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1. 发明授权

US11933746B2 Device for hosting a probe solution of molecules in a plurality of independent cells 有权
公开(公告)号：US11933746B2
公开(公告)日：2024-03-19
申请号：US17781098
申请日：2020-11-16
申请人： Paul Scherrer Institut
发明人： Soichiro Tsujino , Takashi Tomizaki , Michal Kepa
IPC分类号： G01N23/20 , G01N23/20016 , G01N23/20025 , G01N23/205
CPC分类号： G01N23/20025 , G01N23/20016 , G01N23/205 , G01N2223/0561 , G01N2223/307 , G01N2223/309 , G01N2223/321 , G01N2223/3306 , G01N2223/40 , G01N2223/501 , G01N2223/602
摘要： A device to host a crystallization medium, such as a solution, for crystal growth and a system for X-ray diffraction experiments to determine the atomic structure of crystals. A plurality of cells have a well, a sample holder placed in the well. The solution is hosted in the sample holder between thin-plates or one thin-plate. A cap seals an opening to the cell and each sample holder can be extracted independently from each well. A system for automated X-ray diffraction experiments for small crystals in the sample holder extracted from the wells utilizes an ultrasonic acoustic levitator to determine the crystal structure at atomic resolution. X-ray diffraction images are generated by scanning the X-ray beam over the levitated sample holder along a spiral trajectory by rotating the sample holder and moving in the direction perpendicular to the X-ray beam and the rotation axis at the same time.

2. 发明公开

US20240077437A1 Monitoring properties of X-ray beam during X-ray analysis 审中-公开
公开(公告)号：US20240077437A1
公开(公告)日：2024-03-07
申请号：US17902926
申请日：2022-09-05
申请人： BRUKER TECHNOLOGIES LTD.
发明人： Alexander Krokhmal , Asher Peled
IPC分类号： G01N23/223
CPC分类号： G01N23/223 , G01N2223/076 , G01N2223/3306 , G01N2223/507
摘要： A system for X-ray analysis, includes: (a) an X-ray analysis assembly configured to (i) direct an X-ray beam to impinge on a surface of a sample, and (ii) receive fluorescence radiation excited from the sample in response to the impinged X-ray beam, (b) a target assembly including measurement targets: placed in an optical path between the X-ray analysis assembly and the sample, and configured to move between (i) one or more first positions in which one or more of the measurement targets are positioned in the X-ray beam, and (ii) one or more second positions in which the optical path is unobstructed by the target assembly, and (c) a processor, configured to control movement of the target assembly between the first and second positions, for alternately, (i) monitoring properties of the X-ray beam using the measurement targets, and (ii) performing the X-ray analysis at a measurement site of the sample.

3. 发明公开

US20230384248A1 TRANSMISSIVE SMALL-ANGLE SCATTERING DEVICE 审中-公开
公开(公告)号：US20230384248A1
公开(公告)日：2023-11-30
申请号：US18228021
申请日：2023-07-31
申请人： RIGAKU CORPORATION
发明人： Naoki Matsushima , Kiyoshi Ogata , Sei Yoshihara , Yoshiyasu Ito , Kazuhiko Omote , Hiroshi Motono , Shigematsu Asano , Katsutaka Horada , Sensui Yasuda
IPC分类号： G01N23/201 , G01N23/20016 , G01N23/20025
CPC分类号： G01N23/201 , G01N23/20016 , G01N23/20025 , G01N2223/054 , G01N2223/3306 , G01N2223/6116
摘要： A transmission type small-angle scattering device of the present invention includes a goniometer 10 including a rotation arm 11. The rotation arm 11 is freely turnable around a θ-axis extending in a horizontal direction from an origin with a vertical arrangement state of the rotation arm 11 being defined as the origin, and has a vertical arrangement structure in which an X-ray irradiation unit 20 is installed on a lower-side end portion of the rotation arm 11, and a two-dimensional X-ray detector 30 is installed on an upper-side end portion of the rotation arm 11 to form a vertical arrangement structure.

4. 发明授权

US11796491B2 X-ray spectroscopic analysis apparatus and elemental analysis method 有权
公开(公告)号：US11796491B2
公开(公告)日：2023-10-24
申请号：US17554415
申请日：2021-12-17
申请人： SHIMADZU CORPORATION
发明人： Shinji Miyauchi , Susumu Adachi , Asaka Kohiyama , Takuro Izumi , Takashi Omori , Kenji Sato
IPC分类号： G01N23/207 , G01N23/223
CPC分类号： G01N23/2076 , G01N23/223 , G01N2223/076 , G01N2223/1016 , G01N2223/316 , G01N2223/3306
摘要： A spectroscopic element and a detector are disposed along a circumference of one Rowland circle. The spectroscopic element has a spectral surface whose length, measured along the Rowland circle, is shorter than a length in the Rowland circle plane, of an irradiation surface irradiated with excitation beams emitted to a sample holder. The spectroscopic element and the sample holder are disposed to separate a group of characteristic X-rays within a common spectral range of the spectroscopic element.

5. 发明授权

US09958403B1 Arrangement for X-Ray tomography 有权
公开(公告)号：US09958403B1
公开(公告)日：2018-05-01
申请号：US15728252
申请日：2017-10-09
申请人： FEI Company
发明人： Pavel Stejskal , Marek Un{hacek over (c)}ovský , Tomá{hacek over (s)} Vystav{hacek over (e)}l , Alan Frank de Jong , Bart Buijsse , Pierre Bleuet
IPC分类号： G01N23/00 , G01N23/04 , G21K7/00
CPC分类号： G01N23/046 , G01N23/2251 , G01N2223/1016 , G01N2223/204 , G01N2223/309 , G01N2223/3306 , G01N2223/401 , G01N2223/417 , G01N2223/419 , G21K7/00 , H01J37/28 , H01J2237/2807
摘要： A method of investigating a specimen using X-ray tomography, comprising (a) mounting the specimen to a specimen holder, (b) irradiating the specimen with a beam of X-rays along a first line of sight through the specimen, and (c) detecting a flux of X-rays transmitted through the specimen and forming a first image. Then (d) repeating the steps (b) and (c) for a series of different lines of sight through the specimen, thereby producing a corresponding series of images. The method further comprises (e) performing a mathematical reconstruction on said series of images, so as produce a tomogram of at least part of the specimen, wherein the specimen is disposed within a substantially cylindrical metallic shell with an associated cylindrical axis, the beam of X-rays is produced by directing a beam of charged particles onto a zone of said metallic shell, so as to produce a confined X-ray source at said zone, and the series of different lines of sight is achieved by rotating said shell about said cylindrical axis, thereby causing relative motion of said zone relative to the specimen.

6. 发明申请

US20170336706A1 X-RAY BIOPSY SPECIMEN IMAGER AND METHODS 审中-公开
公开(公告)号：US20170336706A1
公开(公告)日：2017-11-23
申请号：US15590631
申请日：2017-05-09
申请人： LI-COR, INC.
发明人： HAN-WEI WANG
IPC分类号： G03B42/02 , A61B6/00 , G01N23/223 , G01N23/04
CPC分类号： G03B42/026 , A61B5/0071 , A61B6/032 , A61B6/035 , A61B6/4417 , A61B6/466 , A61B6/486 , A61B6/5205 , A61B6/5247 , A61B6/545 , A61B6/547 , G01N23/046 , G01N23/223 , G01N33/4833 , G01N2223/04 , G01N2223/041 , G01N2223/071 , G01N2223/309 , G01N2223/3306 , G01N2223/612 , G01N2223/6126 , G03B42/02
摘要： Methods and devices are disclosed for the tomographic imaging of a biological sample from almost all rotational perspectives in three-dimensional space and with multiple imaging modalities. A biological sample is positioned on an imaging stage that is capable of nearly full 360-degree rotation in at least one of two substantially orthogonal axes. Positioned about the stage is an X-ray imaging module enabling the recording of a series of images. A reflected light imaging module can also be positioned about the stage to enable recording of black and white or color white light images. A computer can use the images to construct three-dimensional models of the sample and to render images of the sample conveying information from one or more imaging channels.

7. 发明授权

US09625257B2 Coordinate measuring apparatus and method for measuring an object 有权
公开(公告)号：US09625257B2
公开(公告)日：2017-04-18
申请号：US14323522
申请日：2014-07-03
申请人： Ralf Christoph , Wolfgang Rauh
发明人： Ralf Christoph , Wolfgang Rauh
IPC分类号： G01N23/00 , G01B15/00 , A61B6/00 , G01B15/04 , G01N23/04 , G01T7/00 , G01T7/10 , G01N23/083
CPC分类号： G01B15/00 , A61B6/4417 , A61B6/583 , A61B6/584 , G01B15/04 , G01N23/046 , G01N23/083 , G01N2223/1006 , G01N2223/3306 , G01N2223/419 , G01T7/005 , G01T7/10
摘要： The invention relates to a coordinate measuring apparatus for measuring an object, having an x-ray sensory mechanism as a first sensory mechanism that is provided with an x-ray source and at least one x-ray sensor which detects the x-rays, and a second sensory mechanism such as a tactile and/or an optical sensory mechanism that can be placed in the x, y, and/or z direction of the coordinate measuring apparatus in relation to the object. In order to be able to easily measure also large-size test objects, the x-ray sensory mechanism can be positioned in the coordinate measuring apparatus according to the second sensory mechanism.

8. 发明授权

US09500600B2 Radiation image acquisition system 有权
标题翻译：辐射图像采集系统
公开(公告)号：US09500600B2
公开(公告)日：2016-11-22
申请号：US14415273
申请日：2013-06-18
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Mototsugu Sugiyama , Toshiyasu Suyama
IPC分类号： G01N23/04 , G01T1/20
CPC分类号： G01N23/04 , G01N2223/33 , G01N2223/3306 , G01N2223/3308 , G01N2223/424 , G01N2223/505 , G01N2223/6113 , G01N2223/6116 , G01T1/20
摘要： A radiation image acquisition system of an aspect of the present invention includes a radiation source emitting radiation toward an object, a holding unit holding the object, a wavelength conversion member generating scintillation light in response to incidence of the radiation emitted from the radiation source and transmitted through the object, a first imaging means condensing and imaging scintillation light emitted from an incidence surface of the radiation of the wavelength conversion member, a second imaging means condensing and imaging scintillation light emitted from a surface opposite to the incidence surface of the wavelength conversion member, a holding unit position adjusting means adjusting the position of the holding unit between the radiation source and the wavelength conversion member, and an imaging position adjusting means adjusting the position of the first imaging means.
摘要翻译：本发明的一个方面的放射线图像采集系统包括：朝向物体发射辐射的辐射源，保持物体的保持单元，响应于从辐射源发射的辐射的入射产生闪烁光的波长转换部件，通过该目的，第一成像装置冷凝并成像从波长转换部件的辐射的入射表面发射的闪烁光，第二成像装置，将从与波长转换部件的入射面相反的表面发射的闪烁光成像，调节所述保持单元在所述辐射源与所述波长转换构件之间的位置的保持单元位置调整装置，以及调整所述第一成像装置的位置的成像位置调节装置。

9. 发明授权

US09222900B2 X-ray diffraction method of mapping grain structures in a crystalline material sample, and an X-ray diffraction apparatus 有权
$X-ray diffraction method of mapping grain structures in a crystalline material sample, and an X-ray diffraction apparatus$
标题翻译：在晶体材料样品中测定晶粒结构的X射线衍射方法和X射线衍射装置
公开(公告)号：US09222900B2
公开(公告)日：2015-12-29
申请号：US13785755
申请日：2013-03-05
申请人： Danmarks Tekniske Universitet
发明人： Erik Mejdal Lauridsen , Stefan Othmar Poulsen , Christian Holzner , Michael Feser
IPC分类号： G01N23/20 , G01N23/207 , G01N23/205
CPC分类号： G01N23/207 , G01N23/205 , G01N2223/056 , G01N2223/3306 , G01N2223/605 , G01N2223/606 , G01N2223/607 , G01N2223/648 , G01N2223/649
摘要： An X-ray diffraction method of mapping grain structures in a polycrystalline material sample, where an X-ray detector detects substantially line-shaped segments from beams diffracted from at least some of the grains. A processing device analyzes values received from the X-ray detector and identifies at least the position and the length of the line-shaped segments. The line-shaped segments are paired as originating from diffractions from the same grain and the positions of the paired line-shaped segments are used in determining the crystallographic grain position of this grain within in the polycrystalline material sample. The length of the paired line-shaped segments is used in determining a width of this grain.
摘要翻译：在多晶材料样品中映射晶粒结构的X射线衍射方法，其中X射线检测器从至少一些晶粒衍射的光束检测出基本上线状的段。处理装置分析从X射线检测器接收到的值，并且至少识别线状段的位置和长度。线形片段由来自相同晶粒的衍射构成，并且成对的线状片段的位置用于确定该晶粒在多晶材料样品内的结晶晶粒位置。成对的线状段的长度用于确定该颗粒的宽度。

10. 发明授权

US08989345B2 Method for evaluation of density profile in carbon/carbon material and method for production of standard density test block used therein 有权
标题翻译：炭/碳材料密度分布评估方法及其制备标准密度试块的方法
公开(公告)号：US08989345B2
公开(公告)日：2015-03-24
申请号：US13583431
申请日：2010-07-12
申请人： Dong Ryun Kim , Nam Gyun Yun
发明人： Dong Ryun Kim , Nam Gyun Yun
IPC分类号： G01N23/06 , G01N23/083 , G01N9/24 , G01N23/04 , G01N1/28
CPC分类号： G01N23/046 , G01N9/24 , G01N2001/2893 , G01N2223/3306 , G01N2223/419 , G01N2223/633 , Y10T29/4998
摘要： Disclosed are a method for evaluating a local density profile in a carbon/carbon material and a method for producing a standard density test block capable of quantitatively evaluating the density profile in the carbon/carbon material, wherein the method for evaluating the density profile includes a first step of preparing a standard density test block to be inserted in the carbon/carbon material, wherein the standard density test block is produced by using the same type of material as the carbon/carbon material and thereafter inserted in the carbon/carbon material, a second step of radiating X-rays onto the carbon/carbon material having the standard density test block inserted so as to obtain and correct computed tomographic image, and a third step of measuring a physical density by use of a linear attenuation coefficient of the computed tomographic image, whereby the local density profile can accurately be evaluated by use of a nondestructive testing and additionally such method can be utilized as an excellent means for improving processes and ensuring quality.
摘要翻译：公开了一种用于评估碳/碳材料中的局部密度分布的方法以及用于定量评价碳/碳材料中的密度分布的标准密度测试块的制备方法，其中用于评价密度分布的方法包括制备插入到碳/碳材料中的标准密度测试块的第一步骤，其中通过使用与碳/碳材料相同类型的材料然后插入碳/碳材料中制备标准密度测试块，将X射线照射到具有插入的标准密度测试块的碳/碳材料上以获得和校正计算机断层图像的第二步骤;以及第三步骤，通过使用所计算的线性衰减系数来测量物理密度断层图像，由此可以通过使用非破坏性测试来精确地评估局部密度分布，另外这种方法可以是b e被用作改进流程和确保质量的极好手段。

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