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1. 发明申请

US20060250613A1 Method and applications to enhance and image optical signals from biological objects 审中-公开
标题翻译：从生物对象增强和成像光信号的方法和应用
公开(公告)号：US20060250613A1
公开(公告)日：2006-11-09
申请号：US11404964
申请日：2006-04-14
申请人： Joseph Demuth , Patrick Treado , John Maier , David Tuschel
发明人： Joseph Demuth , Patrick Treado , John Maier , David Tuschel
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/32 , G01N21/658
摘要： A method and apparatus for imaging biological objects. A SERS surface is provided having enhancing structures uniformly distributed on the surface. The surface includes a two dimensional area of at least 5×105 nm. The enhancing structures may have a size, in at least one dimension of height, width and length, ranging from 100 nm to 1000 nm. A biological material is deposited on the SERS surface. The biological material on the SERS surface is illuminated using a monochromatic light source producing Raman scattered photons. The Raman scattered photons are filtered using a tunable filter into a plurality of predetermined wavelength bands. A two-dimensional array detector detects the filtered Raman scattered photons, in a spatially accurate manner. The results of filtering and detecting steps are combined to produce a plurality of spectrally resolved Raman images of the biological material.
摘要翻译：一种用于成像生物体的方法和装置。提供了具有均匀分布在表面上的增强结构的SERS表面。该表面包括至少5×10 5 nm的二维区域。增强结构可以在100nm至1000nm范围内的高度，宽度和长度的至少一个尺寸中具有尺寸。生物材料沉积在SERS表面上。使用产生拉曼散射光子的单色光源照射SERS表面上的生物材料。使用可调滤波器将拉曼散射光子滤波成多个预定波长带。二维阵列检测器以空间准确的方式检测经过滤波的拉曼散射光子。滤波和检测步骤的结果被组合以产生生物材料的多个光谱分辨的拉曼图像。

2. 发明申请

US20070008525A1 Method for Raman imaging of semiconductor materials 审中-公开
标题翻译：半导体材料拉曼成像方法
公开(公告)号：US20070008525A1
公开(公告)日：2007-01-11
申请号：US11520348
申请日：2006-09-13
申请人： David Tuschel , Patrick Treado , Joseph Demuth
发明人： David Tuschel , Patrick Treado , Joseph Demuth
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01J3/28 , G01N21/274 , G01N21/6489 , G01N21/65
摘要： An ion implanted semiconductor surface is illuminated with a flood illumination of monochromatic radiation, and an image of the surface is taken using light which has been Raman scattered. The illumination and imaging system are calibrated by flood illuminating a uniformly Raman scattering surface.
摘要翻译：用单色辐射的泛光照射照射离子注入的半导体表面，并且使用已经被拉曼散射的光进行表面的图像。照明和成像系统通过泛光照射均匀的拉曼散射表面来校准。

3. 发明申请

US20070182959A1 Dynamic imaging of biological cells and other subjects 有权
标题翻译：生物细胞和其他科目的动态成像
公开(公告)号：US20070182959A1
公开(公告)日：2007-08-09
申请号：US10556038
申请日：2005-06-30
申请人： John Maier , Patrick Treado , David Tuschel , Thomas Voigt
发明人： John Maier , Patrick Treado , David Tuschel , Thomas Voigt
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6456 , G01J3/2803 , G01J3/32 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/656
摘要： The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminated portion at a plurality of discrete times. The Raman-shifted light can be assessed at a plurality of Raman shift (RS) values at each of the discrete times, and the RS values can be selected to be characteristic of a pre-selected component at each of the discrete times. Multivariate analysis of Raman spectral features of the images thus obtained can yield the location and chemical identity of components in the field of view. This information can be combined or overlaid with other spectral data (e.g., a visible microscopic image) obtained from the field of view.
摘要翻译：本发明涉及动态化学成像方法，包括细胞成像方法。该方法包括以基本上单色的光照亮电池的至少一部分，并且在多个离散时间评估从照射部分散射的拉曼偏移光。可以在每个离散时间处以多个拉曼位移（RS）值评估拉曼移位的光，并且可以将每个离散时间的RS值选择为预选择的分量的特征。如此获得的图像的拉曼光谱特征的多变量分析可以产生视场中部件的位置和化学特性。该信息可以与从视野获得的其他光谱数据（例如，可见显微镜图像）组合或覆盖。

4. 发明申请

US20060268266A1 Method and apparatus for compact spectrometer for multipoint sampling of an object 有权
公开(公告)号：US20060268266A1
公开(公告)日：2006-11-30
申请号：US11366660
申请日：2006-03-03
申请人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
发明人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01N21/6456 , G01N2021/6421 , G01N2201/0221
摘要： The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.

5. 发明申请

US20060209301A1 Method and apparatus for compact spectrometer for fiber array spectral translator 有权
标题翻译：用于光纤阵列光谱转换器的紧凑型光谱仪的方法和装置
公开(公告)号：US20060209301A1
公开(公告)日：2006-09-21
申请号：US11366531
申请日：2006-03-03
申请人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
发明人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0237 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/32 , G01J3/36 , G01J3/447 , G01N21/65 , G01N2201/0846
摘要： The disclosure relates to a portable system having a fiber array spectral translator (“FAST”) for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

6. 发明申请

US20060001867A1 Method and apparatus for spectral modulation compensation 有权
标题翻译：光谱调制补偿的方法和装置
公开(公告)号：US20060001867A1
公开(公告)日：2006-01-05
申请号：US10879632
申请日：2004-06-30
申请人： John Maier , Jason Neiss , Shona Stewart , Matthew Nelson , Joseph Demuth , Patrick Treado
发明人： John Maier , Jason Neiss , Shona Stewart , Matthew Nelson , Joseph Demuth , Patrick Treado
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01J3/0297 , G01J3/44 , G01N2021/656
摘要： The embodiments disclosed herein generally relate to identifying and removing background noise in spectroscopic imaging of a sample. Because white-light has essentially constant intensity at every wavelength, background noise caused by white light can be identified and removed from spectroscopic measurements including Raman spectroscopy. Thus, once the Raman spectrum for a sample is obtained, it may be corrected to remove the white-light dispersive spectrum in accordance with the embodiments disclosed herein.
摘要翻译：本文公开的实施例通常涉及在样本的光谱成像中识别和去除背景噪声。因为白光在每个波长处具有基本恒定的强度，所以可以从包括拉曼光谱的光谱测量中识别和去除由白光引起的背景噪声。因此，一旦获得样品的拉曼光谱，就可以根据本文公开的实施方案来校正其去除白光色散谱。

7. 发明申请

US20060276697A1 Non-invasive biochemical analysis 有权
标题翻译：非侵入性生化分析
公开(公告)号：US20060276697A1
公开(公告)日：2006-12-07
申请号：US11146458
申请日：2005-06-07
申请人： Joseph Demuth , Patrick Treado , John Maier , Jeffrey Cohen
发明人： Joseph Demuth , Patrick Treado , John Maier , Jeffrey Cohen
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/1455 , A61B5/415 , A61B5/418
摘要： The invention relates to methods and devices for assessing one or more blood components in an animal. The present invention permits non-invasive assessment of blood components in a body structure containing blood and other tissue types by assessing multiple regions of a tissue surface for an optical characteristic of blood and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the blood component for one or more regions that exhibit the optical characteristic of blood.
摘要翻译：本发明涉及用于评估动物体内一种或多种血液成分的方法和装置。本发明通过评估血液的光学特性的组织表面的多个区域并分别评估一种或多种光学（例如，拉曼或NIR）特征，允许对包含血液和其它组织类型的体内结构中的血液成分进行非侵入性评估的血液成分用于表现出血液光学特性的一个或多个区域。

8. 发明申请

US20060203238A1 Method and apparatus for compact spectrometer for detecting hazardous agents 有权
标题翻译：用于检测危险物质的紧凑型光谱仪的方法和装置
公开(公告)号：US20060203238A1
公开(公告)日：2006-09-14
申请号：US11366532
申请日：2006-03-03
申请人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
发明人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01J3/45
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/28 , G01J3/2823 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2201/0221
摘要： The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种便携式系统，用于获得具有第一和第二空间尺寸的样本的空间上准确的波长分辨图像，该图像可以用于通过用光照射样品来检测危险剂，形成全部或全部图像使用拉曼的样品的一部分移动来自样品的光，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

9. 发明授权

US07414725B2 Method and apparatus for a microscope image selector 有权
标题翻译：显微镜图像选择器的方法和装置
公开(公告)号：US07414725B2
公开(公告)日：2008-08-19
申请号：US11902874
申请日：2007-09-26
申请人： Xinghua Wang , Thomas Voigt , David Tuschel , Chenhui Wang , Patrick Treado
发明人： Xinghua Wang , Thomas Voigt , David Tuschel , Chenhui Wang , Patrick Treado
IPC分类号： G01N21/25 , G02B21/00
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0291 , G01J3/36 , G01J3/44 , G01N21/359 , G01N21/59 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/656
摘要： The disclosure generally relates to a multimode imaging apparatus for simultaneously obtaining multiple wavelength-discriminative spectral images of a sample. In one embodiment, the apparatus includes an image selector having a rotator assembly, the rotator assembly housing a first plurality of optical components, the image selector adapted to receive a illuminating photons having a first wavelength and direct the illuminating photons to the sample, the image selector adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; a microscope turret housing a second plurality of components, the microscope turret adapted to receive illuminating photons having a second wavelength and direct the photons to the sample; the microscopic turret adapted to receive illuminating photons interacted with the sample and selectively direct said interacted photons to one of a plurality of detection sources; wherein substantially all of the interacted photons are selectively directed one of a plurality of detection sources to form multiple wavelength discriminative spectral images of the sample simultaneously.
摘要翻译：本公开总体上涉及用于同时获得样本的多个波长鉴别光谱图像的多模式成像装置。在一个实施例中，该装置包括具有旋转器组件的图像选择器，旋转体组件容纳第一多个光学部件，图像选择器适于接收具有第一波长的照明光子并将照射光子引导到样本，图像选择器，适于接收与样本相互作用的照明光子，并选择性地将所述相互作用的光子引导到多个检测源之一; 显微镜转台，其容纳第二多个部件，所述显微镜转台适于接收具有第二波长并且将所述光子引导到所述样品的照明光子; 适于接收与样品相互作用的照明光子并且选择性地将所述相互作用的光子引导到多个检测源中的一个的微观炮塔; 其中基本上所有相互作用的光子被选择性地指向多个检测源中的一个，以同时形成样品的多个波长鉴别光谱图像。

10. 发明申请

US20060170916A1 Method and apparatus for variable-field illumination 审中-公开
标题翻译：用于可变场照明的方法和装置
公开(公告)号：US20060170916A1
公开(公告)日：2006-08-03
申请号：US11045051
申请日：2005-01-31
申请人： Thomas Voigt , David Tuschel , Jingyun Zhang , Patrick Treado
发明人： Thomas Voigt , David Tuschel , Jingyun Zhang , Patrick Treado
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0208 , G01J3/0224 , G01N21/65
摘要： The disclosure relates to identifying one or more regions of interest within a broader field of view of a dynamic sample using one or more optical components and illuminating photons. Once the region of interest is identified within a section of the broader field of view, chemical information in the form of Raman spectrum is obtained from the region of interest by focusing the illuminating photons or the optical components on the region of interest.
摘要翻译：本公开涉及使用一个或多个光学组件和照射光子来识别动态样本的更宽视野内的一个或多个感兴趣区域。一旦在较宽视场的一部分内识别出感兴趣区域，则通过将照射光子或光学部件聚焦在感兴趣区域上，从感兴趣的区域获得拉曼光谱形式的化学信息。

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