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1. 发明授权

US07947681B2 Methods of administering tetrahydrobiopterin, associated compositions, and methods of measuring 有权
标题翻译：四氢生物蝶呤，相关组合物和测量方法的施用方法
公开(公告)号：US07947681B2
公开(公告)日：2011-05-24
申请号：US12577509
申请日：2009-10-12
申请人： Daniel I. Oppenheimer , Alejandro Dorenbaum , Augustus Okhamafe , Erik Foehr , Sianna Castillo , Paul J. Kostel
发明人： Daniel I. Oppenheimer , Alejandro Dorenbaum , Augustus Okhamafe , Erik Foehr , Sianna Castillo , Paul J. Kostel
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0053 , A61K9/0065 , A61K9/0095 , A61K9/08 , A61K9/1652 , A61K9/2027 , A61K9/2054 , A61K9/2086 , A61K9/4808 , A61K9/4858 , A61K9/4891 , A61K45/06 , C07B63/00 , C07D487/04 , G01N27/62 , G01N30/7233 , G01N33/6848 , H01J49/004 , Y10T436/147777 , A61K2300/00
摘要： The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
摘要翻译：本发明涉及给予四氢生物喋呤的治疗方法，包括口服剂型，静脉内制剂和食物。本文还公开了用于测量样品中生物蝶呤和生物蝶呤的代谢物的量的生物蝶呤测定法。

2. 发明申请

US20100111918A1 METHODS OF ADMINISTERING TETRAHYDROBIOPTERIN, ASSOCIATED COMPOSITIONS, AND METHODS OF MEASURING 有权
标题翻译：管理四氢叶酸酯，相关组合物的方法和测量方法
公开(公告)号：US20100111918A1
公开(公告)日：2010-05-06
申请号：US12577509
申请日：2009-10-12
申请人： Daniel I. Oppenheimer , Alejandro Dorenbaum , Augustus Okhamafe , Erik Foehr , Sianna Castillo , Paul J. Kostel
发明人： Daniel I. Oppenheimer , Alejandro Dorenbaum , Augustus Okhamafe , Erik Foehr , Sianna Castillo , Paul J. Kostel
IPC分类号： A61K38/43 , A61K33/22 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0053 , A61K9/0065 , A61K9/0095 , A61K9/08 , A61K9/1652 , A61K9/2027 , A61K9/2054 , A61K9/2086 , A61K9/4808 , A61K9/4858 , A61K9/4891 , A61K45/06 , C07B63/00 , C07D487/04 , G01N27/62 , G01N30/7233 , G01N33/6848 , H01J49/004 , Y10T436/147777 , A61K2300/00
摘要： The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
摘要翻译：本发明涉及给予四氢生物喋呤的治疗方法，包括口服剂型，静脉内制剂和食物。本文还公开了用于测量样品中生物蝶呤和生物蝶呤的代谢物的量的生物蝶呤测定法。

3. 发明申请

US20110281880A1 METHODS OF ADMINISTERING TETRAHYDROBIOPTERIN, ASSOCIATED COMPOSITIONS, AND METHODS OF MEASURING 审中-公开
标题翻译：管理四氢叶酸酯，相关组合物的方法和测量方法
公开(公告)号：US20110281880A1
公开(公告)日：2011-11-17
申请号：US13097223
申请日：2011-04-29
申请人： Daniel I. Oppenheimer , Alejandro Dorenbaum , Augustus Okhamafe , Erik Foehr , Sianna Castillo , Paul J. Kostel
发明人： Daniel I. Oppenheimer , Alejandro Dorenbaum , Augustus Okhamafe , Erik Foehr , Sianna Castillo , Paul J. Kostel
IPC分类号： A61K31/519 , G01N33/48 , C12Q1/25 , A61P9/00 , A61P7/06 , A61P25/00 , C07D475/04 , A61P3/00
CPC分类号： A61K31/519 , A61K9/0019 , A61K9/0053 , A61K9/0065 , A61K9/0095 , A61K9/08 , A61K9/1652 , A61K9/2027 , A61K9/2054 , A61K9/2086 , A61K9/4808 , A61K9/4858 , A61K9/4891 , A61K45/06 , C07B63/00 , C07D487/04 , G01N27/62 , G01N30/7233 , G01N33/6848 , H01J49/004 , Y10T436/147777 , A61K2300/00
摘要： The present invention is directed to treatment methods of administering tetrahydrobiopterin, including in oral dosage forms, in intravenous formulations, and with food. Also disclosed herein are biopterin assays for measuring the amount of biopterin and metabolites of biopterin in a sample.
摘要翻译：本发明涉及给予四氢生物喋呤的治疗方法，包括口服剂型，静脉内制剂和食物。本文还公开了用于测量样品中生物蝶呤和生物蝶呤的代谢物的量的生物蝶呤测定法。

4. 发明授权

US5567807A Processes for the purification of human recombinant decorin and the detection of guanidinium ions 失效
标题翻译：人重组核心蛋白聚糖纯化方法和胍离子的检测
公开(公告)号：US5567807A
公开(公告)日：1996-10-22
申请号：US272919
申请日：1994-07-08
申请人： William S. Craig , John R. Harper , Paul J. Kostel , Jonathan R. Parker , Thomas S. Vedvick
发明人： William S. Craig , John R. Harper , Paul J. Kostel , Jonathan R. Parker , Thomas S. Vedvick
IPC分类号： G01N30/02 , A61K38/00 , A61P35/00 , A61P43/00 , B01D41/04 , C07K14/00 , C07K14/47 , C07K14/78 , C12N15/09 , C12Q1/00 , G01N30/06 , G01N30/26 , G01N30/46 , G01N30/88 , G01N30/96 , G01N33/53 , G01N33/68 , C07K1/20
CPC分类号： G01N33/5308 , C07K14/4725 , G01N33/68 , Y10T436/173845
摘要： The present invention is directed to a process for the production of substantially pure human recombinant decorin which involves the combination of three separate stages characterized by contacting decorin-containing cell culture medium with (1) a first strong anionic exchange resin; then with (2) a hydrophobic interactive chromatographic resin; and finally with (3) a second strong anionic exchange resin. By using a combination of steps, and certain reagents, in particular a 2.4 to 3 molar GuHCl solution to elute decorin from a hydrophobic interactive column, the process of this invention provides a more convenient and reproducible process for purifying human recombinant decorin. The invention also provides a process for detecting the presence of guanidinium ions in a sample solution. The detection process involves contacting a sample solution suspected of containing guanidinium ions with a cation exchange resin and eluting the guanidinium ions present in tire sample solution with an aqueous buffer solution having a pH of about 1.5 to about 2. This is followed by contacting the eluant with a cation suppressor columns and simultaneously flowing a suppressor regenerate solution in the opposite direction on the opposite side of the permeable membrane of the column, and finally, detecting the presence of guanidinium ions in the eluant from the ion exchange column which was contacted with the suppressor column by use of a conductivity detector.
摘要翻译：本发明涉及生产基本上纯的人重组核心蛋白聚糖的方法，其涉及三个独立阶段的组合，其特征在于使含有核蛋白聚糖的细胞培养基与（1）第一强阴离子交换树脂接触; 然后用（2）疏水交互色谱树脂; 最后用（3）第二强阴离子交换树脂。通过使用步骤的组合和某些试剂，特别是2.4至3摩尔的GuHCl溶液从疏水相互作用的色谱柱洗脱核心蛋白聚糖，本发明的方法提供了一种更方便和可重现的纯化人重组核心蛋白聚糖的方法。本发明还提供了检测样品溶液中胍离子的存在的方法。检测过程包括将怀疑含有胍离子的样品溶液与阳离子交换树脂接触，并用pH为约1.5至约2的pH缓冲溶液洗脱存在于轮胎样品溶液中的胍离子。然后将洗脱液用阳离子抑制柱，同时在柱的可渗透膜的相对侧沿相反方向流动抑制剂再生溶液，最后，检测离离子交换柱的洗脱液中胍基离子的存在，该离子交换柱与抑制柱通过使用电导率检测器。

5. 发明授权

US5763276A Processes for the purification of human recombinant decorin and the detection of guandinium ions 失效
标题翻译：人重组核心蛋白聚糖纯化方法和胍离子的检测
公开(公告)号：US5763276A
公开(公告)日：1998-06-09
申请号：US619916
申请日：1996-03-20
申请人： William S. Craig , John R. Harper , Sam D. Hernandez , Paul J. Kostel , Jonathan R. Parker , Thomas S. Vedvick
发明人： William S. Craig , John R. Harper , Sam D. Hernandez , Paul J. Kostel , Jonathan R. Parker , Thomas S. Vedvick
IPC分类号： G01N30/02 , A61K38/00 , A61P35/00 , A61P43/00 , B01D41/04 , C07K14/00 , C07K14/47 , C07K14/78 , C12N15/09 , C12Q1/00 , G01N30/06 , G01N30/26 , G01N30/46 , G01N30/88 , G01N30/96 , G01N33/53 , G01N33/68 , G01N33/00 , C07K1/20 , G01N27/00
CPC分类号： G01N33/5308 , C07K14/4725 , G01N33/68 , Y10T436/173845
摘要： The invention provides a process for detecting the presence of guanidinium ions in a sample solution. The detection process involves contacting a sample solution suspected of containing guanidinium ions with a cation exchange resin and eluting the guanidinium ions present in the sample solution with an aqueous buffer solution having a pH of about 1.5 to about 2. This is followed by contacting the eluant with a cation suppressor column and simultaneously flowing a suppressor regenerate solution in the opposite direction on the opposite side of the permeable membrane of the column, and finally, detecting the presence of guanidinium ions in the eluant from the ion exchange column which was contacted with the suppressor column by use of a conductivity detector.
摘要翻译：本发明提供了检测样品溶液中胍离子的存在的方法。检测过程包括将怀疑含有胍离子的样品溶液与阳离子交换树脂接触，并用pH为约1.5至约2的pH缓冲溶液洗脱存在于样品溶液中的胍离子。然后将洗脱液用阳离子抑制柱，同时在柱的可渗透膜的相对侧沿相反方向流动抑制剂再生溶液，最后，检测离离子交换柱的洗脱液中胍基离子的存在，该离子交换柱与抑制柱通过使用电导率检测器。

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