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1. 发明申请

US20190017915A1 METHOD AND APPARATUS FOR MEASURING GEL PARTICLE 审中-公开
公开(公告)号：US20190017915A1
公开(公告)日：2019-01-17
申请号：US16066479
申请日：2016-12-26
申请人： PROJECT KBF CO., LTD.
发明人： Toru OBATA , Juichiro UKON
IPC分类号： G01N15/06 , G01N21/82 , G01N21/51
CPC分类号： G01N15/06 , G01N21/51 , G01N21/82 , G01N2015/0053 , G01N2015/0693 , G01N2021/0325 , G01N2021/4709
摘要： Provided is a gel particle measuring apparatus for detecting scattered light generated by light irradiation at a production start time point of a gel particle, and performing measurement promptly and accurately while suppressing attenuation of the scattered light in a solvent in which the phenomenon occurs. The gel particle measuring apparatus includes: a sample cell (1) configured to accommodate a sample (S) and a solution containing a reagent (R); a stirrer (2) configured to continuously stir a mixed solution (W) in the sample cell (1); a light source (3) configured to irradiate the mixed solution (W) in the sample cell (1) with coherent irradiation light (Bm); a backscattered light detector (4) configured to detect, out of light scattered in the mixed solution (W) in the sample cell (1), a backscattered light component returning toward the light source (3); a light path adjuster (5) configured to adjust an incident portion surface of the sample cell (1) so that a detection light path (ST) of, out of the light scattered in the mixed solution (W) in the sample cell (1), light traveling toward the backscattered light detector (4) is different from a reflection light path (DT) of reflection light (Bm0) reflected from a surface of the sample cell (1); and a measurement device (6) configured to determine at least a production start time point of the gel particle (G) in the mixed solution (W) based on a detection output of the backscattered light detector (4).

2. 发明申请

US20180120292A1 BLOOD COAGULATION ANALYSIS METHOD, BLOOD COAGULATION ANALYZER, AND COMPUTER PROGRAM 审中-公开
公开(公告)号：US20180120292A1
公开(公告)日：2018-05-03
申请号：US15795383
申请日：2017-10-27
申请人： SYSMEX CORPORATION
发明人： Merin THOMAS , Keiichi YAMAGUCHI , Hiroshi KURONO
IPC分类号： G01N33/49 , G01N33/487 , G01N21/59
CPC分类号： G01N33/4905 , G01N21/59 , G01N21/82 , G01N33/48792 , G01N33/86 , G01N2201/062 , G01N2201/12 , G01N2333/7454
摘要： A blood coagulation analysis method according to an embodiment includes: calculating blood coagulation time based on data which represents a coagulation curve indicating a temporal change in an optical detection value of a blood specimen added with a measurement reagent; and determining an early reaction error by using a result of determination of conformity between a shape of the coagulation curve represented by the data and a shape of a reference coagulation curve.

3. 发明授权

US09696329B2 Automatic analyzer 有权
公开(公告)号：US09696329B2
公开(公告)日：2017-07-04
申请号：US14402906
申请日：2013-05-24
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Akihisa Makino , Hajime Yamazaki , Keiko Yoshikawa , Manabu Ando , Masahiko Iijima
IPC分类号： G01N35/02 , G01N35/10 , G01N33/86 , G01N21/82 , G01N21/11 , G01N35/00 , G01N35/04
CPC分类号： G01N35/025 , G01N21/11 , G01N21/82 , G01N33/86 , G01N35/00584 , G01N35/00693 , G01N35/0092 , G01N35/1004 , G01N2021/115 , G01N2035/00425 , G01N2035/00673 , G01N2035/0094 , G01N2035/0097 , G01N2035/0437 , G01N2035/0453
摘要： A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.

4. 发明申请

US20170184579A1 DIGITAL CONTROL OF ON-CHIP MAGNETIC PARTICLE ASSAY 审中-公开
公开(公告)号：US20170184579A1
公开(公告)日：2017-06-29
申请号：US15456049
申请日：2017-03-10
申请人： Silicon BioDevices, Inc.
发明人： Octavian FLORESCU , Daniel WONG , Tracie MARTIN , Duane YAMASAKI , Remy CROMER
IPC分类号： G01N33/543 , C12Q1/68 , G06K19/06 , B01L3/00
CPC分类号： G01N33/54326 , B01L3/502761 , B01L3/561 , B01L2200/0605 , B01L2200/0668 , B01L2200/148 , B01L2200/16 , B01L2300/023 , B01L2300/027 , B01L2300/0636 , B01L2300/0838 , B01L2300/0874 , B01L2300/12 , B01L2400/0406 , B01L2400/043 , C12Q1/686 , G01N21/255 , G01N21/82 , G01N27/745 , G01N2201/061 , G01N2201/068 , G06F21/602 , G06K19/06028 , G06K19/06037 , G16H50/20 , Y02A90/26
摘要： An assay system and method for use in the field of chemical testing is disclosed. The assay system can be used for filtering whole blood for testing on an integrated circuit containing digital control functionality.

5. 发明申请

US20170122943A1 METHOD FOR ASSAYING CREATINE KINASE MB ISOZYME AND KIT TO BE USED THEREIN 审中-公开
公开(公告)号：US20170122943A1
公开(公告)日：2017-05-04
申请号：US15301847
申请日：2015-04-13
申请人： WAKO PURE CHEMICAL INDUSTRIES, LTD.
发明人： Kazuma HANAI , Shinichi ODAGAKI , Tsutomu MASUDA
IPC分类号： G01N33/573 , G01N21/82 , G01N33/545
CPC分类号： G01N33/573 , G01N21/82 , G01N33/543 , G01N33/545 , G01N2333/9123
摘要： The invention provides a method for measuring CK-MB in a sample by reacting the sample with a first antibody against CK-MB, a second antibody against CK-MB which recognizes an epitope different from that recognized by the first antibody, and an anti-CK-B antibody which recognizes a region of the 1st to 100th amino acid from N-terminus of the amino acid sequence of the subunit B of creatine kinase (step 1); measuring an optical change generated by the reaction (step 2); and determining a quantity of CK-MB in the sample on the basis of the result obtained in the step 2 (step 3). The invention also provides a kit to be used in the method, and a method for avoiding influence of creatine kinase BB isozyme in measuring CK-MB, comprising treating a sample with the anti-CK-B antibody.

6. 发明申请

US20170122930A1 OPTICAL THROMBOELASTOGRAPHY SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20170122930A1
公开(公告)日：2017-05-04
申请号：US15319093
申请日：2015-06-01
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： Seemantini K. Nadkarni , Zeinab Hajjarian , Markandey Tripathi , Diane Tshikudi
IPC分类号： G01N33/49 , B01L3/00 , G01N21/51 , G01N33/86
CPC分类号： G01N33/4905 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0864 , B01L2400/0487 , B01L2400/0688 , G01N11/00 , G01N15/00 , G01N21/272 , G01N21/51 , G01N21/82 , G01N33/86 , G01N2015/0092 , G01N2015/0222 , G01N2021/479 , G01N2021/825 , G01N2201/0221 , G01N2203/0094
摘要： Hand-held optical thromboelastographic sensor and method of using the same for simultaneous assessment of multiple parameters of blood coagulation at a point-of-care. The sensor includes an optical system registering laser speckle intensities associated with portions of a blood sample delivered through a fluid switch to analysis chambers of a cartridge of the sensor, and data-processing circuitry programmed to derive the multiple parameters from speckle intensity. The circuitry may be part of a mobile device configured to operate without communication with a central server and/or data storage.

7. 发明申请

US20160305889A1 METHOD FOR MEASURING CONCENTRATION OF TEST SUBSTANCE, AND DETECTION APPARATUS 审中-公开
标题翻译：测量物质浓度的方法和检测装置
公开(公告)号：US20160305889A1
公开(公告)日：2016-10-20
申请号：US15030183
申请日：2014-10-20
申请人： OSAKA UNIVERSITY
发明人： Hiroyuki YOSHIKAWA , Eiichi TAMIYA , Shuhei IMURA
IPC分类号： G01N21/82 , G01N21/78 , C12Q1/26
CPC分类号： G01N21/82 , C12Q1/26 , G01N21/78 , G01N33/535 , G01N33/581 , G01N2021/7773 , G01N2201/06113 , G01N2201/062 , G01N2333/904
摘要： The present invention provide a method for detecting a test substance utilizing a color development caused by an enzyme reaction, or a color development caused by a specific interaction such as an antigen-antibody reaction and an enzyme reaction, the test substance being detected rapidly, sensitively and quantitatively without using a spectroscopic measurement device. The method for measuring a concentration of a test substance by the present invention comprises the steps of: generating a peroxide from the test substance; obtaining a polymerized substance by bringing an oxidoreductase for producing a polymerized substance and a substrate of the oxidoreductase for producing a polymerized substance into contact with the peroxide; and irradiating the polymerized substance with light to record a temporal variation information of an intensity of scattered light generated from an irradiation point.
摘要翻译：本发明提供一种利用酶反应引起的显色或由抗原 - 抗体反应和酶反应等特定相互作用引起的显色检测检测物质的方法，检测物质被快速检测并且定量地不使用光谱测量装置。通过本发明测定被检物质的浓度的方法包括以下步骤：从测试物质产生过氧化物; 通过使生成聚合物质的氧化还原酶和用于制备聚合物质的氧化还原酶的底物与过氧化物接触来获得聚合物质; 并用光照射聚合物，记录从照射点产生的散射光的强度的时间变化信息。

8. 发明申请

US20160291039A1 Testing Device For Identifying Antigens And Antibodies In Biofluids 审中-公开
标题翻译：用于鉴定生物流体中的抗原和抗体的测试装置
公开(公告)号：US20160291039A1
公开(公告)日：2016-10-06
申请号：US15175477
申请日：2016-06-07
申请人： Monash University
发明人： Gil Garnier , Wei Shen , Mohidus Samad Khan , Xu Li , George Thouas
IPC分类号： G01N33/80 , G01N21/82 , G01N33/558
CPC分类号： G01N33/80 , G01N21/82 , G01N30/90 , G01N33/558 , G01N2021/752 , G01N2021/757 , G01N2021/825 , Y02A50/58
摘要： A testing device for identifying an antigen or antibody within a biofluid sample including: a substrate having a hydrophilic surface thereon; the surface including a collection zone, and at least one detection zone extending therefrom; wherein the biofluid sample can be mixed with a specific antigen or antibody, and deposited on the collection zone and transferred by capillary action to the detection zone; the antigen or antibody in the biofluid sample reacting with an appropriate said antibody or antigen thereby resulting in a visual indication within the detection zone.
摘要翻译：一种用于鉴定生物流体样品内的抗原或抗体的测试装置，包括：其上具有亲水表面的基底; 所述表面包括收集区，以及至少一个从其延伸的检测区; 其中所述生物流体样品可以与特定的抗原或抗体混合，并且沉积在所述收集区上并通过毛细作用转移到所述检测区; 生物流体样品中的抗原或抗体与合适的所述抗体或抗原反应，从而导致检测区内的视觉指示。

9. 发明授权

US09453798B2 Method for determination of system parameters for reducing crude unit corrosion 有权
标题翻译：确定减少粗单位腐蚀的系统参数的方法
公开(公告)号：US09453798B2
公开(公告)日：2016-09-27
申请号：US13095042
申请日：2011-04-27
申请人： Rodney H. Banks , Steven R. Ciota , Sascha J. Welz
发明人： Rodney H. Banks , Steven R. Ciota , Sascha J. Welz
IPC分类号： G01N1/34 , G01N21/80 , G01N21/83 , G01N21/77 , G01N21/64 , G01N21/78 , G01N33/28 , G01N35/08 , G01N17/00 , G01N21/82 , G01N31/22
CPC分类号： G01N21/77 , G01N1/34 , G01N17/00 , G01N21/6428 , G01N21/643 , G01N21/78 , G01N21/80 , G01N21/82 , G01N21/83 , G01N31/22 , G01N33/2835 , G01N35/08 , G01N2021/6421 , G01N2021/6432 , G01N2021/6441 , G01N2021/6491 , G01N2021/7786 , Y10T436/19 , Y10T436/25125
摘要： The invention provides a method and apparatus for determining the amount of various materials in a liquid sample. Because the apparatus is particularly resilient it can be used repeatedly with very harsh liquid samples such as boot water from an oil refinery. The apparatus uses at least one volume and/or concentration independent optical analysis method to determine at least one of: the pH, amount of chloride, and/or amount of iron in the sample. The optical property can be colorimetric, fluorescent or both and result from adding dyes, complexing agents, turbidity inducing compounds, and other optically effecting reagents to the sample. Because the measurements are concentration and volume independent they can be done continuously, quickly, and avoid the inconvenient start and stop procedures in prior art measurement regimens.
摘要翻译：本发明提供一种用于确定液体样品中各种材料的量的方法和装置。因为该装置特别弹性，所以可以用非常苛刻的液体样品反复使用，例如来自炼油厂的靴子水。该装置使用至少一种体积和/或浓度的光学分析方法来确定样品中的pH，氯化物量和/或铁量中的至少一种。光学特性可以是比色，荧光或两者，并且由添加染料，络合剂，浊度诱导化合物和其它光学效应试剂引起。因为测量是集中和体积独立的，所以它们可以连续，快速地完成，并且避免现有技术测量方案中不方便的启动和停止程序。

10. 发明授权

US09282260B2 Visualizing polynuclear aromatic hydrocarbons within the near infrared spectrum 有权
标题翻译：在近红外光谱范围内观察多核芳烃
公开(公告)号：US09282260B2
公开(公告)日：2016-03-08
申请号：US13849865
申请日：2013-03-25
申请人： Baker Hughes Incorporated
发明人： Marco Respini
IPC分类号： H04N5/33 , G01N21/359 , G01N21/64 , G01N21/82 , G02B21/00
CPC分类号： H04N5/33 , G01N21/359 , G01N21/6458 , G01N21/82 , G02B21/0004
摘要： Microscopy techniques may be used to visualize polynuclear aromatic hydrocarbons where an optical microscope is combined with an imaging device. The combination of these devices allows for images to be produced when visualized in the near infrared spectrum, such as a wavelength ranging from about 700 nm to about 2500 nm to be passed through the optical microscope.
摘要翻译：可以使用显微技术来观察多晶芳烃，其中光学显微镜与成像装置组合。这些装置的组合允许在近红外光谱（例如从约700nm至约2500nm的波长范围内）可视化时产生图像以通过光学显微镜。

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