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1. 发明授权

US07122154B1 Apparatus for testing breath alcohol with discrimination between alveolar and upper respiratory tract alcohol 失效
标题翻译：用于检测呼吸酒精的装置，区分肺泡和上呼吸道酒精
公开(公告)号：US07122154B1
公开(公告)日：2006-10-17
申请号：US08363615
申请日：1994-12-23
申请人： Glenn C. Forrester , Roger Allen , Roger Herrera , Daniel S. Goldberger , James R. Braig
发明人： Glenn C. Forrester , Roger Allen , Roger Herrera , Daniel S. Goldberger , James R. Braig
IPC分类号： G01N33/497
CPC分类号： A61B5/097 , G01N33/4972 , Y10S436/90 , Y10T436/204165 , Y10T436/204998
摘要： A method and infrared sensing device for determining the concentration of alveolar alcohol in a breath sample exhaled by a subject into an infrared sensing device. The presence of alcohol from the upper respiratory tract of the subject is detected by continuously monitoring alcohol and carbon dioxide, normalizing alcohol values with respect to carbon dioxide, calculating a difference between normalized alcohol concentration and carbon dioxide concentration over time, integrating (summing) the difference, and comparing the integrated difference with a threshold. This technique accurately and consistently detects the presence of mouth alcohol in the sample before the presence of carbon dioxide which originates in deep lung breath.
摘要翻译：一种用于确定受试者呼出的呼吸样品中的肺泡醇浓度成红外感测装置的方法和红外感测装置。通过连续监测酒精和二氧化碳，对二氧化碳标准化酒精度值，计算标准化酒精浓度与二氧化碳浓度之间的差异随时间的推移，检测来自受试者上呼吸道的酒精含量（总和）差异，并将积分差异与阈值进行比较。该技术在二氧化碳的存在之前准确且一致地检测出样品中口腔醇的存在，这种二氧化碳起源于深肺呼吸。

2. 发明授权

US5376555A Method for testing breath alcohol with discrimination between alveolar and upper respiratory tract alcohol 失效
标题翻译：用于检测呼吸酒精的方法，区分肺泡和上呼吸道酒精
公开(公告)号：US5376555A
公开(公告)日：1994-12-27
申请号：US202282
申请日：1994-02-25
申请人： Glenn C. Forrester , Roger Allen , Roger Herrera , Daniel S. Goldberger , James R. Braig
发明人： Glenn C. Forrester , Roger Allen , Roger Herrera , Daniel S. Goldberger , James R. Braig
IPC分类号： G01N33/497 , G01N21/61
CPC分类号： A61B5/097 , G01N33/4972 , Y10S436/90 , Y10T436/204165 , Y10T436/204998
摘要： A method and infrared sensing device for determining the concentration of alveolar alcohol in a breath sample exhaled by a subject into an infrared sensing device. The presence of alcohol from the upper respiratory tract of the subject is detected by continuously monitoring alcohol and carbon dioxide, normalizing alcohol values with respect to carbon dioxide, calculating a difference between normalized alcohol concentration and carbon dioxide concentration over time, integrating (summing) the difference, and comparing the integrated difference with a threshold. This technique accurately and consistently detects the presence of mouth alcohol in the sample before the presence of carbon dioxide which originates in deep lung breath.
摘要翻译：一种用于确定受试者呼出的呼吸样品中的肺泡醇浓度成红外感测装置的方法和红外感测装置。通过连续监测酒精和二氧化碳，对二氧化碳标准化酒精度值，计算标准化酒精浓度与二氧化碳浓度之间的差异随时间的推移，检测来自受试者上呼吸道的酒精含量（总和）差异，并将积分差异与阈值进行比较。该技术在二氧化碳的存在之前准确且一致地检测出样品中口腔醇的存在，这种二氧化碳起源于深肺呼吸。

3. 发明授权

US07593108B2 Method of determining analyte concentration in a sample using infrared transmission data 有权
标题翻译：使用红外线传输数据确定样品中分析物浓度的方法
公开(公告)号：US07593108B2
公开(公告)日：2009-09-22
申请号：US11841878
申请日：2007-08-20
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
IPC分类号： G01N33/48 , G01N21/00 , A61B5/00
CPC分类号： A61B5/14546 , A61B5/14532 , G01N21/03 , G01N21/314 , G01N21/35
摘要： A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.
摘要翻译：一种方法确定样品中的分析物浓度。样品包括分析物和物质。该方法包括提供样品的吸收数据。该方法还包括提供该物质的参考吸收数据。该方法还包括计算吸收数据的物质贡献。该方法还包括从吸收数据中减去物质贡献，由此提供基本上不含该物质贡献的校正吸收数据。

4. 发明授权

US06631282B2 Device for isolating regions of living tissue 失效
标题翻译：用于隔离活组织区域的装置
公开(公告)号：US06631282B2
公开(公告)日：2003-10-07
申请号：US09970021
申请日：2001-10-02
申请人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian Cortella , Mark D. Agostino
发明人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian Cortella , Mark D. Agostino
IPC分类号： A61B500
CPC分类号： A61B5/6841 , A61B5/061 , A61B5/14532 , A61B5/1455
摘要： A device and method are provided for use with a non-invasive optical measurement system, such as a thermal gradient spectrometer for improved determination of analyte concentrations within living tissue. In a preferred embodiment, a site selector is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The site selector attaches to a thermal mass window of the spectrometer and thus forms an interface between the patient's skin and the thermal mass window. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the site selector is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the site selector will again form an interface between the gradient spectrometer and the same location of skin as before.
摘要翻译：提供了一种用于非侵入式光学测量系统的装置和方法，所述非侵入性光学测量系统例如用于改善生物体内分析物浓度测定的热梯度光谱仪。在优选实施例中，站点选择器被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。站点选择器连接到光谱仪的热质量窗口，从而形成患者皮肤和热质量窗口之间的界面。当光谱仪必须临时从病人的皮肤上移除时，例如允许患者移动，将场地选择器固定在前臂上，以保持皮肤上一致的测量部位。当光谱仪后来重新连接到患者时，站点选择器将再次形成梯度光谱仪和与之前相同的皮肤位置之间的界面。

5. 发明授权

US06580934B1 Method and apparatus for determining analyte concentration using phase and magnitude detection of a radiation transfer function 失效
标题翻译：使用辐射传递函数的相位和幅度检测来确定分析物浓度的方法和装置
公开(公告)号：US06580934B1
公开(公告)日：2003-06-17
申请号：US09538164
申请日：2000-03-30
申请人： James R. Braig , Charles E. Kramer , Bernhard B. Sterling , Daniel S. Goldberger , Peng Zheng , Arthur M. Shulenberger , Rick Trembino , Richard A. King , Casper W. Barnes
发明人： James R. Braig , Charles E. Kramer , Bernhard B. Sterling , Daniel S. Goldberger , Peng Zheng , Arthur M. Shulenberger , Rick Trembino , Richard A. King , Casper W. Barnes
IPC分类号： A61B500
CPC分类号： A61B5/0059 , G01N21/35
摘要： A method and apparatus of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. The modulation of the temperature gradient is controlled by a surface temperature modulation. A transfer function is determined that relates the surface temperature modulation to the modulation of the measured infrared radiation. Reference and analytical signals are detected. In the presence of the selected analyte, phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample.
摘要翻译：描述了测定试样的分析物浓度的方法和装置。在测试样品中引入温度梯度，红外辐射检测器测量所选分析物的吸收峰和参考波长的辐射。温度梯度的调制由表面温度调制控制。确定将表面温度调制与所测量的红外辐射的调制相关联的传递函数。检测参考和分析信号。在所选分析物的存在下，检测到传递函数中的相位和幅度差异。测量，相关和处理与分析物浓度关系的这些相位和幅度差异，以确定测试样品中的分析物浓度。

6. 发明授权

US6161028A Method for determining analyte concentration using periodic temperature modulation and phase detection 失效
公开(公告)号：US6161028A
公开(公告)日：2000-12-12
申请号：US267121
申请日：1999-03-10
申请人： James R. Braig , Charles E. Kramer , Bernhard B. Sterling , Daniel S. Goldberger , Peng Zheng , Arthur M. Shulenberger , Rick Trebino , Richard A. King , Casper W. Barnes
发明人： James R. Braig , Charles E. Kramer , Bernhard B. Sterling , Daniel S. Goldberger , Peng Zheng , Arthur M. Shulenberger , Rick Trebino , Richard A. King , Casper W. Barnes
IPC分类号： A61B5/00 , G01N21/35
CPC分类号： A61B5/0059 , G01N21/35
摘要： A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.

7. 发明授权

US5313941A Noninvasive pulsed infrared spectrophotometer 失效
标题翻译：无创脉冲红外分光光度计
公开(公告)号：US5313941A
公开(公告)日：1994-05-24
申请号：US10634
申请日：1993-01-28
申请人： James R. Braig , Daniel S. Goldberger
发明人： James R. Braig , Daniel S. Goldberger
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , G01N21/35 , G01N21/3581
摘要： A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range where the blood constituent has a strong and distinguishable absorption spectrum. The long wavelength infrared energy is passed through a finger or other vascularized appendage and the measurement made. To prevent the high energy source from burning or causing patient discomfort, only short bursts or pulses of energy are sent through the finger with a very low duty cycle and low optical bandwidth. The bursts are further synchronized with systole and diastole of the cardiac cycle so that only two pulses are sent per heart beat, one during diastole and one during systole. The detection signals measured during application of these bursts of energy are then used to calculate the concentration of the blood constituents in accordance with a polynomial equation.
摘要翻译：一种以非侵入性方式监测葡萄糖，乙醇和其他血液成分的方法和装置。通过监测血液成分具有强烈且可区分的吸收光谱的长红外波长范围内的所需血液成分的红外吸收来进行测量。长波长红外能量通过手指或其他血管附着物进行测量。为了防止高能源燃烧或引起患者不适，只有短脉冲或能量脉冲通过手指以非常低的占空比和低的光学带宽发送。脉冲进一步与心动周期的收缩和舒张同步，使得每个心跳只发送两个脉冲，一个在舒张期期间发送，一个在心脏收缩期间发送。然后使用在应用这些脉冲能量期间测量的检测信号根据多项式方程计算血液成分的浓度。

8. 发明授权

US5067492A Disposable airway adapter 失效
标题翻译：一次性气道适配器
公开(公告)号：US5067492A
公开(公告)日：1991-11-26
申请号：US564179
申请日：1990-08-07
申请人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
发明人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
IPC分类号： A61B5/08 , A61B5/083 , A61B5/097
CPC分类号： A61B5/0836 , A61B5/097
摘要： A disposable endotracheal airway adapter for use in proximity of a patient's mouth in the measurement of the concentraton of respiratory gases. The disposable airway adapter of the invention provides a conduit for patient respiratory gases and allows the passage of infrared radiation through the gases for measuring the constituent concentration of the respiratory gases while keeping the patient gases from coming in contact with the analyzer mechanism. The body of the airway adapter is designed to connect in series with the airway tubing which connects a patient to a mechanical respirator or anesthesia breathing circuit. The body of the airway adapter is very light in weight and is formed of inexpensive material such as polyethylene or polypropylene so that it may be manufactured inexpensively and discarded after each use. An inexpensive optical window in the adapter is also formed of material such as polyethylene or polypropylene so that the gas analyzer can pass light into the sample for analysis. Preferably, the optical windows of the invention are made of the same material as the adapter body. Since the adapter of the invention may be disposed of after use on a single patient, sterilization expenses and cross-contamination may be minimized. Also, calibrating integrity is maintained through a calibration process which accounts for the non-linearity of the absorption spectra of the window material in the region of interest.
摘要翻译：用于测量呼吸气体浓度的患者口腔附近的一次性气管插管气道适配器。本发明的一次性气道适配器提供用于患者呼吸气体的导管，并允许红外辐射通过气体，用于测量呼吸气体的组成浓度，同时保持患者气体不与分析器机构接触。气道适配器的主体设计成与将患者连接到机械呼吸器或麻醉呼吸回路的气道管串联连接。气道适配器的主体重量非常轻，并且由诸如聚乙烯或聚丙烯的廉价材料形成，使得可以在每次使用后廉价地制造和丢弃。适配器中的廉价的光学窗口也由诸如聚乙烯或聚丙烯的材料形成，使得气体分析仪可以将光通过样品进行分析。优选地，本发明的光学窗口由与适配器主体相同的材料制成。由于本发明的适配器可以在使用后在单个患者身上处理，因此可以使灭菌费用和交叉污染最小化。此外，校准完整性通过考虑到感兴趣区域中窗口材料的吸收光谱的非线性的校准过程来维持。

9. 发明申请

US20080212071A1 METHOD OF DETERMINING ANALYTE CONCENTRATION IN A SAMPLE USING INFRARED TRANSMISSION DATA 有权
标题翻译：使用红外传输数据确定样品中分析物浓度的方法
公开(公告)号：US20080212071A1
公开(公告)日：2008-09-04
申请号：US11841878
申请日：2007-08-20
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philp C. Hartstein , Robert D. Gaffney
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philp C. Hartstein , Robert D. Gaffney
IPC分类号： G01N21/00
CPC分类号： A61B5/14546 , A61B5/14532 , G01N21/03 , G01N21/314 , G01N21/35
摘要： A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.
摘要翻译：一种方法确定样品中的分析物浓度。样品包括分析物和物质。该方法包括提供样品的吸收数据。该方法还包括提供该物质的参考吸收数据。该方法还包括计算吸收数据的物质贡献。该方法还包括从吸收数据中减去物质贡献，由此提供基本上不含该物质贡献的校正吸收数据。

10. 发明授权

US07096124B2 Method of determining an analyte concentration in a sample from an absorption spectrum 失效
标题翻译：从吸收光谱确定样品中分析物浓度的方法
公开(公告)号：US07096124B2
公开(公告)日：2006-08-22
申请号：US11062110
申请日：2005-02-18
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Kenneth G. Witte
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Kenneth G. Witte
IPC分类号： G06F19/00
CPC分类号： A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B2562/0295 , G01N21/274 , G01N21/314 , G01N21/35 , G01N27/3271
摘要： A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.
摘要翻译：一种方法确定包含分析物和物质的样品中的分析物浓度。该方法包括提供样品的吸收光谱。吸收光谱具有吸收基线。该方法还包括移动吸收光谱，使得吸收基线大约等于所选吸收波长范围内的选定吸收值。该方法还包括从吸收光谱中减去物质贡献。因此，该方法提供基本上不含该物质的贡献的校正吸收光谱。

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