专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20190218169A1 BRANCHED TRIALKYL AMINE OXIDES 审中-公开
公开(公告)号：US20190218169A1
公开(公告)日：2019-07-18
申请号：US16243232
申请日：2019-01-09
申请人： Eastman Chemical Company
发明人： Stephanie Kay Clendennen , Vasudev R. Bhonde , Damon Ray Billodeaux , Matthew Allen Boone , Kim Dumoleijn , Stijn Simonne Paul Van de Vyver , Kristof Moonen , Neil Warren Boaz
IPC分类号： C07C207/02 , C07C201/00 , C11D1/75 , C11D1/83 , C11D1/835 , C11D1/94 , C11D3/395 , C11D3/39 , C11D11/00 , C11D3/43 , C09D7/63 , C09K8/584 , C10L1/18
CPC分类号： C07C211/04 , A61K8/416 , A61K8/44 , A61K8/466 , A61Q5/02 , A61Q19/10 , C07C201/00 , C07C207/02 , C07C229/12 , C07C309/14 , C07H5/06 , C09D7/63 , C09K8/584 , C10L1/18 , C11D1/75 , C11D1/83 , C11D1/835 , C11D1/90 , C11D1/94 , C11D3/3942 , C11D3/395 , C11D3/43 , C11D11/0017 , C11D11/0023
摘要： The invention provides branched trialkylamine oxides with improved properties. The trialkylamine oxides of the invention produced from branched trialkylamines, in one embodiment, can be made using certain branched C10-12 enals and aldehydes. The invention also provides an trialkylamine oxide having the formula: wherein R5, R6 and R7 are independently at least one of C3H7, C2H5, CH3, or H, or mixtures thereof; and wherein R5 and R6 are not H at the same time. In one embodiment, the trialkylamine oxides of the invention can be useful in making various products, for example, as surfactants.

2. 发明申请

US20180312829A1 Directed modification of glucosamine synthase mutant and application thereof 审中-公开
公开(公告)号：US20180312829A1
公开(公告)日：2018-11-01
申请号：US15613286
申请日：2017-06-05
申请人： Yangzhou Rixing Bio-Tech Co.,Ltd , Jiangnan University
发明人： Jinsong Shi , Zhenghong Xu , Chao Zhang , Jinsong Gong , Heng Li , Zhenzhong Ding , Xiang Fang , Wanhong Zhang
IPC分类号： C12N15/09 , C12N15/70 , C12N9/10 , C12P19/26
CPC分类号： C12N15/09 , C07H5/06 , C07H11/04 , C12N9/00 , C12N9/10 , C12N9/1096 , C12N15/70 , C12P19/02 , C12P19/26 , C12Y206/01016
摘要： The present invention discloses a directionally modified glucosamine synthase mutant and its application. The amino acid sequence of the glucosamine synthase mutant is as shown in sequence list SEQ ID No. 1, and the nucleotide sequence is as shown in sequence list SEQ ID No. 2. The genetic engineering bacteria of glucosamine synthase is successfully constructed. In order to improve the tolerance of recombinant bacteria against glucosamine, the glucosamine synthase is directionally modified. A glucosamine synthase mutant is selected from the mutant library via high-throughput screening method, the amino acid changes in the mutant induces the spatial conformational change in the enzyme, so as enlarged the region where the enzyme and substrate combines, therefor the combination efficiency of the enzyme and the substrate is increased. The glucosamine synthase of the present invention has various advantages, such as rich in raw material of glucose, and a convenient subsequent extraction.

3. 发明申请

US20180008720A1 Dually Derivatized Chitosan Nanoparticles and Methods of Making and Using the Same for Gene Transfer In Vivo 审中-公开
公开(公告)号：US20180008720A1
公开(公告)日：2018-01-11
申请号：US15489199
申请日：2017-04-17
申请人： ENGENE, INC.
发明人： Jun GAO , Eric HSU , Anthony CHEUNG
IPC分类号： C08L5/08 , C07H13/04 , C12N15/11 , C08B37/08 , C07H5/06 , C12N15/87 , A61K9/51
CPC分类号： A61K47/61 , A61K9/5161 , A61K47/6939 , C07H5/06 , C07H13/04 , C08B37/003 , C08L5/08 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2320/32
摘要： Provided herein is chitosan dually derivatized with arginine and gluconic acid; and methods of making and using the same, e.g., for gene delivery in vivo.

4. 发明授权

US09796999B2 Detection of oligosaccharides 有权
公开(公告)号：US09796999B2
公开(公告)日：2017-10-24
申请号：US14706794
申请日：2015-05-07
申请人： BIOMARIN PHARMACEUTICAL INC.
发明人： Brett E. Crawford , Jillian R. Brown , Charles A. Glass
IPC分类号： C12Q1/527 , C07H3/06 , C07H3/04 , C07H13/04 , C07H5/06 , A61K31/702 , G01N33/66 , C07H7/033 , C07H11/00
CPC分类号： C12Q1/527 , A61K31/702 , C07H3/04 , C07H3/06 , C07H5/06 , C07H7/033 , C07H11/00 , C07H13/04 , G01N33/66 , G01N2333/988 , G01N2400/40 , G01N2800/042 , G01N2800/52 , G01N2800/7071
摘要： Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an individual suffering from a disorder associated with abnormal glycosaminoglycan accumulation.

5. 发明授权

US09493603B2 Carbohydrate binders and materials made therewith 有权
标题翻译：碳水化合物粘合剂和由其制成的材料
公开(公告)号：US09493603B2
公开(公告)日：2016-11-15
申请号：US13696452
申请日：2011-05-07
申请人： Gert R. Mueller , Charles Fitch Appley , Benedicte Pacorel , Carl A. Hampson
发明人： Gert R. Mueller , Charles Fitch Appley , Benedicte Pacorel , Carl A. Hampson
IPC分类号： C08G12/00 , C08G14/00 , C08G16/00 , C08L5/00
CPC分类号： C07H5/06 , C03C25/25 , C08G12/00 , C08G14/00 , C08G16/00 , D21H19/12
摘要： A binder comprising a polymeric binder comprising the products of a carbohydrate reactant and nucleophile is disclosed. The binder is useful for consolidating loosely assembled matter, such as fibers. Fibrous products comprising fibers in contact with a carbohydrate reactant and a nucleophile are also disclosed. The binder composition may be cured to yield a fibrous product comprising fibers bound by a cross-linked polymer. Further disclosed are methods for binding fibers with the carbohydrate reactant and polyamine based binder.
摘要翻译：公开了一种包含含有碳水化合物反应物和亲核试剂产物的聚合物粘合剂的粘合剂。粘合剂可用于固结松散组装的物质，例如纤维。还公开了包含与碳水化合物反应物和亲核试剂接触的纤维的纤维产品。粘合剂组合物可以固化以产生包含被交联聚合物结合的纤维的纤维产品。进一步公开的是将纤维与碳水化合物反应物和多胺基粘合剂结合的方法。

6. 发明申请

US20160280732A1 MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF 审中-公开
标题翻译：咪唑啉酮类似物，合成方法及其用途
公开(公告)号：US20160280732A1
公开(公告)日：2016-09-29
申请号：US15057019
申请日：2016-02-29
申请人： President and Fellows of Harvard College
发明人： Daniel Evan Kahne , Suzanne Walker Kahne , Hirokazu Tsukamoto
IPC分类号： C07H13/12 , C07H1/00
CPC分类号： C07H13/12 , C07F9/65586 , C07H1/00 , C07H5/06
摘要： The present invention provides compounds of Formula (I): or a pharmaceutically acceptable form thereof; wherein R1, R2, R3, R 6, R7, R12, RXX, Ra, and Rb are as defined herein, and G is a group of Formula (a), (b), or (c): wherein X1, X2, X3, X4, X5, X6, X7, Y, Rc, Rd, Rz, a, d, e, x, n, and m are as defined herein. The present invention further provides pharmaceutical compositions comprising a compound of Formula (I), kits comprising such compositions, methods of use and treatment, and preparative methods.
摘要翻译：其中X1，X2，X3，X4，X5，X6，X7，Y，Rc，Rd，Rz，a，d，e，x，n和m如本文所定义。本发明还提供包含式（I）化合物，包含这种组合物的试剂盒，使用和处理方法以及制备方法的药物组合物。

7. 发明申请

US20160213763A1 NOVEL GLYCAN CONJUGATES AND METHODS OF USE THEREOF 审中-公开
标题翻译：新型糖果混合物及其使用方法
公开(公告)号：US20160213763A1
公开(公告)日：2016-07-28
申请号：US14832993
申请日：2015-08-21
申请人： Academia Sinica
发明人： Chi-Huey Wong , Chung-Yi Wu
IPC分类号： A61K39/00 , C07H7/02 , C07H15/04 , C07K16/30
CPC分类号： A61K39/0011 , A61K31/7028 , A61K31/715 , A61K2039/55511 , A61K2039/6037 , A61K2039/627 , C07H5/02 , C07H5/04 , C07H5/06 , C07H15/04 , C07H15/26 , C07K16/3076 , C07K16/44 , C08B37/006
摘要： The present disclosure is directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA3/SSEA4/GloboH associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globo-series glycosphingolipid synthesis. The present disclosure relates to methods and compositions which can modulate the globo-series glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globo-series glycosphingolipid SSEA3/SSEA4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globo-series synthetic pathway. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.
摘要翻译：本公开涉及针对SSEA3 / SSEA4 / GloboH相关表位（天然和修饰）的疫苗，抗体和/或免疫原性缀合物组合物，其引发可用于调节globo系列鞘糖脂合成的抗体和/或结合片段生产。本公开涉及可以调节globo系列鞘糖脂合成的方法和组合物。特别地，本公开涉及可以调节生物合成途径中的globo系列鞘糖脂SSEA3 / SSEA4 / GloboH的合成的糖酵母抑制剂化合物及其组合物和使用方法; 特别是糖酵解抑制剂靶向α-4GalT; β-4GalNAcT-I; 或β-3GalT-V酶在globo系列合成途径中。此外，本公开还涉及使用本文所述的组合物治疗或检测过度增殖性疾病和/或病症的方法。

8. 发明申请

US20150352136A1 NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS 有权
标题翻译：新型氨基酸类及其在遗传性疾病治疗中的应用
公开(公告)号：US20150352136A1
公开(公告)日：2015-12-10
申请号：US14738892
申请日：2015-06-14
申请人： Technion Research & Development Foundation Limited
发明人： Timor BAASOV , Tamar Ben-Yosef , Igor Nudelman , Annie Rebibo-Sabbah , Dalia Shallom-Shezifi , Mariana Hainrichson
IPC分类号： A61K31/7036 , B65D25/20 , A61K9/00
CPC分类号： A61K31/7036 , A61K9/0053 , B65D25/205 , C07H5/06
摘要： A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
摘要翻译：提供了一类新的巴霉素衍生的氨基糖苷类，其表现出有效的终止密码子突变抑制活性，对真核细胞的低毒性和高选择性。还提供了制备这些巴布霉素衍生的氨基糖苷类及其中间体的化学和化学酶法，以及含有它们的药物组合物及其在治疗遗传疾病中的用途。

9. 发明申请

US20150307915A1 DETECTION OF OLIGOSACCHARIDES 有权
标题翻译：检测寡糖
公开(公告)号：US20150307915A1
公开(公告)日：2015-10-29
申请号：US14706794
申请日：2015-05-07
申请人： BIOMARIN PHARMACEUTICAL INC.
发明人： Brett E. CRAWFORD , Jillian R. BROWN , Charles A. GLASS
IPC分类号： C12Q1/527 , C07H7/033 , C07H11/00
CPC分类号： C12Q1/527 , A61K31/702 , C07H3/04 , C07H3/06 , C07H5/06 , C07H7/033 , C07H11/00 , C07H13/04 , G01N33/66 , G01N2333/988 , G01N2400/40 , G01N2800/042 , G01N2800/52 , G01N2800/7071
摘要： Provided herein are processes for detecting oligosaccharides in a biological sample. In specific instances, the biological sample is provided from an individual suffering from a disorder associated with abnormal glycosaminoglycan accumulation.
摘要翻译：本文提供了检测生物样品中寡糖的方法。在具体情况下，生物样品由患有与异常糖胺聚糖累积相关的病症的个体提供。

10. 发明申请

US20150218196A1 SELECTIVE OXIDATION OF CARBOHYDRATES 有权
标题翻译：碳水化合物的选择性氧化
公开(公告)号：US20150218196A1
公开(公告)日：2015-08-06
申请号：US14409604
申请日：2013-06-20
申请人： Rijksuniversiteit Groningen
发明人： Adriaan Jacobus Minnaard , Manuel Jäger , Aditya Lakshmi Narasimha Raju Gottumukkala , Johannes Gerardus de Vries , Andreas Alexander Bastian , Andreas Herrmann
IPC分类号： C07H3/02 , C07H17/04 , C07H5/06 , C07H3/04
CPC分类号： C07H15/222 , C07H1/00 , C07H3/02 , C07H3/04 , C07H3/06 , C07H5/06 , C07H15/04 , C07H15/18 , C07H15/22 , C07H15/224 , C07H15/226 , C07H15/228 , C07H15/23 , C07H15/232 , C07H15/234 , C07H17/04 , C07H23/00
摘要： The invention relates to the field of carbohydrate chemistry. Provided is a process for the regioselective oxidation of a single secondary hydroxy function of a carbohydrate substrate comprising two or more secondary hydroxy functions, comprising contacting the carbohydrate substrate in a solvent in the presence of a transition metal catalyst complex with an oxidizing agent to yield a mono-oxidized carbohydrate.
摘要翻译：本发明涉及碳水化合物化学领域。提供了一种用于区域选择性氧化包含两个或更多个次级羟基官能团的碳水化合物底物的单次级羟基官能团的方法，包括在过渡金属催化剂配合物与氧化剂存在下使碳水化合物底物在溶剂中接触，得到单氧化碳水化合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式