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1. 发明授权

US08431349B2 Compositions and methods for early pregnancy diagnosis 有权
标题翻译：早孕诊断的组成和方法
公开(公告)号：US08431349B2
公开(公告)日：2013-04-30
申请号：US12747514
申请日：2008-12-12
申请人： Nagappan Mathialagan , Robert M. Roberts , Michael F. McGrath , Jonathan Green
发明人： Nagappan Mathialagan , Robert M. Roberts , Michael F. McGrath , Jonathan Green
IPC分类号： G01N33/53 , C12N5/20 , C07K16/42 , C07K16/24
CPC分类号： G01N33/6803 , C07K16/18 , G01N2333/471
摘要： Disclosed are antibodies and methods for detecting pregnancy in an animal. In certain aspects antibodies used binds immunologically to at least two PAGs selected from PAG4, PAG6, PAG9, PAG16, PAG17, PAG19, PAG20 and PAG21. Antibody encoding nucleic acids are also provided, as are kits, methods of use and additional antibody related compositions.
摘要翻译：公开了用于在动物中检测怀孕的抗体和方法。在某些方面，使用的抗体与选自PAG4，PAG6，PAG9，PAG16，PAG17，PAG19，PAG20和PAG21的至少两种PAG免疫结合。还提供抗体编码核酸，试剂盒，使用方法和另外的抗体相关组合物。

2. 发明申请

US20110076705A1 COMPOSITIONS AND METHODS FOR EARLY PREGNANCY DIAGNOSIS 有权
标题翻译：早期怀孕诊断的组成和方法
公开(公告)号：US20110076705A1
公开(公告)日：2011-03-31
申请号：US12747514
申请日：2008-12-12
申请人： Nagappan Mathialagan , Roberts M. Robert , Michael F. McGrath , Jonathan Green
发明人： Nagappan Mathialagan , Roberts M. Robert , Michael F. McGrath , Jonathan Green
IPC分类号： G01N33/566 , C07K16/18 , C07K16/40 , C12N5/16 , C07H21/00 , C07K1/14 , C07K1/22
CPC分类号： G01N33/6803 , C07K16/18 , G01N2333/471
摘要： Disclosed are antibodies and methods for detecting pregnancy in an animal. In certain aspects antibodies used binds immunologically to at least two PAGs selected from PAG4, PAG6, PAG9, PAG16, PAG17, PAG19, PAG20 and PAG21. Antibody encoding nucleic acids are also provided, as are kits, methods of use and additional antibody related compositions.
摘要翻译：公开了用于在动物中检测怀孕的抗体和方法。在某些方面，使用的抗体与选自PAG4，PAG6，PAG9，PAG16，PAG17，PAG19，PAG20和PAG21的至少两种PAG免疫结合。还提供抗体编码核酸，试剂盒，使用方法和另外的抗体相关组合物。

3. 外观设计

USD674633S1 Rolled paper product dispenser 有权
公开(公告)号：USD674633S1
公开(公告)日：2013-01-22
申请号：US29408990
申请日：2011-12-19
申请人： Jonathan Green , Bastiaan Roelof Tjaden , Joseph Elisabeth Oberdorf
设计人： Jonathan Green , Bastiaan Roelof Tjaden , Joseph Elisabeth Oberdorf

4. 发明授权

US08192946B2 Assays for detecting pregnancy-associated glycoproteins 有权
标题翻译：检测妊娠相关糖蛋白的分析
公开(公告)号：US08192946B2
公开(公告)日：2012-06-05
申请号：US12422231
申请日：2009-04-10
申请人： Jonathan Green , Bhanu Prakash Telugu
发明人： Jonathan Green , Bhanu Prakash Telugu
IPC分类号： C12Q1/37
CPC分类号： C12Q1/37 , G01N2333/96416 , G01N2800/36
摘要： Disclosed are methods and compositions for detecting pregnancy in an animal by means of assaying peptidase activity of one or more Pregnancy Associated Glycoproteins (PAGs). In certain aspects, methods also comprising use of an antibody that binds immunologically to a PAG that displays proteolytic activity are provided. Substrates of proteolytic PAGs are also provided, as are kits, and methods of use. Further, methods of purifying PAGs based on their proteolytic activity are also provided.
摘要翻译：公开了通过测定一种或多种妊娠相关糖蛋白（PAG）的肽酶活性来检测动物中怀孕的方法和组合物。在某些方面，提供了还包括使用与显示蛋白水解活性的PAG免疫学结合的抗体的方法。还提供蛋白水解PAG的底物，试剂盒和使用方法。此外，还提供了基于其蛋白水解活性来纯化PAG的方法。

5. 发明申请

US20110015930A1 UNIFIED COMMUNICATION SYSTEM 审中-公开
标题翻译：统一通信系统
公开(公告)号：US20110015930A1
公开(公告)日：2011-01-20
申请号：US12876514
申请日：2010-09-07
申请人： John Ward , Haydar Haba , Charles Studt , Peter Antypas , Jonathan Green
发明人： John Ward , Haydar Haba , Charles Studt , Peter Antypas , Jonathan Green
IPC分类号： G10L13/08
CPC分类号： H04M3/42229 , H04M3/5307 , H04M2203/2061 , H04M2203/4509 , H04M2207/20
摘要： A unified communication system is disclosed that allows a variety of end point types to participate in a communication event using a common, unified communication system. In some implementations, a calling party interacts with a client application residing on an endpoint to make a communication request to another endpoint. A communication event manager residing in the unified communication system selects a script from a repository of scripts based on the communication event and the capabilities of the endpoints. A communication event execution engine receives a user profile associated with at least one of the endpoints. The user profile can be configured by the user to describe the user's preferences for how the communication should be processed by the unified communication system.
摘要翻译：公开了统一的通信系统，其允许各种端点类型使用公共的统一通信系统来参与通信事件。在一些实现中，主叫方与驻留在端点上的客户端应用进行交互以向另一端点发送通信请求。驻留在统一通信系统中的通信事件管理器基于通信事件和端点的能力从脚本存储库中选择脚本。通信事件执行引擎接收与至少一个端点相关联的用户简档。用户配置文件可以由用户配置，以描述用户对统一通信系统如何处理通信的偏好。

6. 发明申请

US20110007732A1 Unified Communication System 审中-公开
标题翻译：统一通信系统
公开(公告)号：US20110007732A1
公开(公告)日：2011-01-13
申请号：US12499607
申请日：2009-07-08
申请人： John Ward , Haydar Haba , Charles Studt , Peter Antypas , Jonathan Green
发明人： John Ward , Haydar Haba , Charles Studt , Peter Antypas , Jonathan Green
IPC分类号： H04L12/66 , G10L19/00
CPC分类号： H04M3/42229 , H04M3/5307 , H04M2203/2061 , H04M2203/4509 , H04M2207/20
摘要： A unified communication system is disclosed that allows a variety of end point types to participate in a communication event using a common, unified communication system. In some implementations, a calling party interacts with a client application residing on an endpoint to make a communication request to another endpoint. A communication event manager residing in the unified communication system selects a script from a repository of scripts based on the communication event and the capabilities of the endpoints. A communication event execution engine receives a user profile associated with at least one of the endpoints. The user profile can be configured by the user to describe the user's preferences for how the communication should be processed by the unified communication system.
摘要翻译：公开了统一的通信系统，其允许各种端点类型使用公共的统一通信系统来参与通信事件。在一些实现中，主叫方与驻留在端点上的客户端应用进行交互以向另一端点发送通信请求。驻留在统一通信系统中的通信事件管理器基于通信事件和端点的能力从脚本存储库中选择脚本。通信事件执行引擎接收与至少一个端点相关联的用户简档。用户配置文件可以由用户配置，以描述用户对统一通信系统如何处理通信的偏好。

7. 发明授权

US07345088B2 Pharmaceutical composition for use for the treatment of malignancies comprising in combination a bisphosphonates, a cox-2 inhibitor and a taxol 失效
标题翻译：用于治疗恶性肿瘤的药物组合物，其包含双膦酸盐，cox-2抑制剂和紫杉醇的组合
公开(公告)号：US07345088B2
公开(公告)日：2008-03-18
申请号：US10493042
申请日：2002-10-18
申请人： Jonathan Green , Allan Lipton , Lois Mary Witters
发明人： Jonathan Green , Allan Lipton , Lois Mary Witters
IPC分类号： A61K31/335
CPC分类号： A61K45/06 , A61K31/335 , A61K31/337 , A61K31/365 , A61K31/415 , A61K31/42 , A61K31/635 , A61K31/66 , A61K2300/00
摘要： A pharmaceutical composition for treatment of malignancies, in particular a malignant disease which is associated with the development of bone metastases or excessive bone resorption, comprises in combination a bisphosphonates, COX-2 inhibitor and/or a taxol or derivative thereof for simultaneous, sequential or separate use. Also provided is a method of treating a patient suffering from a malignant disease comprising administering to the patient an effective amount of a bisphosphonates, an effective amount of a COX-2 inhibitor and/or and effective amount of a taxol or derivative thereof.
摘要翻译：用于治疗恶性肿瘤的药物组合物，特别是与骨转移或过度骨吸收发展有关的恶性疾病包括联合使用双膦酸盐，COX-2抑制剂和/或紫杉醇或其衍生物，用于同时，顺序或单独使用。还提供了治疗患有恶性疾病的患者的方法，包括向患者施用有效量的双膦酸盐，有效量的COX-2抑制剂和/或有效量的紫杉醇或其衍生物。

8. 发明授权

US5965547A Use of certain methanebishosphonic acid derivatives to prevent prosthesis loosening and prosthesis migration 失效
标题翻译：使用某些甲烷二膦酸衍生物防止假体松动和假体迁移
公开(公告)号：US5965547A
公开(公告)日：1999-10-12
申请号：US732324
申请日：1996-10-28
申请人： Allen E. Goodship , John Kenwright , Jonathan Green
发明人： Allen E. Goodship , John Kenwright , Jonathan Green
IPC分类号： A61F2/46 , A61K31/66 , A61K31/675 , A61P43/00
CPC分类号： A61K31/66 , A61K31/675
摘要： The invention relates to the use of certain methanebisphosphonic acid derivatives (for the manufacture of a pharmaceutical composition) for the prevention and treatment of prosthesis loosening and prosthesis migration in mammals including man.
摘要翻译： PCT No.PCT / IB95 / 00288 Sec。 371日期1996年10月28日第 102（e）日期1996年10月28日PCT提交1995年4月24日PCT公布。公开号WO95 / 30421 日期1995年11月16日本发明涉及某些甲烷二膦酸衍生物（用于制造药物组合物）用于预防和治疗包括人在内的哺乳动物假体松动和假体迁移的用途。

9. 发明授权

US5133972A Topically administrable pharmaceutical preparations 失效
标题翻译：主要管理药物制剂
公开(公告)号：US5133972A
公开(公告)日：1992-07-28
申请号：US546345
申请日：1990-06-29
申请人： Pier G. Ferrini , Carlo Voellmy , Peter H. Stahl , Jonathan Green
发明人： Pier G. Ferrini , Carlo Voellmy , Peter H. Stahl , Jonathan Green
IPC分类号： A61K9/00 , A61K9/70 , A61K31/66 , A61K31/675 , A61P17/00 , A61P43/00 , C07F9/38
CPC分类号： A61K9/7053 , A61K31/66 , A61K31/675 , A61K9/7061 , A61K9/7076 , A61K9/7084
摘要： The invention relates to topically adminstrable pharmaceutical preparations containing pharmaceutically acceptable methanediphosphonic acid derivatives of formula ##STR1## and their salts, wherein each of R.sub.1 and R.sub.2 is halogen, or wherein R.sub.1 is hydrogen and R.sub.2 is Ar--S-- or Het.sub.1 --NH--, in which Ar is unsubstituted or substituted phenyl and Het.sub.1 is unsubstituted or substituted, monocyclic, 5- or 6-membered monoaza-, diaza- or thiaza-aryl that is bonded via a ring carbon atom, or wherein R.sub.1 is hydrogen or hydroxy and R.sub.2 is --A--R.sub.3, in which A is alkylene and, on the one hand, R.sub.3 is Het.sub.2, which is Het.sub.1 bonded via a ring carbon or ring nitrogen atom, or, on the other hand, R.sub.3 is hydrogen, or amino that is unsubsituted or mono- or di-substituted by identical or different substituents selected from alkyl, cycloalkyl, Ar-alkyl, Ar-O-alkyl, Ar-S-alkyl and Het.sub.1 -alkyl, or that is disubstituted by optionally Ar-containing alkylene, wherein two alkylene carbon atoms mar additionally be linked to one another via alkylene and Ar and Het.sub.1 are each as defined above, with the proviso that when R.sub.2 is --A--R.sub. 3, A is ethylene and R.sub.3 is unsubstituted or C.sub.1 -C.sub.3 alkyl-substituted amino, R.sub.1 is other than hydroxy.
摘要翻译：本发明涉及含有药学上可接受的式（I）的甲二膦酸衍生物及其盐的局部给药药物制剂，其中R1和R2各自为卤素，或其中R1为氢，R2为Ar-S-或Het1- NH-，其中Ar是未取代或取代的苯基，Het1是未经取代或取代的单环，5或6元单氮杂，二氮杂 - 或噻唑基 - 芳基，其通过环碳原子键合，或其中R1是氢或羟基和R 2是-A-R 3，其中A是亚烷基，一方面，R 3是Het 2，其是通过环碳或环氮原子键合的Het1，或者另一方面，R 3是氢，或未被取代或被相同或不同的选自烷基，环烷基，Ar-烷基，Ar-O-烷基，Ar-S-烷基和Het1 - 烷基的取代基取代或被取代的氨基，或被任意Ar- 其中两个亚烷基碳原子另外与一个a连接通过亚烷基，Ar和Het1各自如上所定义，条件是当R 2是-A-R 3时，A是亚乙基，R 3是未取代的或C 1 -C 3烷基取代的氨基，R 1不是羟基。

10. 发明授权

US08851326B2 Folded sheet dispenser with overfill prevention device 有权
标题翻译：具有防溢流装置的折页机
公开(公告)号：US08851326B2
公开(公告)日：2014-10-07
申请号：US13274957
申请日：2011-10-17
申请人： Paul Francis Tramontina , Jonathan Green , Wolfgang Heich
发明人： Paul Francis Tramontina , Jonathan Green , Wolfgang Heich
IPC分类号： B65D83/08
CPC分类号： A47K10/424
摘要： The present invention provides a dispenser for folded sheets having an overfill prevention device, which effectively prevents the dispenser from being overfilled with folded sheet material. The result of the present invention is that a maintainer of the dispenser will have a difficult time overfilling the dispenser.
摘要翻译：本发明提供一种用于折叠片材的分配器，其具有防溢出装置，其有效地防止分配器被折叠的片材过度填充。本发明的结果是分配器的维护者将难以超过分配器的时间。

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