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1. 发明授权

US08655453B2 Connecting electrical sources to electrode nodes in a medical device 有权
标题翻译：将电源连接到医疗设备中的电极节点
公开(公告)号：US08655453B2
公开(公告)日：2014-02-18
申请号：US12541611
申请日：2009-08-14
申请人： Jonathan C. Werder , Todd D. Heathershaw
发明人： Jonathan C. Werder , Todd D. Heathershaw
IPC分类号： A61N1/04
CPC分类号： A61N1/36082 , A61N1/0551 , A61N1/36185
摘要： This disclosure describes electrical stimulators that include some electrical sources (e.g., current sources, voltage sources) that are directly connected to a plurality of electrode nodes, and other electrical sources that may be selectively connected to selected ones of the plurality of electrode nodes via a switching unit, such as a multiplexer. One example stimulator comprises a processor, a plurality of electrode nodes, and a stimulation generator that is coupled to the processor and to the plurality of electrode nodes. The stimulation generator comprises a plurality of negative electrical sources, a switching unit, and at least one positive electrical source. The negative electrical sources are each directly connected to a different one of the plurality of electrode nodes. The switching unit is connected to each of the plurality of electrode nodes. The at least one positive electrical source is connected to the switching unit. The switching unit is configured to connect the at least one positive electrical source to a selected one or more of the plurality of electrode nodes.
摘要翻译：本公开描述了电刺激器，其包括直接连接到多个电极节点的一些电源（例如，电流源，电压源），以及可以经由一个或多个电极节点选择性地连接到多个电极节点中的选定电极节点的其他电源开关单元，例如多路复用器。一个示例性刺激器包括处理器，多个电极节点和耦合到处理器和多个电极节点的刺激发生器。刺激发生器包括多个负电源，开关单元和至少一个正电源。负电源各自直接连接到多个电极节点中的不同的一个。开关单元连接到多个电极节点中的每一个。至少一个正电源连接到开关单元。开关单元被配置为将至少一个正电源连接到多个电极节点中选定的一个或多个电极节点。

2. 发明申请

US20100042187A1 CONNECTING ELECTRICAL SOURCES TO ELECTRODE NODES IN A MEDICAL DEVICE 有权
标题翻译：将电源连接到医疗设备中的电极点
公开(公告)号：US20100042187A1
公开(公告)日：2010-02-18
申请号：US12541611
申请日：2009-08-14
申请人： Jonathan C. Werder , Todd D. Heathershaw
发明人： Jonathan C. Werder , Todd D. Heathershaw
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/0551 , A61N1/36185
摘要： This disclosure describes electrical stimulators that include some electrical sources (e.g., current sources, voltage sources) that are directly connected to a plurality of electrode nodes, and other electrical sources that may be selectively connected to selected ones of the plurality of electrode nodes via a switching unit, such as a multiplexer. One example stimulator comprises a processor, a plurality of electrode nodes, and a stimulation generator that is coupled to the processor and to the plurality of electrode nodes. The stimulation generator comprises a plurality of negative electrical sources, a switching unit, and at least one positive electrical source. The negative electrical sources are each directly connected to a different one of the plurality of electrode nodes. The switching unit is connected to each of the plurality of electrode nodes. The at least one positive electrical source is connected to the switching unit. The switching unit is configured to connect the at least one positive electrical source to a selected one or more of the plurality of electrode nodes.
摘要翻译：本公开描述了电刺激器，其包括直接连接到多个电极节点的一些电源（例如，电流源，电压源），以及可以经由一个或多个电极节点选择性地连接到多个电极节点中的选定电极节点的其他电源开关单元，例如多路复用器。一个示例性刺激器包括处理器，多个电极节点和耦合到处理器和多个电极节点的刺激发生器。刺激发生器包括多个负电源，开关单元和至少一个正电源。负电源各自直接连接到多个电极节点中的不同的一个。开关单元连接到多个电极节点中的每一个。至少一个正电源连接到开关单元。开关单元被配置为将至少一个正电源连接到多个电极节点中选定的一个或多个电极节点。

3. 发明授权

US08565864B2 Techniques for data retention upon detection of an event in an implantable medical device 有权
标题翻译：检测植入式医疗设备中的事件时的数据保留技术
公开(公告)号：US08565864B2
公开(公告)日：2013-10-22
申请号：US13349404
申请日：2012-01-12
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC分类号： A61B5/04
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. These include initiating loop recording in an implantable medical device upon determination of a neurological event, wherein loop recording comprises storing a data record of a plurality of data records in a data structure, the plurality of data records representing information about determined neurological events. Methods and apparatus can further include determining a priority index for the plurality of data records based on severity levels of the determined neurological events and replacing older data records of the plurality of data records on the data structure with new data records according to the priority index, wherein the new data records selectively replace those data records in the data structure having the lowest associated priority index.
摘要翻译：用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。这些包括在确定神经学事件时在可植入医疗装置中启动循环记录，其中循环记录包括将多个数据记录的数据记录存储在数据结构中，所述多个数据记录表示关于确定的神经系统事件的信息。方法和装置还可以包括基于所确定的神经病学事件的严重性水平确定多个数据记录的优先级索引，并根据优先级索引用新的数据记录替换数据结构上的多个数据记录的较旧的数据记录，其中新数据记录选择性地替换具有最低相关优先级索引的数据结构中的那些数据记录。

4. 发明授权

US08209019B2 System and method for utilizing brain state information to modulate cardiac therapy 有权
标题翻译：利用脑状态信息调制心脏治疗的系统和方法
公开(公告)号：US08209019B2
公开(公告)日：2012-06-26
申请号：US11796577
申请日：2007-04-27
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
IPC分类号： A61N1/00 , A61B5/02
CPC分类号： A61B5/0402 , A61B5/0031 , A61B5/02 , A61B5/0245 , A61B5/0476 , A61B5/0816 , A61B5/1135 , A61B5/4094 , A61N1/36064 , A61N1/36082 , A61N1/3621 , A61N1/365 , A61N1/36521 , A61N1/36585 , A61N1/37288 , A61N1/3962
摘要： A system for regulating or modulating cardiac therapy using brain state information. The modulation may include suppressing standard, prescribed cardiac therapy for a period of time or it may involve modulating the type of cardiac therapy delivered In another embodiment, a system is provided for determining whether a cardiac event is categorized as neurologically matched, and, if so, modulating the therapeutic output to the heart.
摘要翻译：使用脑状态信息调节或调节心脏治疗的系统。调节可以包括在一段时间内抑制标准的，规定的心脏治疗，或者可以涉及调节递送的心脏治疗的类型。在另一个实施例中，提供了一种用于确定心脏事件是否被分类为神经学匹配的系统，如果是调节心脏的治疗输出。

5. 发明授权

US08108033B2 Techniques for data retention upon detection of an event in an implantable medical device 有权
标题翻译：检测植入式医疗设备中的事件时的数据保留技术
公开(公告)号：US08108033B2
公开(公告)日：2012-01-31
申请号：US11264974
申请日：2005-11-02
申请人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
发明人： Touby A. Drew , Jonathon E. Giftakis , David L. Carlson , Eric J. Panken , Jonathan C. Werder , Nina M. Graves
IPC分类号： A61B5/04
CPC分类号： A61B5/4094 , A61B5/0006 , A61B5/0031 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/031 , A61B5/04001 , A61B5/04012 , A61B5/0402 , A61B5/0476 , A61B5/0816 , A61B5/1118 , A61B5/165 , A61B5/4082 , A61B5/686 , A61B5/7232 , A61B5/7282 , A61N1/36132 , A61N1/36135 , A61N1/36521 , A61N1/36585 , A61N1/3702 , A61N1/37252 , A61N1/37282 , G06F17/30336 , G06F19/00 , G06F19/3418 , G16H10/60 , G16H40/63
摘要： Methods and apparatus for storing data records associated with a medical monitoring event in a data structure. Upon detection of a possible occurrence of a physiological event by one group of monitoring elements, an implanted device records data received from another group of monitoring elements. The implanted device obtains and stores the data in the data record in a first data structure that is age-based. Before an oldest data record is lost, the oldest data record may be stored in a second data structure that is priority index-based. The priority index may be determined by a severity level and may be further determined by associated factors. The implanted device may organize, off-load, report, and/or display a plurality of data records based on an associated priority index. Additionally, the implanted device may select a subset or composite of physiologic channels from the available physiologic channels based on a selection criterion.
摘要翻译：用于存储与数据结构中的医疗监视事件相关联的数据记录的方法和装置。在通过一组监测元件检测到生理事件的可能发生时，植入装置记录从另一组监测元件接收的数据。植入装置以基于年龄的第一数据结构获得并存储在数据记录中的数据。在最旧的数据记录丢失之前，最早的数据记录可以存储在基于优先级索引的第二数据结构中。优先权索引可以由严重性级别确定，并且可以由相关因素进一步确定。植入的装置可以基于相关联的优先级索引来组织，卸载，报告和/或显示多个数据记录。另外，植入装置可以基于选择标准从可用生理通道中选择生理通道的子集或复合物。

6. 发明申请

US20110190851A1 STIMULATION MODE SWITCHING BASED ON TISSUE IMPEDANCE STABILITY 有权
标题翻译：基于组织阻力稳定性的刺激模式切换
公开(公告)号：US20110190851A1
公开(公告)日：2011-08-04
申请号：US12699668
申请日：2010-02-03
申请人： Kevin J. Kelly , Matthew J. Michaels , Gregory F. Molnar , Jonathan C. Werder
发明人： Kevin J. Kelly , Matthew J. Michaels , Gregory F. Molnar , Jonathan C. Werder
IPC分类号： A61N1/08 , A61N1/36
CPC分类号： A61B5/053 , A61N1/00 , A61N1/3614 , A61N1/36521 , A61N1/3702
摘要： Implantable medical devices switch from a constant current mode of operation to a constant voltage mode of operation. The switching may be based on the device determining that tissue impedance stability has occurred. The determination may be a measurement of output voltage stability of the constant current source or based on other factors such as an amount of time that has elapsed. The switching may be as the result of an externally generated request such as by a clinician via an external device. The implantable medical device may begin constant voltage mode by utilizing stimulation parameters based on those initially programmed for constant current mode and based upon a measurement of voltage amplitude being output by the constant current source prior to the switch.
摘要翻译：可植入医疗设备从恒定电流工作模式切换到恒压工作模式。切换可以基于确定发生了组织阻抗稳定性的设备。该确定可以是恒定电流源的输出电压稳定性的测量，或者基于其他因素，例如已经经过的时间量。切换可能是外部产生的请求的结果，例如由临床医生经由外部设备。可植入医疗装置可以通过利用基于最初为恒定电流模式编程的刺激参数并且基于在切换之前由恒定电流源输出的电压幅度的测量来开始恒定电压模式。

7. 发明授权

US07761146B2 Method and apparatus for detection of nervous system disorders 有权
标题翻译：用于检测神经系统疾病的方法和装置
公开(公告)号：US07761146B2
公开(公告)日：2010-07-20
申请号：US11609432
申请日：2006-12-12
申请人： David L Carlson , Eric J Panken , Touby A. Drew , Jonathan C. Werder
发明人： David L Carlson , Eric J Panken , Touby A. Drew , Jonathan C. Werder
IPC分类号： A61B5/04
CPC分类号： A61B5/0478 , A61B5/4094 , A61B5/7221 , A61B5/7275 , A61N1/36082 , G06F19/00
摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Other embodiments include prediction of seizure activity based upon analysis of physiological signal levels. An embodiment of the invention monitors the quality of physiological signals, and may be able to compensate for signals of low signal quality. A further embodiment of the invention includes detection of seizure activity following the delivery of therapy.
摘要翻译：用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。其他实施方案包括基于生理信号水平的分析预测癫痫发作活动。本发明的实施例监测生理信号的质量，并且可能能够补偿低信号质量的信号。本发明的另一个实施方案包括在递送治疗后检测发作活动。

8. 发明申请

US20100121213A1 SEIZURE DISORDER EVALUATION BASED ON INTRACRANIAL PRESSURE AND PATIENT MOTION 审中-公开
公开(公告)号：US20100121213A1
公开(公告)日：2010-05-13
申请号：US12359037
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
IPC分类号： A61B5/0478 , A61B5/03 , A61B5/103 , A61N1/36
CPC分类号： A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.

9. 发明申请

US20080269842A1 Implantable medical device for treating neurological conditions with an initially disabled cardiac therapy port and leadless ECG sensing 有权
标题翻译：用于治疗神经病症的植入式医疗装置，其具有初始禁用的心脏治疗端口和无引导心电图感测
公开(公告)号：US20080269842A1
公开(公告)日：2008-10-30
申请号：US11796382
申请日：2007-04-27
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken
IPC分类号： A61N1/36
CPC分类号： A61N1/375 , A61N1/36082 , A61N1/36114 , A61N1/36585 , A61N1/37 , A61N1/3756
摘要： An implantable medical device such as an implantable pulse generator that includes EEG sensing for monitoring and treating neurological conditions, and leadless ECG sensing for monitoring cardiac signals. The device includes a connector block with provisions for cardiac leads which may be used/enabled when needed. If significant co-morbid cardiac events are observed in patients via the leadless ECG monitoring, then cardiac leads may be subsequently connected for therapeutic use.
摘要翻译：可植入的医疗装置，例如植入式脉冲发生器，其包括用于监测和治疗神经病症的脑电图感测，以及用于监测心脏信号的无引导心电图感测。该装置包括具有用于心脏引线的装置的连接器块，其可以在需要时使用/启用。如果通过无引导心电图监测在患者中观察到显着的并发心脏事件，则心脏引线可以随后连接用于治疗用途。

10. 发明授权

US07149572B2 Phase shifting of neurological signals in a medical device system 有权
标题翻译：医疗器械系统中的神经信号相移
公开(公告)号：US07149572B2
公开(公告)日：2006-12-12
申请号：US10687570
申请日：2003-10-15
申请人： Mark G. Frei , Jonathan C. Werder , David L. Carlson
发明人： Mark G. Frei , Jonathan C. Werder , David L. Carlson
IPC分类号： A61B5/04
CPC分类号： A61M5/1723 , A61B5/048 , A61B5/4094 , A61M5/14276 , A61N1/36082 , A61N1/36135 , A61N1/37229 , A61N2/006 , G06F19/00
摘要： Method and apparatus for phase shifting neurological signals received from monitoring elements of a medical device. The medical device comprises a plurality of monitoring elements each receiving a neurological signal. The device processes the neurological signals and identifies a time shift of the neurological signals relative to each other. The neurological signals are then time shifted according to the time shift upon which the signals are utilized to provide closed-loop feedback control of a treatment therapy.
摘要翻译：用于从医疗装置的监视元件接收的相移神经信号的方法和装置。医疗装置包括多个监测元件，每个监测元件接收神经信号。该装置处理神经信号并识别神经信号相对于彼此的时间偏移。神经信号然后根据信号被用于提供治疗治疗的闭环反馈控制的时间偏移而被时移。

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