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1. 发明授权

US09358395B2 Neural modulation devices and methods 有权
标题翻译：神经调制装置及方法
公开(公告)号：US09358395B2
公开(公告)日：2016-06-07
申请号：US14453183
申请日：2014-08-06
申请人： EnteroMedics Inc.
发明人： Katherine S. Tweden , Jonathan J. Waataja , Adrianus P. Donders , Mark B. Knudson
IPC分类号： A61N1/36 , A61N1/05 , A61N1/372 , A61N1/378
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/0551 , A61N1/36053 , A61N1/36085 , A61N1/36117 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/3787
摘要： A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
摘要翻译：一种用于设计用于治疗或治疗与受试者相关的胃肠疾病或与体重过重相关的病症的系统，所述系统包括至少一个被配置成植入患者体内并置于迷走神经的电极，所述电极还被配置为施加在向电极施加治疗周期时对迷走神经进行治疗; 可植入神经调节器，用于放置在皮肤层下面的患者体内，所述可植入神经调节器被配置为产生治疗周期，其中所述治疗周期包括传递电信号的接通时间，所述电信号包括：a）以大约150-10,000Hz的第一选定频率施加的一组脉冲，其中脉冲组的每个脉冲具有至少0.01毫秒且小于第一选定频率的周期的脉冲宽度。

2. 发明授权

US09174040B2 Nerve stimulation and blocking for treatment of gastrointestinal disorders 有权
标题翻译：神经刺激和阻塞用于治疗胃肠道疾病
公开(公告)号：US09174040B2
公开(公告)日：2015-11-03
申请号：US14019126
申请日：2013-09-05
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/18 , A61N1/06 , A61N1/22 , A61N1/05 , A61N1/32 , A61N1/36
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
摘要： At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
摘要翻译：通过刺激患者的肠神经系统来治疗多种胃肠道疾病中的至少一种，以增强肠神经系统的功能性色调。治疗包括在靠近胃肠器官的迷走神经支配的至少一个部位的刺激部位电刺激患者的迷走神经。电刺激包括在刺激部位施加刺激信号。在靠近刺激部位的近端阻塞位置，将可选的近端电阻塞信号施加到迷走神经。选择近端阻塞信号以至少部分阻断近端阻塞部位处的神经冲动。

3. 发明申请

US20140316478A1 SYSTEMS FOR REGULATION OF BLOOD PRESSURE AND HEART RATE 有权
标题翻译：用于调节血压和心率的系统
公开(公告)号：US20140316478A1
公开(公告)日：2014-10-23
申请号：US14319529
申请日：2014-06-30
申请人： EnteroMedics Inc.
发明人： Katherine S. Tweden , Richard R. Wilson , Mark B. Knudson , Dennis Dong-Won Kim , Deepak Bhole
IPC分类号： A61N1/36 , A61N1/378 , A61N1/372
CPC分类号： A61N1/36117 , A61N1/36053 , A61N1/36114 , A61N1/36139 , A61N1/37211 , A61N1/3787
摘要： A method and apparatus for treating a condition associated with impaired blood pressure and/or heart rate in a subject comprising applying an electrical treatment signal, wherein the electrical treatment signal is selected to at least partially block nerve impulses, or in some embodiments, to augment nerve impulses.
摘要翻译：一种用于治疗与受试者中受损的血压和/或心率相关的病症的方法和装置，包括施加电治疗信号，其中所述电治疗信号被选择为至少部分阻断神经冲动，或在一些实施例中增加神经冲动

4. 发明申请

US20130197600A1 BULIMIA TREATMENT 有权
标题翻译：布利马治疗
公开(公告)号：US20130197600A1
公开(公告)日：2013-08-01
申请号：US13758223
申请日：2013-02-04
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61F5/00
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is bulimia. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.
摘要翻译：通过包括将电极定位在迷走神经上的方法来治疗至少部分地由支配患者的多个器官中的至少一个的迷走神经活动表征的患者的多种病症中的至少一种。将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。在一些实施方案中，该疾病是贪食症。该信号可以是阻塞或刺激信号。在一些实施方案中，所述信号被选择为至少部分地下调迷走神经的神经活动。

5. 发明授权

US09162062B2 Controlled vagal blockage therapy 有权
标题翻译：受控迷走神经阻滞治疗
公开(公告)号：US09162062B2
公开(公告)日：2015-10-20
申请号：US14028030
申请日：2013-09-16
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/36 , A61N1/05 , A61N1/32
CPC分类号： A61N1/36085 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36178
摘要： A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
摘要翻译：用于治疗至少部分由迷走神经活动表征的多种疾病中的至少一种的方法包括将电极定位在由迷走神经支配的身体器官周围。将电信号施加到电极以调节迷走神经活性。电信号被施加在为信号选择的频率上，以向迷走神经产生神经传导阻滞，其中神经传导阻滞被选择以至少部分阻断迷走神经上的脉冲。电信号的应用被停止。重复信号的应用和信号的中断，并且选择停止和应用的持续时间来治疗疾病。

6. 发明申请

US20150012065A1 Electrode Band System and Methods of Using the System to Treat Obesity 有权
标题翻译：电极带系统和使用该系统治疗肥胖的方法
公开(公告)号：US20150012065A1
公开(公告)日：2015-01-08
申请号：US14480242
申请日：2014-09-08
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/36 , A61F5/00
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is obesity. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.
摘要翻译：通过包括将电极定位在迷走神经上的方法来治疗至少部分地由支配患者的多个器官中的至少一个的迷走神经活动表征的患者的多种病症中的至少一种。将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。在一些实施方案中，该疾病是肥胖症。该信号可以是阻塞或刺激信号。在一些实施方案中，所述信号被选择为至少部分地下调迷走神经的神经活动。

7. 发明申请

US20140350632A1 NEURAL MODULATION DEVICES AND METHODS 有权
标题翻译：神经调制装置及方法
公开(公告)号：US20140350632A1
公开(公告)日：2014-11-27
申请号：US14453183
申请日：2014-08-06
申请人： EnteroMedics Inc.
发明人： Katherine S. Tweden , Jonathan J. Waataja , Adrianus P. Donders , Mark B. Knudson
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61N1/0509 , A61N1/0551 , A61N1/36053 , A61N1/36085 , A61N1/36117 , A61N1/36171 , A61N1/36178 , A61N1/37235 , A61N1/3787
摘要： A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
摘要翻译：一种用于设计用于治疗或治疗与受试者相关的胃肠疾病或与体重过重相关的病症的系统，所述系统包括至少一个被配置成植入患者体内并置于迷走神经的电极，所述电极还被配置为施加在向电极施加治疗周期时对迷走神经进行治疗; 可植入神经调节器，用于放置在皮肤层下面的患者体内，所述可植入神经调节器被配置为产生治疗周期，其中所述治疗周期包括传递电信号的接通时间，所述电信号包括：a）以大约150-10,000Hz的第一选定频率施加的一组脉冲，其中脉冲组的每个脉冲具有至少0.01毫秒且小于第一选定频率的周期的脉冲宽度。

8. 发明申请

US20140172039A1 CONTROLLED VAGAL BLOCKAGE THERAPY 有权
标题翻译：控制性VAGAL阻塞治疗
公开(公告)号：US20140172039A1
公开(公告)日：2014-06-19
申请号：US14028030
申请日：2013-09-16
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/36
CPC分类号： A61N1/36085 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36178
摘要： A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
摘要翻译：用于治疗至少部分由迷走神经活动表征的多种疾病中的至少一种的方法包括将电极定位在由迷走神经支配的身体器官周围。将电信号施加到电极以调节迷走神经活性。电信号被施加在为信号选择的频率上，以向迷走神经产生神经传导阻滞，其中神经传导阻滞被选择以至少部分阻断迷走神经上的脉冲。电信号的应用被停止。重复信号的应用和信号的中断，并且选择停止和应用的持续时间来治疗疾病。

9. 发明授权

US09586046B2 Electrode band system and methods of using the system to treat obesity 有权
标题翻译：电极带系统和使用该系统治疗肥胖的方法
公开(公告)号：US09586046B2
公开(公告)日：2017-03-07
申请号：US14480242
申请日：2014-09-08
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/36 , A61N1/05 , A61N1/32 , A61F5/00 , A61N1/372
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is obesity. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.
摘要翻译：通过包括将电极定位在迷走神经上的方法来治疗至少部分地由支配患者的多个器官中的至少一个的迷走神经活动表征的患者的多种病症中的至少一种。将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。在一些实施方案中，该疾病是肥胖症。该信号可以是阻塞或刺激信号。在一些实施方案中，所述信号被选择为至少部分地下调迷走神经的神经活动。

10. 发明申请

US20170021174A1 METHODS AND SYSTEMS FOR GLUCOSE REGULATION 有权
标题翻译：葡萄糖调节方法与系统
公开(公告)号：US20170021174A1
公开(公告)日：2017-01-26
申请号：US15098704
申请日：2016-04-14
申请人： EnteroMedics, Inc.
发明人： Arnold W. Thornton , Dennis Dong-won Kim , Mark B. Knudson , Katherine S. Tweden , Richard R. Wilson
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05
CPC分类号： A61N1/36053 , A61M5/00 , A61N1/0551 , A61N1/36007 , A61N1/36167 , A61N1/37211 , A61N1/37235
摘要： Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, and the splanchnic is used to modify the production of GLP-1 and GIP, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating with or without pharmaceutical agents are used to modify the production of GLP-1 and GIP, to treat impaired glucose regulation.
摘要翻译：用于治疗与受试者中的葡萄糖调节受损有关的病症的各种方法和装置包括在一个实施方案中，将神经传导阻滞物施用于至少部分阻断神经脉冲的神经传导阻滞位置处的阻断部位的靶神经。在另一个实施方案中，下调和/或上调与或不与药剂的组合用于治疗葡萄糖调节受损。在其他实施方案中，使用诸如迷走神经及其分支以及内脏的各种神经的上调或下调来改变GLP-1和GIP的产生，从而控制葡萄糖水平。在另外的实施方案中，使用具有或不具有药剂的下调和/或上调的组合来改变GLP-1和GIP的产生，以治疗葡萄糖调节受损。

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