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1. 发明申请

US20120029176A1 Chromatography Media And Method 有权
标题翻译：色谱介质和方法
公开(公告)号：US20120029176A1
公开(公告)日：2012-02-02
申请号：US13191992
申请日：2011-07-27
申请人： David Yavorsky , John Amara , Joaquin Umana , William Cataldo , Mikhail Kozlov , Matthew Stone
发明人： David Yavorsky , John Amara , Joaquin Umana , William Cataldo , Mikhail Kozlov , Matthew Stone
IPC分类号： B01D15/08 , B01D15/10 , B01D15/36 , C07K1/20 , B01D15/32 , C07K1/22 , C07K1/18 , B01D15/04 , B01D15/38
CPC分类号： B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/28023 , B01J20/28059 , B01J20/285 , B01J20/287 , B01J20/3244 , B01J41/20 , B01J47/014 , B01J47/127 , C07K1/18 , C07K16/00 , C12N7/00 , C12N7/02 , G01N2030/521 , Y10S502/52724 , Y10T428/2938 , Y10T428/2973
摘要： Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
摘要翻译：来自成形纤维的用于色谱的吸附介质，特别是离子交换层析。在某些实施方案中，与普通纤维相比，功能化成形纤维呈现原纤化或脊状结构，其大大增加了纤维的表面积。本文还公开了一种向高表面积纤维添加提供阳离子交换或阴离子交换官能团的表面侧基官能团的方法。这种侧链官能团可用于生物分子的离子交换色谱纯化，如单克隆抗体（mAb）。

2. 发明授权

US09029517B2 Chromatography media and method 有权
标题翻译：色谱介质和方法
公开(公告)号：US09029517B2
公开(公告)日：2015-05-12
申请号：US13191992
申请日：2011-07-27
申请人： David Yavorsky , John Amara , Joaquin Umana , William Cataldo , Mikhail Kozlov , Matthew Stone
发明人： David Yavorsky , John Amara , Joaquin Umana , William Cataldo , Mikhail Kozlov , Matthew Stone
IPC分类号： B01J20/28 , B01J47/12 , C07K1/18 , C07K1/20 , C07K1/22 , B01D15/32 , B01D15/36 , B01D15/38 , B01J20/285 , B01J20/287 , B01J20/32 , B01J39/26 , B01J41/20 , B01J47/00
CPC分类号： B01J39/26 , B01D15/327 , B01D15/361 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/28023 , B01J20/28059 , B01J20/285 , B01J20/287 , B01J20/3244 , B01J41/20 , B01J47/014 , B01J47/127 , C07K1/18 , C07K16/00 , C12N7/00 , C12N7/02 , G01N2030/521 , Y10S502/52724 , Y10T428/2938 , Y10T428/2973
摘要： Adsorptive media for chromatography, particularly ion-exchange chromatography, derived from a shaped fiber. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Also disclosed herein is a method to add surface pendant functional groups that provides cation-exchange or anion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of biomolecules, such as monoclonal antibodies (mAbs).
摘要翻译：来自成形纤维的用于色谱的吸附介质，特别是离子交换层析。在某些实施方案中，与普通纤维相比，官能化成形纤维呈现原纤化或脊状结构，其大大增加了纤维的表面积。本文还公开了向高表面积纤维添加提供阳离子交换或阴离子交换官能团的表面侧基官能团的方法。这种侧链官能团可用于生物分子的离子交换色谱纯化，如单克隆抗体（mAb）。

3. 发明授权

US09791525B2 Methods of preparing and operating an MRI multi-channel coil 有权
公开(公告)号：US09791525B2
公开(公告)日：2017-10-17
申请号：US14235475
申请日：2011-08-01
申请人： Mikhail Kozlov , Robert Turner
发明人： Mikhail Kozlov , Robert Turner
IPC分类号： G01V3/00 , G01R33/36 , G01R33/3415 , G01R33/561 , G01R33/565
CPC分类号： G01R33/36 , G01R33/3415 , G01R33/365 , G01R33/5612 , G01R33/5659
摘要： A method of preparing a multi-channel coil, in particular for magnetic resonance imaging (MRI) or for a medical treatment device, wherein the multi-channel coil comprises at least two coil rows being axially arranged along a longitudinal direction (z), wherein each of the at least two coil rows comprises a plurality of coil elements being azimuthally distributed relative to the longitudinal direction (z), comprises the steps of a) electro-magnetic decoupling of the coil rows relative to each other, and b) minimizing a reflected power (Pref_row) individually of each of the coil rows. Furthermore, a method of operating a multi-channel coil, in particular for magnetic resonance imaging (MRI) or for a medical treatment device, and a multi-channel coil, which is prepared using to the above method are described.

4. 发明授权

US08968756B2 Fabrication of biscrolled fiber using carbon nanotube sheet 有权
标题翻译：使用碳纳米管片材制造双曲线纤维
公开(公告)号：US08968756B2
公开(公告)日：2015-03-03
申请号：US13322880
申请日：2010-05-27
申请人： Shaoli Fang , Marcio Dias Lima , Xavier N. Lepro-Chavez , Javier Carretero-Gonzalez , Elizabeth Castillo-Martinez , Raquel Ovalle-Robles , Carter Sebastian Haines , David Michael Novitski , Mohammad H. Haque , Chihye Lewis-Azad , Mikhail Kozlov , Anvar A. Zakhidov , Ray H. Baughman
发明人： Shaoli Fang , Marcio Dias Lima , Xavier N. Lepro-Chavez , Javier Carretero-Gonzalez , Elizabeth Castillo-Martinez , Raquel Ovalle-Robles , Carter Sebastian Haines , David Michael Novitski , Mohammad H. Haque , Chihye Lewis-Azad , Mikhail Kozlov , Anvar A. Zakhidov , Ray H. Baughman
IPC分类号： A01N25/34 , H01M4/133 , D01F9/12 , H01M4/131 , H01M4/1391 , H01M4/1393 , H01M4/58 , H01M4/587 , H01M4/96 , D02G3/16 , A61L15/18 , A61L17/04 , H01M8/00 , H01M10/0525
CPC分类号： H01M4/04 , A61K9/7007 , A61L15/18 , A61L17/04 , A61L31/024 , A61L31/16 , A61L2300/108 , A61L2300/414 , A61L2300/418 , A61L2400/12 , B01J21/063 , B01J21/18 , B01J21/185 , B01J23/42 , B01J35/0006 , B01J35/004 , B01J35/06 , B01J37/0215 , B01J37/0238 , B05D3/12 , B05D5/00 , C23C14/04 , C23C14/58 , C23C16/04 , C23C16/56 , D01F9/12 , D02G3/16 , D10B2101/122 , H01B12/06 , H01G11/86 , H01M4/0402 , H01M4/131 , H01M4/133 , H01M4/1391 , H01M4/1393 , H01M4/5825 , H01M4/587 , H01M4/96 , H01M8/00 , H01M10/0525 , Y02E60/122 , Y02E60/50 , Y10T428/2918 , Y10T428/2929
摘要： Fabrication of yarns or other shaped articles from materials in powder form (or nanoparticles or nanofibers) using carbon nanotube/nanofiber sheet as a platform (template). This includes methods for fabricating biscrolled yarns using carbon nanotube/nanofiber sheets and biscrolled fibers fabricated thereby.
摘要翻译：使用碳纳米管/纳米纤维片作为平台（模板）从粉末形式的材料（或纳米颗粒或纳米纤维）制造纱线或其他成型制品。这包括使用碳纳米管/纳米纤维片材制造双曲线纱线的方法和由此制造的双曲线纤维。

5. 发明申请

US20150028869A1 Method for Multi-Mode, Multi-Load, and Multi-Domain Optimization of a Multi-Channel Near-Field RF Transmitter 有权
标题翻译：多通道近场射频发射机的多模，多负载和多域优化方法
公开(公告)号：US20150028869A1
公开(公告)日：2015-01-29
申请号：US14384974
申请日：2012-03-14
申请人： Mikhail Kozlov , Robert Turner
发明人： Mikhail Kozlov , Robert Turner
IPC分类号： G01R33/54 , G01R33/36
CPC分类号： G01R33/54 , G01R33/3607 , G01R33/5612
摘要： The invention relates to a method for optimization of a performance of a multi-channel transmitter including several transmit elements, particularly in a magnetic resonance imaging device. The method includes: (a) Exciting the transmit elements of the multi-channel transmitter by electric excitation signals comprising a specific power, with the power of the excitation signals partially reflected by the transmit elements of the multichannel transmitter, (b) Determining a reflected power which is reflected by the multi-channel transmitter during excitation of the transmit elements, (c) Determining reflection coefficients Sxx of the multi-channel transmitter, (d) Determining reflection coefficients Sxy of the multi-channel transmitter, (e) Calculating a performance criterion representing the performance of the multi-channel transmitter, with the performance criterion based on the reflected power, the reflection coefficients Sxx and the reflection coefficients Sxy, and (f) Tuning the multi-channel transmitter so that the performance criterion is optimized.
摘要翻译：本发明涉及一种用于优化包括多个发射元件的多信道发射机的性能的方法，特别是在磁共振成像设备中。该方法包括：（a）通过包括特定功率的电激励信号来激励多信道发射机的发射元件，激励信号的功率部分地被多信道发射机的发射元件反射，（b）确定反射的（c）确定多声道发射机的反射系数Sxx，（d）确定多声道发射机的反射系数Sxy，（e）计算多声道发射机的反射系数Sxy，表示多通道发射机的性能的性能标准，其中基于反射功率的性能标准，反射系数Sxx和反射系数Sxy，以及（f）调谐多通道发射机，使得性能标准被优化。

6. 发明申请

US20140152309A1 METHODS OF PREPARING AND OPERATING AN MRI MULTI-CHANNEL COIL 有权
标题翻译：制作和操作MRI多通道线圈的方法
公开(公告)号：US20140152309A1
公开(公告)日：2014-06-05
申请号：US14235475
申请日：2011-08-01
申请人： Mikhail Kozlov , Robert Turner
发明人： Mikhail Kozlov , Robert Turner
IPC分类号： G01R33/36
CPC分类号： G01R33/36 , G01R33/3415 , G01R33/365 , G01R33/5612 , G01R33/5659
摘要： A method of preparing a multi-channel coil, in particular for magnetic resonance imaging (MRI) or for a medical treatment device, wherein the multi-channel coil comprises at least two coil rows being axially arranged along a longitudinal direction (z), wherein each of the at least two coil rows comprises a plurality of coil elements being azimuthally distributed relative to the longitudinal direction (z), comprises the steps of a) electro-magnetic decoupling of the coil rows relative to each other, and b) minimizing a reflected power (Pref—row) individually of each of the coil rows. Furthermore, a method of operating a multi-channel coil, in particular for magnetic resonance imaging (MRI) or for a medical treatment device, and a multi-channel coil, which is prepared using to the above method are described.
摘要翻译：一种制备多通道线圈的方法，特别是用于磁共振成像（MRI）或医疗处理装置，其中多通道线圈包括沿纵向方向（z）轴向布置的至少两个线圈排，其中所述至少两个线圈列中的每一个包括相对于纵向方向（z）方位分布的多个线圈元件，包括以下步骤：a）线圈列相对于彼此的电磁去耦，以及b）使每个线圈列分别具有反射功率（Pref-row）。此外，描述了使用上述方法制备的操作多通道线圈的方法，特别是用于磁共振成像（MRI）或医疗处理装置以及多通道线圈。

7. 发明授权

US08642807B2 Crystallized diacetylenic indicator compounds and methods of preparing the compounds 有权
标题翻译：结晶二乙炔指示剂化合物及其制备方法
公开(公告)号：US08642807B2
公开(公告)日：2014-02-04
申请号：US13529605
申请日：2012-06-21
申请人： Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik
发明人： Ray H. Baughman , Lee J. Hall , Mikhail Kozlov , Dawn E. Smith , Thaddeus Prusik
IPC分类号： C07C275/20 , G01K11/12 , G01D21/00
CPC分类号： G01K11/12 , C07C273/02 , C07C275/20 , C09B69/10 , G01K3/04 , G01N21/78 , G01N31/22 , G01N31/229
摘要： Crystallized diacetylenic compounds having certain crystallographic and other characteristics; diacetylenic compounds and mixtures crystallized from diacetylenic solutions; methods of preparing and identifying solvent systems for dissolving diacetylenic compounds; diacetylenic solutions; methods of recrystallizing diacetylenic compounds; crystals of 2,4-hexadiyn-1,6-bis(alkylurea) compounds; and ambient condition indicators and time-temperature condition indicators comprising crystallized diacetylenic compounds.
摘要翻译：具有某些晶体学特性的结晶二炔化合物; 二乙炔化合物和从二乙炔溶液中结晶的混合物; 制备和鉴定溶解二乙炔化合物的溶剂体系的方法; 二乙酰溶液; 二乙炔化合物重结晶方法; 2,4-己二炔-1,6-双（烷基脲）化合物的晶体; 环境条件指标和包含结晶二乙炔化合物的时间 - 温度条件指标。

8. 发明申请

US20130203969A1 USE OF SMALL MOLECULES IN METHODS FOR PURIFICATION OF BIOMOLECULES 审中-公开
标题翻译：在生物分子纯化方法中使用小分子
公开(公告)号：US20130203969A1
公开(公告)日：2013-08-08
申请号：US13566320
申请日：2012-08-03
申请人： Jad Jaber , Wilson Moya , Ajish Potty , Alison Dupont , Matthew T. Stone , Mikhail Kozlov
发明人： Jad Jaber , Wilson Moya , Ajish Potty , Alison Dupont , Matthew T. Stone , Mikhail Kozlov
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , B01D15/327 , B01D15/361 , B01D15/3804 , B01D15/3847 , C07K1/30
摘要： The present invention relates to novel and improved methods for the purification of biomolecules. In particular, the present invention relates to methods of protein purification which employ small molecules, which include at least one non-polar group and at least one cationic group or which include at least one non-polar group and at least one anionic group.
摘要翻译：本发明涉及用于纯化生物分子的新颖和改进的方法。特别地，本发明涉及使用包括至少一个非极性基团和至少一个阳离子基团或包括至少一个非极性基团和至少一个阴离子基团的小分子的蛋白质纯化方法。

9. 发明授权

US08435406B2 Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same 有权
标题翻译：用于基于聚合伯胺的膜离子交换色谱的介质，含有该介质的吸附装置和使用其的色谱方案和纯化方法
公开(公告)号：US08435406B2
公开(公告)日：2013-05-07
申请号：US13363397
申请日：2012-02-01
申请人： Mikhail Kozlov , Wilson Moya , Michael W. Phillips , Senthilkumar Ramaswamy , Brian Gagnon
发明人： Mikhail Kozlov , Wilson Moya , Michael W. Phillips , Senthilkumar Ramaswamy , Brian Gagnon
IPC分类号： B01D15/08
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities even at high conductivities and pH.
摘要翻译：介质和装置，例如包括这种介质的阴离子交换剂，其中介质是具有涂覆聚合物如聚烯丙基胺的表面的膜。与基于季铵盐（包括三甲基铵配体）的常规配体相比，所得到的膜提供了更强的蛋白质杂质结合和优于宿主细胞蛋白质从生物样品中的去除。还描述了用于纯化单克隆抗体的色谱方法和方法，其中阴离子交换吸附剂置于亲和柱（例如蛋白A或蛋白G亲和柱）的下游，以及任选的一种或多种抛光装置如阳离子交换柱。阳离子交换池（或不使用阳离子交换剂的亲和柱交换池）的稀释很少或不需要，以降低样品的电导率。即使在高电导率和pH下，吸附剂也能很好地结合宿主细胞蛋白质和其他杂质。

10. 发明申请

US20120006752A1 Enhanced Clarification Media 审中-公开
公开(公告)号：US20120006752A1
公开(公告)日：2012-01-12
申请号：US13102081
申请日：2011-05-06
申请人： KS Cheng , Senthil Ramaswamy , Brian Gagnon , Maybelle Woo , Mikhail Kozlov
发明人： KS Cheng , Senthil Ramaswamy , Brian Gagnon , Maybelle Woo , Mikhail Kozlov
IPC分类号： B01D15/08 , B01D39/18
CPC分类号： B01J20/3212 , B01J20/3274 , B01J20/3282
摘要： Media and devices, such as nitrocellulose-based filters, wherein the media is coated with a polymer such as a polyallylamine. The resulting device offers strong binding of protein impurities and superior removal of host cell proteins from biological samples.

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