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    • 5. 发明授权
    • Storage-stable transdermal patch
    • 储存稳定的透皮贴剂
    • US5008110A
    • 1991-04-16
    • US269513
    • 1988-11-10
    • Arnold G. BeneckeDaniel J. KinneAndrew J. Wnuk
    • Arnold G. BeneckeDaniel J. KinneAndrew J. Wnuk
    • A61F13/02A61K9/70A61M37/00
    • A61K9/703A61F13/022A61F13/0259A61K9/7084
    • A shelf-stable device for transdermally administering an active pharmaceutical to a patient. The device includes a drug reservoir that contains the drug formulation. In one preferred embodiment of the present invention, the drug reservoir is sandwiched between an upper and a lower solvent barrier film that are made from a material such as a polyester that will not absorb the drug and/or skin permeating enhancing solvent, if any, contained within the reservoir. The drug reservoir and solvent barrier films are encapsulated within a hermetically-sealed compartment that protects the drug formulation from common environmental factors such as water vapor, oxygen, and light which can adversely affect the stability and efficacy of the drug formulation. The hermetically-sealed compartment also prevents the drug formulation from coming into contact with and possibly dissolving the adhesive used to secure the device to the patients's skin. In another particularly preferred embodiment of the present invention, the device's drug reservoir is encapsulated within a hermetically-sealed compartment that is made from solvent/environment barrier films that serve the dual functions of preventing the device's components from absorbing the drug/solvent formulation from the reservoir, and protecting the drug/solvent formulation from common environmental factors.
    • 6. 发明授权
    • Coupling structure for a leaching chamber
    • 浸出室的耦合结构
    • US06698975B1
    • 2004-03-02
    • US10228852
    • 2002-08-27
    • Arnold G. Benecke
    • Arnold G. Benecke
    • E02B1300
    • E03F1/003
    • A leaching chamber is configured to be coupled in series to another such leaching chamber located forward of the chamber and to yet another such leaching chamber located rearward of said leaching chamber. The leaching chamber comprises a conduit extending about an axis to define an axially extending cavity. The conduit includes an axially front section having an overlying wall and a rear section having an underlying wall. The overlying wall is configured to overlie the underlying wall of the forward chamber when the chambers are coupled together. The underlying wall is configured to underlie an overlying wall of the rearward chamber when said chambers are coupled together. A projection extends from the front section of the conduit. A pocket is located at the rear section of the conduit. The projection is configured to be received by the pocket of the front chamber, and the pocket is configured to receive the projection of the rear chamber. A notched structure extends radially inward from the front section and has a notch that is spaced from the front edge of the front section. The notched structure is configured to capture in the notch the underlying wall of the forward chamber when the chambers are coupled together.
    • 浸出室被配置成串联耦合到位于室前方的另一个这样的浸出室,以及位于所述浸出室后面的另一个这样的浸出室。 浸出室包括围绕轴线延伸的导管,以限定轴向延伸的空腔。 导管包括具有上覆壁的轴向前部,和具有下壁的后部。 当所述腔室联接在一起时,覆盖的壁构造成覆盖在前室的下面的壁上。 当所述腔室联接在一起时,底壁构造成位于后室的上覆壁的下面。 突出部从导管的前部延伸。 口袋位于导管的后部。 突出部被构造成由前室的凹部接收,并且口袋构造成容纳后室的突出部。 缺口结构从前部向内径向延伸,并具有与前部前缘间隔开的凹口。 凹口结构构造成当腔室联接在一起时,在凹口中捕获前腔室的下壁。
    • 9. 发明授权
    • Pump dispenser for fluent products featuring a reciprocable plunger and
diaphragm seal
    • 用于流体产品的泵分配器,具有往复式柱塞和隔膜密封
    • US4671432A
    • 1987-06-09
    • US789871
    • 1985-10-21
    • Arnold G. BeneckeDouglas H. BensonWilliam H. Goodman, Jr.Robert H. Van Coney
    • Arnold G. BeneckeDouglas H. BensonWilliam H. Goodman, Jr.Robert H. Van Coney
    • B65D47/34B67D7/02B67D5/42F16J3/02
    • B67D7/0205
    • A pump dispenser for fluent products is disclosed as inluding a container for housing the fluent product, dispensing outlet means on the container, a follower piston closing the lower end of the container below the product, and means for varying the volume within such dispenser. The volume varying means comprises a plunger adapted to be reciprocated within the dispenser to alternately decrease the volume therewithin and, following such decrease, return to its original position thereby increasing the volume within the dispenser. The plunger further comprises a peripheral skirt having predetermined outer lateral dimensions at its lower distal end, and an enlarged attachment head on such lower distal end. The attachment head has predetermined outer lateral dimensions which are larger than the outer lateral dimensions of such lower distal end therey effectively forming a reentrant portion on the plunger above the enlarged head. A flexible thin-walled diaphragm adapted to isolate and seal the volume reducing means from the fluent product is connected about its outer periphery to the dispenser. The diaphragm further has a central portion substantially conforming to the enlarged attachment head and reentrant portion of the plunger thereby effectively locking the diaphragm to the plunger and its attachment head. The attached diaphragm is thereby adapted to provide a substantially frictionless seal between the reciprocable plunger and the fluent product. The unique structure and combination of the plunger and flexible diaphragm of the subject pump dispenser provides for ease of manufacturing and handling of such pump dispenser subassembly.
    • 公开了用于流体产品的泵分配器,其包括用于容纳流体产品的容器,在容器上分配出口装置,将产品下方的容器的下端封闭的随动活塞,以及用于改变该分配器内的体积的装置。 体积变化装置包括适于在分配器内往复运动的柱塞,以交替地减小其中的体积,并且在这种减小之后返回到其初始位置,从而增加分配器内的体积。 柱塞还包括在其下远端具有预定的外侧尺寸的周边裙部,以及在该较低远端上的扩大的附接头。 附接头具有比其下端远端的外侧尺寸大的预定外侧尺寸,其有效地在放大头部上方的柱塞上形成凹入部。 柔性薄壁隔膜适于将流体产品的体积减小装置隔离并密封,其外周围连接到分配器。 隔膜还具有基本上与柱塞的扩大的附接头和可重入部分相符的中心部分,从而将隔膜有效地锁定到柱塞及其附接头上。 因此,附接的膜片适于在可往复运动的活塞和流体产品之间提供基本上无摩擦的密封。 主体泵分配器的柱塞和柔性隔膜的独特结构和组合提供了这种泵分配器子组件的制造和处理的容易性。