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1. 发明申请

US20190217273A1 CHROMATOGRAPHIC MATERIALS 审中-公开
公开(公告)号：US20190217273A1
公开(公告)日：2019-07-18
申请号：US16359328
申请日：2019-03-20
申请人： Waters Technologies Corporation
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/283 , C07F7/18 , B01J20/28 , B01D15/26 , B01D15/30 , B01D15/32 , B01D15/40 , B01J20/288 , B01J20/32 , B01J20/289 , B01D53/02 , B01J20/22 , B01J20/30
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1804
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

2. 发明申请

US20190187109A1 PURIFICATION ELEMENTS FOR DISPENSING A PURIFIED LIQUID 审中-公开
公开(公告)号：US20190187109A1
公开(公告)日：2019-06-20
申请号：US16223330
申请日：2018-12-18
申请人： Waters Technologies Corporation
发明人： Moon Chul Jung , Abhijit Tarafder , Wade P. Leveille
IPC分类号： G01N30/14 , B01D15/26 , B01D15/18
CPC分类号： G01N30/14 , B01D15/18 , B01D15/26 , G01N1/34 , G01N30/32 , G01N30/34 , G01N2030/143 , G01N2030/342
摘要： In various aspects provided are purification media and containers for dispensing a purified liquid are provided herein where a high surface area-to-volume chemically interactive purification media positioned at the outlet of a container that purifies the liquid as it is dispensed and/or extracted.

3. 发明申请

US20190048101A1 Rubber and By-Product Extraction Systems and Methods 审中-公开
公开(公告)号：US20190048101A1
公开(公告)日：2019-02-14
申请号：US16055771
申请日：2018-08-06
申请人： Kultevat, Inc.
发明人： Anthony Nocera, JR. , Daniel R. Swiger
IPC分类号： C08C1/04 , C08C1/12 , C08C1/14 , C07H1/08 , B01D11/02 , B01D11/04 , B01D15/26
CPC分类号： C08C1/04 , B01D11/0257 , B01D11/0284 , B01D11/0288 , B01D11/0296 , B01D11/0434 , B01D11/0488 , B01D11/0492 , B01D15/26 , C07H1/08 , C08C1/12 , C08C1/14
摘要： Systems and methods for extracting useful by-products and natural rubber from non-Hevea rubber bearing plants are disclosed.

4. 发明授权

US09790573B2 Method for purification of 225AC from irradiated 226RA-targets 有权
公开(公告)号：US09790573B2
公开(公告)日：2017-10-17
申请号：US15359053
申请日：2016-11-22
申请人： Actinium Pharmaceuticals Inc.
发明人： Josue Manuel Moreno Bermudez , Andreas Turler , Richard Henkelmann , Eva Kabai , Ernst Huenges
IPC分类号： A61K51/00 , A61M36/14 , C22B60/02 , C22B7/00 , B01D15/20 , G21G1/00
CPC分类号： C22B60/0295 , A61K51/00 , B01D15/206 , B01D15/26 , C22B7/005 , C22B7/007 , C22B7/009 , G21G1/001 , G21G4/08 , G21G2001/0089
摘要： The present invention describes a method for purification of 225Ac from irradiated 226Ra-targets provided on a support comprising a leaching treatment of the 225Ra-targets for leaching essentially for the entirety of 223Ac and 226Ra with nitric or hydrochloric acid, followed by a first extraction chromatography for separating 225Ac from 226Ra and other Ra-isotops and a second extraction chromotography for separating 225Ac from 210Po and 210Pb. The finally purified 225Ac can be used to prepare compositions useful for pharmaceutical purposes.

5. 发明授权

US09675959B2 Porous silicon oxynitride materials for chromatographic separation and method of their preparation 有权
公开(公告)号：US09675959B2
公开(公告)日：2017-06-13
申请号：US13872081
申请日：2013-04-27
申请人： Xinmiao Liang , Huihui Wan , Xingya Xue
发明人： Xinmiao Liang , Huihui Wan , Xingya Xue
IPC分类号： B01D15/26 , B01J20/28 , B01J20/283 , B01J20/32 , B01J20/288 , C01B21/082 , B01D15/22 , B01J20/282 , B01J20/281
CPC分类号： B01J20/288 , B01D15/26 , B01J20/28057 , B01J20/28069 , B01J20/28083 , B01J20/281 , B01J20/282 , B01J20/283 , B01J20/3204 , B01J20/3246 , B01J20/3248 , C01B21/0823 , C01P2002/86 , C01P2002/87 , C01P2004/61 , C01P2004/62 , C01P2006/12 , C01P2006/14 , C01P2006/16 , Y10T428/2982
摘要： Novel material for chromatographic separations, processes for its preparation, and separation devices containing the chromatographic material. In particular, the novel materials are porous silicon oxynitride materials, which desirably can be surface modified and have enhanced stability at high pH. The novel porous silicon oxynitride material may offer efficient chromatographic separations, and hold great promise as packing material for chromatographic separations.

6. 发明申请

US20160214920A1 Methods of Purifying Cannabinoids, Compositions and Kits Thereof 有权
标题翻译：大麻素，组合物和试剂盒的净化方法
公开(公告)号：US20160214920A1
公开(公告)日：2016-07-28
申请号：US15004848
申请日：2016-01-22
申请人： Phytoplant Research S.L.
发明人： Xavier Nadal Roura
IPC分类号： C07C65/19 , C07C37/68 , B01D15/26 , C07C37/84 , C07C39/23 , C07C51/43 , C07C39/19
CPC分类号： C07C37/685 , A61K36/185 , A61K2236/00 , B01D15/26 , C07C37/84 , C07C39/19 , C07C39/23 , C07C51/43 , C07C65/19
摘要： The present specification discloses methods of purifying one or more cannabinoids from a plant material, purified cannabinoids and pharmaceutical compositions comprising one or more cannabinoids produced by the disclosed method, methods and uses for treating a disease or condition employing such purified cannabinoids and pharmaceutical compositions.
摘要翻译：本说明书公开了从植物材料纯化一种或多种大麻素的方法，纯化的大麻素和包含一种或多种通过所公开的方法生产的大麻素的药物组合物，用于治疗使用这种纯化大麻素和药物组合物的疾病或病症的方法和用途。

7. 发明授权

US09127043B2 Purification of immunoglobulins 有权
标题翻译：免疫球蛋白的纯化
公开(公告)号：US09127043B2
公开(公告)日：2015-09-08
申请号：US13254697
申请日：2010-03-04
申请人： Robert S. Gronke , Héctor Zaanoni
发明人： Robert S. Gronke , Héctor Zaanoni
IPC分类号： B01D15/26 , B01D15/38 , C07K1/22
CPC分类号： C07K1/22 , B01D15/26 , B01D15/3804 , B01D15/3828 , B01D2015/3838 , C07K1/165
摘要： The present invention pertains to improved methods of using dye-ligand affinity chromatography for the isolation of antibodies or proteins comprising an antibody fragment (such as Fc fusion proteins) from a mixture of undesirable contaminants. In particular, the use of an organic polymer such as polyethylene glycol (PEG) in the elution phase of an antibody/dye-ligand chromatography isolation procedure results in improved separation of target antibodies from undesirable contaminants. The methods described herein are particularly useful in separating or removing antibody aggregates, misfolded antibodies, and virus contaminants from target antibodies.
摘要翻译：本发明涉及使用染料 - 配体亲和层析从不想要的污染物的混合物分离包含抗体片段（例如Fc融合蛋白）的抗体或蛋白质的改进方法。特别地，在抗体/染料 - 配体色谱分离方法的洗脱阶段中使用有机聚合物如聚乙二醇（PEG）导致靶抗体与不期望的污染物的分离改善。本文描述的方法特别可用于从靶抗体中分离或去除抗体聚集体，错误折叠的抗体和病毒污染物。

8. 发明申请

US20140353255A1 POROUS COMPOSITE PARTICULATE MATERIALS, METHODS OF MAKING AND USING SAME, AND RELATED APPARATUSES 审中-公开
标题翻译：多孔复合颗粒材料，制备和使用它们的方法和相关装置
公开(公告)号：US20140353255A1
公开(公告)日：2014-12-04
申请号：US14463525
申请日：2014-08-19
申请人： BRIGHAM YOUNG UNIVERSITY , US SYNTHETIC CORPORATION
发明人： David Scott Jensen , Andrew E. Dadson
IPC分类号： B01J20/32 , B01J20/281 , B01D15/26
CPC分类号： B01J20/3293 , B01D15/26 , B01J13/14 , B01J13/22 , B01J20/0211 , B01J20/0218 , B01J20/28004 , B01J20/28016 , B01J20/28019 , B01J20/28057 , B01J20/281 , B01J20/286 , B01J20/3204 , B01J20/3223 , B01J20/3234 , B01J20/3236 , B01J20/324 , B01J20/3268 , B01J20/3272 , B01J20/3282 , B01J20/3289 , B01J20/3295 , B01J2220/52 , B01J2220/58 , B01J2220/82
摘要： In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, niobium carbide, zirconia, noble metals, combinations of the foregoing, or other acid-base-resistant materials and the core particle may include at least one exterior layer of non-diamond carbon. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography and solid phase extraction.
摘要翻译：在一个实施方案中，多孔复合颗粒材料包括多个复合颗粒。每个复合颗粒包括至少部分地被一层或多层耐酸碱性壳颗粒包围的耐酸碱性芯颗粒。壳颗粒通过聚合物层粘附到芯颗粒。壳颗粒和/或芯颗粒可以由在苛刻的化学条件下稳定的耐酸碱材料制成。例如，壳颗粒可以由金刚石，石墨碳，碳化硅，氮化硼，碳化钨，碳化铌，氧化锆，贵金属，前述的组合或其它耐酸碱材料和芯颗粒制成包括至少一个非金刚石碳外层。本文公开的多孔复合颗粒材料和相关方法和装置可以用于分离技术，包括但不限于色谱和固相萃取。

9. 发明申请

US20130323134A1 Methods and Apparatus for Treating a Hydrocarbon Stream 审中-公开
标题翻译：用于处理烃流的方法和装置
公开(公告)号：US20130323134A1
公开(公告)日：2013-12-05
申请号：US13904813
申请日：2013-05-29
申请人： UOP LLC
发明人： Mark G. Riley , Wugeng Liang , Deng-Yang Jan , Adam Gross
IPC分类号： B01D15/26 , B01J8/00
CPC分类号： B01D15/26 , B01D15/00 , B01J8/00 , B01J20/165 , B01J20/18 , B01J20/2808 , C07C7/005 , C07C7/13 , C07C15/04
摘要： Disclosed is an apparatus for removing water, nitrogen compounds, and unsaturated aliphatic compounds from a hydrocarbon feed stream including a water removal zone, a nitrogen removal zone, and an unsaturated aliphatic compound removal zone. By on aspect, the water removal zone includes a water selective adsorbent, the nitrogen removal zone includes a nitrogen selective adsorbent, and the unsaturated aliphatic compound removal zone includes an unsaturated aliphatic compound removal material.
摘要翻译：公开了一种从包含除水区，除氮区和不饱和脂肪族化合物除去区的烃进料流中除去水，氮化合物和不饱和脂肪族化合物的装置。一方面，除水区包括水选择性吸附剂，除氮区包括氮选择性吸附剂，不饱和脂族化合物除去区包括不饱和脂肪族化合物去除物质。

10. 发明申请

US20130274454A1 METHODS FOR OBTAINING LIQUID FROM A SOLID PHASE 有权
标题翻译：从固体相中获取液体的方法
公开(公告)号：US20130274454A1
公开(公告)日：2013-10-17
申请号：US13834901
申请日：2013-03-15
申请人： Cambridge Enterprise Limited
发明人： Yii Leng Chua
IPC分类号： B01D15/20
CPC分类号： B01D15/20 , B01D11/02 , B01D11/0219 , B01D15/00 , B01D15/02 , B01D15/24 , B01D15/245 , B01D15/26 , B01D17/02 , B01D17/0202 , C12N15/1006 , C12N15/101 , C12N15/1017
摘要： A method for obtaining a liquid from a porous solid phase is described. The method comprises forming a liquid seal at a first end of a porous solid phase to which a liquid is bound, wherein liquid of the liquid seal is immiscible with the liquid bound to the solid phase, and applying a pressure differential across the porous solid phase to cause the immiscible liquid to move through the porous solid phase towards a second end of the porous solid phase, thereby displacing the liquid bound to the porous solid phase towards the second end and releasing this liquid from the second end. Recovery of liquid from the solid phase using such methods is increased compared with corresponding methods in which no liquid seal is formed. In preferred embodiments, the liquid used to form the liquid seal is a mineral oil. The methods have particular application in nucleic acid extractions which utilise capture of nucleic acid to a solid phase. Kits and apparatus for performing the methods are also described.
摘要翻译：描述了从多孔固相中获得液体的方法。该方法包括在多孔固相的第一端形成液体密封，液体与液体结合在一起，其中液体密封液体与与固相结合的液体不混溶，并在多孔固相上施加压力差以使不相容的液体朝向多孔固相的第二端移动通过多孔固相，从而将结合到多孔固相的液体移向第二端并从第二端释放该液体。与其中没有形成液体密封的相应方法相比，使用这种方法从固相中回收液体。在优选的实施方案中，用于形成液体密封的液体是矿物油。该方法在利用核酸捕获到固相的核酸提取中具有特别的应用。还描述了用于执行该方法的套件和装置。

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