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1. 发明申请

US20190204202A1 Non-Activated Platelet Transfusion Methods for Enhancement of Patient Treatment Outcomes 审中-公开
公开(公告)号：US20190204202A1
公开(公告)日：2019-07-04
申请号：US16209387
申请日：2018-12-04
申请人： Lightintegra Technology Inc.
发明人： Elisabeth Maurer , Daniel Millar
IPC分类号： G01N15/06 , A61K35/19
CPC分类号： G01N15/06 , A61K35/19 , G01N2015/0693
摘要： To reduce the complexity and risk associated with activated platelet transfusions, thrombocytopenic patients are transfused with exclusively non-activated platelets. A preferred embodiment is through routine screening of platelet units in the hospital blood bank using dynamic light scattering and selective allocation of platelets, with non-activated platelets being exclusively transfused to thrombocytopenic patients, especially patients with cancers such as hematologic malignancies. Activated platelets typically contain activated factors of the innate immune system called complement, transforming growth factor beta (TGFβ), interleukin 6 (IL-6), CD40 ligand (CD40L) and C-reactive protein (CRP) for example. Some of these activated factors have already been shown to correlate with microparticles and others are expected to correlate: the higher the platelet activation the more microparticles and the higher the concentration of these factors. By transfusing only non-activated platelets, therapeutic outcomes are enhanced.

2. 发明申请

US20190170724A1 DISTINGUISHING FLUIDS BASED UPON DETERMINATION AND ANALYSIS OF DIGITAL IMAGE COLOR SPACE CHARACTERISTICS 审中-公开
公开(公告)号：US20190170724A1
公开(公告)日：2019-06-06
申请号：US15831513
申请日：2017-12-05
申请人： International Business Machines Corporation
发明人： Venkat K. BALAGURUSAMY , Donna N Eng Dillenberger , Joseph Ligman
IPC分类号： G01N33/28 , G06T7/00 , G06T7/20
CPC分类号： G01N33/28 , G01N11/00 , G01N15/0227 , G01N15/06 , G01N33/00 , G01N33/146 , G01N33/2858 , G01N2011/006 , G01N2011/008 , G01N2015/0053 , G01N2015/0693 , G01N2021/1765 , G01N2291/028 , G06K9/4652 , G06T7/0004 , G06T7/20
摘要： A first series of images of a first fluid is received. A first set of fluid characteristics of the first fluid is determined from the first series of images. A second series of images of a second fluid is received. A second set of fluid characteristics of the second fluid is determined from the second series of images. A match is determined to be found between the first set of fluid characteristics and the second set of fluid characteristics. The second fluid is identified based upon determining that the first set of fluid characteristics matches the second set of fluid characteristics.

3. 发明申请

US20190113451A1 PORTABLE DIFFRACTION-BASED IMAGING AND DIAGNOSTIC SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20190113451A1
公开(公告)日：2019-04-18
申请号：US16025615
申请日：2018-07-02
申请人： The General Hospital Corporation
发明人： Ralph Weissleder , Hakho Lee , Hyungsoon Im , Cesar Castro
IPC分类号： G01N21/47 , G01N33/574 , C12Q1/70 , G01N15/02 , G01N15/06 , G03H1/08 , G01N33/569 , G03H1/04
CPC分类号： G01N21/4788 , C12Q1/708 , G01N15/0211 , G01N15/0227 , G01N15/06 , G01N15/0612 , G01N33/56972 , G01N33/57407 , G01N33/57411 , G01N2015/0065 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G03H1/0443 , G03H1/0866 , G03H2001/0447
摘要： The disclosure features systems and methods for measuring and diagnosing target constituents bound to labeling particles in a sample. The systems include a radiation source, a sample holder, a detector configured to obtain one or more diffraction patterns of the sample each including information corresponding to optical properties of sample constituents, and an electronic processor configured to, for each of the one or more diffraction patterns: (a) analyze the diffraction pattern to obtain amplitude information and phase information corresponding to the sample constituents; (b) identify one or more particle-bound target sample constituents based on at least one of the amplitude information and the phase information; and (c) determine an amount of at least one of the particle-bound target sample constituents in the sample based on at least one of the amplitude information and the phase information.

4. 发明申请

US20180321147A1 MICRO OBJECT DETECTION APPARATUS 审中-公开
公开(公告)号：US20180321147A1
公开(公告)日：2018-11-08
申请号：US15772405
申请日：2016-12-08
申请人： MITSUBISHI ELECTRIC CORPORATION
发明人： Kenya NAKAI
IPC分类号： G01N21/49 , G01N15/06 , G01N21/21 , G01N15/02
CPC分类号： G01N21/49 , G01N15/0205 , G01N15/0211 , G01N15/06 , G01N15/1434 , G01N15/1459 , G01N21/0303 , G01N21/05 , G01N21/21 , G01N21/53 , G01N2015/0046 , G01N2015/0053 , G01N2015/0687 , G01N2015/0693 , G01N2015/1452 , G01N2015/1486 , G01N2015/1488 , G01N2015/1493
摘要： A micro object detection apparatus includes an optical system. The first optical system includes a first reflection region, a second reflection region, and a light reception element. The first reflection region has an ellipsoidal shape, and reflects scattered light scattered when irradiation light hits a particle to direct the scattered light to the light reception element, by utilizing two focal point positions of the ellipsoidal shape. The second reflection region reflects scattered light coming from the particle to direct the scattered light to the first reflection region, so that the scattered light is directed to the light reception element by utilizing the ellipsoidal shape of the first reflection region. The light flux diameter of the scattered light reflected by the second reflection region is larger than the particle, at the position of the particle at which the scattered light is generated.

5. 发明申请

US20180313816A1 ACOUSTIC SEPARATION OF PARTICLES FOR BIOPROCESSING 审中-公开
公开(公告)号：US20180313816A1
公开(公告)日：2018-11-01
申请号：US15965368
申请日：2018-04-27
申请人： THE CHARLES STARK DRAPER LABORATORY, INC.
发明人： Jason O. Fiering , Kenneth T. Kotz
IPC分类号： G01N33/49 , B01D21/28 , A61M1/36
CPC分类号： B01L3/502753 , A61M1/3678 , B01L3/502761 , B01L2200/0652 , B01L2400/0436 , B03B1/04 , C12N5/0075 , G01N15/02 , G01N15/06 , G01N2015/0065 , G01N2015/0288 , G01N2015/0681 , G01N2015/0687 , G01N2015/1006 , G01N2015/1081
摘要： A method for separating particles in a biofluid includes pretreating the biofluid by introducing an additive, flowing the pretreated biofluid through a microfluidic separation channel, and applying acoustic energy to the microfluidic separation channel. A system for microfluidic separation, capable of separating target particles from non-target particles in a biofluid includes at least one microfluidic separation channel, a source of biofluid, a source of additive, and at least one acoustic transducer coupled to the microfluidic separation channel. A kit for microfluidic particle separation includes a microfluidic separation channel connected to an acoustic transducer, a source of an additive, and instructions for use.

6. 发明申请

US20180306767A1 OPTICAL DENSITY INSTRUMENT AND SYSTEMS AND METHODS USING THE SAME 审中-公开
公开(公告)号：US20180306767A1
公开(公告)日：2018-10-25
申请号：US15958760
申请日：2018-04-20
申请人： bioMerieux, Inc.
发明人： Perry D. STAMM , Joel Patrick HARRISON , Gregory R. MAES , Jeffrey Edward PRICE , Jack R. HOFFMANN, JR. , John Kenneth KORTE , Daniel Joseph PINGEL , Walter J. CLYNES , Sean Gregory FURMAN , Leonard H. SCHLEICHER , Christopher George KOCHER , Brian David PETERSON , Jacky S. YAM
IPC分类号： G01N33/487 , G01N21/27 , G01N1/10 , G01N21/47 , G01N21/59
CPC分类号： B01L3/50853 , B01L2200/14 , B01L2300/0654 , B01L2300/0803 , B01L2300/12 , G01N1/10 , G01N15/06 , G01N21/01 , G01N21/0303 , G01N21/274 , G01N21/4738 , G01N21/474 , G01N21/4785 , G01N21/51 , G01N21/5907 , G01N21/8806 , G01N21/93 , G01N33/487 , G01N33/48735 , G01N2015/0693 , G01N2021/0168 , G01N2021/0389 , G01N2021/4769 , G01N2021/598 , G01N2201/126 , G01N2201/12707
摘要： Instruments, systems, and methods for measuring optical density of microbiological samples are provided. In particular, optical density instruments providing improved safety, efficiency, comfort, and convenience are provided. Such optical density instruments include a handheld portion and a base station. The optical density instruments may be used in systems and methods for measuring optical density of biological samples.

7. 发明申请

US20180269250A1 SYSTEMS AND METHODS FOR OPTICAL PERCEPTION 审中-公开
公开(公告)号：US20180269250A1
公开(公告)日：2018-09-20
申请号：US15921899
申请日：2018-03-15
申请人： Symmetry Sensors, Inc.
发明人： Vincent Y. Chow
IPC分类号： H01L27/146 , H04N5/351
CPC分类号： H04N5/378 , G01N15/06 , G01N15/1404 , G01N15/1429 , G01N15/1436 , G01N15/1459 , G01N15/1475 , G01N2015/0693 , G01N2015/1479 , G01N2015/1486 , G01N2015/1497 , G06K9/6206 , H01L27/14609 , H01L27/14625 , H01L27/14643 , H01L27/14665 , H04N5/351
摘要： A system and method for optical perception can include a current confining pixel (CCP) that includes a detector pair, the detector pair including a first detector and a second detector, coupled together in an inverse polarity configuration such that the current confining pixel defines a sense node and a reference node together forming a differential output across the pair of detectors. The system and method can include a plurality of CCPs arranged in a CCP array, coupled together in any suitable manner; receiving, at a current confining pixel (CCP), an input signal; generating a differential output signal based on the input signal; and, analyzing an output of a CCP.

8. 发明授权

US10054534B1 Group calibration of environmental sensors 有权
公开(公告)号：US10054534B1
公开(公告)日：2018-08-21
申请号：US15156954
申请日：2016-05-17
申请人： Airviz Inc.
发明人： Illah Nourbakhsh , Joshua Schapiro , Michael D. Taylor
IPC分类号： G01N33/00 , G01D18/00 , G01K15/00 , G02B6/00 , G01N15/14 , G01N15/06 , G01N15/10
CPC分类号： G01N15/1429 , G01N15/06 , G01N2015/0046 , G01N2015/0693 , G01N2015/1068
摘要： Systems and methods batch calibrate environmental sensors. Candidate environmental sensors and a high-performance reference sensor are located in an enclosure with a particle excitation system that controls the particle concentration in the enclosure. The calibration process includes multiple phases with different particle concentrations, and the candidate and reference sensors continuously report their particle counts to a calibration server during these phases. Based on the collected data, the calibration server: (i) identifies for removal candidate sensors with outlying behavior through statistical analysis; and (ii) computes calibration values for the particle count estimation algorithms for the remaining candidate sensors that are optimized to minimize the error relative to the reference sensor(s).

9. 发明申请

US20180231448A1 PARTICLE-MEASURING APPARATUS 审中-公开
公开(公告)号：US20180231448A1
公开(公告)日：2018-08-16
申请号：US15888664
申请日：2018-02-05
申请人： Paragon AG
发明人： Ralf Moenkemoeller
IPC分类号： G01N15/02
CPC分类号： G01N15/0211 , G01N15/06 , G01N15/1459 , G01N21/53 , G01N21/85 , G01N2015/0046 , G01N2015/0693 , G01N2015/1486 , G01N2021/8578
摘要： A particle-measuring apparatus (1) for determining the particle mass concentration in aerosols having different properties has an aerosol photometer (2), by means of which a photometer measured value, which is dependent on the particle mass concentration in the aerosol, can be measured, and an evaluation unit (9), into which photometer measured values measured by the aerosol photometer (2) can be input and in which the input photometer measured values can be processed in order to output corrected particle mass concentration values.In order to provide a particle-measuring apparatus or a corresponding method that can be used to determine the particle mass concentration in a mobile manner, for example in a vehicle, or with different aerosol properties in different regions, it is proposed that respective calibration factors are stored in a memory (17) of the evaluation unit (9) for different aerosols, in that the particle-measuring apparatus (1) has an optical particle counter (10), by means of which the particle size distribution of aerosols can be detected and can be input into the evaluation unit (9) of the particle-measuring apparatus (1), in that the particle size distribution currently detected by the optical particle counter (10) can be compared in the evaluation unit (9) with particle size distributions, stored in the memory (17) of the evaluation unit (9), of the different aerosols associated with the stored calibration factors, and in that, by means of the evaluation unit (9), the stored calibration factor associated with the aerosol for which the particle size distribution has the most matches with the particle size distribution currently detected by the optical particle counter (10) can be selected for a determination of the particle mass concentration of the aerosol currently being measured.

10. 发明申请

US20180188169A1 UTILIZING UPDRAFT FLOW IN A FAN-LESS DUST SENSOR 审中-公开
公开(公告)号：US20180188169A1
公开(公告)日：2018-07-05
申请号：US15397527
申请日：2017-01-03
申请人： Honeywell International Inc.
发明人： Kevin Cai , Ouyang Yang , Anna Liu
IPC分类号： G01N21/51 , G01N21/94
CPC分类号： G01N21/51 , G01N15/06 , G01N15/1459 , G01N21/94 , G01N2015/0003 , G01N2015/0046 , G01N2015/0693 , G01N2015/1486 , G01N2201/0612
摘要： Embodiments relate to systems and methods for providing airflow within a particulate matter sensor. A particulate matter sensor may comprise an air duct, a light source configured to pass light through the air duct, a extender connected to the light source configured to dissipate thermal energy generated by the light source, and to generate a updraft of airflow into the air duct, a photodetector located in the air duct, and a computing device coupled to the photodetector. The computing device has a processor and a memory storing instructions which, when executed by the processor, determines a mass concentration of particles in the air duct based on an output of the photodetector.

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