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1. 发明授权

US08292808B2 Implantable sensor method and system 有权
标题翻译：植入式传感器方法和系统
公开(公告)号：US08292808B2
公开(公告)日：2012-10-23
申请号：US12211783
申请日：2008-09-16
申请人： Michael E. Miller , Rajiv Shah
发明人： Michael E. Miller , Rajiv Shah
IPC分类号： A61B5/00 , A61B5/05 , A61M31/00
CPC分类号： A61B5/6847 , A61B5/0031 , A61B5/04 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14552 , A61B5/14865 , A61B5/6882 , A61B17/3468 , A61M1/1698 , A61M5/14276 , A61M5/1723 , A61M2230/20 , A61M2230/201 , G06F19/00
摘要： Systems and methods for non-vascular sensor implantation and for measuring physiological parameters in areas of a body where the physiological parameters are heterogeneous. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the implant unit area. A sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area. A subcutaneous area of the body may be tunneled for sensor placement. Spatially separated sensing elements may be used for detecting individual amounts of the physiological parameter. An overall amount of the physiological parameter may be determined by calculating a statistical measurement of the individual sensed amounts in the area. Another embodiment of the invention, a multi-analyte measuring device, may include a substrate having an electrode array on one side and an integrated circuit on another side.
摘要翻译：用于非血管传感器植入和用于测量生理参数异质的身体的生理参数的系统和方法。植入单元植入身体的一个区域，允许在植入单元区域周围形成异物胶囊。传感器可以被引导到诸如腹膜空间，皮下组织，异物胶囊或其他区域的体腔中。身体的皮下区域可以被隧道用于传感器放置。空间分离的感测元件可用于检测生理参数的各个量。生理参数的总量可以通过计算该区域中各个感测量的统计测量来确定。本发明的多分析物测量装置的另一实施例可以包括在一侧具有电极阵列的基板和在另一侧的集成电路。

2. 发明申请

US20110184380A1 SYSTEM AND METHOD FOR PROVIDING CLOSED LOOP INFUSION FORMULATION DELIVERY 有权
标题翻译：用于提供封闭环路输注配方交付的系统和方法
公开(公告)号：US20110184380A1
公开(公告)日：2011-07-28
申请号：US13009531
申请日：2011-01-19
申请人： TIMOTHY J. STARKWEATHER , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： TIMOTHY J. STARKWEATHER , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.
摘要翻译：一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。该算法计算具有比例，导数和基础速率分量的传送量。可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。交付量的安全限制可能包含在算法中。该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。生物状态由感测装置感测到，该感测装置向控制器提供信号。所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。

3. 发明申请

US20110112506A1 SYSTEM AND METHOD FOR PROVIDING CLOSED LOOP INFUSION FORMULATION DELIVERY 有权
公开(公告)号：US20110112506A1
公开(公告)日：2011-05-12
申请号：US13009519
申请日：2011-01-19
申请人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

4. 发明授权

US08506550B2 Method and system for non-vascular sensor implantation 有权
公开(公告)号：US08506550B2
公开(公告)日：2013-08-13
申请号：US11286471
申请日：2005-11-24
申请人： Michael E. Miller , Rajiv Shah
发明人： Michael E. Miller , Rajiv Shah
IPC分类号： A61M31/00
CPC分类号： A61B5/145 , A61B5/0031 , A61B5/14532 , A61B5/14865 , A61B5/4839 , A61B5/6882 , A61B17/3468 , A61B2560/063 , A61M5/14276 , A61M2230/20 , A61M2230/201 , H05K3/4061
摘要： A method and system for non-vascular sensor implantation. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the area of the implant unit. The sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area of the body. A subcutaneous area of the body may be tunneled to place the sensor. The system may include an implant unit such as, for example, for delivering drug to a human body and a sensor for detecting a physiological parameter. The sensor may be separate from and connectable to the implant unit and may be placed in a non-vascular area of the human body.

5. 发明授权

US07833157B2 Multilumen catheter 有权
标题翻译：多元导管
公开(公告)号：US07833157B2
公开(公告)日：2010-11-16
申请号：US12121647
申请日：2008-05-15
申请人： Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
发明人： Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61M25/0032 , A61B5/028 , A61B5/14532 , A61B5/1486 , A61B5/415 , A61M5/14244 , A61M5/1723 , A61M25/0017 , A61M25/0023 , A61M2025/0003 , A61M2025/0046 , A61M2230/201 , Y10T29/49826
摘要： A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants. Also, a central line catheter for delivering fluids directly into a main artery or vein near the heart, which contains a first lumen to deliver a fluid through the central line catheter and a second lumen containing a sensor capable indicating a characteristic level in blood. The first lumen delivers the fluid downstream of the sensor to prevent any interference between the fluid delivery and the sensor readings. In other versions, the central line catheter can have additional lumens for additional purposes. In addition, the central line catheter can further include a flush sleeve to remove debris around the sensor.
摘要翻译：一种多管导管，其具有延伸到导管内腔内的管道。流明可用于血液，药物或其他药物。流明也可用于传感器。患者外部的连接元件将管道连接到管腔。也在患者外部的管连接到输注构件，一个或多个输注系统可以连接到输注构件，以向患者输送血液，药物和其他药剂。具有感测元件的传感器可以延伸穿过传感器内腔并且位于患者的内部以用于生理参数感测。传感器的外部部分可以连接到相关联的电子设备，以提供对生理参数的自动监测以及对输入的自动传送和控制。另外，一种用于将流体直接输送到心脏附近的主动脉或静脉的中心线导管，其包含用于通过中心线导管输送流体的第一内腔和包含能够指示血液中的特征水平的传感器的第二腔。第一个内腔在传感器的下游传送流体，以防止流体输送和传感器读数之间的任何干扰。在其他版本中，中心线导管可以具有另外的流明用于其他目的。此外，中心线导管还可以包括冲洗套筒以去除传感器周围的碎屑。

6. 发明授权

US07025760B2 Method and system for non-vascular sensor implantation 有权
公开(公告)号：US07025760B2
公开(公告)日：2006-04-11
申请号：US10034627
申请日：2001-12-27
申请人： Michael E. Miller , Rajiv Shah
发明人： Michael E. Miller , Rajiv Shah
IPC分类号： A61K9/22
CPC分类号： A61B5/145 , A61B5/0031 , A61B5/14532 , A61B5/6882 , A61B17/3468 , A61M1/1698 , A61M5/14276 , A61M2230/20 , A61M2230/201
摘要： A method and system for non-vascular sensor implantation. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the area of the implant unit. The sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area of the body. A subcutaneous area of the body may be tunneled to place the sensor. The system may include an implant unit such as, for example, for delivering drug to a human body and a sensor for detecting a physiological parameter. The sensor may be separate from and connectable to the implant unit and may be placed in a non-vascular area of the human body.

7. 发明授权

US08795224B2 System and method for providing closed loop infusion formulation delivery 有权
公开(公告)号：US08795224B2
公开(公告)日：2014-08-05
申请号：US13009531
申请日：2011-01-19
申请人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

8. 发明授权

US08777896B2 System and method for providing closed loop infusion formulation delivery 有权
标题翻译：用于提供闭环输注制剂递送的系统和方法
公开(公告)号：US08777896B2
公开(公告)日：2014-07-15
申请号：US13009519
申请日：2011-01-19
申请人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.
摘要翻译：一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。该算法计算具有比例，导数和基础速率分量的传送量。可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。交付量的安全限制可能包含在算法中。该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。生物状态由感测装置感测到，该感测装置向控制器提供信号。所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。

9. 发明申请

US20110112505A1 SYSTEM AND METHOD FOR PROVIDING CLOSED LOOP INFUSION FORMULATION DELIVERY 有权
公开(公告)号：US20110112505A1
公开(公告)日：2011-05-12
申请号：US13009508
申请日：2011-01-19
申请人： TIMOTHY J. STARKWEATHER , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： TIMOTHY J. STARKWEATHER , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

10. 发明申请

US20110046457A1 MULTILUMEN CATHETER 审中-公开
标题翻译：多层导管
公开(公告)号：US20110046457A1
公开(公告)日：2011-02-24
申请号：US12917162
申请日：2010-11-01
申请人： Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
发明人： Rebecca Gottlieb , Rajiv Shah , Mary M. Morris , Victor Giron , Michael E. Miller , Bradley J. Enegren
IPC分类号： A61B5/145 , B23P17/04
CPC分类号： A61M25/0032 , A61B5/028 , A61B5/14532 , A61B5/1486 , A61B5/415 , A61M5/14244 , A61M5/1723 , A61M25/0017 , A61M25/0023 , A61M2025/0003 , A61M2025/0046 , A61M2230/201 , Y10T29/49826
摘要： A multilumen catheter having tubings extending into lumens within the catheter. The lumens may be used for blood, drugs or other medicants. The lumens may also be used for sensors. The junction element, external to the patient, connects the tubings to the lumens. The tubings, also external to the patient, connect to infusion members, to which one or more infusion systems may be connected to deliver blood, drugs and other medicants to the patient. A sensor having a sensing element may extend through the sensor lumen and be positioned internal to the patient for physiological parameter sensing. An external portion of the sensor may be connected to associated electronics to provide automatic monitoring of the physiological parameters and automatic delivery and control of the infusants. Also, a central line catheter for delivering fluids directly into a main artery or vein near the heart, which contains a first lumen to deliver a fluid through the central line catheter and a second lumen containing a sensor capable indicating a characteristic level in blood. The first lumen delivers the fluid downstream of the sensor to prevent any interference between the fluid delivery and the sensor readings. In other versions, the central line catheter can have additional lumens for additional purposes. In addition, the central line catheter can further include a flush sleeve to remove debris around the sensor.
摘要翻译：一种多管导管，其具有延伸到导管内腔内的管道。流明可用于血液，药物或其他药物。流明也可用于传感器。患者外部的连接元件将管道连接到管腔。也在患者外部的管连接到输注构件，一个或多个输注系统可以连接到输注构件，以向患者输送血液，药物和其他药剂。具有感测元件的传感器可以延伸穿过传感器内腔并且位于患者的内部以用于生理参数感测。传感器的外部部分可以连接到相关联的电子设备，以提供对生理参数的自动监测以及对输入的自动传送和控制。另外，一种用于将流体直接输送到心脏附近的主动脉或静脉的中心线导管，其包含用于通过中心线导管输送流体的第一内腔和包含能够指示血液中的特征水平的传感器的第二腔。第一个内腔在传感器的下游传送流体，以防止流体输送和传感器读数之间的任何干扰。在其他版本中，中心线导管可以具有另外的流明用于其他目的。此外，中心线导管还可以包括冲洗套筒以去除传感器周围的碎屑。

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