cells including a cell derived from a stem cell and a mesenchymal cell. The cell derived from a stem cell is a cell obtained by differentiating a stem cell in vitro. The cell is a cell of one or more types selected from the group consisting of an endodermal cell, an ectodermal cell, and a mesodermal cell. The population is cultured in the recesses (10) together with a vascular cell or a secretor factor. Each recess (10) includes a space in which cells are movable. When a volume of the space is represented by V mm3 and the number of mesenchymal cells seeded in the space is represented by N, V is 400 or less and N/V is in a range from 35 to 3000.

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