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1. 发明授权

US3829574A Hypoglycemic pharmaceutical compositions and methods of use 失效
标题翻译：超临界药物组合物及其使用方法
公开(公告)号：US3829574A
公开(公告)日：1974-08-13
申请号：US29880172
申请日：1972-10-06
申请人： BOEHRINGER SOHN INGELHEIM
发明人： KUTTER E , KLEEMANN M , GRISS G , GRELL W
IPC分类号： A61K31/47 , A61K31/64 , C07D217/24 , A61K27/00
CPC分类号： C07D217/24 , A61K31/47 , A61K31/64 , Y10S514/884
摘要： Hypoglycemic pharmaceutical compositions containing a 2-(p-(N''cycloalkyl-carbamido-N-sulfonyl)-phenethyl)-1,2,3,4-tetrahydro1,3 -dioxo-4,4-dimethyl-isoquinoline of the formula

WHEREIN R1 is hydrogen, chlorine, bromine or alkoxy of one to four carbon atoms, and R2 is cyclohexyl or adamantyl-(1), OR AN ALKALI METAL SALT THEREOF; AND A METHOD OF LOWERING THE BLOOD SUGAR LEVEL THEREWITH.

2. 发明授权

US3708486A 2-(p-(n'-cycloalkyl-carbamido-n-sulfonyl)-phenethyl)-1,2,3,4-tetrahydro-1,3-dioxo-4,4-dimethyl-isoquinolines and alkali metal salts thereof 失效
标题翻译： 2-（P-（N'-环烷基 - 碳酰氨基-N-磺酰基） - 苯乙基）-1,2,3,4-四氢-1,3-二氧代-4,4-二甲基异喹啉及其碱金属盐
公开(公告)号：US3708486A
公开(公告)日：1973-01-02
申请号：US3708486D
申请日：1970-04-06
申请人： BOEHRINGER SOHN INGELHEIM
发明人： KUTTER E , GRISS G , GRELL W , KLEEMANN M
IPC分类号： A61K31/47 , A61K31/64 , C07D217/24 , C07D35/30
CPC分类号： A61K31/47 , A61K31/64 , C07D217/24 , Y10S514/866
摘要： 2-(P-(N''-CYCLOALKYL - CARBAMIDO - N - SULFONYL) - PHENETHYL)-1,2,3,4,-TETRAHYDRO - 1,3 - DIOX - 4,4 - DIMETHYL-ISOQUINOLINES OF THE FORMULA

2-((4-(R2-NH-CO-NH-SO2-)PHENYL)-CH2-CH2-),4,4-DI(CH3),

7-R1-1,2,3,4-TETRAHYDROISOQUINOLINE-1,3-DIONE

WHEREIN R1 IS HYDROGEN, CHLORINE, BROMINE OR ALKOXYL OF 1 TO 4 CARBON ATOMS, AND R2 IS CYCLOHEXYL OR ADAMANTYL-(1) AND ALKALI METAL SALTS THEREOF, USEFUL AS HYPOGLYCEMICS IN WARM-BLOODED ANIMALS.

3. 发明授权

US3804849A 2-amino-4,5,7,8-tetrahydro-6h-thiazolo or oxazolo(5,4-d)azepines and salts 失效
标题翻译： 2-氨基-4,5,7,8-四氢-6H-噻唑或奥昔洛尔（5,4-D）盐酸盐和盐
公开(公告)号：US3804849A
公开(公告)日：1974-04-16
申请号：US16906571
申请日：1971-08-04
申请人： BOEHRINGER SOHN INGELHEIM
发明人： GRISS G , KLEEMANN M , GRELL W , BALLHAUSE H
IPC分类号： C07D498/04 , C07D513/04 , C07D99/04 , C07D99/10
CPC分类号： C07D513/04 , Y10S514/916 , Y10S514/937 , Y10S514/96 , Y10S514/962 , Y10S514/966
摘要： COMPOUNDS OF THE FORMULA

2-(R2-NH-),6-R1-5,6,7,8-TETRAHYDRO-4H-THIAZOLO(4,5-D)-

AZEPINE OR

2-NH2,6-R1-5,6,7,8-TETRAHYDRO-4H-OXAZOLO(4,5-D)AZEPINE

WHEREIN R1 IS HYDROGEN, STRAIGHT OR BRANCHED ALKYL OF 1 TO 4 CARBON ATOMS, HYDROXY-ALKYL OF 1 TO 4 CARBON ATOMS, ALKYL, CHLOALKYL, HEXAHYDROBENZYL, PHENYL, PHENETHYL, BENZYL, MONO-OR DI-HAOBENZYL OR (ALKYL OR 1 TO 3 THOXYBENZYL, TRIFULOROMETHYL-BENZYL OR (ALKYL OF 1 TO 3 CARBON ATOMS)-BENZYL, AND R2 IS HYDROGEN, STRAIGHT OR BRANCHED ALKYL OF 1 TO 5 CARBON ATOMS, ALLYL, CYCLOALKYL, PHENYL, BENZYL OR PHENETHYL, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, THE COMPOUNDS AS WEL AS THEIR SALTS ARE USEFUL AS HYPOTENSIVES, SEDATIVES, ANTITUSSIVES AND ANTIPHLOGISTICS.

4. 发明授权

US3725388A N-acyl-7-(n{41 -cycloalkyl-ureido-n{40 -sulfonyl)-isoquinolines and -benzazepines and alkali metal salts thereof 失效
标题翻译： N-ACY-7-（N {41-环丙基 - 尿嘧啶-N（40-磺基） - 异喹啉和苯并吖庚因及其碱金属盐
公开(公告)号：US3725388A
公开(公告)日：1973-04-03
申请号：US3725388D
申请日：1970-06-25
申请人： BOEHRINGER SOHN INGELHEIM
发明人： KLEEMANN M , KUTTER E , GRELL W , GRISS G
IPC分类号： C07D217/06 , C07D223/16 , C07D35/42 , C07D41/08
CPC分类号： C07D223/16 , C07D217/06
摘要： WHEREIN R1 is straight or branched alkyl of one to four carbon atoms, phenyl, alkoxy of one to three carbon atoms - phenyl, tolyl, trifluoromethyl-phenyl, monohalo-phenyl, dihalo-phenyl, 2methoxy-5-chlorophenyl, diphenyl, Alpha -naphthyl, 1,2,3,4tetrahydronaphthyl-(1), indanyl-(1) or benzoyl, R2 is n-butyl, cycloalkyl of five to eight carbon atoms, alkyl of one to two carbon atoms - cycloalkyl of five to eight carbon atoms, or adamantyl-(1), A is a carbon-to-carbon bond, alkylene of one to five carbon atoms or phenyl-alkylene of one to five carbon atoms, and N IS 1 OR 2, AS WELL AS ALKALI METAL AND ALKALINE EARTH METAL SALTS THEREOF; THE COMPOUNDS AND THEIR SALTS ARE USEFUL AS HYPOGLYCEMICS IN WARM-BLOODED ANIMALS.

Compounds of the formula
摘要翻译：式WHEREIN R1的化合物是一至四个碳原子的直链或支链烷基，苯基，一至三个碳原子的烷氧基 - 苯基，甲苯基，三氟甲基 - 苯基，一卤代 - 苯基，二卤代 - 苯基，2-甲氧基-5- 氯苯基，二苯基，α-萘基，1,2,3,4-四氢萘基 - （1），茚满基 - （1）或苯甲酰基，R2是正丁基，5-8个碳原子的环烷基，一至二个碳原子的烷基 5至8个碳原子的原子 - 环烷基，或金刚烷基 - （1），A是碳 - 碳键，一至五个碳原子的亚烷基或一至五个碳原子的苯基 - 亚烷基，N IS 1 OR 2，作为阿尔卡利金属和碱性金属的金属盐; 化合物及其销售有助于血液动力学中的高血压。

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