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1. 发明申请

US20190170707A1 TWO-DIMENSIONAL LIQUID CHROMATOGRAPHIC ANALYZER 审中-公开
公开(公告)号：US20190170707A1
公开(公告)日：2019-06-06
申请号：US16267929
申请日：2019-02-05
申请人： HITACHI HIGH-TECH SCIENCE CORPORATION
发明人： Katsutoshi SHIMIZU , Hideko KANAZAWA
IPC分类号： G01N30/30 , G01N30/54 , G01N30/46
CPC分类号： G01N30/30 , G01N30/463 , G01N30/54 , G01N2030/3007
摘要： A two-dimensional liquid chromatographic analyzer, in which a temperature control part changes a temperature in a single-step manner and switches the temperature at a high speed. Also, the temperature control part has a holder around a separation column so that the temperature of the separation column can be changed to a preset temperature. A first separation column thereof changes elution time(s) of the objective component(s) by temperature modulation and the mobile phase of the first separation column is an aqueous mobile phase having a constant composition.

2. 发明申请

US20180259495A1 TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY 审中-公开
公开(公告)号：US20180259495A1
公开(公告)日：2018-09-13
申请号：US15913043
申请日：2018-03-06
申请人： The Board of Regents of the University of Oklahoma
发明人： Shaorong Liu , Zaifang Zhu
IPC分类号： G01N30/60 , C07K1/16 , G01N33/68 , G01N1/40 , G01N30/16
CPC分类号： G01N30/6034 , C07K1/16 , C07K1/165 , G01N1/4077 , G01N30/16 , G01N30/463 , G01N30/466 , G01N33/6842 , G01N35/1097 , G01N2030/027
摘要： A two-dimensional liquid chromatography (2D-LC) apparatus and method of its use, the apparatus constructed with (1) a first dimension (first-D) having at least one first chromatography column, (2) at least one multi-port stream selector in fluid communication with the at least one first chromatography column for receiving an effluent therefrom, and (3) a second dimension (second-D) having a plurality of second chromatography columns, each second chromatography column in fluid communication with a corresponding port of the at least one multi-port stream selector for receiving an effluent fraction of the effluent from the at least one first chromatography column, thereby enabling simultaneous chromatographic separation by the plurality of second chromatography columns of a set of multiple effluent fractions outputted from the at least one first chromatography column.

3. 发明申请

US20180196019A1 MODIFIER STREAM ELUTION OF TRAP COLUMN FOR MULTIDIMENSIONAL COMPRESSIBLE FLUID-BASED CHROMATOGRAPHY 审中-公开
公开(公告)号：US20180196019A1
公开(公告)日：2018-07-12
申请号：US15850146
申请日：2017-12-21
申请人： Waters Technologies Corporation
发明人： Michael O. Fogwill , Isabelle François
IPC分类号： G01N30/26 , G01N30/60
CPC分类号： G01N30/26 , G01N30/20 , G01N30/34 , G01N30/462 , G01N30/463 , G01N30/465 , G01N30/60 , B01D15/40
摘要： A method of performing a chromatographic separation includes modulating a portion of a flowstream to a trap column to retain at least one analyte from the flowstream on the trap column. A flow of a modifier is provided through the trap column to generate an elution comprising the at least one analyte. A flow of a compressible fluid-based chromatography (CFC) mobile phase or CFC solvent is merged with the elution from the trap column to generate a diluted elution. Carbon dioxide may be used as the CFC solvent or as a component of the CFC mobile phase. The diluted elution is provided to a CFC column where at least one analyte is focused at a head of the CFC column. Examples of a flowstream that may be used include an eluent from a chromatography column or a fluid flow from an extraction system.

4. 发明申请

US20180161718A1 FLUIDIC DEVICES AND METHODS USING THEM 审中-公开
公开(公告)号：US20180161718A1
公开(公告)日：2018-06-14
申请号：US15694882
申请日：2017-09-04
申请人： PERKINELMER HEALTH SCIENCES, INC.
发明人： Andrew Tipler
IPC分类号： B01D53/04 , G01N30/46 , G01N30/62 , G01N30/72 , G01N30/32 , G01N30/60
CPC分类号： B01D53/0446 , G01N30/463 , G01N30/465 , G01N30/6095 , G01N30/62 , G01N30/72 , G01N2030/328 , Y10T137/877
摘要： Certain embodiments described herein are directed to chromatography systems that include a microfluidic device configured to provide three-way switching or switching between three or more inputs or outputs. The microfluidic device can be fluidically coupled to one or more switching valves to provide for selective control of fluid flow in the chromatography system.

5. 发明申请

US20180128720A1 LIQUID PHASE CHROMATOGRAPH 审中-公开
公开(公告)号：US20180128720A1
公开(公告)日：2018-05-10
申请号：US15531706
申请日：2014-11-27
申请人： Hunun Demeter Instruments Co. Ltd.
发明人： Feng Wang
IPC分类号： G01N1/34 , G01N30/20 , G01N30/60 , G01N30/88 , B01D15/16 , B01D15/42 , G01N35/10
CPC分类号： G01N1/34 , B01D15/163 , B01D15/426 , G01N30/20 , G01N30/40 , G01N30/463 , G01N30/465 , G01N30/6039 , G01N30/88 , G01N35/1097 , G01N2030/027 , G01N2030/402
摘要： A liquid chromatography having an on-line cleaning function, comprising a first flow channel (L3), a second flow channel (L21), an analysis flow channel (L22) and waste liquid flow channels, further comprising a cleaning flow channel (L25), a direction switch valve (V1) and a multi-flow channel switch valve (V2), etc. The liquid chromatography changes the flow path of the liquid by changing the communication relationship between the two-position switch valves, thus realizes the on-line cleaning function for a first chromatographic column (C1), a middle chromatographic column (C2), a filter or a protector (B2) respectively, and realize the simultaneous on-line cleaning function for the first chromatographic column (C1) and the middle chromatographic column (C2).

6. 发明申请

US20170131244A1 SECONDARY STAGE FLUID SEPARATION DEVICE DETACHABLY CONNECTABLE WITH PRIMARY STAGE FLUID SEPARATION DEVICE 审中-公开
公开(公告)号：US20170131244A1
公开(公告)日：2017-05-11
申请号：US15320123
申请日：2014-06-25
申请人： Agilent Technologies, Inc.
发明人： Klaus Witt , Stephan Buckenmaier , Konstantin Shoykhet
IPC分类号： G01N30/46 , B01D15/18
CPC分类号： G01N30/463 , B01D15/1878 , G01N30/32 , G01N30/465 , G01N30/88 , G01N2030/322 , G01N2030/8881
摘要： A secondary stage sample separation device for separating at least a portion of a fluidic sample includes a fluidic interface configured for forming a detachable fluidic coupling between a primary stage sample separation device and the secondary separation device so that the fluidic sample separated by the primary stage sample separation device is fluidically supplyable to the secondary stage sample separation device via the fluidic interface for further separation, wherein the secondary stage sample separation device is further configured for separating at least a portion of the supplied fluidic sample independent of a flow rate of the fluidic sample supplied from the primary stage sample separation device at the fluidic interface.

7. 发明申请

US20170074841A1 METHOD OF AND APPARATUS FOR FORMULATING MULTICOMPONENT DRUG 审中-公开
公开(公告)号：US20170074841A1
公开(公告)日：2017-03-16
申请号：US15344833
申请日：2016-11-07
申请人： TSUMURA & CO.
发明人： Yoshikazu MORI , Keiichi NODA , Bunsho MAKINO
IPC分类号： G01N30/86 , G01N33/15 , G06F19/00 , G01N30/74
CPC分类号： G01N30/8686 , G01N30/463 , G01N30/8624 , G01N30/8675 , G01N30/8679 , G01N33/15 , G01N2030/8886 , G06F19/703 , G06F19/707 , G06K9/00543
摘要： Provided are a method of and an apparatus for formulating a multicomponent drug capable of surely making a multicomponent drug meeting criteria for productization with high accuracy into a product. The method and apparatus obtain a chromatogram from an extract or a base of a multicomponent drug, evaluate whether the base meets the criteria for productization based on the obtained chromatogram with high accuracy, and subject the base determined in the high-accuracy evaluating as an accepted one meeting the criteria to dosage form processing, to produce a formulated drug having a given dosage form. The high quality evaluation is realized by performing peak assignment of a target fingerprint obtained from a chromatogram to a reference fingerprint with high accuracy.

8. 发明授权

US09341604B2 Devices and methods for adaptive micro-gas chromatography 有权
标题翻译：适应性微气相色谱的装置和方法
公开(公告)号：US09341604B2
公开(公告)日：2016-05-17
申请号：US14357157
申请日：2012-11-08
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： Xudong Fan , Yogesh B. Gianchandani , Jing Liu
IPC分类号： G01N30/46 , G01N30/60 , G01N30/72
CPC分类号： G01N30/461 , G01N30/46 , G01N30/463 , G01N30/465 , G01N30/466 , G01N30/468 , G01N30/6095 , G01N30/72
摘要： The present disclosure provides adaptive methods for gas chromatography analysis of a gas sample comprising one or more target analytes (such as a micro-gas chromatography) and adaptive gas chromatography devices for carrying out such analytical methods. Broadly, the system can regulate flow into a downstream chromatographic column by detecting one or more upstream conditions. For example, one adaptive chromatography device comprises a first column, a modulator component, and a second column. A first detector or sensor detects the presence of target analytes upstream from the second column, while a second detector detects the presence of target analytes eluted from the second column. The modulator component assembly is responsive to an output generated by the first detector and adaptively regulates fluid flow into the second column. Such adaptive chromatography (micro-GC) systems have higher separation speed, better analyte identification capability, and far greater energy savings.
摘要翻译：本公开提供了用于气体样品的气相色谱分析的自适应方法，所述气体样品包含一种或多种靶分析物（例如微气相色谱）和用于进行这种分析方法的适应性气相色谱装置。通常，系统可以通过检测一个或多个上游条件来调节流入下游色谱柱的流量。例如，一个自适应色谱装置包括第一列，调制器组件和第二列。第一检测器或传感器检测来自第二列上游的目标分析物的存在，而第二检测器检测从第二列洗脱的目标分析物的存在。调制器部件组件响应于由第一检测器产生的输出并且自适应地调节流入第二列的流体流。这种自适应色谱（micro-GC）系统具有更高的分离速度，更好的分析物识别能力和更大的能量节省。

9. 发明申请

US20160131619A1 VALVE AND SPLITTING SYSTEM FOR MULTI-DIMENSIONAL LIQUID ANALYSIS 审中-公开
标题翻译：用于多维液体分析的阀和分离系统
公开(公告)号：US20160131619A1
公开(公告)日：2016-05-12
申请号：US14996784
申请日：2016-01-15
申请人： Regents of the University of Minnesota
发明人： Carl W. Sims , Peter W. Carr , Marcelo Roberto Filgueira , Klaus Witt
IPC分类号： G01N30/46 , G01N30/32 , G01N30/10
CPC分类号： G01N30/463 , G01N30/10 , G01N30/32 , G01N30/465 , G01N30/7233 , G01N2030/324
摘要： A multi-dimensional liquid analysis system includes a flow splitter for separating mobile phase outflow from a first dimension liquid analysis system into fist and second liquid split outlet flows. Volumetric flow rate control of the split outlet flows is provided by a flow control pump which withdraws one of the split outlet flows from the flow splitter at a controlled withdrawal flow rate to define the other split outlet flow rate as the difference between the outflow rate from the first dimension system and the withdrawal flow rate. In this manner, accurate and consistent flow division can be accomplished, which is particularly useful for multi-dimensional liquid analysis.
摘要翻译：多维液体分析系统包括分流器，用于将流动相流出物与第一维液体分析系统分离成第一和第二液体分流出口流。分流出口流量的体积流量控制由流量控制泵提供，流量控制泵以受控的排出流量从分流器中抽出一个分流出口流，以将另一个分流出口流量定义为流出速率第一维系统和提取流量。以这种方式，可以实现精确和一致的流动分配，这对于多维液体分析特别有用。

10. 发明申请

US20150346171A1 DATA PROCESSING DEVICE FOR COMPREHENSIVE TWO-DIMENSIONAL CHROMATOGRAPH 审中-公开
标题翻译：用于全面二维色谱的数据处理设备
公开(公告)号：US20150346171A1
公开(公告)日：2015-12-03
申请号：US14438259
申请日：2012-10-25
申请人： SHIMADZU CORPORATION
发明人： Megumi HIROOKA
IPC分类号： G01N30/86
CPC分类号： G01N30/8651 , G01N30/463 , G01N30/8675 , G01N2030/8854
摘要： In a GC×GC data processor (23), a modulation time estimation unit (24) creates a one-dimensional chromatogram from chromatogram data items collected by a comprehensive two-dimensional GC, and retrieves a shift time on which a peak position after an entire curve of the chromatogram being shifted in a temporal axis direction coincides with a peak position of the peak on the original chromatogram. Since the resolution of a primary column (12) is low, the same compound is introduced into a secondary column (14) in consecutive modulation times. Accordingly, on the one-dimensional chromatogram, peaks originating from the same compound appear in the respective consecutive modulation times. The interval between the peaks substantially coincides with the modulation time. Therefore, the shift time retrieved as described above is regarded as the modulation time. Thus, the modulation time is automatically estimated from the chromatogram data items, thereby negating the need of user input or capture from an analysis control unit (3).
摘要翻译：在GC×GC数据处理器（23）中，调制时间估计单元（24）从通过综合二维GC收集的色谱图数据项创建一维色谱图，并且检索在其之后的峰值位置色谱图在时间轴方向上移动的整个曲线与原始色谱图上的峰的峰位置一致。由于主列（12）的分辨率低，所以在连续调制时间内将相同的化合物引入第二列（14）。因此，在一维色谱图上，源自相同化合物的峰出现在相应的连续调制时间内。峰之间的间隔基本上与调制时间一致。因此，如上所述检索的移位时间被认为是调制时间。因此，从色谱数据项自动地估计调制时间，从而不需要用户从分析控制单元（3）输入或捕获。

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