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1. 发明授权

US08771516B2 Membranes having improved performance 有权
标题翻译：具有改进性能的膜
公开(公告)号：US08771516B2
公开(公告)日：2014-07-08
申请号：US13320699
申请日：2010-05-19
申请人： Bernd Krause , Carina Zweigart , Heinrich Behr
发明人： Bernd Krause , Carina Zweigart , Heinrich Behr
IPC分类号： A61M1/18 , A61M1/34 , B01D61/24 , B01D71/68 , B01D71/42 , B01D71/56 , B01D69/08 , B29C47/08
CPC分类号： B01D69/088 , A61M1/16 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/3413 , A61M1/3496 , A61M2205/15 , B01D71/56 , B01D71/68
摘要： Permselective asymmetric membranes suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved performance, including improved sieving characteristics, providing enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The improved sieving characteristics are due to a narrow pore size distribution of the membranes created in the production process. Processes for the preparation of these membranes, devices comprising these membranes, and the use of these membranes in hemodialysis, hemodiafiltration and hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.
摘要翻译：选择性不对称膜适合于例如用于血液透析，血液透析过滤和血液的血液滤过，并且具有改善的性能，包括改善的筛分特性，提供中等分子量物质的增强的去除。具有20至40kDa分子量的炎性介质。改进的筛分特性是由于在生产过程中产生的膜的孔径分布窄。用于制备这些膜的方法，包括这些膜的装置以及这些膜在血液透析，血液透析滤过和血液血液滤过以及生物处理，血浆分离和蛋白质溶液的制备中的用途。

2. 发明申请

US20120074064A1 MEMBRANES HAVING IMPROVED PERFORMANCE 有权
标题翻译：具有改进性能的膜
公开(公告)号：US20120074064A1
公开(公告)日：2012-03-29
申请号：US13320699
申请日：2010-05-19
申请人： Bernd Krause , Carina Zweigart , Heinrich Behr
发明人： Bernd Krause , Carina Zweigart , Heinrich Behr
IPC分类号： B01D71/68 , B29C47/08 , B01D71/42 , B01D61/00 , B01D69/08 , B01D71/56
CPC分类号： B01D69/088 , A61M1/16 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/3413 , A61M1/3496 , A61M2205/15 , B01D71/56 , B01D71/68
摘要： Permselective asymmetric membranes suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved performance, including improved sieving characteristics, providing enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The improved sieving characteristics are due to a narrow pore size distribution of the membranes created in the production process. Processes for the preparation of these membranes, devices comprising these membranes, and the use of these membranes in hemodialysis, hemodiafiltration and hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.
摘要翻译：选择性不对称膜适合于例如用于血液透析，血液透析过滤和血液的血液滤过，并且具有改善的性能，包括改善的筛分特性，提供中等分子量物质的增强的去除。具有20至40kDa分子量的炎性介质。改进的筛分特性是由于在生产过程中产生的膜的孔径分布窄。用于制备这些膜的方法，包括这些膜的装置以及这些膜在血液透析，血液透析滤过和血液血液滤过以及生物处理，血浆分离和蛋白质溶液的制备中的用途。

3. 发明授权

US08596467B2 Hollow fiber membrane and method for manufacturing thereof 有权
公开(公告)号：US08596467B2
公开(公告)日：2013-12-03
申请号：US12446058
申请日：2007-10-11
申请人： Bernd Krause , Hermann Gohl , Markus Hornung , Carina Zweigart
发明人： Bernd Krause , Hermann Gohl , Markus Hornung , Carina Zweigart
IPC分类号： B01D69/08 , B01D69/12 , D01D5/24 , D01F1/08
CPC分类号： B01D71/68 , A61B5/14525 , A61M1/16 , B01D63/02 , B01D69/02 , B01D69/08 , B01D69/087 , B01D71/44 , B01D71/62 , B01D2323/06 , B01D2323/08 , B01D2323/12 , B01D2323/22 , B01D2325/022
摘要： The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10 nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a process for manufacturing thereof and the use thereof.

4. 发明申请

US20110263020A1 MEMBRANE FOR CELL EXPANSION 有权
标题翻译：细胞扩增膜
公开(公告)号：US20110263020A1
公开(公告)日：2011-10-27
申请号：US13120397
申请日：2009-09-23
申请人： Carina Zweigart , Bernd Krause , Markus Neubauer , Reinhold Deppisch , Doris Deppisch
发明人： Carina Zweigart , Bernd Krause , Markus Neubauer , Reinhold Deppisch , Doris Deppisch
IPC分类号： C12N5/071 , B29D23/00 , B29D7/01 , C12N5/0775
CPC分类号： C12N5/0068 , A61L27/26 , A61L27/38 , B01D67/009 , B01D67/0095 , B01D69/02 , B01D69/06 , B01D69/08 , B01D71/44 , B01D71/54 , B01D71/56 , B01D71/68 , B01D2323/34 , B01D2325/36 , C12N2533/30 , C08L81/06
摘要： A membrane which can be used for cultivating cells, in particular adherent cells. The membrane permits the adhesion and proliferation of the cells based on its specific composition comprising polyurethane. The resulting surface characteristics further permit the membrane to be used without any pre-treatment with surface modifying substances. A method for preparing a membrane which can be used for cultivating cells, in particular adherent cells. Methods of using the membrane for cultivating cells, in particular adherent cells.
摘要翻译：可用于培养细胞，特别是贴壁细胞的膜。该膜允许基于其包含聚氨酯的特定组成的细胞的粘附和增殖。所得到的表面特性进一步允许使用膜而不用表面改性物质进行任何预处理。一种制备可用于培养细胞，特别是贴壁细胞的膜的方法。使用膜用于培养细胞，特别是贴壁细胞的方法。

5. 发明授权

US08827087B2 Membranes having improved performance 有权
标题翻译：具有改进性能的膜
公开(公告)号：US08827087B2
公开(公告)日：2014-09-09
申请号：US13320679
申请日：2010-05-19
申请人： Bernd Krause , Carina Zweigart
发明人： Bernd Krause , Carina Zweigart
IPC分类号： B01D71/68 , B01D69/08 , B01D71/76 , B29C47/12 , B01D71/40 , B01D67/00
CPC分类号： B01D69/08 , B01D67/0088 , B01D67/0093 , B01D71/40 , B01D71/68 , B01D71/76
摘要： Permselective asymmetric membranes suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved sieving characteristics providing enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The membranes comprise polyethersulfone and polyvinylpyrrolidone and are coated with hyaluronic acid or copolymers of 2-methacryloyloxyethyl phosphoryl choline and other vinyl polymerizable monomers. Processes for the preparation of these membranes, devices comprising these membranes, and the use of these membranes in hemodialysis, hemodiafiltration and hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.
摘要翻译：选择性不对称膜适合于例如用于血液透析，血液透析过滤和血液的血液滤过，并且具有改善的筛分特性，提供中等分子量物质的增强除去。具有20至40kDa分子量的炎性介质。膜包含聚醚砜和聚乙烯吡咯烷酮，并用透明质酸或2-甲基丙烯酰氧基乙基磷酰胆碱和其它乙烯基可聚合单体的共聚物涂覆。用于制备这些膜的方法，包括这些膜的装置以及这些膜在血液透析，血液透析滤过和血液血液滤过以及生物处理，血浆分离和蛋白质溶液的制备中的用途。

6. 发明授权

US08435751B2 Membrane for cell expansion 有权
标题翻译：细胞扩张膜
公开(公告)号：US08435751B2
公开(公告)日：2013-05-07
申请号：US13120397
申请日：2009-09-23
申请人： Carina Zweigart , Bernd Krause , Markus Neubauer , Doris Deppisch
发明人： Carina Zweigart , Bernd Krause , Markus Neubauer , Reinhold Deppisch
IPC分类号： G01N33/53
CPC分类号： C12N5/0068 , A61L27/26 , A61L27/38 , B01D67/009 , B01D67/0095 , B01D69/02 , B01D69/06 , B01D69/08 , B01D71/44 , B01D71/54 , B01D71/56 , B01D71/68 , B01D2323/34 , B01D2325/36 , C12N2533/30 , C08L81/06
摘要： A membrane which can be used for cultivating cells, in particular adherent cells. The membrane permits the adhesion and proliferation of the cells based on its specific composition comprising polyurethane. The resulting surface characteristics further permit the membrane to be used without any pre-treatment with surface modifying substances. A method for preparing a membrane which can be used for cultivating cells, in particular adherent cells. Methods of using the membrane for cultivating cells, in particular adherent cells.
摘要翻译：可用于培养细胞，特别是贴壁细胞的膜。该膜允许基于其包含聚氨酯的特定组成的细胞的粘附和增殖。所得到的表面特性进一步允许使用膜，而不用表面改性物质进行任何预处理。一种制备可用于培养细胞，特别是贴壁细胞的膜的方法。使用膜用于培养细胞，特别是贴壁细胞的方法。

7. 发明申请

US20120074063A1 MEMBRANES HAVING IMPROVED PERFORMANCE 有权
标题翻译：具有改进性能的膜
公开(公告)号：US20120074063A1
公开(公告)日：2012-03-29
申请号：US13320679
申请日：2010-05-19
申请人： Bernd Krause , Carina Zweigart
发明人： Bernd Krause , Carina Zweigart
IPC分类号： B01D71/68 , B29C47/12 , B01D67/00 , B01D61/24 , B01D69/08
CPC分类号： B01D69/08 , B01D67/0088 , B01D67/0093 , B01D71/40 , B01D71/68 , B01D71/76
摘要： Permselective asymmetric membranes suitable e.g. for hemodialysis, hemodiafiltration and hemofiltration of blood, and having improved sieving characteristics providing enhanced removal of middle molecular weight substances, e.g. inflammatory mediators having a molecular weight between 20 and 40 kDa. The membranes comprise polyethersulfone and polyvinylpyrrolidone and are coated with hyaluronic acid or copolymers of 2-methacryloyloxyethyl phosphoryl choline and other vinyl polymerizable monomers. Processes for the preparation of these membranes, devices comprising these membranes, and the use of these membranes in hemodialysis, hemodiafiltration and hemofiltration of blood, as well as in bioprocessing, plasma fractionation and the preparation of protein solutions.
摘要翻译：选择性不对称膜适合于例如用于血液透析，血液透析过滤和血液的血液滤过，并且具有改善的筛分特性，提供中等分子量物质的增强除去。具有20至40kDa分子量的炎性介质。膜包含聚醚砜和聚乙烯吡咯烷酮，并用透明质酸或2-甲基丙烯酰氧基乙基磷酰胆碱和其它乙烯基可聚合单体的共聚物涂覆。用于制备这些膜的方法，包括这些膜的装置以及这些膜在血液透析，血液透析滤过和血液血液滤过以及生物处理，血浆分离和蛋白质溶液的制备中的用途。

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