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1. 发明授权

US09911028B2 Image acquisition device and image acquisition method for image acquisition device 有权
公开(公告)号：US09911028B2
公开(公告)日：2018-03-06
申请号：US15031083
申请日：2014-01-28
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Fumio Iwase
IPC分类号： G06K9/00 , G02B21/36 , G02B21/06 , G02B21/26 , G02B21/08 , H04N5/232
CPC分类号： G06K9/00134 , G02B21/06 , G02B21/086 , G02B21/26 , G02B21/365 , G02B21/367 , H04N5/23238
摘要： In this image acquisition device, a stage driving unit moves a position of a field of view of an objective lens relative to a sample at a predetermined velocity, and a two-dimensional imaging element sequentially captures an optical image of the sample at a predetermined frame rate. Therefore, time required for acquiring partial images over the entire sample is shortened. Further, in this image acquisition device, the moving velocity of the position of the field of view is a velocity set based on a frame rate of the imaging element. Therefore, the movement of the position of the field of view and the imaging of the imaging element are synchronized with each other, and it is possible to capture only necessary partial images.

2. 发明授权

US09661212B2 Image acquisition device and focusing method for image acquisition device 有权
公开(公告)号：US09661212B2
公开(公告)日：2017-05-23
申请号：US14786574
申请日：2014-03-07
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Hideshi Oishi , Fumio Iwase , Masatoshi Okugawa
IPC分类号： H04N5/225 , H04N5/232 , G02B7/34 , G02B7/36 , G02B21/24 , G02B21/36 , G02B21/18 , H04N5/235 , H04N5/247 , H04N5/262
CPC分类号： H04N5/23212 , G02B7/346 , G02B7/36 , G02B7/365 , G02B21/18 , G02B21/244 , G02B21/245 , G02B21/361 , G02B21/365 , G02B21/367 , H04N5/2351 , H04N5/2353 , H04N5/247 , H04N5/2628
摘要： In an image acquisition device, an optical path difference generating member can form an optical path length difference of a second light image without splitting light in a second optical path. This can suppress the quantity of light required for the second optical path to obtain information of the focal position, whereby a quantity of light can be secured for a first imaging device to capture an image. The image acquisition device synchronizes the movement of a predetermined part of a sample within a field of an objective lens with rolling readout such that each pixel column of a second imaging device is exposed to a light image of the predetermined part in the sample.

3. 发明授权

US09305969B2 Solid-state imaging device operable with two readout modes in two different directions coincident with a moving speed and a moving direction of a moving subject 有权
标题翻译：在两个不同方向可操作两种读出模式的固态成像装置与移动的被摄体的移动速度和移动方向一致
公开(公告)号：US09305969B2
公开(公告)日：2016-04-05
申请号：US13666098
申请日：2012-11-01
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Motohiro Suyama , Akiomi Ujima , Kentaro Maeta , Hisanori Suzuki , Masaharu Muramatsu , Fumio Iwase
IPC分类号： G06M7/00 , H01L27/00 , H01L27/148 , H04N5/3722 , H04N3/14
CPC分类号： H01L27/14843 , H04N3/1525 , H04N3/1537 , H04N5/3722
摘要： A solid-state imaging device 1A includes a CCD-type solid-state imaging element 10 having an imaging plane 12 formed of M×N pixels that are two-dimensionally arrayed in M rows and N columns, N signal readout circuits 20 arranged on one end side in the column direction for each of the columns with respect to the imaging plane 12, and N signal readout circuits 30 arranged on the other end side in the column direction for each of the columns with respect to the imaging plane 12, a semiconductor element 50 for digital-converting and then sequentially outputting as serial signals electrical signals output from the signal readout circuits 20 for each of the columns, and a semiconductor element 60 for digital-converting and then sequentially outputting as serial signals electrical signals output from the signal readout circuits 30 for each of the columns.
摘要翻译：固态成像装置1A包括CCD型固体摄像元件10，其具有由M×N个像素形成的成像面12，二维排列成M行N列，N个信号读出电路20配置在一个相对于成像面12的各列的列方向的端侧，以及相对于摄像面12对于列的列方向配置在另一端侧的N个信号读出电路30，半导体元件50，用于数字转换，然后顺序地输出作为串行信号从每个列的信号读出电路20输出的电信号;以及半导体元件60，用于数字转换，然后顺序地输出作为串行信号从信号输出的电信号每列的读出电路30。

4. 发明授权

US10348954B2 Image acquisition device and method and system for creating focus map for specimen 有权
公开(公告)号：US10348954B2
公开(公告)日：2019-07-09
申请号：US14786581
申请日：2014-04-21
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Fumio Iwase , Masatoshi Okugawa
IPC分类号： G02B21/00 , H04N5/232 , G02B7/36 , G02B21/24 , G02B21/36
摘要： An image acquisition device reciprocates a focal position of an objective lens with respect to a sample in the optical axis direction of the objective lens, while moving a field position of the objective lens with respect to the sample. This makes it possible to acquire contrast information of image data at the field position of the objective lens sequentially as the field position moves with respect to the sample. The image acquisition device acquires the image data by the rolling readout of the image pickup element according to the reciprocation of the focal position of the objective lens.

5. 发明授权

US09054000B2 Solid-state imaging device 有权
标题翻译：固态成像装置
公开(公告)号：US09054000B2
公开(公告)日：2015-06-09
申请号：US13666149
申请日：2012-11-01
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Motohiro Suyama , Akiomi Ujima , Kentaro Maeta , Hisanori Suzuki , Masaharu Muramatsu , Fumio Iwase
IPC分类号： H04N5/225 , H01L27/146
CPC分类号： H01L27/14618 , H01L2224/16 , H01L2224/48091 , H04N5/2253 , H01L2924/00014
摘要： A solid-state imaging device 2A includes a CCD-type solid-state imaging element 10 having an imaging plane 12 formed of M×N pixels that are two-dimensionally arrayed in M rows and N columns and N signal readout circuits 20 arranged on one end side in the column direction for each of the columns with respect to the plane 12 and for outputting electrical signals according to the magnitudes of charges taken out of the respective columns, respectively, a C-MOS-type semiconductor element 50 for digital-converting and sequentially outputting as serial signals electrical signals output from the circuits 20 for each of the columns, a heat transfer member 80 having a main surface 81a and a back surface 81b, and a cooling block 84 provided on the surface 81b, and the semiconductor element 50 and the surface 81a of the heat transfer member 80 are bonded to each other.
摘要翻译：固态成像装置2A包括CCD型固体摄像元件10，该CCD型固体摄像元件10具有由M×N像素构成的摄像面12，二维排列成M行N列，N信号读出电路20配置在一方用于每个列相对于平面12的列方向的端侧，并分别根据从各列取出的电荷的大小输出电信号，用于数字转换的C-MOS型半导体元件并顺序地输出作为串行信号从每个列的电路20输出的电信号，具有主表面81a和后表面81b的传热构件80和设置在表面81b上的冷却块84，以及半导体元件 50和传热构件80的表面81a彼此接合。

6. 发明授权

US10598916B2 Image acquisition device and method and system for acquiring focusing information for specimen 有权
公开(公告)号：US10598916B2
公开(公告)日：2020-03-24
申请号：US16407093
申请日：2019-05-08
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Fumio Iwase , Masatoshi Okugawa
IPC分类号： G02B21/00 , G02B21/36 , H04N5/232 , G02B21/24 , G02B21/02 , G02B21/26 , G02B7/36
摘要： In an image acquisition device, an optical path difference generating member can form an optical path length difference of a second optical image without splitting light in a second optical path. This can suppress the quantity of light required for the second optical path to obtain information of the focal position, whereby a quantity of light can be secured for a first imaging device to capture an image. The image acquisition device synchronizes the movement of a predetermined part of a sample within a field of an objective lens with rolling readout such that each pixel column of a second imaging device is exposed to an optical image of the predetermined part in the sample.

7. 发明授权

US10330910B2 Image acquisition device and method and system for acquiring focusing information for specimen 有权
公开(公告)号：US10330910B2
公开(公告)日：2019-06-25
申请号：US14786576
申请日：2014-04-21
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Fumio Iwase , Masatoshi Okugawa
IPC分类号： G02B21/00 , G02B21/36 , G02B7/36 , G02B21/24 , H04N5/232 , G02B21/02 , G02B21/26
摘要： In an image acquisition device, an optical path difference generating member can form an optical path length difference of a second optical image without splitting light in a second optical path. This can suppress the quantity of light required for the second optical path to obtain information of the focal position, whereby a quantity of light can be secured for a first imaging device to capture an image. The image acquisition device synchronizes the movement of a predetermined part of a sample within a field of an objective lens with rolling readout such that each pixel column of a second imaging device is exposed to an optical image of the predetermined part in the sample.

8. 发明授权

US10422987B2 Image acquisition device and image acquisition method for image acquisition device 有权
公开(公告)号：US10422987B2
公开(公告)日：2019-09-24
申请号：US15030198
申请日：2014-01-28
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Fumio Iwase
IPC分类号： H04N5/00 , G02B21/36 , H04N5/232 , G02B21/06 , G02B21/24 , G06T5/00 , G02B21/08
摘要： In an image acquisition device, imaging is performed using an imaging element capable of rolling reading an optical image of a sample irradiated with instantaneous light. Therefore, the image can be captured with a sufficient S/N ratio even when the optical image is weak. Further, the image acquisition device includes a light source control unit that causes the instantaneous light to be emitted from a light source from the start of exposure of a pixel row of which reading last starts to the start of reading of a pixel row of which the reading first starts. That is, in the image acquisition device, the light source control unit causes the sample to be irradiated with the instantaneous light from the light emitting means during a period of time in which all pixel rows of the imaging element are exposed.

9. 发明申请

US20160080632A1 IMAGE ACQUISITION DEVICE AND METHOD AND SYSTEM FOR CREATING FOCUS MAP FOR SPECIMEN 审中-公开
标题翻译：图像获取装置和用于创建样本聚焦图的方法和系统
公开(公告)号：US20160080632A1
公开(公告)日：2016-03-17
申请号：US14786581
申请日：2014-04-21
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Fumio Iwase , Masatoshi Okugawa
IPC分类号： H04N5/232 , G02B7/36 , G02B21/24 , G02B21/36 , G02B21/00
CPC分类号： H04N5/23212 , G02B7/36 , G02B21/006 , G02B21/244 , G02B21/365 , G02B21/367
摘要： An image acquisition device reciprocates a focal position of an objective lens with respect to a sample in the optical axis direction of the objective lens, while moving a field position of the objective lens with respect to the sample. This makes it possible to acquire contrast information of image data at the field position of the objective lens sequentially as the field position moves with respect to the sample. The image acquisition device acquires the image data by the rolling readout of the image pickup element according to the reciprocation of the focal position of the objective lens.
摘要翻译：在物镜相对于样品的场位置移动的同时，图像采集装置使物镜的焦点位置相对于物镜的光轴方向的样本往复运动。这使得可以随着场位置相对于样本移动而顺序地获取物镜的场位置处的图像数据的对比度信息。图像获取装置通过根据物镜的焦点位置的往复运动的图像拾取元件的滚动读出来获取图像数据。

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