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1. 发明授权

US08452369B2 CMOS compatible microneedle structures 有权
标题翻译： CMOS兼容微针结构
公开(公告)号：US08452369B2
公开(公告)日：2013-05-28
申请号：US12043285
申请日：2008-03-06
申请人： Roeland Huys , Carmen Bartic , Josine Loo
发明人： Roeland Huys , Carmen Bartic , Josine Loo
IPC分类号： A61B5/04
CPC分类号： G06N3/061 , G01N33/48728
摘要： The present invention provides an electronic device for sensing and/or actuating, the electronic device comprising at least one microneedle (10) on a substrate (1), each of the microneedles (10) comprising at least one channel (7, 8) surrounded by an insulating layer (6). The present invention also provides a method for making such an electronic device for sensing and/or actuating.
摘要翻译：本发明提供了一种用于感测和/或致动电子设备的电子设备，该电子设备包括在基底（1）上的至少一个微针（10），每个微针（10）包括至少一个通道（7,8）通过绝缘层（6）。本发明还提供了一种用于制造这种用于感测和/或致动的电子设备的方法。

2. 发明申请

US20080319298A1 CMOS Compatible Microneedle Structures 有权
标题翻译： CMOS兼容微针结构
公开(公告)号：US20080319298A1
公开(公告)日：2008-12-25
申请号：US12043285
申请日：2008-03-06
申请人： Roeland Huys , Carmen Bartic , Josine Loo
发明人： Roeland Huys , Carmen Bartic , Josine Loo
IPC分类号： A61B5/055 , H01L21/283
CPC分类号： G06N3/061 , G01N33/48728
摘要： The present invention provides an electronic device for sensing and/or actuating, the electronic device comprising at least one microneedle (10) on a substrate (1), each of the microneedles (10) comprising at least one channel (7, 8) surrounded by an insulating layer (6). The present invention also provides a method for making such an electronic device for sensing and/or actuating.
摘要翻译：本发明提供了一种用于感测和/或致动电子设备的电子设备，该电子设备包括在基底（1）上的至少一个微针（10），每个微针（10）包括至少一个通道（7,8）通过绝缘层（6）。本发明还提供了一种用于制造这种用于感测和/或致动的电子设备的方法。

3. 发明授权

US08962304B2 Interface device and method for using the same 有权
标题翻译：接口设备及其使用方法
公开(公告)号：US08962304B2
公开(公告)日：2015-02-24
申请号：US12039593
申请日：2008-02-28
申请人： Roeland Huys , Wolfgang Eberle , Carmen Bartic
发明人： Roeland Huys , Wolfgang Eberle , Carmen Bartic
IPC分类号： C12M1/34 , C12M3/00 , G01N33/483 , G01N33/543 , G01N33/50
CPC分类号： G01N33/4836 , G01N33/5008 , G01N33/5436
摘要： The present disclosure is related to an interface device for providing access to a network to be monitored. The interface device includes a plurality of elements, the elements being sensors and/or actuators. A selection circuit is provided for selecting a subset of elements among the plurality of elements, each element of the subset being arranged for outputting and/or receiving a signal. A local memory is provided for storing the subset.
摘要翻译：本公开涉及一种用于提供对要监视的网络的访问的接口设备。接口装置包括多个元件，元件是传感器和/或致动器。提供选择电路用于选择多个元素中的元素的子集，子集的每个元素被布置用于输出和/或接收信号。提供本地存储器用于存储该子集。

4. 发明申请

US20090004685A1 Interface Device and Method for Using the Same 有权
标题翻译：接口设备及其使用方法
公开(公告)号：US20090004685A1
公开(公告)日：2009-01-01
申请号：US12039593
申请日：2008-02-28
申请人： Roeland Huys , Wolfgang Eberle , Carmen Bartic
发明人： Roeland Huys , Wolfgang Eberle , Carmen Bartic
IPC分类号： C12Q1/02 , C12M1/00
CPC分类号： G01N33/4836 , G01N33/5008 , G01N33/5436
摘要： The present disclosure is related to an interface device for providing access to a network to be monitored. The interface device includes a plurality of elements, the elements being sensors and/or actuators. A selection means is provided for selecting a subset of elements among the plurality of elements, each element of the subset being arranged for outputting and/or receiving a signal. A local memory is provided for storing the subset.
摘要翻译：本公开涉及一种用于提供对要监视的网络的访问的接口设备。接口装置包括多个元件，元件是传感器和/或致动器。提供选择装置用于选择多个元素中的元素的子集，子集的每个元素被布置用于输出和/或接收信号。提供本地存储器用于存储该子集。

5. 发明授权

US09551698B2 Microneedle 有权
标题翻译：微针
公开(公告)号：US09551698B2
公开(公告)日：2017-01-24
申请号：US13519894
申请日：2010-12-30
申请人： Roeland Huys , Wolfgang Eberle , Dries Braeken , Liesbeth Micholt
发明人： Roeland Huys , Wolfgang Eberle , Dries Braeken , Liesbeth Micholt
IPC分类号： C12M1/42 , G01N33/487
CPC分类号： G01N33/48728 , C12M35/02
摘要： The electronic device for sensing and/or actuating comprises a device surface to which an biological cell (40) is applied, further comprising a sensor and/or an actuator (25), and an access channel (20) with a channel port (21), said channel port being located in said surface. The access channel (20) is designed such that the biological cell (40) can enter the access channel (20) to thereby provide access to the sensor (25). Particularly the cell (40) forms a protruding portion (41) by entering the access channel (20), which portion is sensed. The access channel (20) may be provided with a specific sensor port at which the sensor (25) is present. The device may be used for sensing or actuating biological cells, such as neurons, for instance in electroporation treatments.
摘要翻译：用于感测和/或致动的电子设备包括施加生物电池（40）的器件表面，还包括传感器和/或致动器（25），以及具有通道端口（21）的接入通道（20）），所述通道端口位于所述表面中。进入通道（20）被设计成使得生物细胞（40）可以进入进入通道（20），从而提供对传感器（25）的通路。特别地，电池（40）通过进入存取通道（20）形成突出部分（41），该部分被感测。进入通道（20）可以设置有传感器（25）所在的特定传感器端口。该装置可用于感测或致动生物细胞，例如神经元，例如在电穿孔治疗中。

6. 发明申请

US20110269172A1 Micro-Electrode Grid Array for Top and Bottom Recording from Samples 审中-公开
标题翻译：用于样品顶部和底部记录的微电极网格阵列
公开(公告)号：US20110269172A1
公开(公告)日：2011-11-03
申请号：US13095293
申请日：2011-04-27
申请人： Wolfgang Eberle , Dries Braeken , Roeland Huys , Dimiter Prodanov
发明人： Wolfgang Eberle , Dries Braeken , Roeland Huys , Dimiter Prodanov
IPC分类号： C12Q1/02 , C12M1/42 , C12N13/00 , H05K3/00
CPC分类号： G01N33/5438 , B01L3/508 , B01L2300/0645 , B01L2300/0816 , Y10T29/49124
摘要： A mixed micro-fluidic multi-electrode grid array (MEGA) device (10) suitable for holding a tissue slice (6) and for recording and/or stimulating neuron cells from said tissue slice (6), the MEGA device (10) comprising at least a top substrate in the form of a grid (4) comprising at least an electrical and/or optical multi-electrode array and a bottom substrate in the form of a stack made of a grid (1) comprising an electrical and/or optical multi-electrode array and a backbone (2) underneath said grid (1) comprising a micro-fluidic perfusion system.Furthermore said MEGA device (10) comprises means (5) for pressing and positioning said first and second substrate together and adhering a tissue slice in between said two substrates.
摘要翻译：一种适用于保持组织切片（6）并用于从所述组织切片（6）记录和/或刺激神经元细胞的混合微流体多电极网格阵列（MEGA）装置（10），所述MEGA装置（10）包括至少包括栅格形式的顶部衬底（4），其至少包括电和/或光学多电极阵列和由栅格（1）制成的堆叠形式的底部衬底，所述栅格包括电和/或光学多电极阵列和包括微流体灌注系统的所述网格（1）下方的骨架（2）。此外，所述MEGA装置（10）包括用于将所述第一和第二基板压入并定位在一起并将组织切片粘附在所述两个基板之间的装置（5）。

7. 发明申请

US20130045528A1 Microneedle 有权
标题翻译：微针
公开(公告)号：US20130045528A1
公开(公告)日：2013-02-21
申请号：US13519894
申请日：2010-12-30
申请人： Roeland Huys , Wolfgang Eberle , Dries Braeken , Liesbeth Micholt
发明人： Roeland Huys , Wolfgang Eberle , Dries Braeken , Liesbeth Micholt
IPC分类号： C12M1/42
CPC分类号： G01N33/48728 , C12M35/02
摘要： The electronic device for sensing and/or actuating comprises a device surface to which an biological cell (40) is applied, further comprising a sensor and/or an actuator (25), and an access channel (20) with a channel port (21), said channel port being located in said surface. The access channel (20) is designed such that the biological cell (40) can enter the access channel (20) to thereby provide access to the sensor (25). Particularly the cell (40) forms a protruding portion (41) by entering the access channel (20), which portion is sensed. The access channel (20) may be provided with a specific sensor port at which the sensor (25) is present. The device may be used for sensing or actuating biological cells, such as neurons, for instance in electroporation treatments.
摘要翻译：用于感测和/或致动的电子设备包括施加生物电池（40）的器件表面，还包括传感器和/或致动器（25），以及具有通道端口（21）的接入通道（20）），所述通道端口位于所述表面中。进入通道（20）被设计成使得生物细胞（40）可以进入进入通道（20），从而提供对传感器（25）的通路。特别地，电池（40）通过进入存取通道（20）形成突出部分（41），该部分被感测。进入通道（20）可以设置有传感器（25）存在的特定传感器端口。该装置可用于感测或致动生物细胞，例如神经元，例如在电穿孔治疗中。

8. 发明申请

US20110257501A1 Bio-Hybrid Implant for Connecting a Neural Interface With a Host Nervous System 审中-公开
标题翻译：生物混合植入物用于连接神经接口与宿主神经系统
公开(公告)号：US20110257501A1
公开(公告)日：2011-10-20
申请号：US13089121
申请日：2011-04-18
申请人： Roeland Huys , Dries Braeken , Dimiter Prodanov , Wolfgang Eberle , Kris Verstreken
发明人： Roeland Huys , Dries Braeken , Dimiter Prodanov , Wolfgang Eberle , Kris Verstreken
IPC分类号： A61N1/05 , A61B5/04 , A61N1/36 , A61N5/06
CPC分类号： A61N1/0551 , A61B5/04001 , A61B5/4041 , A61B2562/125 , A61N1/00 , A61N1/372
摘要： A bio-hybrid implant suitable for recording and/or stimulating cells, the implant comprising (a) at least one closed insulated chamber (1) containing a substrate (502) with a neural interface (13) for connecting neurons to an electronic circuit, (b) at least one flexible guiding channel (10) having a first interface (11) to connect to at least one of the closed insulated chambers (1) and a second interface (9) to connect to a hosts' nerve system (7) or to another insulated chamber.
摘要翻译：一种适用于记录和/或刺激细胞的生物混合植入物，所述植入物包括（a）至少一个封闭的绝缘室（1），其包含用于将神经元连接到电子电路的神经界面（13）的衬底（502）（b）至少一个柔性引导通道（10），其具有连接到至少一个闭合绝缘室（1）的第一界面（11）和与主体神经系统（7）连接的第二界面）或另一个绝缘室。

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