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1. 发明授权

US08965487B2 Process, system and software arrangement for measuring a mechanical strain and elastic properties of a sample 有权
标题翻译：用于测量样品的机械应变和弹性性能的工艺，系统和软件布置
公开(公告)号：US08965487B2
公开(公告)日：2015-02-24
申请号：US11211482
申请日：2005-08-24
申请人： Brett Eugene Bouma , Raymond C. Chan , Guillermo J. Tearney
发明人： Brett Eugene Bouma , Raymond C. Chan , Guillermo J. Tearney
IPC分类号： A61B5/02 , A61B5/00
CPC分类号： A61B5/0066 , A61B5/0059 , A61B5/02007
摘要： A system, process and software arrangement are provided to determining data associated with at least one structural change of tissue. In particular, a first optical coherence tomography (“OCT”) signal which contains first information regarding the tissue at a first stress level, and a second OCT signal which contains second information regarding the tissue at a second stress level are received. The first and second information are compared to produce comparison information. The data associated with the at least one structural change is determined as a function of the comparison information and further information associated with (i) at least one known characteristics of the tissue and/or (ii) characteristics of an OCT system. Further, at least one optical coherence tomography (“OCT”) signal which contains information regarding the tissue can be received, and the modulus of the tissue may be determined as a function of the received at least one OCT signal.
摘要翻译：提供系统，过程和软件布置以确定与组织的至少一个结构变化相关联的数据。特别地，接收包含关于第一应力水平的组织的第一信息的第一光学相干断层摄影（“OCT”）信号和包含关于第二应力水平的组织的第二信息的第二OCT信号。比较第一和第二信息以产生比较信息。与至少一个结构变化相关联的数据被确定为比较信息和与（i）组织的至少一个已知特征和/或（ii）OCT系统的特征相关联的进一步信息的函数。此外，可以接收包含关于组织的信息的至少一个光学相干断层摄影（“OCT”）信号，并且可以根据所接收的至少一个OCT信号来确定组织的模量。

2. 发明申请

US20150253240A1 METHODS, SYSTEMS, ARRANGEMENTS AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING MICRO-OPTICAL COHERENCE TOMOGRAPHY PROCEDURES 审中-公开
标题翻译：方法，系统，安排和计算机可访问介质，用于提供微光学相干计算机程序
公开(公告)号：US20150253240A1
公开(公告)日：2015-09-10
申请号：US14240938
申请日：2012-08-27
申请人： Steven M. Rowe , Guillermo J. Tearney , Brett Eugene Bouma , Linbo Liu , Eric J. Sorscher , Kengyeh Ken Chu , Bradford James Diephuis , Eric James Wilsterman , Gregory Andrew Dierksen
发明人： Steven M. Rowe , Guillermo J. Tearney , Brett Eugene Bouma , Linbo Liu , Eric J. Sorscher , Kengyeh Ken Chu , Bradford James Diephuis , Eric James Wilsterman , Gregory Andrew Dierksen
IPC分类号： G01N21/17 , G01N21/35 , G01N15/02 , G01J9/02 , G01N21/47 , G01J3/45 , G01N29/00 , G01N21/64
CPC分类号： G01N21/17 , G01B9/02044 , G01B9/0205 , G01B9/02091 , G01J3/45 , G01J9/02 , G01N15/0205 , G01N15/14 , G01N21/35 , G01N21/45 , G01N21/4788 , G01N21/4795 , G01N21/6458 , G01N21/6486 , G01N29/00 , G01N2021/653 , G01N2021/655
摘要： Exemplary apparatus and method can be provided for obtaining data regarding a plurality of samples. For example, using at least one arrangement, it is possible to receive interferometric information that is based on radiations provided from a reference and the samples that are provided in respective chambers. Alternatively and/or in addition, based on the interferometric information, it is possible to discriminate between agents to identify a particular agent that affects a particular function within at least one of the samples.
摘要翻译：可以提供示例性的装置和方法来获得关于多个样本的数据。例如，使用至少一种布置，可以接收基于从参考提供的辐射和在各个室中提供的样本的干涉信息。可选地和/或另外，基于干涉信息，可以区分代理以识别影响至少一个样本内的特定功能的特定代理。

3. 发明申请

US20130066215A1 APPARATUS AND METHOD FOR OBTAINING AND PROVIDING IMAGING INFORMATION ASSOCIATED WITH AT LEAST ONE PORTION OF A SAMPLE, AND EFFECTING SUCH PORTION(S) 有权
标题翻译：用于获取和提供与至少一个样品部分相关的成像信息的装置和方法，以及影响这些部分
公开(公告)号：US20130066215A1
公开(公告)日：2013-03-14
申请号：US13614459
申请日：2012-09-13
申请人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin
发明人： Guillermo J. Tearney , Brett Eugene Bouma , Dvir Yelin
IPC分类号： A61B1/07
CPC分类号： A61B1/07 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B18/22 , A61B2017/00061
摘要： Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) second different wavelengths of at least one second electro-magnetic radiation within a second wavelength range can be provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion.
摘要翻译：可以提供示例性装置和过程用于与样品的至少一部分相关联的成像信息。例如，（i）可在提供在样品部分上的第一波长范围内提供至少一个第一电磁辐射的第一不同波长，以便确定该部分的至少一个第一横向位置，和（ii ）可以在该部分上提供在第二波长范围内的至少一个第二电磁辐射的第二不同波长，以便确定该部分的至少一个第二横向位置。第一和第二范围可以在该部分上部分重叠。此外，可以获得从样品返回的至少一个第三电磁辐射电磁辐射与从基准返回的至少一个第四电磁辐射之间的相对相位，以确定该部分的相对深度位置。

4. 发明申请

US20110255561A1 APPARATUS CONFIGURED TO PROVIDE A WAVELENGTH-SWEPT ELECTRO-MAGNETIC RADIATION 审中-公开
标题翻译：配置提供波长扫描电磁辐射的装置
公开(公告)号：US20110255561A1
公开(公告)日：2011-10-20
申请号：US13003983
申请日：2009-07-14
申请人： Brian Goldberg , Guillermo J. Tearney , Brett Eugene Bouma , Reza Motgahian-Nezam
发明人： Brian Goldberg , Guillermo J. Tearney , Brett Eugene Bouma , Reza Motgahian-Nezam
IPC分类号： H01S3/10
CPC分类号： H01S5/141 , G01J3/10 , H01S3/105 , H01S5/02248 , H01S5/101 , H01S5/143
摘要： Exemplary embodiments of apparatus according to the present disclosure are provided. For example, an apparatus for providing electromagnetic radiation to a structure can be provided. In one exemplary embodiment, the apparatus can provide at least one electromagnetic radiation, and include at least one first arrangement which can be configured to generate the electromagnetic radiation(s) having at least one wavelength that varies over time. The exemplary apparatus can also include at least one second arrangement which can be configured to power the first arrangement(s) independently from an external power source. In another exemplary embodiment the apparatus can include at least one particular arrangement which is configured to generate the electromagnetic radiation(s) having at least one wavelength that varies over time. The particular arrangement(s) can include a resonant cavity that has a roundtrip optical transit time of approximately less than 0.7 nsec.
摘要翻译：提供了根据本公开的装置的示例性实施例。例如，可以提供用于向结构提供电磁辐射的装置。在一个示例性实施例中，该装置可以提供至少一个电磁辐射，并且包括至少一个第一布置，其可被配置为产生具有随时间变化的至少一个波长的电磁辐射。示例性装置还可以包括至少一个第二装置，其可被配置为独立于外部电源为第一装置供电。在另一个示例性实施例中，装置可以包括至少一个特定布置，其被配置为产生具有随时间变化的至少一个波长的电磁辐射。具体布置可以包括谐振腔，其具有大约小于0.7纳秒的往返光通过时间。

5. 发明授权

US08032200B2 Methods and systems for tissue analysis 有权
标题翻译：组织分析方法和系统
公开(公告)号：US08032200B2
公开(公告)日：2011-10-04
申请号：US11534095
申请日：2006-09-21
申请人： Guillermo J. Tearney , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： A61B5/00
CPC分类号： A61B5/6885 , A61B1/00082 , A61B1/0615 , A61B1/07 , A61B5/0066 , A61B5/0068 , A61B5/0075 , A61B5/0084 , A61B5/02007 , A61B5/7207 , A61B5/7257 , G01N21/49
摘要： The invention relates to methods and systems to optically analyze samples such as tissue based on speckle patterns of microscopic motion, such as Brownian motion.
摘要翻译：本发明涉及基于诸如布朗运动的微观运动的斑纹图案光学分析诸如组织的样品的方法和系统。

6. 发明授权

US07982879B2 Methods and systems for performing angle-resolved fourier-domain optical coherence tomography 有权
标题翻译：用于进行角度分辨的傅里叶变换光学相干断层扫描的方法和系统
公开(公告)号：US07982879B2
公开(公告)日：2011-07-19
申请号：US11677278
申请日：2007-02-21
申请人： Adrien E. Desjardins , Benjamin J. Vakoc , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Adrien E. Desjardins , Benjamin J. Vakoc , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , A61B5/0066 , A61B5/0073 , G01B9/02043 , G01B9/02087 , G01B9/02091 , G01B2290/70 , G01N2021/4714
摘要： Arrangements, apparatus and methods are provided according to exemplary embodiments of the present invention. In particular, at least one first electro-magnetic radiation may be received and at least one second electro-magnetic radiation within a solid angle may be forwarded to a sample. The second electro-magnetic radiation may be associated with the first electro-magnetic radiation. A plurality of third electro-magnetic radiations can be received from the sample which is associated with the second electro-magnetic radiation, and at least one portion of the third electro-magnetic radiation is provided outside a periphery of the solid angle. Signals associated with each of the third electro-magnetic radiations can be simultaneously detected, with the signals being associated with information for the sample at a plurality of depths thereof. The depths can be determined using at least one of the third electro-magnetic radiations without a need to utilize another one of the third electro-magnetic radiations.
摘要翻译：根据本发明的示例性实施例提供了安排，装置和方法。特别地，可以接收至少一个第一电磁辐射，并且将立体角内的至少一个第二电磁辐射转发到样品。第二电磁辐射可以与第一电磁辐射相关联。可以从与第二电磁辐射相关联的样品接收多个第三电磁辐射，并且第三电磁辐射的至少一部分设置在立体角的外围。可以同时检测与每个第三电磁辐射相关联的信号，其中信号与样品在其多个深度处的信息相关联。可以使用第三电磁辐射中的至少一个来确定深度，而不需要利用第三电磁辐射中的另一个。

7. 发明授权

US07903257B2 Apparatus and method for ranging and noise reduction of low coherence interferometry (LCI) and optical coherence tomography (OCT) signals by parallel detection of spectral bands 有权
标题翻译：用于通过光谱带的并行检测的低相干干涉测量（LCI）和光学相干断层扫描（OCT）信号的测距和降噪的装置和方法
公开(公告)号：US07903257B2
公开(公告)日：2011-03-08
申请号：US11954794
申请日：2007-12-12
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： G01B11/02 , G01B9/02 , G01J3/45
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。信号保持不变。喷射噪声的降低增加了系统的动态范围和灵敏度。

8. 发明申请

US20090036770A1 METHOD AND APPARATUS FOR DETERMINATION OF ATHEROSCLEROTIC PLAQUE TYPE BY MEASUREMENT OF TISSUE OPTICAL PROPERTIES 有权
标题翻译：用于通过测量组织光学性质来确定角质层型的方法和装置
公开(公告)号：US20090036770A1
公开(公告)日：2009-02-05
申请号：US12188623
申请日：2008-08-08
申请人： Guillermo J. Tearney , Brett Eugene Bouma
发明人： Guillermo J. Tearney , Brett Eugene Bouma
IPC分类号： A61B5/05
CPC分类号： G01B9/02014 , A61B1/00165 , A61B5/0066 , A61B5/0084 , G01B9/02007 , G01B9/02072 , G01B9/02083 , G01B9/02088 , G01B9/02091 , G01B2290/70
摘要： Methods for diagnosing vulnerable atherosclerotic plaque using optical coherence tomography to measure tissue optical properties, including backreflectance of heterogeneous layers, such as plaque cap, lipid pool composition and macrophage presence. Methods also include measurement of spatially and temporally dependent reflectance, measurement of multiple wavelength reflectance, low coherence interferometry, polarization and quantification of macrophage content.
摘要翻译：使用光学相干断层扫描来诊断易受伤害的动脉粥样硬化斑块的方法来测量组织光学性质，包括异质层的后向反射，例如斑块盖，脂质池组成和巨噬细胞存在。方法还包括空间和时间依赖反射率的测量，多波长反射率的测量，低相干干涉测量，极化和巨噬细胞含量的定量。

9. 发明授权

US07366376B2 System and method for optical coherence imaging 有权
标题翻译：光学相干成像系统和方法
公开(公告)号：US07366376B2
公开(公告)日：2008-04-29
申请号：US11241907
申请日：2005-09-29
申请人： Milen Shishkov , Brett Eugene Bouma , Guillermo J. Tearney
发明人： Milen Shishkov , Brett Eugene Bouma , Guillermo J. Tearney
IPC分类号： G02B6/32 , G02B6/12 , G02B6/26 , G02B6/42 , G02B6/44 , G02B6/02 , G02B6/028 , G02B6/032 , G02B6/036
CPC分类号： H04J14/0267 , A61B5/0066 , A61B5/0084 , A61B5/6852 , G02B6/2552 , G02B6/262 , G02B6/2856
摘要： Apparatus and method are provided for transmitting at least one electro-magnetic radiation is provided. In particular, at least one optical fiber having at least one end extending along a first axis may be provided. Further, a light transmissive optical arrangement may be provided in optical cooperation with the optical fiber. The optical arrangement may have a first surface having a portion that is perpendicular to a second axis, and a second surface which includes a curved portion. The first axis can be provided at a particular angle that is more than 0° and less than 90° with respect to the second axis.
摘要翻译：提供了用于传送至少一个电磁辐射的装置和方法。特别地，可以提供至少一个具有沿着第一轴线延伸的至少一个端部的光纤。此外，可以与光纤光学协作地提供透光的光学装置。光学装置可以具有第一表面，其具有垂直于第二轴线的部分，以及包括弯曲部分的第二表面。第一轴可以相对于第二轴线以大于0°且小于90°的特定角度设置。

10. 发明授权

US07365859B2 System and method for optical coherence imaging 有权
标题翻译：光学相干成像系统和方法
公开(公告)号：US07365859B2
公开(公告)日：2008-04-29
申请号：US11225840
申请日：2005-09-12
申请人： Seok-Hyun Yun , Brett Eugene Bouma , Guillermo J. Tearney , Johannes F. deBoer
发明人： Seok-Hyun Yun , Brett Eugene Bouma , Guillermo J. Tearney , Johannes F. deBoer
IPC分类号： G01B11/02
CPC分类号： G01B9/02014 , G01B9/02004 , G01B9/02044 , G01B9/02069 , G01B9/02077 , G01B9/02091 , G01B2290/45 , G01B2290/70 , G01N21/4795
摘要： A system and method for imaging of a sample, e.g., biological sample, are provided. In particular, at least one source electro-magnetic radiation forwarded to the sample and a reference may be generated. A plurality of detectors may be used, at least one of the detectors capable of detecting a signal associated with a combination of at least one first electro-magnetic radiation received from the sample and at least one second electro-magnetic radiation received from the reference. At least one particular detector may have a particular electrical integration time, and can receive at least a portion of the signal for a time duration which has a first portion with a first power level greater than a predetermined threshold and a second portion immediately preceding or following the first portion. The second portion may have a second power level that is less than the predetermined threshold, and extends for a time period which may be, e.g., approximately more than 10% of the particular electrical integration time.
摘要翻译：提供了用于成像样品例如生物样品的系统和方法。特别地，可以产生转发到样品的至少一个源电磁辐射和参考。可以使用多个检测器，所述检测器中的至少一个检测器能够检测与从样本接收的至少一个第一电磁辐射的组合相关联的信号和从参考接收的至少一个第二电磁辐射。至少一个特定检测器可以具有特定的电积分时间，并且可以接收信号的至少一部分持续一段持续时间，该持续时间具有第一部分具有大于预定阈值的第一功率电平，以及紧接在之前或之后的第二部分第一部分。第二部分可以具有小于预定阈值的第二功率电平，并且延伸可以是例如大约超过特定电积分时间的10％的时间段。

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