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1. 发明申请

US20190256577A1 PROCESS FOR PREPARATION OF SECRETORY IgA AND SECRETORY IgM 审中-公开
公开(公告)号：US20190256577A1
公开(公告)日：2019-08-22
申请号：US16401322
申请日：2019-05-02
申请人： Stephen C. Brown , Michael R. Simon
发明人： Stephen C. Brown , Michael R. Simon
IPC分类号： C07K16/00 , C07K16/18 , C07K16/06 , C07K14/735
摘要： A process for synthesizing and separating secretory IgA from a mixture of IgA monmer and IgA dimer is provided. The process includes covalently binding affinity tagged or epitope tagged recombinant secretory component to the IgA dimer in the mixture and binding the affinity tagged or an epitope tagged secretory IgA to immobilized moieties on the solid phase support resin to which the affinity tag or epitope tag binds and then eluting the affinity tagged or an epitope tagged secretory IgA with release buffer. A process for synthesizing and separating secretory IgM from a mixture of IgM and other plasma proteins is also provided. The process includes covalently binding affinity tagged or an epitope tagged recombinant secretory component to the IgM in the mixture and binding the affinity tagged or an epitope tagged secretory IgM to immobilized moieties on the solid phase support resin and then eluting the peptide tagged secretory IgM with a release buffer.

2. 发明授权

US10288971B2 Photonic-powered EC devices 有权
公开(公告)号：US10288971B2
公开(公告)日：2019-05-14
申请号：US14423085
申请日：2013-08-23
申请人： Roger W. Phillips , Stephen C. Brown
发明人： Roger W. Phillips , Stephen C. Brown
IPC分类号： G02F1/163 , G02F1/133 , E06B9/24 , G02F1/161 , H04B10/80 , E06B3/663 , E06B7/28
摘要： The embodiments herein relate to electrochromic window systems and components thereof. In particular, the disclosed embodiments relate to systems where electrochromic devices are powered and/or controlled using photonic energy. In an exemplary embodiment, a laser is driven by a driver to deliver photonic power and/or control information into an optical fiber. The optical fiber carries the power and control information to a photovoltaic converter and a controller. The photovoltaic converter and controller may be included within an insulated glass unit in some embodiments. The photovoltaic converter converts the light energy into electrical energy used to power a transition in an optical state of an electrochromic layer or layers within the insulated glass unit. The controller may be used to control the power delivered to the electrochromic layer(s), such that a smooth transition occurs. In some embodiments, control information may be transmitted in an upstream manner to communicate information regarding, for example, the state of an electrochromic device (e.g., current level of tinting, fault status, etc.).

3. 发明授权

US09671665B2 Connectors for smart windows 有权
公开(公告)号：US09671665B2
公开(公告)日：2017-06-06
申请号：US14363769
申请日：2012-12-11
申请人： Stephen C. Brown , Mark A. Collins , Travis D. Wilbur
发明人： Stephen C. Brown , Mark A. Collins , Travis D. Wilbur , Alexander Rumer , Dennis Mullins
IPC分类号： G02F1/153 , G02F1/163 , H01R41/00 , E06B9/24 , E06B3/663 , E06B3/667 , E06B7/28 , H01R25/14 , E06B3/66 , E06B3/673 , E06B7/00 , H01R13/62 , H01R13/631 , H01R13/73 , G02F1/15 , H01R24/76 , H01R103/00
CPC分类号： G02F1/163 , E06B3/66 , E06B3/6612 , E06B3/6621 , E06B3/66304 , E06B3/66309 , E06B3/66328 , E06B3/667 , E06B3/6722 , E06B3/673 , E06B3/67326 , E06B3/67391 , E06B7/00 , E06B7/28 , E06B9/00 , E06B9/24 , E06B2009/2417 , E06B2009/2464 , G02F1/1345 , G02F1/1523 , G02F1/153 , G02F1/161 , H01R4/12 , H01R12/79 , H01R13/6205 , H01R13/6315 , H01R13/73 , H01R24/76 , H01R25/14 , H01R25/162 , H01R41/00 , H01R2103/00 , Y10T29/49117
摘要： This disclosure provides connectors for smart windows. A smart window may incorporate an optically switchable pane. In one aspect, a window unit includes an insulated glass unit including an optically switchable pane. A wire assembly may be attached to the edge of the insulated glass unit and may include wires in electrical communication with electrodes of the optically switchable pane. A floating connector may be attached to a distal end of the wire assembly. The floating connector may include a flange and a nose, with two holes in the flange for affixing the floating connector to a first frame. The nose may include a terminal face that present two exposed contacts of opposite polarity. Pre-wired spacers improve fabrication efficiency and seal integrity of insulated glass units. Electrical connection systems include those embedded in the secondary seal of the insulated glass unit.

4. 发明申请

US20130271812A1 CONTROLLING TRANSITIONS IN OPTICALLY SWITCHABLE DEVICES 有权
公开(公告)号：US20130271812A1
公开(公告)日：2013-10-17
申请号：US13449235
申请日：2012-04-17
申请人： Stephen C. Brown , Deepika Khowal , Namrata Vora
发明人： Stephen C. Brown , Deepika Khowal , Namrata Vora
IPC分类号： G02F1/15
CPC分类号： G02F1/163 , E06B9/24 , E06B2009/2464 , G01J1/0238 , G01J1/4204 , G01J1/4228 , G01J2001/4266 , G01K13/00 , G01N21/59 , G02F1/13318 , G02F1/15 , G02F1/1523 , G02F1/1533 , Y02A30/257 , Y02B80/50
摘要： This disclosure provides systems, methods, and apparatus for controlling transitions in an optically switchable device. In one aspect, a controller for a tintable window may include a processor, an input for receiving output signals from sensors, and instructions for causing the processor to determine a level of tint of the tintable window, and an output for controlling the level of tint in the tintable window. The instructions may include a relationship between the received output signals and the level of tint, with the relationship employing output signals from an exterior photosensor, an interior photosensor, an occupancy sensor, an exterior temperature sensor, and a transmissivity sensor. In some instances, the controller may receive output signals over a network and/or be interfaced with a network, and in some instances, the controller may be a standalone controller that is not interfaced with a network.

5. 发明授权

US08021645B2 Synthesis of human secretory IgA and IgM and the formation of a medicament therefrom 有权
标题翻译：人分泌型IgA和IgM的合成以及从其形成药物
公开(公告)号：US08021645B2
公开(公告)日：2011-09-20
申请号：US12138758
申请日：2008-06-13
申请人： Michael R. Simon , Stephanie M. Chervin , Stephen C. Brown
发明人： Michael R. Simon , Stephanie M. Chervin , Stephen C. Brown
IPC分类号： A61K49/00 , A61K39/02 , A61K39/08
CPC分类号： C07K16/1282 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/76
摘要： A composition for treating a subject is provided. The composition includes antigen specific dimeric secretory IgA and pentameric IgM therapeutic. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided that the modification of antigen specific dimeric secretory IgA and pentameric IgM with secretory component to form a antigen specific dimeric secretory IgA and pentameric secretory IgM therapeutic. The antigen specific dimeric secretory IgA and the pentameric secretory IgM therapeutic is then mixed with formulating agents to create a capsule, tablet, liquid or suppository dosing form. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration.
摘要翻译：提供了一种用于治疗受试者的组合物。该组合物包括抗原特异性二聚体分泌型IgA和五聚体IgM治疗剂。还提供了用于制备用于治疗人类艰难梭菌相关疾病的药物的方法，其中所述抗原特异性二聚体分泌型IgA和具有分泌成分的五聚体IgM的修饰形成抗原特异性二聚分泌型IgA和五聚体分泌型IgM治疗剂。然后将抗原特异性二聚体分泌型IgA和五聚体分泌型IgM治疗剂与配制剂混合以产生胶囊，片剂，液体或栓剂给药形式。该治疗剂适于直接通过微胶囊包被或剂量形式用肠溶衣包被。还提供了用治疗剂进行艰难梭菌治疗的方法，其适于补充同时或之前的抗生素给药。

6. 发明授权

US10359681B2 Multi-pane windows including electrochromic devices and electromechanical systems devices 有权
公开(公告)号：US10359681B2
公开(公告)日：2019-07-23
申请号：US14443353
申请日：2013-11-26
申请人： Stephen C. Brown
发明人： Stephen C. Brown
IPC分类号： B81B7/02 , G02F1/157 , E06B3/66 , E06B9/24 , G02B26/02 , B32B17/10 , G02F1/15 , G02B26/08
摘要： Multi-pane laminates having electrochromic devices and electromechanical systems, multi-pane window units having electrochromic devices and electromechanical systems, single panes with electrochromic devices and electromechanical systems, and methods of fabricating components thereof.

7. 发明授权

US08705162B2 Controlling transitions in optically switchable devices 有权
标题翻译：控制光可切换设备中的转换
公开(公告)号：US08705162B2
公开(公告)日：2014-04-22
申请号：US13449235
申请日：2012-04-17
申请人： Stephen C. Brown , Deepika Khowal , Namrata Vora
发明人： Stephen C. Brown , Deepika Khowal , Namrata Vora
IPC分类号： G02F1/153 , G02F1/07 , G02F1/15 , G02B26/00
CPC分类号： G02F1/163 , E06B9/24 , E06B2009/2464 , G01J1/0238 , G01J1/4204 , G01J1/4228 , G01J2001/4266 , G01K13/00 , G01N21/59 , G02F1/13318 , G02F1/15 , G02F1/1523 , G02F1/1533 , Y02A30/257 , Y02B80/50
摘要： This disclosure provides systems, methods, and apparatus for controlling transitions in an optically switchable device. In one aspect, a controller for a tintable window may include a processor, an input for receiving output signals from sensors, and instructions for causing the processor to determine a level of tint of the tintable window, and an output for controlling the level of tint in the tintable window. The instructions may include a relationship between the received output signals and the level of tint, with the relationship employing output signals from an exterior photosensor, an interior photosensor, an occupancy sensor, an exterior temperature sensor, and a transmissivity sensor. In some instances, the controller may receive output signals over a network and/or be interfaced with a network, and in some instances, the controller may be a standalone controller that is not interfaced with a network.
摘要翻译：本公开提供了用于控制光可切换装置中的转换的系统，方法和装置。在一个方面，用于可隐藏窗口的控制器可以包括处理器，用于接收来自传感器的输出信号的输入，以及用于使处理器确定可着色窗口的色调级别的指令，以及用于控制色调水平的输出在可见的窗口。指令可以包括接收到的输出信号和色调水平之间的关系，其中使用来自外部光电传感器，内部光电传感器，占用传感器，外部温度传感器和透射率传感器的输出信号的关系。在一些情况下，控制器可以通过网络接收输出信号和/或与网络接口，并且在一些情况下，控制器可以是不与网络接口的独立控制器。

8. 发明申请

US20130157493A1 CONNECTORS FOR SMART WINDOWS 有权
公开(公告)号：US20130157493A1
公开(公告)日：2013-06-20
申请号：US13326168
申请日：2011-12-14
申请人： Stephen C. Brown
发明人： Stephen C. Brown
IPC分类号： H01R13/64
CPC分类号： G02F1/163 , E06B3/66 , E06B3/6612 , E06B3/6621 , E06B3/66304 , E06B3/66309 , E06B3/66328 , E06B3/667 , E06B3/6722 , E06B3/673 , E06B3/67326 , E06B3/67391 , E06B7/00 , E06B7/28 , E06B9/00 , E06B9/24 , E06B2009/2417 , E06B2009/2464 , G02F1/1345 , G02F1/1523 , G02F1/153 , G02F1/161 , H01R4/12 , H01R12/79 , H01R13/6205 , H01R13/6315 , H01R13/73 , H01R24/76 , H01R25/14 , H01R25/162 , H01R41/00 , H01R2103/00 , Y10T29/49117
摘要： This disclosure provides connectors for smart windows. A smart window may incorporate an optically switchable pane. In one aspect, a window unit includes an insulated glass unit including an optically switchable pane. A wire assembly may be attached to the edge of the insulated glass unit and may include wires in electrical communication with electrodes of the optically switchable pane. A floating connector may be attached to a distal end of the wire assembly. The floating connector may include a flange and a nose, with two holes in the flange for affixing the floating connector to a first frame. The nose may include a terminal face that present two exposed contacts of opposite polarity.

9. 发明申请

US20080260822A1 SYNTHESIS OF HUMAN SECRETORY IgA AND IgM AND THE FORMATION OF A MEDICAMENT THEREFROM 有权
标题翻译：人类秘密IgA和IgM的合成及其药物的形成
公开(公告)号：US20080260822A1
公开(公告)日：2008-10-23
申请号：US12138758
申请日：2008-06-13
申请人： Michael R. Simon , Stephanie M. Chervin , Stephen C. Brown
发明人： Michael R. Simon , Stephanie M. Chervin , Stephen C. Brown
IPC分类号： A61K9/48 , A61K39/44 , A61K9/28 , A61P31/04
CPC分类号： C07K16/1282 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/76
摘要： A composition for treating a subject is provided. The composition includes antigen specific dimeric secretory IgA and pentameric IgM therapeutic. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided that the modification of antigen specific dimeric secretory IgA and pentameric IgM with secretory component to form a antigen specific dimeric secretory IgA and pentameric secretory IgM therapeutic. The antigen specific dimeric secretory IgA and the pentameric secretory IgM therapeutic is then mixed with formulating agents to create a capsule, tablet, liquid or suppository dosing form. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration.
摘要翻译：提供了一种用于治疗受试者的组合物。该组合物包括抗原特异性二聚体分泌型IgA和五聚体IgM治疗剂。还提供了用于制备用于治疗人类艰难梭菌相关疾病的药物的方法，其中所述抗原特异性二聚体分泌型IgA和具有分泌成分的五聚体IgM的修饰形成抗原特异性二聚分泌型IgA和五聚体分泌型IgM治疗剂。然后将抗原特异性二聚体分泌型IgA和五聚体分泌型IgM治疗剂与配制剂混合以产生胶囊，片剂，液体或栓剂给药形式。该治疗剂适于直接通过微胶囊包被或剂量形式用肠溶衣包被。还提供了用治疗剂进行艰难梭菌治疗的方法，其适于补充同时或之前的抗生素给药。

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