专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11609537B2 Cell analysis method and cell analysis system using a holographic microscope 有权
公开(公告)号：US11609537B2
公开(公告)日：2023-03-21
申请号：US16490123
申请日：2017-03-02
申请人： SHIMADZU CORPORATION , iPS PORTAL, Inc.
发明人： Yasushi Kondo , Shuhei Yamamoto , Mika Okada , Minoru Okada
IPC分类号： G03H1/04 , C12M1/34 , G02B21/36 , G03H1/08 , G01N15/02 , G02B21/00 , G03H1/00 , G01N15/00
摘要： A cell area extraction unit (241) extracts a cell area in a phase image that is created based on a hologram obtained by in-line holographic microscope (IHM). A background value acquisition unit (242) obtains a background value from phase values at a plurality of positions outside the cell area. An intracellular phase value acquisition unit (243) averages a plurality of phase values on a sampling line set at a position close to the periphery of a cell, while avoiding a central portion in which the phase value may be lowered in the cell area, to obtain an intracellular phase value. A phase change amount calculation unit (244) obtains the difference between the intracellular phase value and the background value. A phase change amount determination unit (245) compares the value of the difference with thresholds in two levels to determine whether the cell is in an undifferentiated state or an undifferentiation deviant state. It is thereby possible to automatically make a correct determination while removing the influence of a theoretical measurement error by IHM.

2. 发明公开

US20240120033A1 Estimation Device, Learning Device, Optimization Device, Estimation Method, Learning Method, and Optimization Method 审中-公开
公开(公告)号：US20240120033A1
公开(公告)日：2024-04-11
申请号：US18275969
申请日：2022-01-31
申请人： SHIMADZU CORPORATION
发明人： Takashi Suzuki , Shuhei Yamamoto , Kenichi Toyoda , Hirotaka Kuroda
IPC分类号： G16C20/30 , G01N33/50 , G16C20/70 , G16C20/80
CPC分类号： G16C20/30 , G01N33/5008 , G16C20/70 , G16C20/80
摘要： An estimation device (200) generates quality prediction data (540) indicating a quality of a drug substance of a biopharmaceutical manufactured by culturing cells, by inputting, into a prediction model (420), measurement data (510) including a measurement result obtained by measuring a substance in a culturing vessel at least one timing after a predetermined time period has passed since the cells have been seeded in a medium. The prediction model (420) is generated by executing a learning process using training data (530) that includes measurement data including a measurement result obtained by measuring a substance in a culturing vessel at a plurality of timings after seeding of the cells in the medium, and quality data obtained by analyzing a drug substance of the biopharmaceutical manufactured from the cells.

3. 发明授权

US12067224B2 Data processing system 有权
公开(公告)号：US12067224B2
公开(公告)日：2024-08-20
申请号：US18028950
申请日：2021-04-27
申请人： SHIMADZU CORPORATION
发明人： Ryuji Sawada , Shuhei Yamamoto , Takeshi Ono
IPC分类号： G06F17/00 , G06F3/04845 , G06F3/04847 , G06T3/40
CPC分类号： G06F3/04845 , G06F3/04847 , G06T3/40 , G06T2200/24
摘要： A data processing system includes an information processing device (2) and an information display device (4). The information processing device (2) includes a registration data holder (10) that holds image data registered in the data processing system (1), a field display part (12) configured to display, on the information display device, a display field including a plurality of image display areas, having the same size with each other, for displaying the image data, and an image display part (14) configured to display, in the image display area of the display field, a plurality of pieces of image data optionally selected from the image data held in the registration data holder (10), and the image display part (14) is configured to change an enlargement or reduction ratio of a plurality of pieces of the image data displayed in the image display area of the display field in conjunction with each other based on operation by the user.

4. 外观设计

USD978167S1 Display screen or portion thereof with graphical user interface of a cell image analyzer 有权
公开(公告)号：USD978167S1
公开(公告)日：2023-02-14
申请号：US29776139
申请日：2021-03-29
申请人： SHIMADZU CORPORATION
设计人： Shuhei Yamamoto , Ryuji Sawada , Takeshi Ono

5. 发明授权

US11106178B2 Cell observation device 有权
公开(公告)号：US11106178B2
公开(公告)日：2021-08-31
申请号：US16490131
申请日：2017-03-03
申请人： SHIMADZU CORPORATION
发明人： Momoyo Yamakawa , Shuhei Yamamoto
IPC分类号： G03H1/00 , G01N21/45 , G03H1/04 , G03H1/22
摘要： In a microscopic observation unit (10), hologram data is acquired at each measurement position on a cell culture plate (13) while a light-source section (11) and other related sections are gradually moved by a moving section (15). Every time a set of data for one measurement position is acquired, a measurement monitoring image creator (24) creates a thumbnail image by reducing the size of a hologram image which is based on original data (two-dimensional distribution of light intensity). A display processor (25) pastes the create thumbnail image to progressively complete the hologram image of the entire plate to be displayed on a display unit (27). A measurement operator watches the hologram image during the execution of the measurement. When it has been concluded that the ongoing measurement is inappropriate, the operator presses a measurement stop button to immediately discontinue the measurement. Thus, When there is a problem with the measurement, such as a foreign object mixed in the sample, the measurement can be discontinued before a phase image or intensity image based on the hologram data is reconstructed on the server after the completion of the entire measurement, so as to avoid wasting time for the useless measurement.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式