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1. 发明授权

US08399229B2 Mobile magnetic traps and platforms for micro/nano particle manipulation 失效
标题翻译：用于微/纳米颗粒操作的移动磁捕获器和平台
公开(公告)号：US08399229B2
公开(公告)日：2013-03-19
申请号：US12950130
申请日：2010-11-19
申请人： Ratnasingham Sooryakumar , Dhriti Sooryakumar , Gregory Vieira , Jeffrey J. Chalmers
发明人： Ratnasingham Sooryakumar , Dhriti Sooryakumar , Gregory Vieira , Jeffrey J. Chalmers
IPC分类号： B03C1/035
CPC分类号： B03C1/288 , B01L3/502761 , B01L2300/0861 , B01L2400/043 , B03C1/01 , B03C1/032 , B03C1/033 , B03C2201/18 , B03C2201/26 , B82Y25/00 , C07K1/22 , C07K1/24
摘要： Magnetic array platforms such as nano or micro-wire networks that produce trapping, manipulation, and transport of micro- or nano-scale particles such as non-biological entities such as magnetic particles and cells, viruses, DNA, proteins, and other biological entities having magnetic particles labeled or tethered thereto are provided. Methods of manipulating, transporting, and sorting micro- or nano-scale particles are described.
摘要翻译：诸如纳米或微线网络的磁阵列平台，其产生微尺度或纳米尺度颗粒如磁性颗粒和细胞，病毒，DNA，蛋白质和其他生物实体的非生物实体的捕获，操纵和传输提供标记或束缚的磁性颗粒。描述了操作，运输和分选微尺度或纳米尺度颗粒的方法。

2. 发明申请

US20110272282A1 SYSTEMS AND METHODS FOR ENHANCED SCODA 审中-公开
标题翻译：用于增强SCODA的系统和方法
公开(公告)号：US20110272282A1
公开(公告)日：2011-11-10
申请号：US13128387
申请日：2009-11-10
申请人： Andrea Marziali , David John Broemeling , Joel Pel , Jason Donald Thompson , Jaryn Perkins , Thomas Willis , Herbert Heyneker , Darren Gray , Carolina Tropini
发明人： Andrea Marziali , David John Broemeling , Joel Pel , Jason Donald Thompson , Jaryn Perkins , Thomas Willis , Herbert Heyneker , Darren Gray , Carolina Tropini
IPC分类号： C07K1/26 , C25B9/00
CPC分类号： C07K1/24 , B01D57/02 , C12N15/101 , C12Q1/6806 , C12Q2565/125 , C12Q2525/125
摘要： Methods and apparatus for concentrating particles may be applied, for example, to concentrating DNA, RNA, proteins and the like. Proteins may be pre-treated to facilitate concentration by scodaphoresis. The pre-treatment may comprise, for example, heating or chemical treatment to denature and/or apply a net charge to the protein, binding handle particles to the protein and combinations thereof. High-conductivity samples may be subjected to a conductivity-reduction step to facilitate electrical injection of target particles into scodaphoresis media. The conductivity-reduction step may comprise a buffer exchange process or a salt extraction process, for example. Methods and apparatus can allow two or more different types of target particles to be extracted from the same sample and separately concentrated. These various aspects may be applied individually or in any combination.
摘要翻译：用于浓缩颗粒的方法和装置可以用于例如浓缩DNA，RNA，蛋白质等。可以预先处理蛋白质以促进通过scopaphoresis的浓缩。预处理可以包括例如加热或化学处理以使蛋白质变性和/或施加净电荷，将手段颗粒结合到蛋白质及其组合。可以对高电导率样品进行电导率降低步骤，以便于将目标颗粒电注射到电泳培养基中。导电性降低步骤可以包括例如缓冲液交换过程或盐提取过程。方法和装置可以允许从相同样品中提取两种或更多种不同类型的靶颗粒，并分别浓缩。这些各个方面可以单独地或以任何组合应用。

3. 发明授权

US07641778B2 Gel electroelution and sample separation devices and associated processes 失效
标题翻译：凝胶电洗脱和样品分离装置及相关工艺
公开(公告)号：US07641778B2
公开(公告)日：2010-01-05
申请号：US11655440
申请日：2007-01-19
申请人： James H. Lenke , Matthew Powell
发明人： James H. Lenke , Matthew Powell
IPC分类号： G01N27/447
CPC分类号： C07K1/24 , C07K1/26 , G01N27/4473 , H01J49/165
摘要： A gel electroelution device can have a gel spot column having upstream and downstream openings in fluid communication with an inlet and outlet, respectively. The gel spot column receives a gel spot and negative and positive electrodes are fluid communication with the inlet and outlet, respectively. A gel electroelution process can involve flowing a buffer solution through the gel spot in a first direction, and creating an electric field across the gel spot in the same direction. A separator device can have a generally cylindrical collection reservoir in fluid communication with inlet, filtrate, and retentate ports, a filter intermediate the inlet and filtrate ports. The inlet and retentate ports can intersect the collection reservoir in a manner to induce a cyclonic flow. A flow separation process can involve inducing a generally cyclonic flow in the collection reservoir, and filtering the fluid therein to retain the retentate.
摘要翻译：凝胶电洗脱装置可以具有分别具有与入口和出口流体连通的上游和下游开口的凝胶点色柱。凝胶点柱接收凝胶点，负极和正极分别与入口和出口流体连通。凝胶电洗脱过程可以包括使缓冲溶液沿着第一方向流过凝胶点，并且在相同方向上在凝胶点上产生电场。分离器装置可以具有与入口，滤液和滞留物端口流体连通的大致圆柱形的收集容器，在入口和滤液端口之间的过滤器。入口和滞留端口可以以引起气旋流的方式与收集容器相交。流动分离过程可以包括在收集容器中诱导一般气旋流，并且过滤其中的流体以保留滞留物。

4. 发明申请

US20080272001A1 PRODUCTION LINE TREATMENT FOR ORGANIC PRODUCT 审中-公开
标题翻译：生产线处理有机产品
公开(公告)号：US20080272001A1
公开(公告)日：2008-11-06
申请号：US12173908
申请日：2008-07-16
申请人： Li Zhang , Yongchang Zheng , Russell J. MacDonald , Yuander A. Ju (aka Alex Ju)
发明人： Li Zhang , Yongchang Zheng , Russell J. MacDonald , Yuander A. Ju (aka Alex Ju)
IPC分类号： G01N27/26
CPC分类号： B01D61/46 , B01D61/445 , C07K1/24 , C12M47/12
摘要： A fluid from a fermentation process or the like is passed or circulated through chambers of a bipolar membrane electrodialysis unit to separate an ionizable organic acid stream and at least one co-ion or residual stream. The organic acid stream is preferably concentrated (e.g., by recirculation, dewatering or both), and a product is recovered from the concentrated stream, for example by crystallization, and other outputs from the electrodialysis unit may be integrated with overall treatment and applied elsewhere in the treatment system. Depleted feed may be returned upstream to enhance yield, condition the medium or form a by-product. Treatment systems of the invention may replace a cation exchange bed and/or various filter arrangements, and recirculation of the feed and product flows through the unit enhance recovery, separation and quality of the target species. An ED chamber may include a filling of ion exchange beads to maintain a desired operating efficiency as the feed is depleted, and the straight-through operation effectively operates as pre-filtration stage to provide downstream product-bearing flows with processing characteristics for enhanced treatment, recovery and product quality. When operated to treat a downstream waste, systems allow additional recovery of value in the form of product, unexpended nutrients, co-factors and/or other components present in the waste.
摘要翻译：来自发酵过程等的流体通过或循环通过双极膜电渗析装置的室，以分离出可电离的有机酸流和至少一种共离子或残余流。优选浓缩有机酸流（例如通过再循环，脱水或两者），并且例如通过结晶从浓缩物流中回收产物，并且来自电渗析装置的其它输出可以与整体处理相结合并在其它地方应用治疗系统。消耗的饲料可以向上游返回以提高产量，调节培养基或形成副产物。本发明的处理系统可以替代阳离子交换床和/或各种过滤器装置，并且通过该单元的进料和产物流的再循环增强了目标物种的回收，分离和质量。 ED室可以包括填充离子交换珠以在进料耗尽时保持期望的操作效率，并且直通操作有效地作为预过滤阶段进行操作以提供具有用于增强处理的加工特性的下游产品流动流，恢复和产品质量。当操作处理下游废物时，系统允许以产品，未用的营养物，辅因子和/或废物中存在的其他成分的形式额外回收价值。

5. 发明申请

US20070221861A1 Electrospray ionization process and add-on device with sample injection tip 失效
标题翻译：电喷雾电离过程和带有样品注射头的附加装置
公开(公告)号：US20070221861A1
公开(公告)日：2007-09-27
申请号：US11642413
申请日：2006-12-20
申请人： James H. Lenke , Matthew Powell
发明人： James H. Lenke , Matthew Powell
IPC分类号： H01J49/00
CPC分类号： C07K1/24 , C07K1/26 , G01N27/4473 , H01J49/165 , H01J49/167
摘要： A process for ionizing a liquid can comprising flowing the liquid through a capillary wire bonding tip and applying sufficient voltage to electrospray the liquid sample as it exits therefrom. The electrospray ionization process can further involve passing a liquid sample through an axially disposed aperture in a ceramic capillary wire bonding tip in which the terminus of the aperture flares into a bell-shape where the liquid sample exits therefrom. An add-on device can include gel electroelution and separating devices, and a ceramic capillary sample injection tip for carrying out the aforesaid electrospray ionization process. An adjustably mounted cartridge can also be provided with the add-on device for interchangeably receiving the ceramic capillary sample injection tip.
摘要翻译：一种用于电离液体罐的方法，包括使液体流过毛细管线接合尖端并施加足够的电压，以使液体样品从其离开时电喷雾。电喷雾离子化过程还可以包括使液体样品通过陶瓷毛细管引线接合尖端中的轴向设置的孔，其中孔的末端在其中液体样品从其中出来的钟形状中闪烁。附加装置可以包括凝胶电洗脱和分离装置，以及用于进行上述电喷雾离子化过程的陶瓷毛细管样品注射尖端。可调节安装的盒还可以设置有用于可互换地接收陶瓷毛细管样品注射尖端的附加装置。

6. 发明申请

US20070221834A1 Gel electroelution and sample separation devices and associated processes 失效
标题翻译：凝胶电洗脱和样品分离装置及相关工艺
公开(公告)号：US20070221834A1
公开(公告)日：2007-09-27
申请号：US11655440
申请日：2007-01-19
申请人： James H. Lenke , Matthew Powell
发明人： James H. Lenke , Matthew Powell
IPC分类号： H01J49/00
CPC分类号： C07K1/24 , C07K1/26 , G01N27/4473 , H01J49/165
摘要： A gel electroelution device can have a gel spot column having upstream and downstream openings in fluid communication with an inlet and outlet, respectively. The gel spot column receives a gel spot and negative and positive electrodes are fluid communication with the inlet and outlet, respectively. A gel electroelution process can involve flowing a buffer solution through the gel spot in a first direction, and creating an electric field across the gel spot in the same direction. A separator device can have a generally cylindrical collection reservoir in fluid communication with inlet, filtrate, and retentate ports, a filter intermediate the inlet and filtrate ports. The inlet and retentate ports can intersect the collection reservoir in a manner to induce a cyclonic flow. A flow separation process can involve inducing a generally cyclonic flow in the collection reservoir, and filtering the fluid therein to retain the retentate.
摘要翻译：凝胶电洗脱装置可以具有分别具有与入口和出口流体连通的上游和下游开口的凝胶点色柱。凝胶点柱接收凝胶点，负极和正极分别与入口和出口流体连通。凝胶电洗脱过程可以包括使缓冲溶液沿着第一方向流过凝胶点，并且在相同方向上在凝胶点上产生电场。分离器装置可以具有与入口，滤液和滞留物端口流体连通的大致圆柱形的收集容器，在入口和滤液端口之间的过滤器。入口和滞留端口可以以引起气旋流的方式与收集容器相交。流动分离过程可以包括在收集容器中诱导一般气旋流，并且过滤其中的流体以保留滞留物。

7. 发明授权

US07041208B2 Microfluidic devices and methods for two-dimensional separations 失效
标题翻译：用于二维分离的微流体装置和方法
公开(公告)号：US07041208B2
公开(公告)日：2006-05-09
申请号：US10317148
申请日：2002-12-11
申请人： Sau Lan Tang Staats
发明人： Sau Lan Tang Staats
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N30/92 , B01L3/502707 , B01L3/502753 , B01L2200/0689 , B01L2200/12 , B01L2300/0822 , B01L2300/0874 , B01L2300/0887 , B01L2400/0421 , B01L2400/0487 , B01L2400/086 , C07K1/24 , C07K1/285 , G01N27/44773 , G01N30/6026 , G01N30/6095 , G01N30/90 , G01N30/463
摘要： A microfluidic device includes first and second substrates and a microfluidic cavity formed in one of the first and second substrates. The microfluidic cavity has a width (W) and a depth (D), wherein the other of the first and second substrates encloses the microfluidic cavity and a width (W) to depth (D) ratio is at least 100 with the depth (D) being from about 10 μm to about 150 μm. The device also includes a plurality of ports formed in the other of the first and second substrates to permit access to the microfluidic cavity and a third substrate disposed on the second substrate and including microchannels formed therein. The microchannels are formed so that a plurality of ports formed in the second substrate for sample selection and sample output communicate therewith.
摘要翻译：微流体装置包括第一和第二基底和形成在第一和第二基底之一中的微流体腔。微流体空腔具有宽度（W）和深度（D），其中第一和第二基板中的另一个包围微流体空腔，宽度（W）至深度（D）的比率至少为100，深度（D ）为约10um至约150mum。该装置还包括形成在第一和第二基板中的另一个中的多个端口，以允许访问微流体空腔，以及设置在第二基板上并包括形成在其中的微通道的第三基板。微通道形成为使得形成在第二基板中的用于样品选择和样品输出的多个端口与其通信。

8. 发明授权

US06925390B2 Customized microfluidic device design, ordering, and manufacturing 失效
标题翻译：定制的微流体设备设计，订购和制造
公开(公告)号：US06925390B2
公开(公告)日：2005-08-02
申请号：US10164022
申请日：2002-06-06
申请人： Sau Lan Tang Staats
发明人： Sau Lan Tang Staats
IPC分类号： B01L3/00 , B01L3/02 , B01L9/00 , B29C67/00 , B81B1/00 , B81C3/00 , B81C99/00 , C07K1/24 , C40B60/14 , G01N27/447 , G01N30/28 , G01N30/60 , G01N30/90 , G01N30/92 , G01N35/10 , H01J49/04 , G06F11/00
CPC分类号： H01J49/04 , B01J2219/0036 , B01L3/0241 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L9/527 , B01L2200/021 , B01L2200/027 , B01L2200/0689 , B01L2200/12 , B01L2300/0822 , B01L2300/0874 , B01L2300/0887 , B01L2400/027 , B01L2400/0421 , B01L2400/0481 , B01L2400/0487 , B29C64/386 , B81B2201/058 , B81C99/006 , C07K1/24 , C40B60/14 , G01N27/44773 , G01N27/44782 , G01N27/44791 , G01N30/6026 , G01N30/6095 , G01N30/90 , G01N30/92 , G01N35/1074 , G01N2030/285 , G01N2035/1039 , G01N30/463
摘要： Processes and systems are described for designing microfluidic devices, via an interactive process involving communication between a requestor and a provider over an electronic network.
摘要翻译：描述了通过涉及在电子网络上的请求者和提供者之间的通信的交互过程来设计微流体设备的过程和系统。

9. 发明申请

US20040100268A1 Method and apparatus for separating biological molecules 失效
标题翻译：用于分离生物分子的方法和装置
公开(公告)号：US20040100268A1
公开(公告)日：2004-05-27
申请号：US10450498
申请日：2003-11-17
发明人： Giles Hugo William Sanders , John Hassard , Stuart Hassard , Dimitrios Sideris
IPC分类号： G01N027/60
CPC分类号： G01N27/44795 , C07K1/24 , C07K1/28 , G01N27/44773
摘要： A system for separating biological molecules includes a chip (10) on which there is an electrophoresis separation microchannel (16). At the start of the channel there is an isoelectric focusing section (14) containing a gel having a pH gradient. Molecules to be separated are placed in the focusing section (14) and move to an equilibrium position under the influence of an electric field. The electrophoretic state of the molecules is then changed, and a high voltage potential applied across the entire length of the focusing and separation sections. The molecules migrate under the influence of the electric field from the focusing section into the separation section where their position and velocity are tracked. From a knowledge of position and velocity, a user can determine both charge/mass ratio and isoelectric equilibrium point for each molecule. The gels can be replicated in the chip to allow parallel analysis, and hence comparisons, to take place.
摘要翻译：用于分离生物分子的系统包括其上存在电泳分离微通道（16）的芯片（10）。在通道的开始处，存在含有具有pH梯度的凝胶的等电聚焦部分（14）。要分离的分子被放置在聚焦部分（14）中并在电场的影响下移动到平衡位置。然后改变分子的电泳状态，并且在聚焦和分离部分的整个长度上施加高电压电位。分子在电场的影响下从聚焦部分迁移到其位置和速度被跟踪的分离部分。根据位置和速度的知识，用户可以确定每个分子的电荷/质量比和等电点平衡点。凝胶可以在芯片中复制，以便进行并行分析，从而进行比较。

10. 发明授权

US11642671B2 Electrowetting on dielectric (EWOD) device to perform liquid-to-liquid extraction (LLE) of biomolecules and systems and methods for using the EWOD device 有权
公开(公告)号：US11642671B2
公开(公告)日：2023-05-09
申请号：US17850242
申请日：2022-06-27
申请人： Board of Regents, The University of Texas System
发明人： Hyejin Moon , Shubhodeep Paul
IPC分类号： B01L3/00 , C07K1/24 , B01D11/04
CPC分类号： B01L3/50273 , B01D11/0496 , B01L3/502784 , C07K1/24 , B01L2400/0427
摘要： A method and system for performing biomolecule extraction are provided that use liquid-to-liquid extraction (LLE) in combination with an electrowetting on dielectric (EWOD) device to provide a biomolecule extraction solution that has high extraction efficiency and that is less costly and easier to use than current state of the art methods and systems. The system and method are well suited for, but not limited to, extraction of DNA, RNA and protein molecules.

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