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1. 发明申请

US20060250613A1 Method and applications to enhance and image optical signals from biological objects 审中-公开
标题翻译：从生物对象增强和成像光信号的方法和应用
公开(公告)号：US20060250613A1
公开(公告)日：2006-11-09
申请号：US11404964
申请日：2006-04-14
申请人： Joseph Demuth , Patrick Treado , John Maier , David Tuschel
发明人： Joseph Demuth , Patrick Treado , John Maier , David Tuschel
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/32 , G01N21/658
摘要： A method and apparatus for imaging biological objects. A SERS surface is provided having enhancing structures uniformly distributed on the surface. The surface includes a two dimensional area of at least 5×105 nm. The enhancing structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material is deposited on the SERS surface. The biological material on the SERS surface is illuminated using a monochromatic light source producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter into a plurality of predetermined wavelength bands. A two-dimensional array detector detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.
摘要翻译：一种用于成像生物体的方法和装置。提供了具有均匀分布在表面上的增强结构的SERS表面。该表面包括至少5×10 5 nm的二维区域。增强结构可以在100nm至1000nm范围内的高度，宽度和长度的至少一个尺寸中具有尺寸。生物材料沉积在SERS表面上。使用产生拉曼散射光子的单色光源照射SERS表面上的生物材料。使用可调滤波器将拉曼散射光子滤波成多个预定波长带。二维阵列检测器以空间准确的方式检测经过滤波的拉曼散射光子。滤波和检测步骤的结果被组合以产生生物材料的多个光谱分辨的拉曼图像。

2. 发明申请

US20070008525A1 Method for Raman imaging of semiconductor materials 审中-公开
标题翻译：半导体材料拉曼成像方法
公开(公告)号：US20070008525A1
公开(公告)日：2007-01-11
申请号：US11520348
申请日：2006-09-13
申请人： David Tuschel , Patrick Treado , Joseph Demuth
发明人： David Tuschel , Patrick Treado , Joseph Demuth
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/28 , G01N21/274 , G01N21/6489 , G01N21/65
摘要： An ion implanted semiconductor surface is illuminated with a flood illumination of monochromatic radiation, and an image of the surface is taken using light which has been Raman scattered. The illumination and imaging system are calibrated by flood illuminating a uniformly Raman scattering surface.
摘要翻译：用单色辐射的泛光照射照射离子注入的半导体表面，并且使用已经被拉曼散射的光进行表面的图像。照明和成像系统通过泛光照射均匀的拉曼散射表面来校准。

3. 发明申请

US20060268266A1 Method and apparatus for compact spectrometer for multipoint sampling of an object 有权
公开(公告)号：US20060268266A1
公开(公告)日：2006-11-30
申请号：US11366660
申请日：2006-03-03
申请人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
发明人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01N21/6456 , G01N2021/6421 , G01N2201/0221
摘要： The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.

4. 发明授权

US07045757B1 Apparatus and method for chemical imaging of a biological sample 有权
标题翻译：用于生物样品化学成像的装置和方法
公开(公告)号：US07045757B1
公开(公告)日：2006-05-16
申请号：US11097161
申请日：2005-04-04
申请人： David Tuschel , John Maier , Joseph Demuth
发明人： David Tuschel , John Maier , Joseph Demuth
IPC分类号： H01L27/00
CPC分类号： G01N21/6428 , G01J3/02 , G01J3/027 , G01J3/10 , G01N21/65 , G01N2021/6417 , G01N2021/6471 , G01N2201/067
摘要： In one embodiment, the disclosure relates to a method for determining illumination parameters for a stained sample, the method may include providing a stained sample and obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.
摘要翻译：在一个实施方案中，本公开涉及一种用于确定染色样品的照明参数的方法，所述方法可包括提供染色样品并获得样品的吸收带; 获得样品的发射带，并根据样品的吸收带和发射带确定样品的照射参数。

5. 发明申请

US20060209301A1 Method and apparatus for compact spectrometer for fiber array spectral translator 有权
标题翻译：用于光纤阵列光谱转换器的紧凑型光谱仪的方法和装置
公开(公告)号：US20060209301A1
公开(公告)日：2006-09-21
申请号：US11366531
申请日：2006-03-03
申请人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
发明人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0237 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/32 , G01J3/36 , G01J3/447 , G01N21/65 , G01N2201/0846
摘要： The disclosure relates to a portable system having a fiber array spectral translator (“FAST”) for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

6. 发明申请

US20060001867A1 Method and apparatus for spectral modulation compensation 有权
标题翻译：光谱调制补偿的方法和装置
公开(公告)号：US20060001867A1
公开(公告)日：2006-01-05
申请号：US10879632
申请日：2004-06-30
申请人： John Maier , Jason Neiss , Shona Stewart , Matthew Nelson , Joseph Demuth , Patrick Treado
发明人： John Maier , Jason Neiss , Shona Stewart , Matthew Nelson , Joseph Demuth , Patrick Treado
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01J3/0297 , G01J3/44 , G01N2021/656
摘要： The embodiments disclosed herein generally relate to identifying and removing background noise in spectroscopic imaging of a sample. Because white-light has essentially constant intensity at every wavelength, background noise caused by white light can be identified and removed from spectroscopic measurements including Raman spectroscopy. Thus, once the Raman spectrum for a sample is obtained, it may be corrected to remove the white-light dispersive spectrum in accordance with the embodiments disclosed herein.
摘要翻译：本文公开的实施例通常涉及在样本的光谱成像中识别和去除背景噪声。因为白光在每个波长处具有基本恒定的强度，所以可以从包括拉曼光谱的光谱测量中识别和去除由白光引起的背景噪声。因此，一旦获得样品的拉曼光谱，就可以根据本文公开的实施方案来校正其去除白光色散谱。

7. 发明申请

US20060276697A1 Non-invasive biochemical analysis 有权
标题翻译：非侵入性生化分析
公开(公告)号：US20060276697A1
公开(公告)日：2006-12-07
申请号：US11146458
申请日：2005-06-07
申请人： Joseph Demuth , Patrick Treado , John Maier , Jeffrey Cohen
发明人： Joseph Demuth , Patrick Treado , John Maier , Jeffrey Cohen
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/1455 , A61B5/415 , A61B5/418
摘要： The invention relates to methods and devices for assessing one or more blood components in an animal. The present invention permits non-invasive assessment of blood components in a body structure containing blood and other tissue types by assessing multiple regions of a tissue surface for an optical characteristic of blood and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood component for one or more regions that exhibit the optical characteristic of blood.
摘要翻译：本发明涉及用于评估动物体内一种或多种血液成分的方法和装置。本发明通过评估血液的光学特性的组织表面的多个区域并分别评估一种或多种光学（例如，拉曼或NIR）特征，允许对包含血液和其它组织类型的体内结构中的血液成分进行非侵入性评估的血液成分用于表现出血液光学特性的一个或多个区域。

8. 发明申请

US20060203238A1 Method and apparatus for compact spectrometer for detecting hazardous agents 有权
标题翻译：用于检测危险物质的紧凑型光谱仪的方法和装置
公开(公告)号：US20060203238A1
公开(公告)日：2006-09-14
申请号：US11366532
申请日：2006-03-03
申请人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
发明人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01J3/45
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/28 , G01J3/2823 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2201/0221
摘要： The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种便携式系统，用于获得具有第一和第二空间尺寸的样本的空间上准确的波长分辨图像，该图像可以用于通过用光照射样品来检测危险剂，形成全部或全部图像使用拉曼的样品的一部分移动来自样品的光，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

9. 发明申请

US20060001868A1 System and method for spectroscopy and imaging 审中-公开
标题翻译：用于光谱和成像的系统和方法
公开(公告)号：US20060001868A1
公开(公告)日：2006-01-05
申请号：US10879633
申请日：2004-06-30
申请人： Shona Stewart , Matthew Nelson , Joseph Demuth , Patrick Treado
发明人： Shona Stewart , Matthew Nelson , Joseph Demuth , Patrick Treado
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/0297 , G01N21/65
摘要： The disclosure relates to a substrate material for the improved detection, resolution and imaging of biological material for spectroscopic characterization by Raman of optical imaging spectroscopy. The substrate provides a uniform, optically flat, highly reflective surface which can be made hydrophobic to prevent spreading of the sample and facilitating its optical evaluation. Moreover, the substrate can be coated with a material that does not emit Raman scattered photons when exposed to said illuminating photons. The principles disclosed herein allow a low spectroscopic background particularly suitable for examining small samples or samples having low concentrations of the suspected component.
摘要翻译：本公开涉及用于通过光学成像光谱法的拉曼进行光谱表征的生物材料的改进的检测，分辨和成像的基底材料。衬底提供均匀的光学平坦的高反射表面，其可以被制成疏水性以防止样品的扩散并且便于其光学评估。此外，当暴露于所述照射光子时，衬底可以涂覆有不发射拉曼散射光子的材料。本文公开的原理允许低光谱背景特别适合于检查具有低浓度可疑成分的小样品或样品。

10. 发明申请

US20070280612A1 Method and apparatus for fiberscope 有权
公开(公告)号：US20070280612A1
公开(公告)日：2007-12-06
申请号：US11798483
申请日：2007-05-14
申请人： Patrick Treado , Matthew Nelson , Joseph Demuth
发明人： Patrick Treado , Matthew Nelson , Joseph Demuth
IPC分类号： G02B6/04 , G01J3/00 , G01J3/44 , G01N21/47 , G01N21/55 , G02B6/02
CPC分类号： A61B1/00165 , A61B1/043 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01J3/02 , G01J3/021 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0291 , G01J3/32 , G01J3/44 , G01J2003/1213 , G01N21/33 , G01N21/359 , G01N21/474 , G01N21/645 , G01N21/65 , G01N2021/3155 , G01N2021/4742 , G01N2021/6419 , G01N2021/6421 , G01N2021/6484 , G01N2021/656 , G02B6/06 , G02B6/29398 , G02B23/2423 , G02B23/2469
摘要： The disclosure generally relates to a method and apparatus for a fiberscope. In one embodiment, the disclosure relates to a chemical imaging fiberscope for imaging and collecting optical spectra from a sample having at least one illumination fiber for transmitting light from a first an a second light source to a distal end of a fiberscope; a dichroic mirror disposed at said distal end of the fiberscope such that light from said first light source passes substantially straight through said mirror and light of a predetermined wavelength from said second light source is substantially reflected by said mirror toward said sample to thereby illuminate said sample; and at least one collection fiber for receiving light from said illuminated sample and transmitting the received light to an optical device.

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