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1. 发明授权

US11212245B1 Detection of forged e-mail messages at e-mail gateway 有权
公开(公告)号：US11212245B1
公开(公告)日：2021-12-28
申请号：US16597609
申请日：2019-10-09
申请人： Ritchied Ding , Rocky Qu , Robert Yang
发明人： Ritchied Ding , Rocky Qu , Robert Yang
IPC分类号： G06F15/16 , H04L12/58 , G06Q10/10 , H04L29/06 , G06F40/30
摘要： An e-mail message is sent from a public e-mail address via the e-mail account of a user and delivered to an e-mail gateway. The message is destined for the e-mail account of a recipient. The gateway determines that the public e-mail address is on a list of users desiring two-factor authentication. The gateway determines that the message contains an anomaly indicating fraud or possible forgery. The gateway sends a two-factor authentication message to a hidden e-mail account of the user. The user reviews the message and responds with a confirmation message either confirming that the message is legitimate or indicating that it is a forgery. If the message is legitimate the gateway allows the message to be delivered to the recipient; if not, the message remains in quarantine and is not delivered. The gateway exists at the user's corporation, the recipient's corporation or is hosted at a third-party cloud service.

2. 发明授权

US08404838B2 Inhibitors of tyrosine kinase receptor dimerization 有权
公开(公告)号：US08404838B2
公开(公告)日：2013-03-26
申请号：US13157472
申请日：2011-06-10
申请人： Garland R. Marshall , Linda J. Pike , Robert Yang
发明人： Garland R. Marshall , Linda J. Pike , Robert Yang
IPC分类号： C07D473/00
CPC分类号： C07D241/38 , C07D241/46 , C07D401/06 , C07D409/06 , C07D473/24 , C07D487/04 , C40B30/02 , G06F19/16 , G06F19/706
摘要： The teachings relate to methods of identifying inhibitors of dimerization of tyrosine receptor kinases such as EGFR. The methods comprise providing, on a digital computer, a molecular model comprising a complex of extracellular dimerization domains of an RTK, docking a chemical databases to the molecular model, scoring the compounds comprised by the database, and identifying one or more high-scoring compounds. The methods further comprise testing a compound for RTK inhibitory activity in vitro, and testing a compound for specificity as an RTK inhibitor. Also disclosed are compounds selected by the described methods, and methods of treatment using the compounds. Two compounds (NSC11241 and NSC56452) are disclosed that inhibit EGF receptor kinase activation in a dose-dependent manner.

3. 发明申请

US20110312919A1 INHIBITORS OF TYROSINE KINASE RECEPTOR DIMERIZATION 有权
标题翻译：酪氨酸激酶受体二聚体的抑制剂
公开(公告)号：US20110312919A1
公开(公告)日：2011-12-22
申请号：US13157472
申请日：2011-06-10
申请人： Garland R. Marshall , Linda J. Pike , Robert Yang
发明人： Garland R. Marshall , Linda J. Pike , Robert Yang
IPC分类号： A61K31/498 , A61K31/655 , C12N5/09 , A61P35/00 , A61K31/517 , C12N9/99 , A61K31/381 , A61K31/52
CPC分类号： C07D241/38 , C07D241/46 , C07D401/06 , C07D409/06 , C07D473/24 , C07D487/04 , C40B30/02 , G06F19/16 , G06F19/706
摘要： The teachings relate to methods of identifying inhibitors of dimerization of tyrosine receptor kinases such as EGFR. The methods comprise providing, on a digital computer, a molecular model comprising a complex of extracellular dimerization domains of an RTK, docking a chemical databases to the molecular model, scoring the compounds comprised by the database, and identifying one or more high-scoring compounds. The methods further comprise testing a compound for RTK inhibitory activity in vitro, and testing a compound for specificity as an RTK inhibitor. Also disclosed are compounds selected by the described methods, and methods of treatment using the compounds. Two compounds (NSC11241 and NSC56452) are disclosed that inhibit EGF receptor kinase activation in a dose-dependent manner.
摘要翻译：该教导涉及鉴定酪氨酸受体激酶如EGFR的二聚化抑制剂的方法。所述方法包括在数字计算机上提供包含RTK的细胞外二聚化结构域的复合物的分子模型，将化学数据库与分子模型对接，评估由数据库包含的化合物，以及鉴定一种或多种高得分化合物。所述方法还包括在体外测试化合物的RTK抑制活性，并测试化合物作为RTK抑制剂的特异性。还公开了通过所述方法选择的化合物和使用该化合物的治疗方法。公开了以剂量依赖性方式抑制EGF受体激酶活化的两种化合物（NSC11241和NSC56452）。

4. 发明申请

US20050136414A1 Methods and compositions for making locus-specific arrays 审中-公开
标题翻译：用于制作位点特异性阵列的方法和组合物
公开(公告)号：US20050136414A1
公开(公告)日：2005-06-23
申请号：US10746249
申请日：2003-12-23
申请人： Kevin Gunderson , David Barker , Mark Chee , Tim McDaniel , Robert Yang
发明人： Kevin Gunderson , David Barker , Mark Chee , Tim McDaniel , Robert Yang
IPC分类号： C12Q1/68 , C12M1/34 , C12P19/34
CPC分类号： C12Q1/6837 , C12Q2525/161
摘要： The present invention includes methods and compositions relating to locus-specific arrays. More specifically, this invention includes methods for making locus-specific arrays from universal arrays in situ, the custom arrays made using those methods, and methods of using the custom arrays to detect target nucleotides.
摘要翻译：本发明包括与轨迹特异性阵列相关的方法和组合物。更具体地，本发明包括用于从现场通用阵列制备位点特异性阵列的方法，使用这些方法制备的定制阵列，以及使用定制阵列检测靶核苷酸的方法。

5. 发明授权

US4514422A Non-staling gum composition and method of preparation 失效
标题翻译：不稳定的口香糖组合物及其制备方法
公开(公告)号：US4514422A
公开(公告)日：1985-04-30
申请号：US333523
申请日：1981-12-22
申请人： Robert Yang , Martin M. Rieger
发明人： Robert Yang , Martin M. Rieger
IPC分类号： A23G4/00 , A23G4/06 , A23G4/08 , A23G4/10 , G11B5/716 , A23G3/30
CPC分类号： A23G4/06 , A23G4/00 , A23G4/08 , A23G4/10 , G11B5/716
摘要： The present invention relates to a gum composition exhibiting improved shelf life and resistance to staling, that comprises a substantially anhydrous mixture of a gum base, at least one sugar alcohol, and glycerin, the glycerin present in an amount ranging from greater than 10% to about 18% by weight of the composition. The gum composition preferably contains no more than 2% by weight of water. The invention includes a method for preparing the gum composition, comprising treating the ingredients thereof, including the glycerin, to remove substantially all water therefrom, thereafter combining the sugar alcohol with the glycerin under agitation and at about 50.degree. C., and adding subsequently thereto the gum base, after which certain additive materials, such as flavorings, and the like may be added with mixing.
摘要翻译：本发明涉及一种口香糖组合物，其具有改善的保存期限和抗老化性能，其包括胶基，至少一种糖醇和甘油的基本上无水的混合物，所述甘油的存在量为大于10％至约18重量％的组合物。口香糖组合物优选含有不超过2重量％的水。本发明包括一种制备口香糖组合物的方法，包括处理其成分，包括甘油，以从其中除去基本上所有的水，然后在搅拌和约50℃下将糖醇与甘油混合，随后加入胶基，然后混合加入某些添加剂如调味剂等。

6. 发明申请

US20090269846A1 Inhibitors of tyrosine kinase receptor dimerization 审中-公开
标题翻译：抑制酪氨酸激酶受体二聚化
公开(公告)号：US20090269846A1
公开(公告)日：2009-10-29
申请号：US12384511
申请日：2009-04-06
申请人： Garland R. Marshall , Linda J. Pike , Robert Yang
发明人： Garland R. Marshall , Linda J. Pike , Robert Yang
IPC分类号： C12N5/06 , G06G7/58 , C07D241/02 , C07D473/02
CPC分类号： C07D241/38 , C07D241/46 , C07D401/06 , C07D409/06 , C07D473/24 , C07D487/04 , G16B15/00 , G16B35/00 , G16C20/50 , G16C20/60
摘要： The teachings relate to methods of identifying inhibitors of dimerization of tyrosine receptor kinases such as EGFR. The methods comprise providing, on a digital computer, a molecular model comprising a complex of extracellular dimerization domains of an RTK, docking a chemical databases to the molecular model, scoring the compounds comprised by the database, and identifying one or more high-scoring compounds. The methods further comprise testing a compound for RTK inhibitory activity in vitro, and testing a compound for specificity as an RTK inhibitor. Also disclosed are compounds selected by the described methods, and methods of treatment using the compounds. Two compounds (NSC11241 and NSC56452) are disclosed that inhibit EGF receptor kinase activation in a dose-dependent manner.
摘要翻译：该教导涉及鉴定酪氨酸受体激酶如EGFR的二聚化抑制剂的方法。所述方法包括在数字计算机上提供包含RTK的细胞外二聚化结构域的复合物的分子模型，将化学数据库对接到分子模型，评估由数据库包含的化合物，以及鉴定一个或多个高得分化合物。所述方法还包括在体外测试化合物的RTK抑制活性，并测试化合物作为RTK抑制剂的特异性。还公开了通过所述方法选择的化合物和使用该化合物的治疗方法。公开了以剂量依赖性方式抑制EGF受体激酶活化的两种化合物（NSC11241和NSC56452）。

7. 发明申请

US20070281003A1 Polymer-Based Films and Drug Delivery Systems Made Therefrom 审中-公开
标题翻译：基于聚合物的薄膜和药物输送系统
公开(公告)号：US20070281003A1
公开(公告)日：2007-12-06
申请号：US11674223
申请日：2007-02-13
申请人： Richard Fuisz , Joseph Fuisz , Garry Myers , Robert Yang , Pradeep Sanghvi
发明人： Richard Fuisz , Joseph Fuisz , Garry Myers , Robert Yang , Pradeep Sanghvi
IPC分类号： A61K9/70
CPC分类号： B29C39/003 , A61J3/00 , A61J2200/20 , A61K9/006 , A61K9/7007 , B29C39/14 , B29C71/02 , F26B13/104
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film. The films contain a polymer component which includes polyethylene oxide, optionally blended with at least one additional polymer. The films may alternatively contain a polymer component which includes polyvinyl alcohol, optionally blended with at least one additional polymer. The films also may contain a pharmaceutical and/or cosmetic active agent.
摘要翻译：本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。期望地，膜在水中分解并且可以通过受控的干燥过程或保持膜所需的均匀性的其它方法形成。膜包含聚合物组分，其包括聚环氧乙烷，任选地与至少一种另外的聚合物共混。膜可以备选地包含聚合物组分，其包括聚乙烯醇，任选地与至少一种另外的聚合物共混。膜也可以含有药物和/或美容活性剂。

8. 发明申请

US20070069416A1 Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom 审中-公开
标题翻译：具有非自聚集均匀异质性的薄膜和由其制成的药物递送系统
公开(公告)号：US20070069416A1
公开(公告)日：2007-03-29
申请号：US11473356
申请日：2006-06-22
申请人： Robert Yang , Richard Fuisz , Gary Myers , Joseph Fuisz
发明人： Robert Yang , Richard Fuisz , Gary Myers , Joseph Fuisz
IPC分类号： B29C37/00 , B29D7/00
CPC分类号： A61K9/7007 , A61K9/0056 , A61K9/006 , A61K9/1635 , A61K9/1652 , A61K9/7015 , A61K31/192 , A61K31/422 , A61K31/435 , A61K31/4525 , A61K31/4545 , A61K31/80 , A61K47/02 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/38 , A61K47/44 , A61K47/46 , C08J5/18
摘要： The invention relates to the film products and methods of their preparation that demonstrate a non-self-aggregating uniform heterogeneity. Desirably the films disintegrate in water and may be formed by a controlled drying process, or other process that maintains the required uniformity of the film.
摘要翻译：本发明涉及其制备的薄膜产品及其制备方法，其表现出非自聚集均匀的异质性。理想地，膜在水中分解，并且可以通过受控的干燥过程或保持膜所需均匀性的其它方法形成。

9. 发明授权

US07339049B1 Polymorphisms in human mitochondrial DNA 失效
标题翻译：人类线粒体DNA多态性
公开(公告)号：US07339049B1
公开(公告)日：2008-03-04
申请号：US08856376
申请日：1997-05-14
申请人： Mark Chee , Anthony Berno , Robert Yang
发明人： Mark Chee , Anthony Berno , Robert Yang
IPC分类号： C07H21/04 , C07H21/02 , C12Q1/68 , C12N1/20 , C12N15/00 , C12N5/02
CPC分类号： C12Q1/6827 , C12Q2565/501 , C12Q2535/131
摘要： The invention provides novel human mitochondrial polymorphisms, and probes and primers for detecting the same. Detection of such polymorphisms is useful in a variety of fields such as forensic analysis, epidemiology and preventive medicine.
摘要翻译：本发明提供新的人线粒体多态性，探针和引物用于检测它们。这种多态性的检测在法医分析，流行病学和预防医学等多个领域都是有用的。

10. 发明申请

US20060160181A1 Fibroblast Growth Factor-23 molecules and uses thereof 审中-公开
标题翻译：成纤维细胞生长因子-23分子及其用途
公开(公告)号：US20060160181A1
公开(公告)日：2006-07-20
申请号：US11238035
申请日：2005-09-28
申请人： Roland Luethy , Robert Yang , Sidney Suggs , Iidiko Sarosi
发明人： Roland Luethy , Robert Yang , Sidney Suggs , Iidiko Sarosi
IPC分类号： C12P21/06 , C07H21/04 , C07K14/50
CPC分类号： C07K14/50
摘要： The present invention provides Fibroblast Growth Factor-23 (FGF-23) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing FGF-23 polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with FGF-23 polypeptides.
摘要翻译：本发明提供成纤维细胞生长因子-23（FGF-23）多肽和编码该多肽的核酸分子。本发明还提供选择性结合剂，载体，宿主细胞和用于产生FGF-23多肽的方法。本发明还提供用于诊断，治疗，改善和/或预防与FGF-23多肽相关的疾病，病症和病症的药物组合物和方法。

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