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1. 发明申请

US20100075952A1 PYRROLO-NITROGENOUS HETEROCYCLIC DERIVATIES,THE PREPARATION AND THE PHARMCETICAL USE THEEOF 失效
标题翻译：吡咯并 - 氮杂环类衍生物，其制备和药物使用
公开(公告)号：US20100075952A1
公开(公告)日：2010-03-25
申请号：US12451466
申请日：2008-05-14
申请人： Peng Cho ChoTang , Yidong Su , Yali Li , Lei Zhang , Fuqiang Zhao , Jialiang Yang , Ying Zhou , Pingyan Bie , Guangtao Qian , Minggang Ju
发明人： Peng Cho ChoTang , Yidong Su , Yali Li , Lei Zhang , Fuqiang Zhao , Jialiang Yang , Ying Zhou , Pingyan Bie , Guangtao Qian , Minggang Ju
IPC分类号： A61K31/55 , C12N9/10 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention provides new pyrrolo-nitrogenous heterocyclic derivatives represented by formula (I) or their salts, the preparation thereof, pharmaceutical compositions containing such derivatives and the use of such derivatives as therapeutic agents, especially as protein kinase inhibitors, wherein each substituent in formula (I) is same as defined in the description.
摘要翻译：本发明提供由式（I）表示的新的吡咯 - 氮杂环衍生物或其盐，其制备方法，含有这些衍生物的药物组合物，以及作为治疗剂，特别是作为蛋白激酶抑制剂的衍生物，其中式 I）与说明书中定义的相同。

2. 发明授权

US08329682B2 Pyrrolo-nitrogenous heterocyclic derivatives, the preparation and the pharmaceutical use thereof 失效
标题翻译：吡咯 - 含氮杂环衍生物，其制备及其药物用途
公开(公告)号：US08329682B2
公开(公告)日：2012-12-11
申请号：US12451466
申请日：2008-05-14
申请人： Peng Cho Tang , Yidong Su , Yali Li , Lei Zhang , Fuqiang Zhao , Jialiang Yang , Ying Zhou , Pingyan Bie , Guangtao Qian , Minggang Ju
发明人： Peng Cho Tang , Yidong Su , Yali Li , Lei Zhang , Fuqiang Zhao , Jialiang Yang , Ying Zhou , Pingyan Bie , Guangtao Qian , Minggang Ju
IPC分类号： C07D519/00 , C07D487/04 , C07D471/04 , A61K31/41 , A61K31/437 , A61P35/00
CPC分类号： C07D487/04
摘要： The invention provides new pyrrolo-nitrogenous heterocyclic derivatives represented by formula (I) or their salts, the preparation thereof, pharmaceutical compositions containing such derivatives and the use of such derivatives as therapeutic agents, especially as protein kinase inhibitors, wherein each substituent in formula (I) is same as defined in the description.
摘要翻译：本发明提供由式（I）表示的新的吡咯 - 氮杂环衍生物或其盐，其制备方法，含有这些衍生物的药物组合物，以及作为治疗剂，特别是作为蛋白激酶抑制剂的衍生物，其中式 I）与说明书中定义的相同。

3. 发明授权

US09043172B2 Estimating virtual machine energy consumption 有权
标题翻译：估计虚拟机能耗
公开(公告)号：US09043172B2
公开(公告)日：2015-05-26
申请号：US13596612
申请日：2012-08-28
申请人： Ying Chen , Li Li , Liang Liu , Hao Wang , Ying Zhou
发明人： Ying Chen , Li Li , Liang Liu , Hao Wang , Ying Zhou
IPC分类号： G01R21/00 , G06F9/455 , G06F1/00 , G06F1/28 , G06F19/00
CPC分类号： G06F1/28 , G06F19/00 , Y02D10/26 , Y02D10/28
摘要： A method and apparatus for estimating virtual machine energy consumption, and in particular, a method and apparatus for estimating virtual machine energy consumption in a computer system. The method includes: obtaining system energy consumption of the system hardware resources; obtaining event information of a plurality of functional units into which the system hardware resources are divided, and mapping the event information to the respective virtual machines; and calculating energy consumption of the virtual machines according to a plurality of energy consumption coefficients corresponding to the plurality of functional units and according to the event information mapped to the functional units of the respective virtual machines.
摘要翻译：一种用于估计虚拟机能量消耗的方法和装置，特别是一种用于估计计算机系统中的虚拟机能量消耗的方法和装置。该方法包括：获取系统硬件资源的系统能耗; 获取所述系统硬件资源划分到的多个功能单元的事件信息，并将所述事件信息映射到各个虚拟机; 以及根据与所述多个功能单元对应的多个能量消耗系数并根据映射到各个虚拟机的功能单元的事件信息来计算虚拟机的能量消耗。

4. 发明授权

US08794013B2 Method and system for nucleation control in a controlled rate freezer (CRF) 有权
标题翻译：控制率冷冻机（CRF）中成核控制的方法和系统
公开(公告)号：US08794013B2
公开(公告)日：2014-08-05
申请号：US13097724
申请日：2011-04-29
申请人： Ying Zhou , Theodore H. Gasteyer, III , Nigel J. Grinter , Alan T. Cheng , Yeu-Chuan Simon Ho , Robert R. Sever
发明人： Ying Zhou , Theodore H. Gasteyer, III , Nigel J. Grinter , Alan T. Cheng , Yeu-Chuan Simon Ho , Robert R. Sever
IPC分类号： F25D25/00 , G01N1/22 , C12M3/00 , A01N1/02 , F25D3/10 , F25D29/00
CPC分类号： A01N1/0289 , A01N1/0257 , A01N1/0284 , F25D3/102 , F25D29/001
摘要： A method and system for controlled rate freezing and nucleation of materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time. The presently disclosed methods to systems also provide nucleation control via temperature quench and depressurized nucleation control.
摘要翻译：提供了控制速率冷冻和成核的方法和系统。本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的材料的能力，其中使用层流和均匀流动的冷冻剂靠近设置在冷却单元内的多个小瓶。生物材料的快速冷却是通过精确地控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。目前公开的系统方法还通过温度骤冷和减压成核控制提供成核控制。

5. 发明申请

US20130323714A1 SYSTEM AND METHOD FOR MICRO-AERATION BASED FERMENTATION 审中-公开
标题翻译：基于微生物发酵的系统和方法
公开(公告)号：US20130323714A1
公开(公告)日：2013-12-05
申请号：US13908462
申请日：2013-06-03
申请人： Alan T. Cheng , Ying Zhou , Paul W. Belanger , Jennifer G. Bugayong
发明人： Alan T. Cheng , Ying Zhou , Paul W. Belanger , Jennifer G. Bugayong
IPC分类号： C12M1/00
CPC分类号： C12M41/48 , C12M21/12 , C12M27/00 , C12M29/06 , C12M29/24 , C12M41/32 , C12M41/34
摘要： A method and apparatus for micro-aeration of large scale fermentation systems is provided. The micro-aeration system includes a fermentation reactor, a sparging apparatus, and a micro-aeration gas mixture delivered to the fermentation reactor via the sparging apparatus. The micro-aeration gas mixture is a very low oxygen concentration mixture comprising an oxygen containing gas and an inert carrier gas that is preferably recycled through the fermentation reactor. The inert carrier gas is preferably nitrogen whereas the oxygen containing gas is oxygen or and is introduced to the fermentation reactor at a minimum superficial velocity of about 0.02 m/sec to produce a uniform dispersion of the oxygen/air throughout the fermentation broth while concurrently mixing the entire fermentation broth. The micro-aeration method and apparatus further comprises a controller operatively coupled to one or more control valves for regulating the micro-aeration conditions in the fermentation reactor.
摘要翻译：提供了一种用于大规模发酵系统微通气的方法和装置。微曝气系统包括通过喷射装置输送到发酵反应器的发酵反应器，喷射装置和微通气气体混合物。微通气气体混合物是包含含氧气体和惰性载气的非常低的氧浓度混合物，其优选通过发酵反应器再循环。惰性载气优选为氮气，而含氧气体为氧气，或以约0.02m / sec的最小表观速度引入发酵反应器，以产生氧气/空气在整个发酵液中的均匀分散，同时混合整个发酵液。微曝气方法和装置还包括操作地耦合到一个或多个控制阀的控制器，用于调节发酵反应器中的微通气条件。

6. 发明申请

US20120323509A1 METHOD AND APPARATUS FOR ESTIMATING VIRTUAL MACHINE ENERGY CONSUMPTION 审中-公开
标题翻译：用于估算虚拟机能耗的方法和装置
公开(公告)号：US20120323509A1
公开(公告)日：2012-12-20
申请号：US13596612
申请日：2012-08-28
申请人： Ying Chen , Li Li , Liang Liu , Hao Wang , Ying Zhou
发明人： Ying Chen , Li Li , Liang Liu , Hao Wang , Ying Zhou
IPC分类号： G06F19/00
CPC分类号： G06F1/28 , G06F19/00 , Y02D10/26 , Y02D10/28
摘要： A method and apparatus for estimating virtual machine energy consumption, and in particular, a method and apparatus for estimating virtual machine energy consumption in a computer system. The method includes: obtaining system energy consumption of the system hardware resources; obtaining event information of a plurality of functional units into which the system hardware resources are divided, and mapping the event information to the respective virtual machines; and calculating energy consumption of the virtual machines according to a plurality of energy consumption coefficients corresponding to the plurality of functional units and according to the event information mapped to the functional units of the respective virtual machines.
摘要翻译：一种用于估计虚拟机能量消耗的方法和装置，特别是一种用于估计计算机系统中的虚拟机能量消耗的方法和装置。该方法包括：获取系统硬件资源的系统能耗; 获取所述系统硬件资源划分到的多个功能单元的事件信息，并将所述事件信息映射到各个虚拟机; 以及根据与所述多个功能单元对应的多个能量消耗系数并根据映射到各个虚拟机的功能单元的事件信息来计算虚拟机的能量消耗。

7. 发明申请

US20120296585A1 METHOD AND APPARATUS FOR ESTIMATING VIRTUAL MACHINE ENERGY CONSUMPTION 有权
公开(公告)号：US20120296585A1
公开(公告)日：2012-11-22
申请号：US13456776
申请日：2012-04-26
申请人： Ying Chen , Li Li , Liang Liu , Hao Wang , Ying Zhou
发明人： Ying Chen , Li Li , Liang Liu , Hao Wang , Ying Zhou
IPC分类号： G06F1/28 , G06F19/00
CPC分类号： G06F1/28 , G06F19/00 , Y02D10/26 , Y02D10/28
摘要： A method and apparatus for estimating virtual machine energy consumption, and in particular, a method and apparatus for estimating virtual machine energy consumption in a computer system. The method includes: obtaining system energy consumption of the system hardware resources; obtaining event information of a plurality of functional units into which the system hardware resources are divided, and mapping the event information to the respective virtual machines; and calculating energy consumption of the virtual machines according to a plurality of energy consumption coefficients corresponding to the plurality of functional units and according to the event information mapped to the functional units of the respective virtual machines.

8. 发明授权

US08248003B2 Vibration frequency adjusting system and method 有权
标题翻译：振动频率调节系统及方法
公开(公告)号：US08248003B2
公开(公告)日：2012-08-21
申请号：US12693515
申请日：2010-01-26
申请人： Ying Zhou
发明人： Ying Zhou
IPC分类号： H02K33/00
CPC分类号： H04M1/72522 , H04M19/047
摘要： A vibration frequency adjusting system and method measures energy of a vibration generated by a vibrator of an electronic device, and converts the vibration energy to a level of electric charge. The system and method further compares the level of electric charge with preset electric charge thresholds, and adjusts the level of electric charge to a preset level of electric charge according to the comparison. Then, the system and method converts the adjusted preset level of electric charge to a voltage, and outputs the voltage to vibrator, so as to adjust the frequency of the vibration according to the voltage.
摘要翻译：振动频率调节系统和方法测量由电子设备的振动器产生的振动的能量，并且将振动能量转换成电荷水平。该系统和方法进一步比较电荷水平与预设电荷阈值，并根据比较将电荷水平调整到预设电荷水平。然后，系统和方法将经调整的预设电平电平转换为电压，并将电压输出到振动器，以便根据电压调节振动频率。

9. 发明授权

US08241904B2 System and method for controlling a mammalian cell culture process 有权
标题翻译：用于控制哺乳动物细胞培养过程的系统和方法
公开(公告)号：US08241904B2
公开(公告)日：2012-08-14
申请号：US12536559
申请日：2009-08-06
申请人： Alan T. Y. Cheng , Ying Zhou , Balazs Hunek , Amitabh Gupta , Nigel Grinter
发明人： Alan T. Y. Cheng , Ying Zhou , Balazs Hunek , Amitabh Gupta , Nigel Grinter
IPC分类号： C12N5/02
CPC分类号： C12N1/38 , C12M27/02 , C12M29/22
摘要： A system and method for controlling a mammalian cell culture process are provided. Such control of the cell culture process involves control of the level of dissolved carbon dioxide in the cell culture media and the resulting ability to prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide with little or no damage to the mammalian cells. The disclosed methods and systems of dissolved carbon dioxide stripping include enhanced surface gas exchange mechanisms within the bioreactor vessel through the use of an upward flow impeller combined with vertical baffles to convert swirling motions of the liquid into a largely vertical flow.
摘要翻译：提供了一种用于控制哺乳动物细胞培养方法的系统和方法。细胞培养过程的这种控制涉及控制细胞培养基中溶解的二氧化碳的水平，并且通过增强对二氧化碳的去除而对哺乳动物细胞几乎没有或没有损伤来实现所产生的渗透压浓度增加的能力。所公开的溶解二氧化碳汽提方法和系统包括通过使用与垂直挡板结合的向上流动叶轮将生物反应器容器内的表面气体交换机制改进为将液体的旋转运动转化成大体垂直的流动。

10. 发明授权

US08178318B2 Method for controlling pH, osmolality and dissolved carbon dioxide levels in a mammalian cell culture process to enhance cell viability and biologic product yield 有权
标题翻译：用于在哺乳动物细胞培养过程中控制pH，重量摩尔渗透压浓度和溶解二氧化碳水平以增强细胞活力和生物产物产率的方法
公开(公告)号：US08178318B2
公开(公告)日：2012-05-15
申请号：US12702428
申请日：2010-02-09
申请人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
发明人： Alan T. Y. Cheng , Ying Zhou , Amitabh Gupta , Balazs Hunek , Nigel Grinter
IPC分类号： C12P21/02
CPC分类号： C12N5/0018 , C12N1/38 , C12N2500/02 , C12N2500/60
摘要： Methods for controlling the level of dissolved carbon dioxide and limiting osmolality in a mammalian cell culture process to enhance cell growth, viability and density, and increase biologic product concentration and yield are provided. Such control of the level of dissolved carbon dioxide and pH as well as the resulting ability to limit osmolality in a mammalian cell culture process is achieved by adopting alternative pH control strategies and CO2 stripping techniques during a mammalian cell culture process. Such pH control techniques and carbon dioxide stripping occur without foam and with little or no damage to the mammalian cells.
摘要翻译：提供了用于在哺乳动物细胞培养过程中控制溶解二氧化碳水平和限制重量克分子渗透浓度以增强细胞生长，活力和密度以及提高生物产物浓度和产量的方法。通过在哺乳动物细胞培养过程中采用替代的pH控制策略和CO 2汽提技术来实现对哺乳动物细胞培养过程中溶解的二氧化碳和pH的水平的控制以及所产生的限制重量克分子渗透浓度的能力。这种pH控制技术和二氧化碳汽提不发生泡沫，对哺乳动物细胞几乎没有或没有损害。

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