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1. 发明授权

US06640130B1 Integrated imaging apparatus 有权
标题翻译：集成成像装置
公开(公告)号：US06640130B1
公开(公告)日：2003-10-28
申请号：US09609544
申请日：2000-07-03
申请人： Jenny E. Freeman , Michael J. Hopmeier , M. Leventen , James Mansfield , Edgar Neil Lewis
发明人： Jenny E. Freeman , Michael J. Hopmeier , M. Leventen , James Mansfield , Edgar Neil Lewis
IPC分类号： A61B600
CPC分类号： A61B5/442 , A61B5/0059 , A61B5/0071 , A61B5/0073 , A61B5/0077 , A61B5/015 , A61B5/14535 , A61B5/1455 , A61B5/415 , A61B5/418 , A61B5/441 , A61B5/444 , A61B5/445
摘要： The invention is directed to imaging methods for performing real-time or near real-time assessment and monitoring. Embodiments of these methods are useful in a plurality of settings including surgery, clinical procedures, tissue assessment, diagnostic procedures, forensic, health monitoring and medical evaluations.
摘要翻译：本发明涉及用于执行实时或接近实时评估和监视的成像方法。这些方法的实施例在多种设置中是有用的，包括手术，临床程序，组织评估，诊断程序，法医，健康监测和医学评估。

2. 发明授权

US06721582B2 Non-invasive tissue glucose level monitoring 失效
标题翻译：非侵入性组织葡萄糖水平监测
公开(公告)号：US06721582B2
公开(公告)日：2004-04-13
申请号：US09785547
申请日：2001-02-20
申请人： Pierre Trepagnier , Jenny Freeman , James Mansfield , Derek Brand , Michael J. Hopmeier , Nikiforos Kollias
发明人： Pierre Trepagnier , Jenny Freeman , James Mansfield , Derek Brand , Michael J. Hopmeier , Nikiforos Kollias
IPC分类号： A61B500
CPC分类号： A61B5/0059 , A61B5/0062 , A61B5/0071 , A61B5/14532 , A61B5/1455 , A61B5/443 , A61B5/444 , A61B5/445
摘要： Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.
摘要翻译：描述了用于对分析物水平进行非侵入性测量并用于监测，分析和调节组织状态（例如组织葡萄糖水平）的仪器和方法。

3. 发明申请

US20120053429A1 Non-Invasive Tissue Glucose-Level Monitoring 审中-公开
标题翻译：非侵入性组织葡萄糖水平监测
公开(公告)号：US20120053429A1
公开(公告)日：2012-03-01
申请号：US13037348
申请日：2011-02-28
申请人： Pierre Trepagnier , Jenny Freeman , James Mansfield , Derek Brand , Michael J. Hopmeier , Nikiforos Kollias
发明人： Pierre Trepagnier , Jenny Freeman , James Mansfield , Derek Brand , Michael J. Hopmeier , Nikiforos Kollias
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/0071 , A61B5/14532
摘要： A non-invasive analyte monitoring instrument has a radiation source for directing excitation radiation to a portion of a surface of a tissue wherein said source emits radiation at a plurality of different wavelengths that excites a target in said tissue causing said target to emit radiation such that the radiation received at the surface provides an analyte level indication of the patient. A radiation detector positioned to receive radiation emitted from the surface wherein said radiation detector is configured to synchronously scan radiation emitted by the target with the excitation radiation. A processing circuit operatively connected to the radiation detector that translates radiation received at the surface to a measurable signal to obtain said analyte level indication, wherein said radiation source comprises a visible light source or an ultraviolet light source and wherein the target is selected from the group consisting of a structural matrix tissue component, a cellular tissue component, a mitochondrial tissue component, a collagen cross link, a pepsin-digestible collagen cross link, a collagenase-digestible collagen cross link, a non-pepsin digestible collagen cross link, an elastin cross link, a tryptophan-containing protein, NADH, FAD, a flavoprotein, and any combination thereof.
摘要翻译：非侵入性分析物监测仪器具有用于将激发辐射引导到组织表面的一部分的辐射源，其中所述源以多个不同波长发射辐射，激发所述组织中的靶，使所述靶发射辐射，使得在表面处接收的辐射提供了患者的分析物水平指示。放射线检测器，定位成接收从表面发射的辐射，其中所述辐射检测器被配置成以激发辐射同步扫描由靶发射的辐射。一种可操作地连接到辐射检测器的处理电路，其将在表面处接收的辐射转换成可测量信号，以获得所述分析物水平指示，其中所述辐射源包括可见光源或紫外光源，并且其中所述靶选自组由结构基质组织成分，细胞组织成分，线粒体组织成分，胶原交联，胃蛋白酶消化型胶原交联，胶原酶消化型胶原交联，非胃蛋白酶消化型胶原交联，弹性蛋白交联，含色氨酸的蛋白质，NADH，FAD，黄素蛋白及其任何组合。

4. 发明授权

US07899518B2 Non-invasive tissue glucose level monitoring 失效
标题翻译：非侵入性组织葡萄糖水平监测
公开(公告)号：US07899518B2
公开(公告)日：2011-03-01
申请号：US11224690
申请日：2005-09-12
申请人： Pierre Trepagnier , Jenny Freeman , James Mansfield , Derek Brand , Michael J. Hopmeier , Nikiforos Kollias
发明人： Pierre Trepagnier , Jenny Freeman , James Mansfield , Derek Brand , Michael J. Hopmeier , Nikiforos Kollias
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0071 , A61B5/14532
摘要： Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.
摘要翻译：描述了用于对分析物水平进行非侵入性测量并用于监测，分析和调节组织状态（例如组织葡萄糖水平）的仪器和方法。

5. 发明申请

US20070016078A1 Systems and methods for in-vivo optical imaging and measurement 审中-公开
标题翻译：体内光学成像和测量的系统和方法
公开(公告)号：US20070016078A1
公开(公告)日：2007-01-18
申请号：US11295162
申请日：2005-12-06
申请人： Clifford Hoyt , James Mansfield , Richard Levenson
发明人： Clifford Hoyt , James Mansfield , Richard Levenson
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0073 , A61B5/1075 , A61B2503/40 , A61B2562/0238 , A61B2562/0242 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N21/763 , G01N2021/6419 , G01N2021/6421
摘要： Disclosed are methods and systems for determining information about a position of the entity within the sample using spectral techniques. For example, the sample may be a living animal, such as a mouse, and the embedded object may be a tumor.
摘要翻译：公开了用于使用光谱技术确定样本中实体的位置的信息的方法和系统。例如，样品可以是活的动物，例如小鼠，并且嵌入的物体可以是肿瘤。

6. 发明申请

US20050108049A1 Executing clinical practice guidelines 有权
标题翻译：执行临床实践指南
公开(公告)号：US20050108049A1
公开(公告)日：2005-05-19
申请号：US10942285
申请日：2004-09-15
申请人： Prabhu Ram , David Berg , John Thrun , Bing Wu , Chandresh Taunk , Robert Abarbanel , James Mansfield
发明人： Prabhu Ram , David Berg , John Thrun , Bing Wu , Chandresh Taunk , Robert Abarbanel , James Mansfield
IPC分类号： G06F20060101 , G06F19/00 , G06F17/60
CPC分类号： G06Q50/22 , G06F19/00 , G06F19/3481 , G16H10/60 , G16H10/65
摘要： A clinical practice guideline can be implemented using a guideline execution engine. The engine can interpret the clinical practice guideline, obtain medical data stored in a clinical information system (CIS), and implement an action in response to execution of the clinical practice guideline based on medical data for a patient obtained from the CIS. The use of the CIS medical data in guideline execution beneficially allows the guideline to be tightly integrated into the real-time workflow of a clinician in a clinical setting and to provide patient-specific guideline recommendations. A VMR/actions interface facilitates communications between a guideline execution system and a CIS by processing a request for medical data from the guideline execution engine and implementing actions on the CIS requested by the guideline execution engine.
摘要翻译：临床实践指南可以使用指南执行引擎实现。引擎可以解释临床实践指南，获取存储在临床信息系统（CIS）中的医学数据，并且根据从CIS获得的患者的医学数据响应于临床实践指南的执行而实施动作。在准则执行中使用CIS医疗数据有益地允许指南在临床环境中紧密地集成到临床医生的实时工作流程中，并提供患者特定的指南建议。 VMR /动作接口通过处理来自指导执行引擎的医疗数据的请求并且执行由指导执行引擎请求的CIS上的动作来促进指导执行系统和CIS之间的通信。

7. 发明申请

US20050222501A1 Multivariate analysis of green to ultraviolet spectra of cell and tissue samples 失效
标题翻译：细胞和组织样品的绿色至紫外光谱的多变量分析
公开(公告)号：US20050222501A1
公开(公告)日：2005-10-06
申请号：US11145342
申请日：2005-06-02
申请人： James Mansfield , Jenny Freeman
发明人： James Mansfield , Jenny Freeman
IPC分类号： A61B5/00 , A61B5/103 , A61B5/145 , A61B5/1455 , A61B5/1459 , G01N21/27 , G01N21/64 , G01N33/483 , G01N33/66
CPC分类号： G01N21/6486 , A61B5/0059 , A61B5/0071 , A61B5/14532 , A61B5/1455 , A61B5/441 , A61B5/445 , A61B5/7264 , G01J3/28 , G01N2201/129
摘要： This invention relates to methods for processing in vivo skin auto-fluorescence spectra for determining blood glucose levels. The invention also relates to methods of classifying cells or tissue samples or quantifying a component of a cell or tissue using a multivariate classification or quantification model.
摘要翻译：本发明涉及用于处理体内皮肤自动荧光光谱以测定血糖水平的方法。本发明还涉及使用多变量分类或定量模型分类细胞或组织样品或定量细胞或组织的组分的方法。

8. 发明申请

US20050007584A1 Hyperspectral imaging calibration device 有权
标题翻译：高光谱成像校准装置
公开(公告)号：US20050007584A1
公开(公告)日：2005-01-13
申请号：US10896232
申请日：2004-07-22
申请人： James Mansfield , Jenny Freeman , Michael Leventon , Michael Hopmeier , Derek Brand
发明人： James Mansfield , Jenny Freeman , Michael Leventon , Michael Hopmeier , Derek Brand
IPC分类号： G01J3/28 , G01J3/44 , G01J4/00
CPC分类号： G01J3/2823 , G01J3/28 , G01J2003/2866
摘要： Hyperspectral imaging calibration devices and methods for their use are described that generate images of three dimensional samples. A calibration device may assume the shape of a desired imaging sample such as a body part and may be sterile prior to placement. The calibration device may include openings or may be modified to expose a region of the sample during use. Spectral images, typically obtained at multiple wavelengths, are made of the calibration device. Algorithms are provided that utilize the spectral images of the calibration device to determine the effects of lighting conditions and sample shape on the sample image to form a calibrated image. Calibrated images produced by these devices and methods can provide information, including clinical data that are less sensitive to lighting and sample shape compared to alternative technologies.
摘要翻译：描述了用于生成三维样本图像的高光谱成像校准装置及其使用方法。校准装置可以呈现期望的成像样品的形状，例如身体部位，并且可以在放置之前是无菌的。校准装置可以包括开口，或者可以被修改以在使用期间暴露样品的区域。通常在多个波长下获得的光谱图像由校准装置制成。提供了利用校准装置的光谱图像来确定照明条件和样品形状对样品图像的影响以形成校准图像的算法。通过这些设备和方法生成的校准图像可以提供信息，包括与替代技术相比对照明和样品形状不太敏感的临床数据。

9. 发明授权

US07289835B2 Multivariate analysis of green to ultraviolet spectra of cell and tissue samples 失效
标题翻译：细胞和组织样品的绿色至紫外光谱的多变量分析
公开(公告)号：US07289835B2
公开(公告)日：2007-10-30
申请号：US11145342
申请日：2005-06-02
申请人： James Mansfield , Jenny Freeman
发明人： James Mansfield , Jenny Freeman
IPC分类号： A61B5/00
CPC分类号： G01N21/6486 , A61B5/0059 , A61B5/0071 , A61B5/14532 , A61B5/1455 , A61B5/441 , A61B5/445 , A61B5/7264 , G01J3/28 , G01N2201/129
摘要： This invention relates to methods for processing in vivo skin auto-fluorescence spectra for determining blood glucose levels. The invention also relates to methods of classifying cells or tissue samples or quantifying a component of a cell or tissue using a multivariate classification or quantification model.
摘要翻译：本发明涉及用于处理体内皮肤自动荧光光谱以测定血糖水平的方法。本发明还涉及使用多变量分类或定量模型分类细胞或组织样品或定量细胞或组织的组分的方法。

10. 发明申请

US20060195022A1 Non-invasive tissue glucose level monitoring 失效
公开(公告)号：US20060195022A1
公开(公告)日：2006-08-31
申请号：US11224690
申请日：2005-09-12
申请人： Pierre Trepagnier , Jenny Freeman , James Mansfield , Derek Brand , Michael Hopmeier , Nikiforos Kollias
发明人： Pierre Trepagnier , Jenny Freeman , James Mansfield , Derek Brand , Michael Hopmeier , Nikiforos Kollias
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0071 , A61B5/14532
摘要： Instruments and methods are described for performing non-invasive measurements of analyte levels and for monitoring, analyzing and regulating tissue status, such as tissue glucose levels.

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