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1. 发明授权

US07692776B2 Chemical imaging explosives (CHIMED) optical sensor 有权
标题翻译：化学成像炸药（CHIMED）光学传感器
公开(公告)号：US07692776B2
公开(公告)日：2010-04-06
申请号：US11645132
申请日：2006-12-22
申请人： Patrick J. Treado , Matthew P. Nelson
发明人： Patrick J. Treado , Matthew P. Nelson
IPC分类号： G01N21/00
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0218 , G01N21/6456 , G01N21/65 , G01N33/227 , G01N2001/024 , G01N2021/6417 , G01N2021/6484
摘要： A system and method of detecting explosive compounds located on a sample. The sample is irradiated with animal-safe ultra-violet radiation generating a fluorescence data set. A fluorescence database is searched based on the fluorescence data set in order to identify a known fluorescence data set. If the searching of the fluorescence database identifies a known fluorescence data set, an area of interest in the sample is identified based on the known fluorescence data set identified in the fluorescence database searching. The area of interest is irradiated with substantially monochromatic radiation to generate a Raman data set of the area of interest. A Raman database is searched based on the Raman data set in order to identify a known Raman data set. An explosive compound in the area of interest is identified based on the known Raman data set identified by searching the Raman database.
摘要翻译：一种检测位于样品上的爆炸性化合物的系统和方法。用动物安全的紫外线辐射照射样品，产生荧光数据集。基于荧光数据集搜索荧光数据库，以识别已知的荧光数据集。如果荧光数据库的搜索识别已知荧光数据集，则基于在荧光数据库搜索中识别的已知荧光数据集来识别样品中的感兴趣区域。用基本上单色的辐射照射感兴趣的区域以产生感兴趣区域的拉曼数据集。基于拉曼数据集搜索拉曼数据库，以便识别已知的拉曼数据集。基于通过搜索拉曼数据库识别的已知拉曼数据集来识别感兴趣区域中的爆炸性化合物。

2. 发明申请

US20090152454A1 METHOD AND APPARATUS FOR AUTOMATED SPECTRAL CALIBRATION 有权
标题翻译：自动光谱校准的方法和装置
公开(公告)号：US20090152454A1
公开(公告)日：2009-06-18
申请号：US12273169
申请日：2008-11-18
申请人： Matthew P. Nelson , Patrick J. Treado
发明人： Matthew P. Nelson , Patrick J. Treado
IPC分类号： G01D18/00
CPC分类号： G01J3/28 , A61B5/0059 , A61B2560/0223 , G01J2003/2866
摘要： The disclosure generally relates to a method and apparatus for automated spectral calibration of a spectroscopy device. In one embodiment, the disclosure relates to a method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a plurality of illuminating photons; receiving, at the spectrometer, a first plurality of photons collected from the sample and a second plurality of photons collected from the calibrant; forming a calibrant spectrum from the first plurality of collected photons and a sample spectrum from the second plurality of collected photons; comparing the calibrant spectrum with a reference spectrum of the calibrant to determine a wavelength-shift in the calibrant spectrum; applying the wavelength-shift to the sample spectrum to obtain a calibrated sample spectrum.
摘要翻译：本发明一般涉及一种用于光谱设备的自动光谱校准的方法和装置。在一个实施方案中，本公开涉及通过以下步骤同时校准和光谱成像的方法：同时用多个照明光子照射样品和校准物; 在光谱仪处接收从样品收集的第一组多个光子和从校准物收集的第二组多个光子; 从所述第一多个收集的光子形成校准谱，以及来自所述第二多个收集的光子的样品光谱; 将校准谱与校准物的参考光谱进行比较，以确定校准谱中的波长漂移; 将波长偏移应用于样本光谱以获得校准的样本光谱。

3. 发明授权

US07474395B2 System and method for image reconstruction in a fiber array spectral translator system 有权
标题翻译：光纤阵列光谱转换系统中图像重建的系统和方法
公开(公告)号：US07474395B2
公开(公告)日：2009-01-06
申请号：US11674552
申请日：2007-02-13
申请人： Matthew P. Nelson , Jason H. Neiss , Patrick J. Treado
发明人： Matthew P. Nelson , Jason H. Neiss , Patrick J. Treado
IPC分类号： G01J3/00
CPC分类号： G01J3/02 , G01J3/0218 , G01J3/0221 , G01J3/28 , G01J3/2803 , G01J3/2823 , G01N21/255 , G01N21/274 , G01N2201/0833
摘要： The disclosure relates generally to methods and apparatus for spectral calibration of a spectroscopic system which includes a fiber array spectral translator. One embodiment relates to a method for obtaining a first image of a known substance using a photon detector and a fiber array spectral translator having plural fibers, wherein the first image comprises at least one pixel; providing a second image of the substance wherein the second image comprises at least one pixel; comparing the first image with the second image; and adjusting at least one pixel of the first image based on the comparison of images to thereby obtain an adjusted image.
摘要翻译：本公开一般涉及包括光纤阵列光谱转换器的光谱系统的光谱校准的方法和装置。一个实施例涉及一种使用光子检测器和具有多个光纤的光纤阵列光谱转换器获得已知物质的第一图像的方法，其中第一图像包括至少一个像素; 提供所述物质的第二图像，其中所述第二图像包括至少一个像素; 将第一图像与第二图像进行比较; 以及基于图像的比较来调整第一图像的至少一个像素，从而获得调整后的图像。

4. 发明授权

US07764371B2 System and method for super resolution of a sample in a fiber array spectral translator system 有权
标题翻译：用于光纤阵列光谱转换器系统中样品超分辨率的系统和方法
公开(公告)号：US07764371B2
公开(公告)日：2010-07-27
申请号：US11675155
申请日：2007-02-15
申请人： Matthew P. Nelson , Jason H. Neiss , Patrick J. Treado
发明人： Matthew P. Nelson , Jason H. Neiss , Patrick J. Treado
IPC分类号： G01J3/00
CPC分类号： G01T1/20
摘要： The disclosure relates generally to methods and apparatus for obtaining a super resolution image of a sample using a fiber array spectral translator system. In one embodiment includes collecting photons from a sample at a first end of a fiber array spectral translator; delivering the photons from a second end of the fiber array spectral translator into a multiple detector rows of a photon detector; interpolating between the multiple detector rows to thereby form interpolated rows; and arranging an output of the multiple detector rows and the interpolated rows so as to obtain a super resolution image of the sample.
摘要翻译：本公开一般涉及使用光纤阵列频谱转换器系统获得样本的超分辨率图像的方法和装置。在一个实施例中，包括在光纤阵列光谱转换器的第一端收集来自样品的光子; 将光子从光纤阵列频谱转换器的第二端传送到光子检测器的多个检测器行中; 在多个检测器行之间内插，从而形成内插行; 并且布置多个检测器行和内插行的输出，以便获得样本的超分辨率图像。

5. 发明授权

US07738095B2 Method and apparatus for compact spectrometer for detecting hazardous agents 有权
标题翻译：用于检测危险物质的紧凑型光谱仪的方法和装置
公开(公告)号：US07738095B2
公开(公告)日：2010-06-15
申请号：US11366532
申请日：2006-03-03
申请人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe , Joseph E. Demuth , Jason H. Neiss , Chenhui Wang
发明人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe , Joseph E. Demuth , Jason H. Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/28 , G01J3/2823 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2201/0221
摘要： The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种便携式系统，用于获得具有第一和第二空间尺寸的样本的空间上准确的波长分辨图像，该图像可以用于通过用光照射样品来检测危险剂，形成全部或全部图像使用拉曼的样品的一部分移动来自样品的光，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

6. 发明申请

US20090128802A1 Time and Space Resolved Standoff Hyperspectral IED Explosives LIDAR Detector 有权
标题翻译：时间和空间解决了高分辨率高分辨率IED爆炸物激光雷达探测器
公开(公告)号：US20090128802A1
公开(公告)日：2009-05-21
申请号：US12199145
申请日：2008-08-27
申请人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
发明人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
IPC分类号： G01J3/44 , G01J3/00
CPC分类号： G01J3/36 , G01J3/02 , G01J3/0221 , G01J3/0264 , G01J3/2823 , G01J3/44 , G01N21/359 , G01N21/6456 , G01N21/65 , G01N21/718 , G01N2021/1738 , G01N2021/174 , G01N2021/1744
摘要： A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.
摘要翻译：爆炸物和爆炸物残留物检测的系统和方法。激光源照射具有未知样品的目标区域，产生发光的光子，散射的光子和等离子体发射的光子。第一光学系统将光引导到目标区域。视频采集装置输出目标区域的动态图像。第二光学系统收集光子，并将收集的光子引导到检测元件的第一二维阵列和/或光纤阵列光谱转换器装置，该装置包括被拉入一维光纤堆叠的光纤的二维阵列。光谱仪耦合到光纤阵列光谱转换器装置的一维光纤堆叠，其中光谱仪的入口狭缝耦合到一维光纤堆叠。

7. 发明申请

US20070206185A1 SYSTEM AND METHOD FOR FIBER ARRAY SPECTRAL TRANSLATOR BASED POLYMORPH SCREENING 有权
标题翻译：用于光纤阵列光纤转换器的聚合物筛选系统和方法
公开(公告)号：US20070206185A1
公开(公告)日：2007-09-06
申请号：US11682302
申请日：2007-03-05
申请人： David Tuschel , Patrick J. Treado , Matthew P. Nelson
发明人： David Tuschel , Patrick J. Treado , Matthew P. Nelson
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/0221 , G01J3/2823 , G01N21/474 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2021/6484 , G01N2201/08 , G01N2201/0833
摘要： The present disclosure describes methods and systems that combine Raman spectroscopy performed in a manner that utilizes one or more of widefield illumination, simultaneous multipoint Raman spectral acquisition, and spectral unmixing for the purpose of high throughput polymorph screening. Features of this methodology include: (a) high throughput polymorph screening to reduce crystal orientation effects on Raman spectra; (b) in-well multi-polymorph screening using increased statistical sampling; and (c) multipoint spectral sampling to enable spectral unmixing.
摘要翻译：本公开描述了组合拉曼光谱的方法和系统，其以利用一种或多种宽场照明，同时多点拉曼光谱采集和光谱解混合的方式进行，以进行高通量多晶型筛选。该方法的特点包括：（a）高通量多晶型筛选以减少对拉曼光谱的晶体取向效应; （b）使用增加的统计学抽样的井内多多态性筛选; 和（c）多点光谱采样以使光谱解混合。

8. 发明申请

US20070205379A1 System and method for structured illumination and collection for improved optical confocality of raman fiber array spectral translator imaging and interactive raman probing 有权
标题翻译：用于结构化照明和采集的系统和方法，用于改进拉曼光纤阵列光谱翻译器成像和交互式拉曼探测的光学共焦
公开(公告)号：US20070205379A1
公开(公告)日：2007-09-06
申请号：US11712917
申请日：2007-03-02
申请人： Matthew P. Nelson , Patrick J. Treado
发明人： Matthew P. Nelson , Patrick J. Treado
IPC分类号： G01J1/58 , G02B6/06 , G01B9/10 , G01N21/64 , F21V9/16
CPC分类号： G01J3/2803 , G01J3/0221 , G01J3/44 , G01N21/474 , G01N21/55 , G01N21/645 , G01N21/6456 , G01N21/65 , G01N2021/6423 , G01N2021/6484 , G01N2201/0833 , G01N2201/0846 , G02B6/06
摘要： The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber array spectral translator-based spectroscopic system is improved through the use of structured illumination and/or structured collection of photons. User input may be received and acted upon to allow a user to interactively in real time and/or near real time view and analyze specific regions of the sample.
摘要翻译：本公开一般涉及使用用于改进样品的成像，光谱分析和交互式探测的光纤阵列基于光谱转换器的（“FAST”）光谱系统的方法和装置。在一个实施例中，通过使用结构化照明和/或光子的结构化收集来提高基于光纤阵列光谱转换器的光谱系统的共焦度。可以接收用户输入并执行操作以允许用户以实时和/或接近实时的方式进行交互式查看和分析样本的特定区域。

9. 发明授权

US07057721B2 Wide field method for detecting pathogenic microorganisms 有权
标题翻译：用于检测病原微生物的广域方法
公开(公告)号：US07057721B2
公开(公告)日：2006-06-06
申请号：US10608470
申请日：2003-06-27
申请人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe
发明人： Charles W. Gardner, Jr. , John S. Maier , Matthew P. Nelson , Robert C. Schweitzer , Patrick J. Treado , G. Steven Vanni , Julianne Wolfe
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0272 , G01J3/10 , G01N21/35 , G01N21/3577 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N2021/6417 , G01N2021/6423 , G01N2021/656 , G01N2201/0221
摘要： Pathogenic microorganisms are detected in a wide field of view and classified by Raman light scattered light from these organisms together with digital pattern recognition of their spectral patterns.
摘要翻译：在广泛的视野中检测致病微生物，并通过来自这些生物的拉曼光散射光以及它们的光谱图案的数字图案识别来分类病原微生物。

10. 发明申请

US20120120393A1 TIME AND SPACE RESOLVED STANDOFF HYPERSPECTRAL IED EXPLOSIVES LIDAR DETECTOR 审中-公开
标题翻译：时间和空间分辨率高分辨率高分辨率激光雷达探测器
公开(公告)号：US20120120393A1
公开(公告)日：2012-05-17
申请号：US13290174
申请日：2011-11-07
申请人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
发明人： Patrick J. Treado , Matthew P. Nelson , Hugh W. Hubble, II , Jason Neiss
IPC分类号： G01J3/44 , G01B11/24
CPC分类号： G01J3/36 , G01J3/02 , G01J3/0221 , G01J3/0264 , G01J3/2823 , G01J3/44 , G01N21/359 , G01N21/6456 , G01N21/65 , G01N21/718 , G01N2021/1738 , G01N2021/174 , G01N2021/1744
摘要： A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.
摘要翻译：爆炸物和爆炸物残留物检测的系统和方法。激光源照射具有未知样品的目标区域，产生发光的光子，散射的光子和等离子体发射的光子。第一光学系统将光引导到目标区域。视频采集装置输出目标区域的动态图像。第二光学系统收集光子，并将收集的光子引导到检测元件的第一二维阵列和/或光纤阵列光谱转换器装置，该装置包括被拉入一维光纤堆叠的光纤的二维阵列。光谱仪耦合到光纤阵列光谱转换器装置的一维光纤堆叠，其中光谱仪的入口狭缝耦合到一维光纤堆叠。

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