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1. 发明授权

US09586046B2 Electrode band system and methods of using the system to treat obesity 有权
标题翻译：电极带系统和使用该系统治疗肥胖的方法
公开(公告)号：US09586046B2
公开(公告)日：2017-03-07
申请号：US14480242
申请日：2014-09-08
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/36 , A61N1/05 , A61N1/32 , A61F5/00 , A61N1/372
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is obesity. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.
摘要翻译：通过包括将电极定位在迷走神经上的方法来治疗至少部分地由支配患者的多个器官中的至少一个的迷走神经活动表征的患者的多种病症中的至少一种。将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。在一些实施方案中，该疾病是肥胖症。该信号可以是阻塞或刺激信号。在一些实施方案中，所述信号被选择为至少部分地下调迷走神经的神经活动。

2. 发明申请

US20140172052A1 NERVE STIMULATION AND BLOCKING FOR TREATMENT OF GASTROINTESTINAL DISORDERS 有权
标题翻译：神经刺激和阻塞治疗胃肠疾病
公开(公告)号：US20140172052A1
公开(公告)日：2014-06-19
申请号：US14019126
申请日：2013-09-05
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/05
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
摘要： At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
摘要翻译：通过刺激患者的肠神经系统来治疗多种胃肠道疾病中的至少一种，以增强肠神经系统的功能性色调。治疗包括在靠近胃肠器官的迷走神经支配的至少一个部位的刺激部位电刺激患者的迷走神经。电刺激包括在刺激部位施加刺激信号。在靠近刺激部位的近端阻塞位置，将可选的近端电阻塞信号施加到迷走神经。近端阻塞信号被选择为至少部分阻断近端阻塞部位处的神经冲动。

3. 发明授权

US09174040B2 Nerve stimulation and blocking for treatment of gastrointestinal disorders 有权
标题翻译：神经刺激和阻塞用于治疗胃肠道疾病
公开(公告)号：US09174040B2
公开(公告)日：2015-11-03
申请号：US14019126
申请日：2013-09-05
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/18 , A61N1/06 , A61N1/22 , A61N1/05 , A61N1/32 , A61N1/36
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
摘要： At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
摘要翻译：通过刺激患者的肠神经系统来治疗多种胃肠道疾病中的至少一种，以增强肠神经系统的功能性色调。治疗包括在靠近胃肠器官的迷走神经支配的至少一个部位的刺激部位电刺激患者的迷走神经。电刺激包括在刺激部位施加刺激信号。在靠近刺激部位的近端阻塞位置，将可选的近端电阻塞信号施加到迷走神经。选择近端阻塞信号以至少部分阻断近端阻塞部位处的神经冲动。

4. 发明申请

US20130197600A1 BULIMIA TREATMENT 有权
标题翻译：布利马治疗
公开(公告)号：US20130197600A1
公开(公告)日：2013-08-01
申请号：US13758223
申请日：2013-02-04
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61F5/00
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is bulimia. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.
摘要翻译：通过包括将电极定位在迷走神经上的方法来治疗至少部分地由支配患者的多个器官中的至少一个的迷走神经活动表征的患者的多种病症中的至少一种。将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。在一些实施方案中，该疾病是贪食症。该信号可以是阻塞或刺激信号。在一些实施方案中，所述信号被选择为至少部分地下调迷走神经的神经活动。

5. 发明申请

US20160193465A1 NERVE STIMULATION AND BLOCKING FOR TREATMENT OF GASTROINTESTINAL DISORDERS 有权
标题翻译：神经刺激和阻塞治疗胃肠疾病
公开(公告)号：US20160193465A1
公开(公告)日：2016-07-07
申请号：US14930233
申请日：2015-11-02
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
摘要： At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.
摘要翻译：通过刺激患者的肠神经系统来治疗多种胃肠道疾病中的至少一种，以增强肠神经系统的功能性色调。治疗包括在靠近胃肠器官的迷走神经支配的至少一个部位的刺激部位电刺激患者的迷走神经。电刺激包括在刺激部位施加刺激信号。在靠近刺激部位的近端阻塞位置，将可选的近端电阻塞信号施加到迷走神经。选择近端阻塞信号以至少部分阻断近端阻塞部位处的神经冲动。

6. 发明授权

US08862233B2 Electrode band system and methods of using the system to treat obesity 有权
标题翻译：电极带系统和使用该系统治疗肥胖的方法
公开(公告)号：US08862233B2
公开(公告)日：2014-10-14
申请号：US13758223
申请日：2013-02-04
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/372 , A61N1/36 , A61F5/37 , A61F5/00 , A61N1/32 , A61N1/05
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is obesity. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve. In embodiments, a system comprises a band comprising a first electrode array and a second electrode array; a signal generator electrically connected to each of said first, and second electrode array; an external programmer configured to: communicate at least one parameter for the neural conduction blocking signal to the implantable controller, wherein the parameter is selected for the neuroconduction blocking signal to i) at least partially downregulate the vagus nerve, ii) allow at least partial recovery of the nerve activity following discontinuation of the neural conduction blocking signal, and iii) reduce pancreatic and biliary output via inhibition of pancreo-biliary output; and an external coil.
摘要翻译：通过包括将电极定位在迷走神经上的方法来治疗至少部分地由支配患者的多个器官中的至少一个的迷走神经活动表征的患者的多种病症中的至少一种。将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。在一些实施方案中，该疾病是肥胖症。该信号可以是阻塞或刺激信号。在一些实施方案中，所述信号被选择为至少部分地下调迷走神经的神经活动。在实施例中，系统包括包括第一电极阵列和第二电极阵列的带; 电连接到所述第一和第二电极阵列中的每一个的信号发生器; 外部编程器被配置为：将至少一个用于所述神经传导阻断信号的参数传达到所述可植入控制器，其中为所述神经传导阻断信号选择所述参数以i）至少部分地下调迷走神经，ii）允许至少部分恢复神经传导阻滞信号停止后的神经活动，以及iii）通过抑制胰胆管输出来减少胰腺和胆汁输出; 和外部线圈。

7. 发明授权

US09162062B2 Controlled vagal blockage therapy 有权
标题翻译：受控迷走神经阻滞治疗
公开(公告)号：US09162062B2
公开(公告)日：2015-10-20
申请号：US14028030
申请日：2013-09-16
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/36 , A61N1/05 , A61N1/32
CPC分类号： A61N1/36085 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36178
摘要： A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
摘要翻译：用于治疗至少部分由迷走神经活动表征的多种疾病中的至少一种的方法包括将电极定位在由迷走神经支配的身体器官周围。将电信号施加到电极以调节迷走神经活性。电信号被施加在为信号选择的频率上，以向迷走神经产生神经传导阻滞，其中神经传导阻滞被选择以至少部分阻断迷走神经上的脉冲。电信号的应用被停止。重复信号的应用和信号的中断，并且选择停止和应用的持续时间来治疗疾病。

8. 发明申请

US20150012065A1 Electrode Band System and Methods of Using the System to Treat Obesity 有权
标题翻译：电极带系统和使用该系统治疗肥胖的方法
公开(公告)号：US20150012065A1
公开(公告)日：2015-01-08
申请号：US14480242
申请日：2014-09-08
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/36 , A61F5/00
CPC分类号： A61N1/36053 , A61F5/0026 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36071 , A61N1/36082 , A61N1/37235
摘要： At least one of a plurality of disorders of a patient characterized at least in part by vagal activity innervating at least one of a plurality of organs of the patient is treated by a method that includes positioning an electrode on a vagus nerve. An electrical signal is applied to the electrode to modulate vagal activity by an amount selected to treat the disorder. In some embodiments, the disorder is obesity. The signal may be a blocking or a stimulation signal. In some embodiments, the signal is selected to, at least in part, downregulate neural activity on the vagus nerve.
摘要翻译：通过包括将电极定位在迷走神经上的方法来治疗至少部分地由支配患者的多个器官中的至少一个的迷走神经活动表征的患者的多种病症中的至少一种。将电信号施加到电极，以通过选择用于治疗病症的量来调节迷走神经活性。在一些实施方案中，该疾病是肥胖症。该信号可以是阻塞或刺激信号。在一些实施方案中，所述信号被选择为至少部分地下调迷走神经的神经活动。

9. 发明申请

US20140172039A1 CONTROLLED VAGAL BLOCKAGE THERAPY 有权
标题翻译：控制性VAGAL阻塞治疗
公开(公告)号：US20140172039A1
公开(公告)日：2014-06-19
申请号：US14028030
申请日：2013-09-16
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/36
CPC分类号： A61N1/36085 , A61N1/05 , A61N1/321 , A61N1/36007 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36178
摘要： A method for treating at least one of a plurality of disorders characterized at least in part by vagal activity includes positioning an electrode around a body organ innervated by the vagus. An electrical signal is applied to the electrode to modulate vagal activity. The electrical signal is applied at a frequency selected for the signal to create a neural conduction block to the vagus with the neural conduction block selected to at least partially block nerve impulses on the vagus. The application of the electrical signal is discontinued. The application of the signal and the discontinuing of the signal are repeated with durations of the discontinuing and the application selected to treat the disorder.
摘要翻译：用于治疗至少部分由迷走神经活动表征的多种疾病中的至少一种的方法包括将电极定位在由迷走神经支配的身体器官周围。将电信号施加到电极以调节迷走神经活性。电信号被施加在为信号选择的频率上，以向迷走神经产生神经传导阻滞，其中神经传导阻滞被选择以至少部分阻断迷走神经上的脉冲。电信号的应用被停止。重复信号的应用和信号的中断，并且选择停止和应用的持续时间来治疗疾病。

10. 发明申请

US20170304615A1 NERVE STIMULATION AND BLOCKING FOR TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
公开(公告)号：US20170304615A1
公开(公告)日：2017-10-26
申请号：US15625755
申请日：2017-06-16
申请人： EnteroMedics Inc.
发明人： Mark B. Knudson , Richard R. Wilson , Katherine S. Tweden , Timothy R. Conrad
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36007 , A61N1/05 , A61N1/0551 , A61N1/321 , A61N1/36053 , A61N1/3606 , A61N1/36071
摘要： At least one of a plurality of gastrointestinal disorders is treated by stimulating an enteric nervous system of a patient to enhance a functional tone of the enteric nervous system. A treatment includes electrically stimulating a vagus nerve of the patient at a stimulation site proximal to at least one site of vagal innervation of a gastrointestinal organ. The electrical stimulation includes applying a stimulation signal at the stimulation site. An optional proximal electrical blocking signal is applied to the vagus nerve at a proximal blocking site proximal to the stimulation site. The proximal blocking signal is selected to at least partially block nerve impulses at the proximal blocking site.

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