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1. 发明申请

US20200373137A1 CLEANING ION OPTIC MULTIPOLE DEVICES 审中-公开
公开(公告)号：US20200373137A1
公开(公告)日：2020-11-26
申请号：US16875900
申请日：2020-05-15
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Jan-Peter Hauschild , Amelia Corinne Peterson , Aivaras Venckus
IPC分类号： H01J49/06 , H01J49/42
摘要： A cleaning device for cleaning electrodes of an ion optical multipole device comprises at least one substantially longitudinal cleaning section, at least one handling section extending axially from the at least one cleaning section and at least one direction section extending axially from the at least one cleaning section. The at least one cleaning section has a larger cross section than the at least one handling section. The at least one direction section is capable of allowing a longitudinal movement of the cleaning device in a first axial direction and resisting a longitudinal movement of the cleaning device in a second, opposite axial direction

2. 发明授权

US10811243B2 Ion supply system and method to control an ion supply system 有权
公开(公告)号：US10811243B2
公开(公告)日：2020-10-20
申请号：US16226417
申请日：2018-12-19
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Amelia Corinne Peterson , Denis Chernyshev , Jan-Peter Hauschild , Erik Couzijn
IPC分类号： H01J49/16 , H01J49/06 , H01J49/04 , H01J49/02
摘要： Disclosed herein is an ion supply system, having an ion source emitting ions into a fore vacuum chamber, an ion transport device having stacked electrodes arranged in the fore vacuum chamber, a control system supplying an oscillatory voltage to the electrodes of the ion transport device and a vacuum chamber, arranged downstream from the ion transport device. A vacuum gauge is arranged in the vacuum chamber. The pressure signal of the vacuum gauge is supplied to the control system supplying the oscillatory voltage to electrodes of the ion transport device. The control system adjusts the amplitude of the oscillatory voltage in accordance with the pressure signal.

3. 发明授权

US09698002B2 Method and apparatus for mass analysis utilizing ion charge feedback 有权
公开(公告)号：US09698002B2
公开(公告)日：2017-07-04
申请号：US15131117
申请日：2016-04-18
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Jan-Peter Hauschild , Oliver Lange , Ulf Fröhlich , Andreas Wieghaus , Alexander Kholomeev , Alexander Makarov
IPC分类号： H01J49/04 , H01J49/00 , H01J49/38 , H01J49/42
CPC分类号： H01J49/4265 , H01J49/0031 , H01J49/027 , H01J49/04 , H01J49/38 , H01J49/4245 , H01J49/425
摘要： A method of mass analysis and a mass spectrometer are provided wherein a batch of ions is accumulated in a mass analyzer; the batch of ions accumulated in the mass analyzer is detected using image current detection to provide a detected signal; the number of ions in the batch of ions accumulated in the mass analyzer is controlled using an algorithm based on a previous detected signal obtained using image current detection from a previous batch of ions accumulated in the mass analyzer; wherein one or more parameters of the algorithm are adjusted based on a measurement of ion current or charge obtained using an independent detector located outside of the mass analyzer.

4. 发明授权

US11087969B2 Charge detection for ION current control 有权
公开(公告)号：US11087969B2
公开(公告)日：2021-08-10
申请号：US16864895
申请日：2020-05-01
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Amelia Corinne Peterson , Jan-Peter Hauschild , Alexander Kholomeev , Alexander A. Makarov
IPC分类号： H01J49/42
摘要： A method for controlling the filling of an ion trap with a predetermined quantity of ions. The method comprises generating an ion current by transmitting ions along an ion path to an ion trap, such that ions are accumulated in the ion trap over a transmission time period, wherein the magnitude of the ion current varies in time. The method further comprises detecting at an ion detector at least some ions from the source of ions during a plurality of distinct sampling time intervals interspersed within the transmission time period, and setting the duration of the transmission time period based on the detection of ions at the ion detector. The time difference between the start of a sampling time interval and the start of an immediately subsequent sampling time interval is less than a timescale for variation of the magnitude of the ion current. A controller for controlling the filling of an ion trap with a predetermined quantity of ions and a mass spectrometer comprising the controller is also described.

5. 发明申请

US20200373146A1 Ion Trap with Elongated Electrodes 审中-公开
公开(公告)号：US20200373146A1
公开(公告)日：2020-11-26
申请号：US16878722
申请日：2020-05-20
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Jan-Peter Hauschild , Alexander A. Makarov , Alexander Kholomeev , Dmitry Grinfeld , Eduard V. Dennisov , Amelia Corinne Peterson
IPC分类号： H01J49/42 , H01J49/06
摘要： An ion trap 1 comprises one ejection electrode 2 for ion trapping having an opening 4, through which ions in the ion trap 1 can be ejected in an ejection direction E and further electrodes 3 for ion trapping, wherein the ejection electrode 2 and the further electrodes 3 are elongated in a longitudinal direction L. The angle α between the longitudinal direction L and the ejection direction E is nearly 90°. The ion trap 1 comprises a primary winding 5 connected to an RF power supply 6, a secondary winding 7 coupling with the primary winding 5 for transforming the RF voltage of the RF power supply 6 supplying the transformed RF signals to the ejection electrode 2 and secondary windings 7′ coupling with the primary winding 5 for transforming the RF voltage of the RF power supply 6 supplying the transformed RF signals to the further electrodes 3. The ion trap 1 comprises a first DC supply 8, a second DC supply 9 and a controller 50, which is applying in a time period a first DC voltage provided by first DC supply 8 via the secondary winding 7 to the ejection electrode 2 to pull ions in the ion trap to the opening 4 of the ejection electrode 2 and a second DC voltage provided by the second DC supply 9 via the secondary windings 7′ to the at least 70% of the further electrodes 3 to push ions in the ion trap to the opening 4 of the ejection electrode 2.

6. 发明授权

US09536722B2 Ion guide 有权
标题翻译：离子导向
公开(公告)号：US09536722B2
公开(公告)日：2017-01-03
申请号：US14428144
申请日：2013-09-19
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Dmitry Grinfeld , Jan-Peter Hauschild , Wilko Balschun , Eduard Denisov , Alexander Makarov
IPC分类号： H01J49/06 , H01J49/00 , H05K1/02
CPC分类号： H01J49/063 , H01J49/0018 , H01J49/062 , H01J49/068 , H05K1/02
摘要： An ion guide for mass spectrometry comprising an electrode arrangement of at least two electrodes, at least one of which is an RF electrode, arranged adjacent to each other but spaced apart on a planar surface of a dielectric material and arranged at a distance from an ion flow path, wherein a portion of the dielectric surface is exposed between an adjacent pair of the spaced apart electrodes and wherein at least one electrode of said adjacent pair of electrodes is arranged to overhang the exposed portion of surface between them such that there is no direct line of sight from the ion flow path to the exposed portion of dielectric surface. The device enables RF guiding of ions accompanied by much reduced charging-up of dielectric surfaces and reduced amount of collisions of neutral species with electrodes.
摘要翻译：一种用于质谱的离子导向器，包括至少两个电极的电极装置，至少两个电极的至少一个是RF电极，彼此相邻布置，但间隔开在电介质材料的平坦表面上并且布置在与离子流动路径，其中电介质表面的一部分暴露在相邻的一对间隔开的电极之间，并且其中所述相邻电极对中的至少一个电极布置成突出在它们之间的表面的暴露部分，使得不存在直接从离子流路到电介质表面的暴露部分的视线。该器件能够使RF引导离子，同时电介质表面的充电很少，并减少了中性物质与电极的碰撞量。

7. 发明授权

US11430646B2 Atmospheric pressure ion source interface 有权
公开(公告)号：US11430646B2
公开(公告)日：2022-08-30
申请号：US17089424
申请日：2020-11-04
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Aivaras Venckus , Hamish Stewart , Christian Albrecht Hock , Jan-Peter Hauschild
IPC分类号： H01J49/00 , H01J49/04 , G01N27/622 , H01J49/14 , H01J49/16 , H01J49/24 , H01J49/40 , H01J49/42
摘要： An interface for receiving ions in a carrier gas from an atmospheric pressure ion source at a spectrometer that is configured to analyse the received ions at a lower pressure includes an interface vacuum chamber having a downstream aperture; a support assembly defining an axial bore arranged to allow a removable capillary tube to extend therethrough; ions being received from the atmospheric pressure ion source through the capillary tube and directed towards the downstream aperture; and a jet disruptor, positioned downstream from the axial bore and configured to disrupt gas flow between the axial bore and the downstream aperture only when the capillary tube is not fully inserted through the axial bore.

8. 发明授权

US11062895B2 Mass spectrometer having improved quadrupole robustness 有权
公开(公告)号：US11062895B2
公开(公告)日：2021-07-13
申请号：US16842967
申请日：2020-04-08
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Amelia Corinne Peterson , Jan-Peter Hauschild , Oliver Lange , Alexander A. Makarov
IPC分类号： H01J49/42 , H01J49/02 , H01J49/00 , H01J49/06
摘要： A method of operating a mass spectrometer, comprising: generating ions from a sample; mass filtering the ions using a quadrupole mass filter having a set of selection parameters to transmit ions within at least one selected range of mass-to-charge ratios narrower than an initial range, wherein the quadrupole comprises four parallel elongate electrodes arranged in opposing pairs to which are applied RF and DC, wherein an attractive DC voltage is applied to one pair of opposing electrodes and a repulsive DC voltage is applied to the other pair; mass analysing or detecting the ions transmitted by the quadrupole mass filter; repeating the steps of generating ions, mass filtering and mass analysing or detecting multiple times; switching a configuration of the pairs of opposing electrodes to which the attractive DC voltage and the repulsive DC voltage are applied multiple times over the course of repeating the steps so that over long term operation the build-up of contamination on each pair of opposing electrodes is substantially equal; and determining mass filtering steps for which quantitative accuracy should be maintained between them and for the determined mass filtering steps maintaining the same configuration of the pairs of opposing electrodes to which the attractive DC voltage and the repulsive DC voltage are applied. The width of the selected mass range may change by not more than 10% when the ion transmission efficiency mass filter falls by 50% or more due to the build-up of contamination on the electrodes.

9. 发明授权

US09460905B2 Method of assessing vacuum conditions in a mass spectrometer with transient signal decay rates 有权
标题翻译：用瞬态信号衰减速率评估质谱仪中真空条件的方法
公开(公告)号：US09460905B2
公开(公告)日：2016-10-04
申请号：US14686012
申请日：2015-04-14
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Konstantin Aizikov , Dirk Nolting , Jan-Peter Hauschild
IPC分类号： H01J49/24 , G01L21/30 , H01J49/42 , H01J49/38
CPC分类号： H01J49/24 , G01L21/30 , H01J49/38 , H01J49/425 , H01J49/4265
摘要： A method is proposed for assessing the vacuum conditions in a mass spectrometer (10) such as an ion cyclotron resonance or orbital trapping mass spectrometer. Such mass spectrometers generate a transient detection signal resulting from ions of one or species in an ion trap (80). The parameters of the trap and/or introduced ions are adjusted so as to cause the decay rate of the transient in respect of the ion species to be dominated by collisional effects. Typically this can be achieved by introducing ions into the trap (80) in quantities such that ion clouds of a particular ion species self bunch. The rate of decay of the transient signal in that case is determined and compared with one or more threshold decay rates. This in turn can provide an indication of vacuum conditions within the trap (80).
摘要翻译：提出了一种用于评估质谱仪（10）如离子回旋共振或轨道捕获质谱仪中的真空条件的方法。这种质谱仪产生由离子阱（80）中的一个或多个物质的离子产生的瞬态检测信号。调节陷阱和/或引入的离子的参数，以使离子种类的瞬变的衰减速率由碰撞效应来支配。通常，这可以通过将离子引入捕集器（80）中以使得特定离子物质的离子云自发束的量来实现。在这种情况下，确定瞬态信号的衰减速率并将其与一个或多个阈值衰减速率进行比较。这又可以提供陷阱（80）内的真空条件的指示。

10. 发明申请

US20140224975A1 Method of Operating a Mass Filter in Mass Spectrometry 有权
标题翻译：在质谱中操作质量过滤器的方法
公开(公告)号：US20140224975A1
公开(公告)日：2014-08-14
申请号：US14180194
申请日：2014-02-13
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Andreas Kuehn , Jan-Peter Hauschild , Dirk Nolting , Oliver Lange , Eugen Damoc
IPC分类号： H01J49/00 , H01J49/02
CPC分类号： H01J49/0031 , H01J49/022 , H01J49/06 , H01J49/4215
摘要： Disclosed herein is a mass spectrometry method having steps of: transmitting ions from an ion source through a mass filter; processing ions received from the mass filter in a discontinuous ion optical device downstream of the mass filter; operating the mass filter for a plurality of periods in a mass/charge ratio (m/z) filtering mode to transmit ions in one or more selected ranges of m/z to the discontinuous ion optical device; and operating the mass filter in a broad mass range mode transmitting ions of a mass range substantially wider than any mass range transmitted in the m/z filtering mode during one or more periods in which the discontinuous ion optical device is not processing ions from the mass filter. Utilization of this method assists to reduce contamination in the mass filter.
摘要翻译：本文公开了一种质谱法，其具有以下步骤：从离子源通过质量过滤器传输离子; 在质量过滤器下游的不连续离子光学装置中处理从质量过滤器接收的离子; 以质量/电荷比（m / z）滤波模式操作质量过滤器多个周期，以将m / z的一个或多个选定范围内的离子传输到不连续离子光学器件; 并且以广泛质量范围模式操作传质质量范围的离子，其质量范围比在m / z滤波模式下传输的任何质量范围宽的质量范围，其中不连续离子光学器件不处理离子的质量过滤。该方法的利用有助于减少质量过滤器中的污染。

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