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    • 1. 发明申请
    • Liver Sinusoid Model
    • 肝正弦模型
    • US20130236972A1
    • 2013-09-12
    • US13413679
    • 2012-03-07
    • Hongseok NohMichael Bouchard
    • Hongseok NohMichael Bouchard
    • C12N5/071C12M3/00
    • C12N5/067C12N2533/54C12N2535/00
    • A liver sinusoid model includes a generally planar substrate having first and second generally parallel microchannels formed therein. A microporous membrane is disposed between and separating the first and second generally parallel microchannels. A first layer of cells lines one side of the membrane in the first microchannel. The first layer of cells are all a first common cell type. A second layer of cells extends parallel to the first layer of cells in one of the first microchannel and the second microchannel. The second layer of cells is all of a second common cell type. A liver sinusoid bioreactor utilizing the inventive model is also disclosed.
    • 肝窦状模型包括具有在其中形成的第一和第二大致平行的微通道的大致平面的基底。 微孔膜设置在第一和第二大致平行的微通道之间并分离。 第一层细胞在第一微通道中排列膜的一侧。 第一层细胞都是第一种细胞类型。 细胞的第二层平行于第一微通道和第二微通道之一中的第一细胞层延伸。 第二层细胞都是第二种细胞类型。 还公开了利用本发明模型的肝窦状生物反应器。
    • 2. 发明授权
    • Implantable micro-system for treatment of hydrocephalus
    • 植入式微系统治疗脑积水
    • US08206334B2
    • 2012-06-26
    • US12755068
    • 2010-04-06
    • Francis A. KralickHongseok Noh
    • Francis A. KralickHongseok Noh
    • A61M19/00
    • F16K99/0001A61M27/006A61M37/0015A61M2037/003A61M2037/0046A61M2037/0061F16K99/0005F16K99/0057F16K2099/0088
    • An implantable system for the treatment of hydrocephalus has a plurality of hollow microneedles in a fixed array. The microneedles have passages there through and are of a size to extend through dura mater with a proximal end on one side of the dura mater and a distal end communicating with the venous system in an area on a second side of the dura mater. An array of microvalves associated with a proximal end of the microneedles include segments movable by a pressure build up of cerebrospinal fluid (CSF) within the interior of the brain to provide open communication between the interior of the brain on one side of the dura mater and the venous system on the second side of the dura mater. A plurality of fluid transmitting members has distal ends communicating with the microvalves and a proximal end communicating with the ventricular space of the brain. The fluid transmitting members transmit CSF from the ventricular space through the microvalves and micro needles in fluid communication with the fluid transmitting members to prevent an excessive pressure build up of CSF within the interior of the brain.
    • 用于治疗脑积水的可植入系统具有固定阵列中的多个中空微针。 微针具有通过其通道并且具有通过硬脑膜延伸的尺寸,其中在硬脑膜的一侧具有近端,并且在硬脑膜的第二侧上的区域中与静脉系统连通的远端。 与微针的近端相关联的一组微型阀包括通过在脑内部的脑脊液(CSF)的压力积累而移动的段,以在硬脑膜的一侧的大脑内部之间提供开放的连通,以及 硬膜第二侧的静脉系统。 多个流体传递构件具有与微阀连通的远端和与脑的心室空间连通的近端。 流体传递构件将CSF从心室空间通过与流体传递构件流体连通的微型阀和微针传送,以防止CSF在脑内部过度压力的形成。
    • 5. 发明申请
    • IMPLANTABLE MICRO-SYSTEM FOR TREATMENT OF HYDROCEPHALUS
    • 用于治疗水肿的可植入微量系统
    • US20100256549A1
    • 2010-10-07
    • US12755068
    • 2010-04-06
    • Francis A. KralickHongseok Noh
    • Francis A. KralickHongseok Noh
    • A61M1/00
    • F16K99/0001A61M27/006A61M37/0015A61M2037/003A61M2037/0046A61M2037/0061F16K99/0005F16K99/0057F16K2099/0088
    • An implantable system for the treatment of hydrocephalus has a plurality of hollow microneedles in a fixed array. The microneedles have passages there through and are of a size to extend through dura mater with a proximal end on one side of the dura mater and a distal end communicating with the venous system in an area on a second side of the dura mater. An array of microvalves associated with a proximal end of the microneedles include segments movable by a pressure build up of cerebrospinal fluid (CSF) within the interior of the brain to provide open communication between the interior of the brain on one side of the dura mater and the venous system on the second side of the dura mater. A plurality of fluid transmitting members has distal ends communicating with the microvalves and a proximal end communicating with the ventricular space of the brain. The fluid transmitting members transmit CSF from the ventricular space through the microvalves and micro needles in fluid communication with the fluid transmitting members to prevent an excessive pressure build up of CSF within the interior of the brain
    • 用于治疗脑积水的可植入系统具有固定阵列中的多个中空微针。 微针具有通过其通道并且具有通过硬脑膜延伸的尺寸,其中在硬脑膜的一侧具有近端,并且在硬脑膜的第二侧上的区域中与静脉系统连通的远端。 与微针的近端相关联的一组微型阀包括通过在脑内部的脑脊液(CSF)的压力积累而移动的段,以在硬脑膜的一侧的大脑内部之间提供开放的连通,以及 硬膜第二侧的静脉系统。 多个流体传递构件具有与微阀连通的远端和与脑的心室空间连通的近端。 流体传递构件将CSF从心室空间通过与流体传递构件流体连通的微型阀和微针,以防止脑内部大脑内的过度压力增加