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1. 发明授权

US08792162B2 Microscope with illumination switching for capturing sample images during detector integration time 有权
标题翻译：具有照明切换的显微镜，用于在检测器集成时间内捕获样品图像
公开(公告)号：US08792162B2
公开(公告)日：2014-07-29
申请号：US13498078
申请日：2010-09-17
申请人： Helmut Lippert , Ralf Wolleschensky , Robert Hauschild
发明人： Helmut Lippert , Ralf Wolleschensky , Robert Hauschild
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G02B21/0032 , G02B21/0076
摘要： A microscope including an illumination device for a light sheet having an approximately planar extension along an illumination axis of an illumination beam path with a transverse axis to the illumination axis. Light emitted from the sample region on axis of detection the illumination axis and the axis of detection as well as the transverse axis and the axis of detection being oriented relative at an non-zero angle. The illumination device includes structure deflecting light to different beam path and thus produces an additional sheet of light, together illuminating the sample region on common illumination axis, and with switches between beam paths. Detection device has a detection lens system for light from by the sample region. The switches include a rapidly switching element with a time
摘要翻译：一种显微镜，包括用于光片的照明装置，所述照明装置具有沿着照明轴线的横向轴线的照明光束路径的照明轴线的近似平面的延伸。从检测轴上的样本区域发射的光照射轴和检测轴以及横轴和检测轴相对于非零角度定向。照明装置包括将光转向不同光束路径的结构，从而产生附加的光束，一起在公共照明轴上照射样品区域以及在光束路径之间切换光束。检测装置具有用于来自样品区域的光的检测透镜系统。这些开关包括具有时间<10ms的快速开关元件，表面检测器的预定积分同步使得样品区域在积分期间被照亮两次。

2. 发明申请

US20120176674A1 MICROSCOPE 有权
标题翻译：显微镜
公开(公告)号：US20120176674A1
公开(公告)日：2012-07-12
申请号：US13498078
申请日：2010-09-17
申请人： Helmut Lippert , Ralf Wolleschensky , Robert Hauschild
发明人： Helmut Lippert , Ralf Wolleschensky , Robert Hauschild
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G02B21/0032 , G02B21/0076
摘要： A microscope including an illumination device for a light sheet having an approximately planar extension along an illumination axis of an illumination beam path with a transverse axis to the illumination axis. Light emitted from the sample region on axis of detection the illumination axis and the axis of detection as well as the transverse axis and the axis of detection being oriented relative at an non-zero angle. The illumination device includes structure deflecting light to different beam path and thus produces an additional sheet of light, together illuminating the sample region on common illumination axis, and with switches between beam paths. Detection device has a detection lens system for light from by the sample region. The switches include a rapidly switching element with a time
摘要翻译：一种显微镜，包括用于光片的照明装置，所述照明装置具有沿着照明轴线的横向轴线的照明光束路径的照明轴线的近似平面的延伸。从检测轴上的样本区域发射的光照射轴和检测轴以及横轴和检测轴相对于非零角度定向。照明装置包括将光转向不同光束路径的结构，从而产生附加的光束，一起在公共照明轴上照射样品区域以及在光束路径之间切换光束。检测装置具有用于来自样品区域的光的检测透镜系统。这些开关包括具有时间<10ms的快速开关元件，表面检测器的预定积分同步使得样品区域在积分期间被照亮两次。

3. 发明申请

US20110036996A1 APPARATUS AND METHOD FOR HIGH SPATIAL RESOLUTION IMAGING OF A STRUCTURE OF A SAMPLE 有权
标题翻译：用于样品结构的高空间分辨率成像的装置和方法
公开(公告)号：US20110036996A1
公开(公告)日：2011-02-17
申请号：US12867291
申请日：2009-02-03
申请人： Ralf Wolleschensky , Helmut Lippert , Christopher Power , Benno Radt
发明人： Ralf Wolleschensky , Helmut Lippert , Christopher Power , Benno Radt
IPC分类号： G01J1/58
CPC分类号： G02B21/002 , G01N21/6458 , G02B21/10 , G02B27/58
摘要： Apparatus and method for high spatial resolution imaging of a sample's structure, including a diffraction-limited resolution volume with a plurality of dye molecules which can be switched between different states and have a distribution density which is greater than the inverse of the diffraction-limited resolution volume, where at least one state is fluorescing, the fluorescence being collected by an objective lens and imaged on a spatially resolving detector by an optical system. At least one light source provided for emitting a switching radiation and for emitting an excitation radiation. At least one of the light sources is arranged to radiate through the sample, and a switching and/or fluorescence excitation of the dye molecules is carried out. The switching is a photoactivation or a photodeactivation of the dye molecules. A focusing arrangement is provided for switching and/or for excitation to generate a line-like illumination region extending in a direction of illumination.
摘要翻译：用于样品结构的高空间分辨率成像的装置和方法，包括具有多个染料分子的衍射限制分辨率体积，其可以在不同状态之间切换并且具有大于衍射受限分辨率的反比的分布密度体积，其中至少一个状态是荧光的，荧光由物镜收集并通过光学系统在空间分辨检测器上成像。提供用于发射切换辐射并用于发射激发辐射的至少一个光源。至少一个光源布置成通过样品辐射，并且进行染料分子的切换和/或荧光激发。切换是染料分子的光活化或光激活。提供了用于切换和/或激发的聚焦装置，以产生在照明方向上延伸的线状照明区域。

4. 发明授权

US08362448B2 Apparatus and method for high spatial resolution imaging of a structure of a sample 有权
标题翻译：用于样品结构的高空间分辨率成像的装置和方法
公开(公告)号：US08362448B2
公开(公告)日：2013-01-29
申请号：US12867291
申请日：2009-02-03
申请人： Ralf Wolleschensky , Helmut Lippert , Christopher Power , Benno Radt
发明人： Ralf Wolleschensky , Helmut Lippert , Christopher Power , Benno Radt
IPC分类号： G01J1/58
CPC分类号： G02B21/002 , G01N21/6458 , G02B21/10 , G02B27/58
摘要： Apparatus and method for high spatial resolution imaging of a sample's structure, including a diffraction-limited resolution volume with a plurality of dye molecules which can be switched between different states and have a distribution density which is greater than the inverse of the diffraction-limited resolution volume, where at least one state is fluorescing, the fluorescence being collected by an objective lens and imaged on a spatially resolving detector by an optical system. At least one light source provided for emitting a switching radiation and for emitting an excitation radiation. At least one of the light sources is arranged to radiate through the sample, and a switching and/or fluorescence excitation of the dye molecules is carried out. The switching is a photoactivation or a photodeactivation of the dye molecules. A focusing arrangement is provided for switching and/or for excitation to generate a line-like illumination region extending in a direction of illumination.
摘要翻译：用于样品结构的高空间分辨率成像的装置和方法，包括具有多个染料分子的衍射限制分辨率体积，其可以在不同状态之间切换并且具有大于衍射受限分辨率的反比的分布密度体积，其中至少一个状态是荧光的，荧光由物镜收集并通过光学系统在空间分辨检测器上成像。提供用于发射切换辐射并用于发射激发辐射的至少一个光源。至少一个光源布置成通过样品辐射，并且进行染料分子的切换和/或荧光激发。切换是染料分子的光活化或光激活。提供了用于切换和/或激发的聚焦装置，以产生在照明方向上延伸的线状照明区域。

5. 发明申请

US20100265575A1 MICROSCOPE 审中-公开
标题翻译：显微镜
公开(公告)号：US20100265575A1
公开(公告)日：2010-10-21
申请号：US12809136
申请日：2008-12-10
申请人： Helmut Lippert , Ralf Wolleschensky
发明人： Helmut Lippert , Ralf Wolleschensky
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G02B21/10 , G02B21/16 , G02B26/0816 , G02B27/0911 , G02B27/58
摘要： A microscope including an imaging objective for imaging a sample on a detector and means for illuminating the sample with a light sheet in the focus plane of the imaging objective. The illumination means includes an illumination source which emits coherent light, and Bessel optics which generate at least two plane waves from the light beam and give propagation directions for the plane waves. The propagation direction of each of the plane waves encloses an acute angle with the focus plane in each instance, the magnitude of the acute angle being identical for each of the plane waves, so that the plane waves undergo constructive interference in the focus plane so that a light sheet is generated. Similarly, the illumination means can also include an optical element by which a rotationally symmetric Bessel beam is generated from the light beam for dynamic generation of a light sheet.
摘要翻译：一种显微镜，包括用于在检测器上成像样品的成像目标和用于在成像物镜的聚焦平面中用光照射样品的装置。照明装置包括发射相干光的照明源和从光束产生至少两个平面波并给出平面波的传播方向的贝塞尔光学器件。每个平面波的传播方向在每种情况下都与焦点平面成锐角，对于每个平面波，锐角的大小相同，使得平面波在聚焦平面中经历相长的干涉，使得产生光照片。类似地，照明装置还可以包括光学元件，通过该光学元件从光束产生旋转对称的贝塞尔光束用于光片的动态生成。

6. 发明授权

US09239454B2 Microscope having light sheet illumination of a sample region 有权
标题翻译：具有样品区域的光照照明的显微镜
公开(公告)号：US09239454B2
公开(公告)日：2016-01-19
申请号：US13498062
申请日：2010-09-17
申请人： Helmut Lippert , Matthias Wald , Michael Goelles , Robert Hauschild , Wolfgang Bathe
发明人： Helmut Lippert , Matthias Wald , Michael Goelles , Robert Hauschild , Wolfgang Bathe
IPC分类号： G01P3/40 , G02B21/00 , G02B21/36 , G02B26/08
CPC分类号： G02B21/0032 , G02B21/0036 , G02B21/006 , G02B21/0064 , G02B21/0076 , G02B21/367 , G02B26/0891
摘要： A microscope including an illumination device providing a light sheet illuminating a sample region, said sheet having a planar extension along an illumination axis of an illumination beam path and a transverse axis lying normal to the illumination axis. A detection device detects light emitted from the sample region on a detection axis the illumination axis and detection axis as well as the transverse axis and the detection axis being oriented relative each other at an angle unequal zero. The detection device has a detection lens system arranged in the detection beam path and splitting means for splitting the detection beam path into two beam sub-paths. A dichroic beam splitter in the infinity region of the surface detectors is about 3 mm thick. Wobble plate(s) disposed orthogonal to each other relative to the detection axis arranged in one of the two beam sub-paths so measured values can be automatically superimposed.
摘要翻译：一种显微镜，包括提供照射样品区域的光片的照明装置，所述片材沿着照明光束路径的照明轴线和垂直于照明轴线的横轴线具有平面延伸。检测装置检测在检测轴上从样本区域发出的光，照明轴和检测轴以及横轴和检测轴相对于彼此以不等于零的角度取向。检测装置具有设置在检测光束路径中的检测透镜系统和用于将检测光束路径分割成两个光束子路径的分离装置。表面检测器的无限区域中的二向色分束器约为3mm厚。摇摆板相对于布置在两个光束子路径之一中的检测轴线彼此正交配置，因此可以自动叠加测量值。

7. 发明授权

US09110301B2 Microscope with a sheet of light 有权
标题翻译：显微镜带一张光
公开(公告)号：US09110301B2
公开(公告)日：2015-08-18
申请号：US13497996
申请日：2010-09-17
申请人： Helmut Lippert , Christopher Power , Robert Hauschild , Matthias Wald
发明人： Helmut Lippert , Christopher Power , Robert Hauschild , Matthias Wald
IPC分类号： G02B21/06 , G02B21/24 , G02B21/00
CPC分类号： G02B21/241 , G02B21/002 , G02B21/06
摘要： A family of microscopes with illumination systems directing a sheet of light having an approximately planar extension in an illumination axis of an illumination beam path and in a transverse axis orthogonally oriented to the illumination axis. The microscopes have detection devices used to detect light that is emitted by a sample region. The detection devices including a detection lens system disposed in the detection beam path and an optical detection element spaced from a front lens of the detection lens system and independently adjustable thereof. The optical detection element continuously varies the size of a detection image field and/or continuously displaces a focal plane of detection in the P-region.
摘要翻译：具有照明系统的一系列显微镜，其在照明光束路径的照明轴线和垂直于照明轴线的横向轴线上引导具有近似平面延伸的光线。显微镜具有用于检测由样品区域发射的光的检测装置。检测装置包括设置在检测光束路径中的检测透镜系统和与检测透镜系统的前透镜间隔开的光学检测元件，并且可独立调节。光检测元件连续地改变检测图像场的大小和/或连续地移位P区域中的检测焦平面。

8. 发明申请

US20120281264A1 MICROSCOPE 有权
标题翻译：显微镜
公开(公告)号：US20120281264A1
公开(公告)日：2012-11-08
申请号：US13498095
申请日：2010-09-17
申请人： Helmut Lippert , Matthias Wald , Michael Goelles , Robert Hauschild
发明人： Helmut Lippert , Matthias Wald , Michael Goelles , Robert Hauschild
IPC分类号： G02B21/06 , G02B26/10
CPC分类号： G02B21/06 , G02B21/0032 , G02B21/0076 , G02B21/16 , G02B26/08 , G02B27/0911
摘要： A family of microscopes include an illumination device which produces a planar light sheet along an illumination axis of an illumination beam path and a transverse axis normal to the illumination axis. A detection device detects light emitted from the sample region along an axis of detection of a detection beam path. The illumination and detection axes as well as the transverse axis and the axis of detection being oriented relative each other at an angle unequal to zero. A light sheet generator also produces rotationally symmetrical light and includes structure and control for rapidly scanning the sample region along the transverse axis. The illumination device includes a second light sheet generator having a first astigmatically active optical element with at least one astigmatic lens for producing a static sheet of light. Selection elements used to select either the first or the second light sheet or both together to produce the sheet of light.
摘要翻译：显微镜系列包括照明装置，其沿着照明光束路径的照明轴线和垂直于照明轴线的横轴产生平面光片。检测装置沿着检测光束路径的检测轴检测从样本区域发射的光。照明和检测轴以及横轴和检测轴线以不等于零的角度相对定向。光片发生器还产生旋转对称的光，并且包括用于沿横轴快速扫描样品区域的结构和控制。照明装置包括具有第一散光活性光学元件的第二光片发生器，该光学元件具有用于产生静态光的至少一个散光透镜。用于选择第一或第二光照片或两者的选择元件一起产生光线。

9. 发明授权

US08848268B2 Microscope with light sheet illumination 有权
标题翻译：显微镜带照明灯
公开(公告)号：US08848268B2
公开(公告)日：2014-09-30
申请号：US13498095
申请日：2010-09-17
申请人： Helmut Lippert , Matthias Wald , Michael Goelles , Robert Hauschild
发明人： Helmut Lippert , Matthias Wald , Michael Goelles , Robert Hauschild
IPC分类号： G02B26/08 , G02B21/06 , G02B21/00
CPC分类号： G02B21/06 , G02B21/0032 , G02B21/0076 , G02B21/16 , G02B26/08 , G02B27/0911
摘要： A family of microscopes include an illumination device which produces a planar light sheet along an illumination axis of an illumination beam path and a transverse axis normal to the illumination axis. A detection device detects light emitted from the sample region along an axis of detection of a detection beam path. The illumination and detection axes as well as the transverse axis and the axis of detection being oriented relative each other at an angle unequal to zero. A light sheet generator also produces rotationally symmetrical light and includes structure and control for rapidly scanning the sample region along the transverse axis. The illumination device includes a second light sheet generator having a first astigmatically active optical element with at least one astigmatic lens for producing a static sheet of light. Selection elements used to select either the first or the second light sheet or both together to produce the sheet of light.
摘要翻译：显微镜系列包括照明装置，其沿着照明光束路径的照明轴线和垂直于照明轴线的横轴产生平面光片。检测装置沿着检测光束路径的检测轴检测从样本区域发射的光。照明和检测轴以及横轴和检测轴线以不等于零的角度相对定向。光片发生器还产生旋转对称的光，并且包括用于沿横轴快速扫描样品区域的结构和控制。照明装置包括具有第一散光活性光学元件的第二光片发生器，该光学元件具有用于产生静态光的至少一个散光透镜。用于选择第一或第二光照片或两者的选择元件一起产生光线。

10. 发明申请

US20120200693A1 MICROSCOPE WITH A SHEET OF LIGHT 有权
标题翻译：微光与光照片
公开(公告)号：US20120200693A1
公开(公告)日：2012-08-09
申请号：US13497996
申请日：2010-09-17
申请人： Helmut Lippert , Christopher Power , Robert Hauschild , Matthias Wald
发明人： Helmut Lippert , Christopher Power , Robert Hauschild , Matthias Wald
IPC分类号： H04N7/18
CPC分类号： G02B21/241 , G02B21/002 , G02B21/06
摘要： A family of microscopes with illumination systems directing a sheet of light having an approximately planar extension in an illumination axis of an illumination beam path and in a transverse axis orthogonally oriented to the illumination axis. The microscopes have detection devices used to detect light that is emitted by a sample region. The detection devices including a detection lens system disposed in the detection beam path and an optical detection element spaced from a front lens of the detection lens system and independently adjustable thereof. The optical detection element continuously varies the size of a detection image field and/or continuously displaces a focal plane of detection in the P-region.
摘要翻译：具有照明系统的一系列显微镜，其在照明光束路径的照明轴线和垂直于照明轴线的横向轴线上引导具有近似平面延伸的光线。显微镜具有用于检测由样品区域发射的光的检测装置。检测装置包括设置在检测光束路径中的检测透镜系统和与检测透镜系统的前透镜间隔开的光学检测元件，并且可独立调节。光检测元件连续地改变检测图像场的大小和/或连续地移位P区域中的检测焦平面。

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