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1. 发明申请

US20130236972A1 Liver Sinusoid Model 审中-公开
标题翻译：肝正弦模型
公开(公告)号：US20130236972A1
公开(公告)日：2013-09-12
申请号：US13413679
申请日：2012-03-07
申请人： Hongseok Noh , Michael Bouchard
发明人： Hongseok Noh , Michael Bouchard
IPC分类号： C12N5/071 , C12M3/00
CPC分类号： C12N5/067 , C12N2533/54 , C12N2535/00
摘要： A liver sinusoid model includes a generally planar substrate having first and second generally parallel microchannels formed therein. A microporous membrane is disposed between and separating the first and second generally parallel microchannels. A first layer of cells lines one side of the membrane in the first microchannel. The first layer of cells are all a first common cell type. A second layer of cells extends parallel to the first layer of cells in one of the first microchannel and the second microchannel. The second layer of cells is all of a second common cell type. A liver sinusoid bioreactor utilizing the inventive model is also disclosed.
摘要翻译：肝窦状模型包括具有在其中形成的第一和第二大致平行的微通道的大致平面的基底。微孔膜设置在第一和第二大致平行的微通道之间并分离。第一层细胞在第一微通道中排列膜的一侧。第一层细胞都是第一种细胞类型。细胞的第二层平行于第一微通道和第二微通道之一中的第一细胞层延伸。第二层细胞都是第二种细胞类型。还公开了利用本发明模型的肝窦状生物反应器。

2. 发明授权

US08206334B2 Implantable micro-system for treatment of hydrocephalus 有权
标题翻译：植入式微系统治疗脑积水
公开(公告)号：US08206334B2
公开(公告)日：2012-06-26
申请号：US12755068
申请日：2010-04-06
申请人： Francis A. Kralick , Hongseok Noh
发明人： Francis A. Kralick , Hongseok Noh
IPC分类号： A61M19/00
CPC分类号： F16K99/0001 , A61M27/006 , A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , F16K99/0005 , F16K99/0057 , F16K2099/0088
摘要： An implantable system for the treatment of hydrocephalus has a plurality of hollow microneedles in a fixed array. The microneedles have passages there through and are of a size to extend through dura mater with a proximal end on one side of the dura mater and a distal end communicating with the venous system in an area on a second side of the dura mater. An array of microvalves associated with a proximal end of the microneedles include segments movable by a pressure build up of cerebrospinal fluid (CSF) within the interior of the brain to provide open communication between the interior of the brain on one side of the dura mater and the venous system on the second side of the dura mater. A plurality of fluid transmitting members has distal ends communicating with the microvalves and a proximal end communicating with the ventricular space of the brain. The fluid transmitting members transmit CSF from the ventricular space through the microvalves and micro needles in fluid communication with the fluid transmitting members to prevent an excessive pressure build up of CSF within the interior of the brain.
摘要翻译：用于治疗脑积水的可植入系统具有固定阵列中的多个中空微针。微针具有通过其通道并且具有通过硬脑膜延伸的尺寸，其中在硬脑膜的一侧具有近端，并且在硬脑膜的第二侧上的区域中与静脉系统连通的远端。与微针的近端相关联的一组微型阀包括通过在脑内部的脑脊液（CSF）的压力积累而移动的段，以在硬脑膜的一侧的大脑内部之间提供开放的连通，以及硬膜第二侧的静脉系统。多个流体传递构件具有与微阀连通的远端和与脑的心室空间连通的近端。流体传递构件将CSF从心室空间通过与流体传递构件流体连通的微型阀和微针传送，以防止CSF在脑内部过度压力的形成。

3. 发明申请

US20070179428A1 IMPLANTABLE MICRO-SYSTEM FOR TREATMENT OF HYDROCEPHALUS 有权
标题翻译：用于治疗水肿的可植入微量系统
公开(公告)号：US20070179428A1
公开(公告)日：2007-08-02
申请号：US11669665
申请日：2007-01-31
申请人： Francis A. Kralick, D.O. , Hongseok Noh
发明人： Francis A. Kralick, D.O. , Hongseok Noh
IPC分类号： A61M5/00
CPC分类号： F16K99/0001 , A61M27/006 , A61M37/0015 , A61M2037/003 , A61M2037/0046 , F16K99/0028 , F16K2099/008 , F16K2099/0088
摘要： An implantable system for the treatment of hydrocephalus includes a plurality of microneedles in a fixed array relative to each other adapted to extend from the subarachnoid space containing CSF surrounding the brain, through dura mater forming the wall of the superior sagital sinus. A microvalve is associated with a proximal end of each of the microneedles and is adapted to permit the flow of cerebrospinal fluid (CSF) from the subarachnoid space through the wall of the superior sagital sinus and deposited in the venous return of the brain. The method of treating hydrocephalus with the system of this invention also constitutes a part of the invention.
摘要翻译：一种用于治疗脑积水的可植入系统包括相对于彼此固定阵列的多个微针，其适于从包含脑周围CSF的蛛网膜下腔延伸穿过形成上矢状窦壁的硬脑膜。微阀与每个微针的近端相关联并且适于允许从蛛网膜下腔通过上矢状窦的壁流动脑脊液（CSF）并沉积在脑的静脉回流中。用本发明的系统治疗脑积水的方法也构成了本发明的一部分。

4. 发明申请

US20160282359A1 MICROFABRICATED QLIDA BIOSENSORS WITH AN EMBEDDED HEATING AND MIXING ELEMENT 审中-公开
标题翻译：具有嵌入式加热和混合元件的微生物QLIDA生物传感器
公开(公告)号：US20160282359A1
公开(公告)日：2016-09-29
申请号：US15172096
申请日：2016-06-02
申请人： Elisabeth Papazoglou , Hongseok Noh , Chengjie Yu , Peter M. Clark
发明人： Elisabeth Papazoglou , Hongseok Noh , Chengjie Yu , Peter M. Clark
IPC分类号： G01N33/58 , B01L3/00 , G01N21/64 , G01N33/543 , G01N33/545
CPC分类号： G01N33/588 , B01L3/50273 , B01L3/502761 , B01L2300/0654 , B01L2400/0418 , B82Y15/00 , G01N21/6428 , G01N21/6486 , G01N33/5438 , G01N33/54393 , G01N33/545 , G01N2021/6439
摘要： An apparatus and method for detecting an analyte are described. The apparatus includes at least one microchannel adapted for an analyte to adhere to an interior surface thereof, a mixing element positioned within at least a portion of the at least one microchannel, a light source for energizing quantum dots conjugated with the analyte within the at least one microchannel, and a detection system for detecting and quantifying fluorescent energy emitted by the quantum dots in one or more predetermined wavelength ranges, wherein each wavelength range being correlated to one and only one type of analyte. The method includes the steps of providing a sample to at least one microchannel coated with an antibody, contacting the sample with a conjugate comprising a quantum dot and an antibody that specifically binds to the analyte, increasing electrothrermal flow of the sample, energizing the quantum dot with a light source, detecting fluorescent emission from the quantum dot, and correlating the fluorescent emission to the presence of or the concentration of the analyte in the sample.
摘要翻译：描述了用于检测分析物的装置和方法。所述装置包括至少一个适于分析物粘附到其内表面上的微通道，位于所述至少一个微通道的至少一部分内的混合元件，用于激发与分析物共轭的量子点的光源一个微通道和用于检测和量化在一个或多个预定波长范围内由量子点发射的荧光能量的检测系统，其中每个波长范围与一种且仅一种类型的分析物相关。该方法包括以下步骤：将样品提供到涂覆有抗体的至少一个微通道，使样品与包含特异性结合分析物的量子点和抗体的缀合物接触，增加样品的电热流动，激发量子点用光源检测来自量子点的荧光发射，并将荧光发射与样品中分析物的存在或浓度相关联。

5. 发明申请

US20100256549A1 IMPLANTABLE MICRO-SYSTEM FOR TREATMENT OF HYDROCEPHALUS 有权
标题翻译：用于治疗水肿的可植入微量系统
公开(公告)号：US20100256549A1
公开(公告)日：2010-10-07
申请号：US12755068
申请日：2010-04-06
申请人： Francis A. Kralick , Hongseok Noh
发明人： Francis A. Kralick , Hongseok Noh
IPC分类号： A61M1/00
CPC分类号： F16K99/0001 , A61M27/006 , A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0061 , F16K99/0005 , F16K99/0057 , F16K2099/0088
摘要： An implantable system for the treatment of hydrocephalus has a plurality of hollow microneedles in a fixed array. The microneedles have passages there through and are of a size to extend through dura mater with a proximal end on one side of the dura mater and a distal end communicating with the venous system in an area on a second side of the dura mater. An array of microvalves associated with a proximal end of the microneedles include segments movable by a pressure build up of cerebrospinal fluid (CSF) within the interior of the brain to provide open communication between the interior of the brain on one side of the dura mater and the venous system on the second side of the dura mater. A plurality of fluid transmitting members has distal ends communicating with the microvalves and a proximal end communicating with the ventricular space of the brain. The fluid transmitting members transmit CSF from the ventricular space through the microvalves and micro needles in fluid communication with the fluid transmitting members to prevent an excessive pressure build up of CSF within the interior of the brain
摘要翻译：用于治疗脑积水的可植入系统具有固定阵列中的多个中空微针。微针具有通过其通道并且具有通过硬脑膜延伸的尺寸，其中在硬脑膜的一侧具有近端，并且在硬脑膜的第二侧上的区域中与静脉系统连通的远端。与微针的近端相关联的一组微型阀包括通过在脑内部的脑脊液（CSF）的压力积累而移动的段，以在硬脑膜的一侧的大脑内部之间提供开放的连通，以及硬膜第二侧的静脉系统。多个流体传递构件具有与微阀连通的远端和与脑的心室空间连通的近端。流体传递构件将CSF从心室空间通过与流体传递构件流体连通的微型阀和微针，以防止脑内部大脑内的过度压力增加

6. 发明授权

US07691077B2 Implantable micro-system for treatment of hydrocephalus 有权
标题翻译：植入式微系统治疗脑积水
公开(公告)号：US07691077B2
公开(公告)日：2010-04-06
申请号：US11669665
申请日：2007-01-31
申请人： Francis A. Kralick , Hongseok Noh
发明人： Francis A. Kralick , Hongseok Noh
IPC分类号： A61M19/00
CPC分类号： F16K99/0001 , A61M27/006 , A61M37/0015 , A61M2037/003 , A61M2037/0046 , F16K99/0028 , F16K2099/008 , F16K2099/0088
摘要： An implantable system for the treatment of hydrocephalus includes a plurality of microneedles in a fixed array relative to each other adapted to extend from the subarachnoid space containing CSF surrounding the brain, through dura mater forming the wall of the superior sagital sinus. A microvalve is associated with a proximal end of each of the microneedles and is adapted to permit the flow of cerebrospinal fluid (CSF) from the subarachnoid space through the wall of the superior sagital sinus and deposited in the venous return of the brain. The method of treating hydrocephalus with the system of this invention also constitutes a part of the invention.
摘要翻译：一种用于治疗脑积水的可植入系统包括相对于彼此固定阵列的多个微针，其适于从包含脑周围CSF的蛛网膜下腔延伸穿过形成上矢状窦壁的硬脑膜。微阀与每个微针的近端相关联并且适于允许从蛛网膜下腔通过上矢状窦的壁流动脑脊液（CSF）并沉积在脑的静脉回流中。用本发明的系统治疗脑积水的方法也构成了本发明的一部分。

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