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1. 发明授权

US06515170B1 Enzymatic oxidative deamination process 有权
公开(公告)号：US06515170B1
公开(公告)日：2003-02-04
申请号：US09843226
申请日：2001-04-26
申请人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Thomas P. Tully , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , William J. Winter , Neal G. Anderson , David A. Lust , Gerard Crispino , Sushil K. Srivastava
发明人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Steven L. Goldberg , Robert M. Johnston , Thomas P. Tully , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , William J. Winter , Neal G. Anderson , David A. Lust , Gerard Crispino , Sushil K. Srivastava
IPC分类号： C07C3200
CPC分类号： C07K5/06139 , A61K38/00 , C07K14/8103 , C12N9/1096
摘要： The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.

2. 发明授权

US6162913A Preparation of [4S-(4.alpha.,7.alpha.,10a.beta.)]-4-amino-octahydro-5-oxo-7H-pyrido[2,1 -b] [1,3]thiazepine-7-carboxylic acid, methyl ester and salts thereof via novel disulfides 有权
标题翻译： [4S-（4α，7α，10aβ）] -4-氨基 - 八氢-5-氧代-7H-吡啶并[2,1-b] [1,3]硫氮杂-7-甲酸甲酯酯及其盐通过新的二硫化物
公开(公告)号：US6162913A
公开(公告)日：2000-12-19
申请号：US349861
申请日：1999-07-08
申请人： Jerome L. Moniot , Sushil K. Srivastava , William J. Winter , John J. Venit , Shankar Swaminathan , Keith Ramig , Paul A. Jass , Mark D. Schwinden , John L. Dillon, Jr. , Saibaba Racha , James Simpson , Chien-Kuang Chen , Shawn K. Pack
发明人： Jerome L. Moniot , Sushil K. Srivastava , William J. Winter , John J. Venit , Shankar Swaminathan , Keith Ramig , Paul A. Jass , Mark D. Schwinden , John L. Dillon, Jr. , Saibaba Racha , James Simpson , Chien-Kuang Chen , Shawn K. Pack
IPC分类号： C07D513/04 , C07B53/00 , C07B61/00 , C07C229/04 , C07C229/22 , C07C261/00 , C07C319/22 , C07C323/59 , C07C323/60 , C07D281/02
CPC分类号： C07D513/04 , C07C323/60 , Y02P20/55
摘要： N-protected-L-homocysteine disulfide of the formula ##STR1## or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula ##STR2## Cleavage of the disulfide bond followed by acid catalyzed cyclization produces the N-protected lactam of formula III which is useful for preparing the pharmaceutically active compound omapatrilat.
摘要翻译：将下式的N-保护的L-高半胱氨酸二硫化物或其活化形式与（S）-2-氨基-6,6-二甲氧基己酸甲酯反应，得到式的二硫化物中间体通过酸催化环化产生式III的N-保护的内酰胺，其可用于制备药物活性化合物omapatrilat。

3. 发明授权

US6031004A Salts of metformin and method 有权
标题翻译：二甲双胍盐和方法
公开(公告)号：US6031004A
公开(公告)日：2000-02-29
申请号：US262526
申请日：1999-03-04
申请人： Peter Timmins , William J. Winter , Sushil K. Srivastava , Alison E. Bretnall , Chenkou Wei , Gerald L. Powers
发明人： Peter Timmins , William J. Winter , Sushil K. Srivastava , Alison E. Bretnall , Chenkou Wei , Gerald L. Powers
IPC分类号： A61K9/20 , A61K9/48 , A61K31/155 , A61K31/18 , A61K31/4965 , A61K45/06 , A61P3/10 , C07C279/26
CPC分类号： C07C279/26
摘要： Novel salts of the antidiabetic agent metformin acre provided which are metformin salts of dibasic acids (2:1 molar ratio), preferably metformin (2:1) fumarate and metformin (2:1) succinate, which may be employed alone or in combination with another antihyperglycemic agent such as glyburide, for treating diabetes. A method for treating diabetes employing the novel metformin salt by itself or in combination with another antidiabetic agent is also provided.
摘要翻译：提供二马来酸二甲双胍的新型盐，其为二元酸二甲双胍盐（2:1摩尔比），优选二甲双胍（2:1）富马酸盐和二甲双胍（2:1）琥珀酸盐，其可以单独使用或与另一种抗高血糖药如格列本脲，用于治疗糖尿病。还提供了使用本发明的新二甲双胍盐或与另一种抗糖尿病药联合治疗糖尿病的方法。

4. 发明授权

US4516491A Roll cross-axis mechanism 失效
标题翻译：辊横轴机构
公开(公告)号：US4516491A
公开(公告)日：1985-05-14
申请号：US537596
申请日：1983-09-30
申请人： William J. Winter
发明人： William J. Winter
IPC分类号： D21G1/00 , B21B13/02 , B21B31/07 , B21B31/20 , D21G1/02 , F16C13/06 , F16C23/04 , B30B3/04
CPC分类号： F16C23/045 , B21B13/023 , B21B31/07 , B21B31/20 , D21G1/0226
摘要： A cross axis roll adjusting mechanism including anti-friction bearing units arranged between a roll journal box and operating devices in a support frame to permit easy cross axis adjustment of a roll as well as a friction floating movement of the adjusted roll.
摘要翻译：一种横轴滚动调节机构，其包括设置在滚动轴颈箱和支撑框架中的操作装置之间的抗摩擦轴承单元，以允许容易地进行辊的横轴调节以及调节辊的摩擦浮动运动。

5. 发明授权

US4514161A Hydraulic roll protection system 失效
标题翻译：液压辊保护系统
公开(公告)号：US4514161A
公开(公告)日：1985-04-30
申请号：US559952
申请日：1983-12-09
申请人： William J. Winter
发明人： William J. Winter
IPC分类号： B21B31/02 , B21B31/32 , B29B7/58 , B29B7/72 , B29C15/00 , B30B3/04
CPC分类号： B21B31/32 , B29B7/584 , B29B7/724 , B21B2201/18 , B21B31/02
摘要： A hydraulic roll protection system in which positioning of an adjustable roll relative to a fixed roll is caused by adjusting screws acting on movable journal boxes through a pressurized piston cylinder device. A relief valve between a hand pump and the cylinder acts to relieve excessive pressures. A switch valve connects the hand pump alternately to advance the roll journal to normal gap positions and to retract the roll from the fixed roll.
摘要翻译：一种液压辊保护系统，其中可调节辊相对于固定辊的定位是通过调节通过加压活塞缸装置作用在可移动轴颈箱上的螺钉引起的。手动泵和气缸之间的安全阀用于缓解过大的压力。切换阀交替地连接手动泵将辊轴颈推进到正常的间隙位置，并使辊从固定辊回缩。

6. 发明申请

US20170292265A1 Insulated Concrete Masonry System 审中-公开
公开(公告)号：US20170292265A1
公开(公告)日：2017-10-12
申请号：US14998409
申请日：2016-04-11
申请人： William J. Winter
发明人： William J. Winter
IPC分类号： E04B2/26 , E04F13/14 , E04F13/08 , E04C1/40 , E04F13/02
CPC分类号： E04B2/26 , E04B2002/0291
摘要： An insulated masonry wall system comprised of special blocks of 24″×16″×8″ dimension filled with reclaimed rubber crumbs resulting in high R values to resist transmission of heat and cold. Insulation is blown and vibrated into the special concrete blocks as walls are developed. Construction of wall will be similar to standard masonry blocks. Facings attached to the blocks can be vinyl and wood siding, brick, stucco, textured acrylic finish, fiber-cement siding hardboard, photovoltaic siding, and wood shakes.

7. 发明授权

US4626111A Self-compensating anti-friction bearing clearance device 失效
标题翻译：自补偿抗摩擦轴承间隙装置
公开(公告)号：US4626111A
公开(公告)日：1986-12-02
申请号：US758733
申请日：1985-07-25
申请人： Archie N. Swasey , William J. Winter
发明人： Archie N. Swasey , William J. Winter
IPC分类号： F16C19/38 , F16C19/52 , F16C25/08 , F16C27/00
CPC分类号： F16C19/385 , F16C19/525 , F16C25/08
摘要： A device for automatically adjusting the clearances in a roller bearing due to thermal expansion, constituting a tapered roller bearing having a dual track oppositely tapered inner race and a pair of single track tapered outer races, each outer race being in communication with a pair of coaxial, hydraulically loaded annular pistons, each of which translates in annular piston cylinders, supplied with hydraulic fluid. The hydraulic pressure of the fluid is maintained through an accumulator at a preselectable constant pressure to permit the outer races to translate axially, against the annular piston, as the inner race expands radially due to thermal expansion. Upon thermal contraction, the pressure forces the annular pistons axially toward the outer races, which, due to the taper of the races and the bearing elements, reduces the clearance created due to the thermal contraction.
摘要翻译：一种用于自动调节由于热膨胀而导致的滚子轴承间隙的装置，构成了具有双轨相对锥形内圈和一对单轨锥形外圈的圆锥滚子轴承，每个外圈与一对同轴液压装载的环形活塞，每个环形活塞在环形活塞气缸中平移，供应液压油。流体的液压通过蓄能器以可选择的恒定压力保持，以允许外圈随着内圈由于热膨胀径向膨胀而相对于环形活塞轴向平移。在热收缩时，压力迫使环形活塞轴向朝向外座圈，由于座圈和轴承元件的锥度，减小了由于热收缩而产生的间隙。

8. 发明授权

US4571096A Self-adjusting minimum clearance bearing 失效
标题翻译：自调节最小间隙轴承
公开(公告)号：US4571096A
公开(公告)日：1986-02-18
申请号：US602539
申请日：1984-04-20
申请人： Archie N. Swasey , William J. Winter
发明人： Archie N. Swasey , William J. Winter
IPC分类号： B21B31/07 , D21G1/02 , F16C13/02 , F16C35/04 , F16C23/00
CPC分类号： F16C13/02 , B21B31/07 , D21G1/0226 , F16C35/04
摘要： A bearing assembly for roll journals comprising a bearing box having one piece of a semi-cylindrical sleeve and fixed relative to a nip line of a roll. A bearing box having the other piece of the bearing sleeve is movable toward a roll journal resting on the first piece to provide a minimum clearance between the roll journal and the bearing sleeve.
摘要翻译：一种用于辊子轴颈的轴承组件，其包括具有一片半圆柱形套筒并相对于辊的辊隙线固定的轴承箱。具有另一个轴承套的一个轴承盒可以朝向搁置在第一件上的辊轴颈移动，以在辊轴颈和轴承套之间提供最小的间隙。

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