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1. 发明申请

US20110076705A1 COMPOSITIONS AND METHODS FOR EARLY PREGNANCY DIAGNOSIS 有权
标题翻译：早期怀孕诊断的组成和方法
公开(公告)号：US20110076705A1
公开(公告)日：2011-03-31
申请号：US12747514
申请日：2008-12-12
申请人： Nagappan Mathialagan , Roberts M. Robert , Michael F. McGrath , Jonathan Green
发明人： Nagappan Mathialagan , Roberts M. Robert , Michael F. McGrath , Jonathan Green
IPC分类号： G01N33/566 , C07K16/18 , C07K16/40 , C12N5/16 , C07H21/00 , C07K1/14 , C07K1/22
CPC分类号： G01N33/6803 , C07K16/18 , G01N2333/471
摘要： Disclosed are antibodies and methods for detecting pregnancy in an animal. In certain aspects antibodies used binds immunologically to at least two PAGs selected from PAG4, PAG6, PAG9, PAG16, PAG17, PAG19, PAG20 and PAG21. Antibody encoding nucleic acids are also provided, as are kits, methods of use and additional antibody related compositions.
摘要翻译：公开了用于在动物中检测怀孕的抗体和方法。在某些方面，使用的抗体与选自PAG4，PAG6，PAG9，PAG16，PAG17，PAG19，PAG20和PAG21的至少两种PAG免疫结合。还提供抗体编码核酸，试剂盒，使用方法和另外的抗体相关组合物。

2. 发明授权

US08431349B2 Compositions and methods for early pregnancy diagnosis 有权
标题翻译：早孕诊断的组成和方法
公开(公告)号：US08431349B2
公开(公告)日：2013-04-30
申请号：US12747514
申请日：2008-12-12
申请人： Nagappan Mathialagan , Robert M. Roberts , Michael F. McGrath , Jonathan Green
发明人： Nagappan Mathialagan , Robert M. Roberts , Michael F. McGrath , Jonathan Green
IPC分类号： G01N33/53 , C12N5/20 , C07K16/42 , C07K16/24
CPC分类号： G01N33/6803 , C07K16/18 , G01N2333/471
摘要： Disclosed are antibodies and methods for detecting pregnancy in an animal. In certain aspects antibodies used binds immunologically to at least two PAGs selected from PAG4, PAG6, PAG9, PAG16, PAG17, PAG19, PAG20 and PAG21. Antibody encoding nucleic acids are also provided, as are kits, methods of use and additional antibody related compositions.
摘要翻译：公开了用于在动物中检测怀孕的抗体和方法。在某些方面，使用的抗体与选自PAG4，PAG6，PAG9，PAG16，PAG17，PAG19，PAG20和PAG21的至少两种PAG免疫结合。还提供抗体编码核酸，试剂盒，使用方法和另外的抗体相关组合物。

3. 发明授权

US06844322B2 Method for induced lactation 有权
标题翻译：诱导性哺乳方法
公开(公告)号：US06844322B2
公开(公告)日：2005-01-18
申请号：US09910473
申请日：2001-07-20
申请人： Michael F. McGrath , Tim H. Klusmeyer , John L. Vicini , Robert H. Schenkel , Edward Alan Reed , Kanaiyalal R. Patel
发明人： Michael F. McGrath , Tim H. Klusmeyer , John L. Vicini , Robert H. Schenkel , Edward Alan Reed , Kanaiyalal R. Patel
IPC分类号： A61K38/27 , A61P5/00 , A61K31/566 , A61K31/573
CPC分类号： A61K38/27 , A61K31/57 , A61K31/565 , A61K2300/00
摘要： Methods for effecting mammary secretion of milk from an animal, without the benefit of an immediately preceding pregnancy are provided. An exemplary embodiment the method comprises elevating an animal's estradiol and progesterone blood level sufficient to maintain a milk-secretion stimulating amount for approximately 5 to 12 consecutive days, wherein the day of the first elevation is defined to be day 0; and elevating an animal's somatotropin blood level sufficient to maintain a milk-secretion stimulating amount for at least 20 days from day 0. In any embodiment the method also optionally includes administering to the animal a milk-secretion stimulating amount of dexamethasone on approximately day 13 of the treatment. Furthermore, any embodiment the method may also optionally include adjusting the photo-period to which the animal is exposed in order to stimulate milk secretion. Any embodiment the method may also include physical stimulation of the animal's mammary gland.
摘要翻译：提供了在没有受益于紧接在前怀孕的情况下从动物进行乳的分泌乳的方法。该方法的一个示例性实施方案包括将动物的雌二醇和孕酮血液水平提高至足以维持乳分泌刺激量约5至12个连续天，其中第一次升高的日期定义为第0天; 并且提高动物的生长激素血液水平足以使得从第0天起至少20天保持乳分泌刺激量。在任何实施方案中，所述方法还任选地包括在大约第13天对动物施用牛奶分泌刺激量的地塞米松治疗。此外，任何实施方案，该方法还可以任选地包括调整动物暴露于照射期以刺激乳分泌。任何实施方案，该方法还可以包括对动物乳腺的物理刺激。

4. 发明授权

US4981956A DNA sequences encoding bovine growth factors 失效
标题翻译：编码牛生长因子的DNA序列
公开(公告)号：US4981956A
公开(公告)日：1991-01-01
申请号：US254332
申请日：1988-10-06
申请人： Brent R. Larsen , Ned R. Siegel , Claire E. Kotts , Michael F. McGrath , Sharon D. Ogden , Gwen G. Krivi , John C. Minnerly
发明人： Brent R. Larsen , Ned R. Siegel , Claire E. Kotts , Michael F. McGrath , Sharon D. Ogden , Gwen G. Krivi , John C. Minnerly
IPC分类号： A23K1/16 , A61K38/00 , C07K14/65
CPC分类号： C07K14/65 , A23K20/147 , A61K38/00
摘要： This invention relates to novel peptides having utility for promotion of growth and/or lactation in animals, to processes and DNA useful in production of such peptides, and to methods utilizing such peptides to promote growth or lactation in animals. In some embodiments, the invention is directed to peptides having bovine IGF-II biological activity, to production of such peptides, and to their use in effecting proliferation of certain cells (e.g. mammary epithelial or muscle) or in enhancing lactation in cattle or other animals.
摘要翻译：本发明涉及可用于促进动物生长和/或哺乳的新型肽，可用于生产这些肽的方法和DNA，以及利用这些肽促进动物生长或哺乳的方法。在一些实施方案中，本发明涉及具有牛IGF-II生物活性的肽，生产这样的肽，以及用于实现某些细胞（例如乳腺上皮或肌肉）的增殖或增强牛或其他动物的哺乳期。

5. 发明授权

US5130300A Method for enhancing growth of mammary parenchyma 失效
公开(公告)号：US5130300A
公开(公告)日：1992-07-14
申请号：US493256
申请日：1990-03-14
申请人： Robert J. Collier , Michael F. McGrath
发明人： Robert J. Collier , Michael F. McGrath
IPC分类号： A61K9/00 , A61K31/557 , A61K38/18 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/30
CPC分类号： A61K31/557 , A61K38/1841 , A61K9/0041
摘要： The growth of milk-producing mammary parenchyma in a mammal can be significantly enhanced by administering to the mammal by intramammary infusion a substance having a mitogenic effect on mammary epithelial cells in said mammal. Good growth enhancement can be achieved using very small quantities of such substances, and in relatively short periods of time.

6. 发明授权

US5059586A Method for enhancing growth of mammary parenchyma 失效
标题翻译：增强乳腺实质增生的方法
公开(公告)号：US5059586A
公开(公告)日：1991-10-22
申请号：US92009
申请日：1987-09-02
申请人： Robert J. Collier , Michael F. McGrath
发明人： Robert J. Collier , Michael F. McGrath
IPC分类号： A61D7/00 , A61K35/30 , A61K38/00 , A61K38/18 , A61K38/22 , A61K38/27 , A61K38/30 , A61P15/00
CPC分类号： A61K38/1808 , A61K38/27 , A61K38/30
摘要： The growth of milk-producing mammary parenchyma in a mammal can be significantly enhanced by administering to the mammal by intramammary infusion a substance having a mitogenic effect on mammary epithelial cells in said mammal. Good growth enhancement can be achieved using very small quantities of such substances, and in relatively short periods of time.
摘要翻译：通过对哺乳动物施用哺乳动物中产奶乳腺实质的生长可以通过对所述哺乳动物的乳腺上皮细胞具有促有丝分裂作用的物质进行乳剂输注而显着增强。使用非常少量的这种物质，并且在相对短的时间内可以实现良好的生长增强。

7. 发明授权

US5182302A Method for enhancing growth of mammary parenchyma using a prostaglandin 失效
标题翻译：使用前列腺素增强乳腺实质增生的方法
公开(公告)号：US5182302A
公开(公告)日：1993-01-26
申请号：US723021
申请日：1991-06-28
申请人： Robert J. Collier , Michael F. McGrath
发明人： Robert J. Collier , Michael F. McGrath
IPC分类号： A61K38/18 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/30
CPC分类号： A61K31/19 , A61K31/557
摘要： The growth of milk-producing mammary parenchyma in a mammal can be significantly enhanced by administering to the mammal by intramammary infusion a substance having a mitogenic effect on mammary epithelial cells in said mammal. Good growth enhancement can be achieved using very small quantities of such substances, and in relatively short periods of time.
摘要翻译：通过对哺乳动物施用哺乳动物中产奶乳腺实质的生长可以通过对所述哺乳动物的乳腺上皮细胞具有促有丝分裂作用的物质进行乳剂输注而显着增强。使用非常少量的这种物质，并且在相对短的时间内可以实现良好的生长增强。

8. 发明授权

US5130299A Method for enhancing growth of mammary parenchyma 失效
标题翻译：增强乳腺实质增生的方法
公开(公告)号：US5130299A
公开(公告)日：1992-07-14
申请号：US723283
申请日：1991-06-28
申请人： Robert J. Collier , Michael F. McGrath
发明人： Robert J. Collier , Michael F. McGrath
IPC分类号： A61K9/00 , A61K31/557 , A61K38/18 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/30
CPC分类号： A61K31/557 , A61K38/1808 , A61K38/22 , A61K38/27 , A61K38/30 , A61K9/0041
摘要： The growth of milk-producing mammary parenchyma in a mammal can be significantly enhanced by administering to the mammal by intramammary infusion a substance having a mitogenic effect on mammary epithelial cells in said mammal. Good growth enhancement can be achieved using very small quantities of such substances, and in relatively short periods of time.
摘要翻译：通过对哺乳动物施用哺乳动物中产奶乳腺实质的生长可以通过对所述哺乳动物的乳腺上皮细胞具有促有丝分裂作用的物质进行乳剂输注而显着增强。使用非常少量的这种物质，并且在相对短的时间内可以实现良好的生长增强。

9. 发明授权

US4783524A Growth factors 失效
标题翻译：生长因子
公开(公告)号：US4783524A
公开(公告)日：1988-11-08
申请号：US888996
申请日：1986-07-31
申请人： Brent R. Larsen , Ned R. Siegel , Claire E. Kotts , Michael F. McGrath , Sharon D. Ogden , Gwen G. Krivi , John C. Minnerly
发明人： Brent R. Larsen , Ned R. Siegel , Claire E. Kotts , Michael F. McGrath , Sharon D. Ogden , Gwen G. Krivi , John C. Minnerly
IPC分类号： C12N15/09 , A23K1/16 , A61K20060101 , A61K35/74 , A61K38/00 , A61K38/27 , A61K38/28 , A61P5/00 , C07H21/04 , C07K14/00 , C07K14/65 , C07K16/00 , C12N20060101 , C12N15/00 , C12P20060101 , C12P21/02 , C07K13/00
CPC分类号： C07K14/65 , A23K20/147 , A61K38/00 , Y10S930/12
摘要： This invention relates to novel peptides having utility for promotion of growth and/or lactation in animals, to processes and DNA useful in production of such peptides, and to methods utilizing such peptides to promote growth or lactation in animals. In some embodiments, the invention is directed to peptides having bovine IGF-II biological activity, to production of such peptides, and to their use in effecting proliferation of certain cells (e.g. mammary epithelial or muscle) or in enhancing lactation in cattle or other animals.
摘要翻译：本发明涉及可用于促进动物生长和/或哺乳的新型肽，可用于生产这些肽的方法和DNA，以及利用这些肽促进动物生长或哺乳的方法。在一些实施方案中，本发明涉及具有牛IGF-II生物活性的肽，生产这样的肽，以及用于实现某些细胞（例如乳腺上皮或肌肉）的增殖或增强牛或其他动物的哺乳期。

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