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1. 发明授权

US09200262B2 Method for the diagnosis of the presence of an ovarian cancer 有权
标题翻译：诊断卵巢癌存在的方法
公开(公告)号：US09200262B2
公开(公告)日：2015-12-01
申请号：US13044289
申请日：2011-03-09
申请人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
发明人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
IPC分类号： A61K39/395 , C12N9/12 , C07K16/30 , C12Q1/68 , G01N33/574
CPC分类号： C12N9/12 , C07K16/3069 , C07K2317/34 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57449 , Y10S435/975
摘要： The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
摘要翻译：本发明提供可以在患有卵巢癌的受试者中表达的分离的抗原多肽。还提供了通过使用本发明的抗原多肽和通过抑制本发明的抗原多肽的基因来预防和/或治疗卵巢癌的卵巢癌的诊断。

2. 发明授权

US07608247B2 Use of outer membrane protein a in treatment/prevention/diagnosis of bacterial infection in central nervous system and/or peripheral blood circulation 有权
标题翻译：使用外膜蛋白a治疗/预防/诊断中枢神经系统和/或外周血液循环中的细菌感染
公开(公告)号：US07608247B2
公开(公告)日：2009-10-27
申请号：US12046165
申请日：2008-03-11
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , I-Jen Huang , Neng-Yao Shih , Ko-Jiunn Liu , Mei-Ru Chen , Wen-Shyang Hsieh , Chi-Hsin Lee
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , I-Jen Huang , Neng-Yao Shih , Ko-Jiunn Liu , Mei-Ru Chen , Wen-Shyang Hsieh , Chi-Hsin Lee
IPC分类号： A61K49/00 , A61K39/108 , A61K39/02
CPC分类号： G01N33/6893 , A61K38/164 , G01N2800/26 , Y02A50/474 , Y02A50/482
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.
摘要翻译：本发明提供了一种通过向哺乳动物施用有效量的外膜蛋白A（OmpA）或其衍生物来治疗和/或预防哺乳动物的中枢神经系统和/或外周血液循环中的细菌感染的方法。还提供了结合OmpA的抗体，其可以测定生物样品中的OmpA水平并检测或诊断中枢神经系统和/或外周血液循环中的细菌感染。

3. 发明申请

US20090232852A1 USE OF OUTER MEMBRANE PROTEIN A (OMPA) IN TREATMENT/PREVENTION/DIAGNOSIS OF INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE AND OTHER GRAM-NEGATIVE BACTERIA 有权
标题翻译：使用外膜蛋白A（OMPA）治疗/预防/诊断由克氏杆菌肺炎和其他灰质细菌引起的感染
公开(公告)号：US20090232852A1
公开(公告)日：2009-09-17
申请号：US12359205
申请日：2009-01-23
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K39/108 , A61K38/16 , A61K39/02 , G01N33/569 , A61K39/112
CPC分类号： G01N33/56916 , A61K38/164 , A61K39/025 , G01N2469/10 , Y02A50/474 , Y02A50/482 , Y02A50/484
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
摘要翻译：本发明提供了一种通过施用有效量的外膜蛋白A（OmpA）来治疗和/或预防哺乳动物中枢神经系统和/或外周血循环中由肺炎克雷伯杆菌和其它革兰氏阴性细菌引起的细菌感染的方法）或其衍生物。还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或哺乳动物的外周血循环。

4. 发明申请

US20080089350A1 Communication system 失效
标题翻译：通讯系统
公开(公告)号：US20080089350A1
公开(公告)日：2008-04-17
申请号：US11892574
申请日：2007-08-24
申请人： I-Ru Liu , Ting-Yi Tsai , Tai-Ho Wu , Yi-Yuan Yang , Hsiu-Ling Chen
发明人： I-Ru Liu , Ting-Yi Tsai , Tai-Ho Wu , Yi-Yuan Yang , Hsiu-Ling Chen
IPC分类号： H04L12/28
CPC分类号： H04B1/006
摘要： A communication system includes a microprocessor, a WiFi device, a WiMAX device, common antennas, and switching devices. The common antennas are for receiving a WiFi signal and a WiMAX signal. Each of the switching devices has an input terminal coupled to the corresponding common antenna, a first output terminal coupled to the WiFi device and a second output terminal coupled to the WiMAX device. When the communication system is applied to a WiFi system, the microprocessor controls the switching devices to isolate the WiMAX signal and transmit the WiFi signal via the first output terminals to the WiFi device; when the communication system is applied to a WiMAX system, the microprocessor controls the switching devices to isolate the WiFi signal and transmit the WiMAX signal via the second output terminals to the WiMAX device.
摘要翻译：通信系统包括微处理器，WiFi设备，WiMAX设备，公共天线和交换设备。普通天线用于接收WiFi信号和WiMAX信号。每个开关装置具有耦合到对应的公共天线的输入端子，耦合到WiFi装置的第一输出端子和耦合到WiMAX装置的第二输出端子。当将通信系统应用于WiFi系统时，微处理器控制切换设备以隔离WiMAX信号并经由第一输出终端将WiFi信号发送到WiFi设备; 当将通信系统应用于WiMAX系统时，微处理器控制切换设备以隔离WiFi信号，并经由第二输出终端向WiMAX设备发送WiMAX信号。

5. 发明申请

US20110159518A1 METHOD FOR THE DIAGNOSIS OF THE PRESENCE OF AN OVARIAN CANCER 审中-公开
标题翻译：用于诊断OVARIAN癌症的方法
公开(公告)号：US20110159518A1
公开(公告)日：2011-06-30
申请号：US13044289
申请日：2011-03-09
申请人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
发明人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
IPC分类号： G01N33/53 , C07H21/04 , C07K16/00
CPC分类号： C12N9/12 , C07K16/3069 , C07K2317/34 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57449 , Y10S435/975
摘要： The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
摘要翻译：本发明提供可以在患有卵巢癌的受试者中表达的分离的抗原多肽。还提供了通过使用本发明的抗原多肽和通过抑制本发明的抗原多肽的基因来预防和/或治疗卵巢癌的卵巢癌的诊断。

6. 发明授权

US07807139B2 Use of outer membrane protein A (OMPA) in treatment/prevention/diagnosis of infections caused by Klebsiella pneumoniae and other gram-negative bacteria 有权
标题翻译：使用外膜蛋白A（OMPA）治疗/预防/诊断由肺炎克雷伯杆菌和其他革兰氏阴性细菌引起的感染
公开(公告)号：US07807139B2
公开(公告)日：2010-10-05
申请号：US12359205
申请日：2009-01-23
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yueh-Lun Lee , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K49/00 , A61K39/00 , A61K39/108
CPC分类号： G01N33/56916 , A61K38/164 , A61K39/025 , G01N2469/10 , Y02A50/474 , Y02A50/482 , Y02A50/484
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
摘要翻译：本发明提供一种通过施用有效量的外膜蛋白A（OmpA）来治疗和/或预防哺乳动物的中枢神经系统和/或外周血循环中由肺炎克雷伯杆菌和其它革兰氏阴性细菌引起的细菌感染的方法）或其衍生物。还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或哺乳动物的外周血循环。

7. 发明申请

US20180319873A1 Antibodies Against Infectious Diseases 审中-公开
公开(公告)号：US20180319873A1
公开(公告)日：2018-11-08
申请号：US15563614
申请日：2016-04-01
申请人： Sy-Jye LEU , Yi-Yuan YANG
发明人： Sy-Jye LEU , Yi-Yuan YANG , Yu-Ching LEE , Ching-Hua SU , Ko-Jiunn LIU , Hsiu-Jung LO , Yun-Liang YANG
IPC分类号： C07K16/14 , C12N9/88 , C07K16/40 , A61K39/00 , A61K45/06 , G01N33/569 , A61P31/10
CPC分类号： C07K16/14 , A61K39/0002 , A61K39/395 , A61K45/06 , A61K2039/505 , A61P31/10 , C07K16/02 , C07K16/18 , C07K16/40 , C07K2317/23 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N9/60 , C12N9/88 , C12Y402/01011 , G01N33/56938 , G01N33/56944 , G01N33/56961 , G01N33/573 , G01N2333/40 , G01N2333/988
摘要： Anti-CaENO1 antibodies and humanized antibodies are provided as an effective diagnostic agent or a therapeutic treatment against infections caused by Candida spp., preferably Candida albicans, Candida tropicalis, fluconazole resistance Candida spp., Strepcococcus, Staphylococcus.

8. 发明申请

US20100111956A1 ANTIGEN POLYPEPTIDE FOR THE DIAGNOSIS AND/OR TREATMENT OF OVARIAN CANCER 有权
标题翻译：用于诊断和/或治疗OVARIAN癌症的抗原多肽
公开(公告)号：US20100111956A1
公开(公告)日：2010-05-06
申请号：US12262085
申请日：2008-10-30
申请人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
发明人： Sy-Jye Leu , Neng-Yao Shih , Yi-Yuan Yang , Ko-Jiunn Liu , I-Jen Huang , Yuan-Soon Ho , Suparat Charoenfuprasert , Yu-Ching Lee
IPC分类号： A61K39/395 , C07K14/47 , C12N15/12 , C07K16/18 , C12Q1/68 , G01N33/566 , A61P35/00
CPC分类号： C12N9/12 , C07K16/3069 , C07K2317/34 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N33/57449 , Y10S435/975
摘要： The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
摘要翻译：本发明提供可以在患有卵巢癌的受试者中表达的分离的抗原多肽。还提供了通过使用本发明的抗原多肽和通过抑制本发明的抗原多肽的基因来预防和/或治疗卵巢癌的卵巢癌的诊断。

9. 发明申请

US20100087373A1 DETECTION AND THERAPY OF BACTERIAL INFECTION CAUSED BY ENTEROBACTERIACEAE 有权
标题翻译：肠杆菌引起的细菌感染的检测和治疗
公开(公告)号：US20100087373A1
公开(公告)日：2010-04-08
申请号：US12569363
申请日：2009-09-29
申请人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
发明人： Yi-Yuan Yang , Hsueh-Hsia Wu , Sy-Jye Leu , Neng-Yao Shih , I-Jen Huang , Ching-Yu Lin , Wen-Shyang Hsieh , Ko-Jiunn Liu , Shih-Yi Huang , Yung-Luen Shih , Chi-Hsin Lee , Yuan-Soon Ho , Shih-Lan Hsu
IPC分类号： A61K38/16 , A61K39/02 , C07K16/12 , G01N33/53
CPC分类号： A61K38/164 , C07K16/1232 , C07K2317/11 , C07K2317/23 , C07K2317/76 , G01N33/56916 , G01N33/6893 , G01N2800/26
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
摘要翻译：本发明提供了一种通过将有效量的外膜蛋白A（OmpA）或其衍生物施用于哺乳动物的中枢神经系统和/或外周血循环中由肠杆菌科细菌引起的细菌感染的治疗和/或预防方法哺乳动物。还提供了一种用于接种哺乳动物以在中枢神经系统和/或外周血循环中产生由肠杆菌科家族引起的细菌感染的抗体的方法，以及检测或诊断由中枢神经系统中肠杆菌科家族引起的细菌感染的方法和/或哺乳动物的外周血循环。还提供了基于疫苗接种方法和检测/诊断方法的抗体和试剂盒。

10. 发明申请

US20090233853A1 USE OF OUTER MEMBRANE PROTEIN A IN TREATMENT/PREVENTION/DIAGNOSIS OF BACTERIAL INFECTION IN CENTRAL NERVOUS SYSTEM AND/OR PERIPHERAL BLOOD CIRCULATION 有权
标题翻译：使用外膜蛋白A治疗/预防/诊断中枢神经系统和/或外周血液循环中的细菌感染
公开(公告)号：US20090233853A1
公开(公告)日：2009-09-17
申请号：US12046165
申请日：2008-03-11
申请人： Yi-Yuan YANG , Hsueh-Hsia WU , Sy-Jye LEU , I-Jen HUANG , Neng-Yao SHIH , Ko-Jiunn LIU , Mei-Ru CHEN , Wen-Shyang HSIEH , Chi-Hsin LEE
发明人： Yi-Yuan YANG , Hsueh-Hsia WU , Sy-Jye LEU , I-Jen HUANG , Neng-Yao SHIH , Ko-Jiunn LIU , Mei-Ru CHEN , Wen-Shyang HSIEH , Chi-Hsin LEE
IPC分类号： A61K38/00 , G01N33/53
CPC分类号： G01N33/6893 , A61K38/164 , G01N2800/26 , Y02A50/474 , Y02A50/482
摘要： The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.
摘要翻译：本发明提供了一种通过向哺乳动物施用有效量的外膜蛋白A（OmpA）或其衍生物来治疗和/或预防哺乳动物的中枢神经系统和/或外周血液循环中的细菌感染的方法。还提供了结合OmpA的抗体，其可以测定生物样品中的OmpA水平并检测或诊断中枢神经系统和/或外周血液循环中的细菌感染。

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