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1. 发明授权

US10717079B2 Microfluidic package and method of making the same 有权
公开(公告)号：US10717079B2
公开(公告)日：2020-07-21
申请号：US15415675
申请日：2017-01-25
申请人： Sandia Corporation
发明人： Darren W. Branch , Philip R. Miller , Thayne L. Edwards , David R. Wheeler
IPC分类号： B01L3/00
摘要： The present invention relates to encapsulated microfluidic packages and methods thereof. In particular embodiments, the package includes a device, a cradle configured to support the device, and a lid having a bonding surface configured to provide a fluidic seal between itself and the device and/or cradle. Other package configurations, as well as methods for making such fluidic seals, are described herein.

2. 发明申请

US20170216840A1 MICROFLUIDIC PACKAGE AND METHOD OF MAKING THE SAME 审中-公开
公开(公告)号：US20170216840A1
公开(公告)日：2017-08-03
申请号：US15415675
申请日：2017-01-25
申请人： Sandia Corporation
发明人： Darren W. Branch , Philip R. Miller , Thayne L. Edwards , David R. Wheeler
IPC分类号： B01L3/00
摘要： The present invention relates to encapsulated microfluidic packages and methods thereof. In particular embodiments, the package includes a device, a cradle configured to support the device, and a lid having a bonding surface configured to provide a fluidic seal between itself and the device and/or cradle. Other package configurations, as well as methods for making such fluidic seals, are described herein.

3. 发明申请

US20150024377A1 APPARATUS COMPRISING MAGNETICALLY ACTUATED VALVES AND USES THEREOF 有权
标题翻译：包括磁力驱动阀的装置及其用途
公开(公告)号：US20150024377A1
公开(公告)日：2015-01-22
申请号：US14157335
申请日：2014-01-16
申请人： Sandia Corporation
发明人： Thayne L. Edwards , Jason C. Harper
IPC分类号： F16K31/08 , C12Q1/04
CPC分类号： G01N33/56911 , B01L3/502738 , B01L2300/0663 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0633 , F16K31/086 , F16K99/003 , F16K99/0046 , F16K2099/0084 , Y10T137/87917
摘要： The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. In some examples, the valve is opened by bringing a magnet in proximity to the valve element to provide a magnetic force that delaminates the valve element from the adhesive coating. In particular, the apparatus can be useful for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.
摘要翻译：本发明部分地涉及一种具有一次使用的常闭型流体阀的装置，其通过结合到粘合剂涂层的阀元件最初保持在关闭位置。阀门使用磁力打开。阀元件包括磁性材料或金属。在一些示例中，通过使磁体靠近阀元件来打开阀，以提供使阀元件从粘合剂涂层分层的磁力。特别地，该装置可用于片上放大和/或检测各种靶标，包括生物靶标和任何可扩增靶标。这样的设备和方法对于现场或实时检测目标是有用的，特别是在有限的资源设置中。

4. 发明申请

US20180338713A1 INTEGRATED FLUIDIC CHIP FOR TRANSDERMAL SENSING OF PHYSIOLOGICAL MARKERS 审中-公开
公开(公告)号：US20180338713A1
公开(公告)日：2018-11-29
申请号：US14538096
申请日：2014-11-11
申请人： Sandia Corporation
发明人： Ronen Polsky , Philip Rocco Miller , Matthew W. Moorman , Susan M. Brozik , Ronald P. Manginell , David R. Wheeler , Thayne L. Edwards
IPC分类号： A61B5/1473 , A61B5/1459 , A61B5/00 , A61B5/145 , A61B5/157 , A61B5/155 , A61B5/15 , A61B10/00
摘要： The present invention is directed to devices and methods for detecting one or more markers in a sample. In particular, such devices integrate a plurality of hollow needles configured to extract or obtain a fluid sample from a subject, as well as transducers to detect a marker of interest (e.g., an electrolyte). In some embodiments, the needles are provided as a disposable cartridge.

5. 发明授权

US09743870B2 Microneedle arrays for biosensing and drug delivery 有权
公开(公告)号：US09743870B2
公开(公告)日：2017-08-29
申请号：US14965755
申请日：2015-12-10
申请人： The Regents of the University of California , North Carolina State University , Sandia Corporation
发明人： Joseph Wang , Joshua Ray Windmiller , Roger Narayan , Philip Miller , Ronen Polsky , Thayne L. Edwards
IPC分类号： A61B5/1473 , A61M5/158 , A61B5/00 , A61B5/145 , G01N33/487 , A61B5/1486 , A61B5/15 , A61B5/157 , A61B10/00 , A61M5/172 , A61M37/00
CPC分类号： A61B5/1473 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/150984 , A61B5/157 , A61B5/4845 , A61B5/6833 , A61B5/685 , A61B5/7282 , A61B10/0045 , A61B2010/008 , A61B2562/028 , A61B2562/046 , A61M5/158 , A61M5/1723 , A61M2005/1726 , A61M2037/0023 , A61M2037/003 , G01N33/48785
摘要： Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

6. 发明授权

US09389231B2 Apparatus comprising magnetically actuated valves and uses thereof 有权
标题翻译：装置包括磁力驱动阀及其用途
公开(公告)号：US09389231B2
公开(公告)日：2016-07-12
申请号：US14157335
申请日：2014-01-16
申请人： Sandia Corporation
发明人： Thayne L. Edwards , Jason C. Harper
IPC分类号： F16K31/06 , G01N33/569 , F16K31/08 , B01L3/00 , F16K99/00
CPC分类号： G01N33/56911 , B01L3/502738 , B01L2300/0663 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0633 , F16K31/086 , F16K99/003 , F16K99/0046 , F16K2099/0084 , Y10T137/87917
摘要： The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. In some examples, the valve is opened by bringing a magnet in proximity to the valve element to provide a magnetic force that delaminates the valve element from the adhesive coating. In particular, the apparatus can be useful for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.
摘要翻译：本发明部分地涉及一种具有一次使用的常闭型流体阀的装置，其通过结合到粘合剂涂层的阀元件最初保持在关闭位置。阀门使用磁力打开。阀元件包括磁性材料或金属。在一些示例中，通过使磁体靠近阀元件来打开阀，以提供使阀元件从粘合剂涂层分层的磁力。特别地，该装置可用于片上放大和/或检测各种靶标，包括生物靶标和任何可扩增靶标。这样的设备和方法对于现场或实时检测目标是有用的，特别是在有限的资源设置中。

7. 发明申请

US20190242888A1 DETECTION OF BIOAGENTS USING A SHEAR HORIZONTAL SURFACE ACOUSTIC WAVE BIOSENSOR 审中-公开
公开(公告)号：US20190242888A1
公开(公告)日：2019-08-08
申请号：US16277618
申请日：2019-02-15
申请人： STC.UNM , SANDIA CORPORATION
发明人： Richard S. Larson , Brian Hjelle , Pam R. Hall , David C. Brown , Marco Bisoffi , Susan M. Brozik , Darren W. Branch , Thayne L. Edwards , David Wheeler
IPC分类号： G01N33/543 , G01N33/553 , C12Q1/6825 , G01N29/032
CPC分类号： G01N33/54373 , C12Q1/6825 , G01N29/032 , G01N33/553 , G01N2291/0422
摘要： Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50×104-fold more sensitive for the detection of SNV. For both pathogens, the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1. The biosensor was able to detect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS). Further, in a proof-of-principle real world application, the SAW biosensor was capable of selectively detecting SNV agents in complex solutions, such as naturally occurring bodies of water (river, sewage effluent) without analyte pre-processing.

8. 发明申请

US20170184581A1 DETECTION OF BIOAGENTS USING A SHEAR HORIZONTAL SURFACE ACOUSTIC WAVE BIOSENSOR 审中-公开
公开(公告)号：US20170184581A1
公开(公告)日：2017-06-29
申请号：US15411576
申请日：2017-01-20
申请人： STC.UNM , SANDIA CORPORATION
发明人： Richard S. Larson , Brian Hjelle , Pam R. Hall , David C. Brown , Marco Bisoffi , Susan M. Brozik , Darren W. Branch , Thayne L. Edwards , David Wheeler
IPC分类号： G01N33/543 , G01N33/553 , G01N29/032 , C12Q1/68
CPC分类号： G01N33/54373 , C12Q1/6825 , G01N29/032 , G01N33/553 , G01N2291/0422
摘要： Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50×104-fold more sensitive for the detection of SNV. For both pathogens, the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1. The biosensor was able to detect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS). Further, in a proof-of-principle real world application, the SAW biosensor was capable of selectively detecting SNV agents in complex solutions, such as naturally occurring bodies of water (river, sewage effluent) without analyte pre-processing.

9. 发明申请

US20170052174A1 SHEAR HORIZONTAL SURFACE ACOUSTIC WAVE (SH-SAW) RESONATORS AND ARRAYS THEREOF 审中-公开
标题翻译：剪切水平表面声波（SH-SAW）谐振器及其阵列
公开(公告)号：US20170052174A1
公开(公告)日：2017-02-23
申请号：US15238361
申请日：2016-08-16
申请人： Sandia Corporation
发明人： Darren W. Branch , Thayne L. Edwards
IPC分类号： G01N33/543 , B01L3/00 , H03H9/13 , G01N29/02 , H03H9/205 , H03H9/02
CPC分类号： G01N33/5438 , B01L3/502715 , B01L2300/0645 , B01L2300/168 , B01L2400/0436 , G01N29/022 , G01N29/036 , G01N2291/0255 , G01N2291/0256 , G01N2291/0423 , H03H9/02685 , H03H9/14552
摘要： The present application relates to a biosensor that employs an acoustic cavity to store mechanical energy. In particular examples, the biosensor includes an electrode region and one or more reflector regions to form the acoustic cavity, as well as a functionalized active area disposed in proximity to the cavity. Methods of making and using such biosensors are also described herein.
摘要翻译：本申请涉及使用声腔来存储机械能的生物传感器。在具体实例中，生物传感器包括电极区域和形成声腔的一个或多个反射器区域以及设置在腔体附近的功能化的有源区域。本文还描述了制备和使用这种生物传感器的方法。

10. 发明授权

US09987427B1 Diagnostic/drug delivery “sense-respond” devices, systems, and uses thereof 有权
公开(公告)号：US09987427B1
公开(公告)日：2018-06-05
申请号：US14746301
申请日：2015-06-22
申请人： Sandia Corporation
发明人： Ronen Polsky , Philip Rocco Miller , Thayne L. Edwards
IPC分类号： A61M5/172 , A61B10/00 , A61B5/145 , A61M37/00 , A61B5/157
CPC分类号： A61M5/1723 , A61B5/157 , A61M37/0015 , A61M2005/1726 , A61M2037/0023 , A61M2037/0061 , A61M2202/048 , A61M2202/30
摘要： The present invention is directed to devices, systems, and methods for detecting and/or monitoring one or more markers in a sample. In particular, such devices integrate a plurality of hollow needles configured to extract or obtain a fluid sample from a subject, as well as transducers to detect a marker of interest.

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