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1. 发明申请

US20170299539A1 SYSTEMS AND METHODS FOR ELECTROCHEMICAL TRIGLYCERIDES ASSAYS 审中-公开
公开(公告)号：US20170299539A1
公开(公告)日：2017-10-19
申请号：US15485871
申请日：2017-04-12
申请人： Polymer Technology Systems, Inc.
发明人： Gary L. Hughes
IPC分类号： G01N27/327 , G01N33/92 , C12Q1/00 , G01N33/543
CPC分类号： G01N27/3272 , C12Q1/005 , G01N33/5438 , G01N33/92 , G01N2333/902 , G01N2333/90203 , G01N2333/9121 , G01N2333/91215 , G01N2333/92
摘要： A system for the electrochemical detection of triglyceride levels includes a test strip including an electrode and a counter electrode, the electrode and counter electrode located proximate to a sample reception area; and a coating on one of the electrode and counter electrode, the coating including a reagent coating for triglycerides.

2. 发明申请

US20170175168A1 RAPID, LOW-SAMPLE-VOLUME CHOLESTEROL AND TRIGLYCERIDE ASSAYS 审中-公开
公开(公告)号：US20170175168A1
公开(公告)日：2017-06-22
申请号：US15364762
申请日：2016-11-30
申请人： Theranos, Inc.
发明人： Douglas Matje , Ian Gibbons , Paul Patel , Elizabeth A. Holmes
IPC分类号： C12Q1/60 , C12Q1/44 , C12Q1/26
CPC分类号： C12Q1/60 , C12Q1/26 , C12Q1/44 , C12Q1/61 , C12Q2326/00 , C12Q2326/90 , C12Q2326/96 , C12Q2523/115 , G01N33/92 , G01N2333/904 , G01N2333/908 , G01N2333/92
摘要： Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed. Assays may be performed in a single reaction mixture, allowing more accurate and precise cholesterol determinations, including ratios of cholesterol sub-fractions to total cholesterol, at less expense, than would be expected by performing several different assays in different reaction mixtures.

3. 发明申请

US20170138960A1 DETECTION, MONITORING AND TREATMENT OF ACUTE MYOCARDIAL INFARCTION 审中-公开
公开(公告)号：US20170138960A1
公开(公告)日：2017-05-18
申请号：US15115750
申请日：2015-02-02
申请人： DIADEXUS, INC.
发明人： Shaoqiu ZHUO
IPC分类号： G01N33/68 , G01N33/543 , A61K33/40 , G01N33/58
CPC分类号： G01N33/6893 , A61K33/40 , G01N33/54306 , G01N33/5436 , G01N33/581 , G01N2333/775 , G01N2333/918 , G01N2333/92 , G01N2800/324
摘要： Detection, monitoring and treatment of acute myocardial infarction (AMI) using a hybrid immunoassay to both Lp-PLA2 and ApoA1. Described herein are assays and method of performing them useful for the detection of AMI. Also described are methods of monitoring a patient at risk for, or suffering from, AMI. Also described herein are methods and assays for treating patient having or at risk of suffering from AMI.

4. 发明授权

US09000132B2 Lipoprotein-associated phospholipase A2 antibody compositions and methods of use 有权
标题翻译：脂蛋白相关磷脂酶A2抗体组合物和使用方法
公开(公告)号：US09000132B2
公开(公告)日：2015-04-07
申请号：US13956139
申请日：2013-07-31
申请人： diaDexus, Inc.
发明人： Paul Levi Miller , Laura Corral
IPC分类号： C07K16/40 , C12N9/20 , G01N33/573
CPC分类号： C07K16/40 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C12N9/20 , C12Y301/01047 , G01N33/573 , G01N2333/92
摘要： The invention provides isolated anti-Lp-PLA2 antibodies that bind to Lp-PLA2. The invention also encompasses compositions comprising an anti-Lp-PLA2 antibody. These compositions can be provided in an article of manufacture or a kit. Another aspect of the invention is an isolated nucleic acid encoding an anti-Lp-PLA2 antibody, as well as an expression vector comprising the isolated nucleic acid. Also provided are cells that produce the anti-Lp-PLA2 antibodies. The invention encompasses a method of producing the anti-Lp-PLA2 antibodies. Other aspects of the invention are a method of detecting an Lp-PLA2 in a subject.
摘要翻译：本发明提供了与Lp-PLA2结合的分离的抗Lp-PLA2抗体。本发明还包括包含抗Lp-PLA2抗体的组合物。这些组合物可以在制品或试剂盒中提供。本发明的另一方面是编码抗Lp-PLA2抗体的分离的核酸，以及包含分离的核酸的表达载体。还提供产生抗Lp-PLA2抗体的细胞。本发明包括生产抗Lp-PLA2抗体的方法。本发明的其它方面是检测受试者中的Lp-PLA2的方法。

5. 发明授权

US08993509B2 Method for treatment of cachexia by administering inhibitors of adipose triglyceride lipase expression or activity 有权
标题翻译：通过施用脂肪甘油三酯脂肪酶表达或活性的抑制剂治疗恶病质的方法
公开(公告)号：US08993509B2
公开(公告)日：2015-03-31
申请号：US13262094
申请日：2010-03-31
申请人： Robert Zimmerman , Rudolf Zechner , Günther Haemmerle , Gerald Höfler , Suman Das , Achim Lass
发明人： Robert Zimmerman , Rudolf Zechner , Günther Haemmerle , Gerald Höfler , Suman Das , Achim Lass
IPC分类号： A01N61/00 , A61K31/00 , A01N57/00 , A61K31/66 , A01N43/00 , A61K31/33 , A01N43/58 , A61K31/50 , A01N43/40 , A61K31/435 , A01N43/44 , C12Q1/44 , A61K31/41 , A61K31/495
CPC分类号： C12Q1/44 , A61K31/41 , A61K31/495 , G01N2333/92 , G01N2500/02 , G01N2500/10 , G01N2500/20 , G01N2800/02 , G01N2800/042
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds are effective in the treatment, and more particularly, that inhibit cachexia, and its associated or related disorders and conditions. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by cachexia, and its associated or related disorders and conditions and/or cachexia, and its associated or related disorders and conditions, such as for example, cancer cachexia and cachexia associated with AIDS, autoimmune disorders, drug addiction, alcoholism, chronic inflammatory disorders, cirrhosis of the liver, anorexia and neurodegenerative disease. In particular, the diagnostic marker and drug target of the invention is the ATGL Lipase, which can be inhibited by e.g. siRNAs and compounds with any of the following structures (I).
摘要翻译：本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物在治疗中是有效的，更具体地，涉及抑制恶病质及其相关或相关的病症和病症。此外，本发明涉及用于治疗恶病质特征的病症的组合物和方法及其相关或相关的疾病和病症和/或恶病质及其相关或相关的病症和病症，例如，与艾滋病相关的癌症恶病质和恶病质，自身免疫性疾病，药物成瘾，酒精中毒，慢性炎性疾病，肝硬化，厌食和神经退行性疾病。特别地，本发明的诊断标记物和药物靶标是ATGL脂肪酶，其可被例如， siRNA和具有以下结构（I）的化合物。

6. 发明申请

US20140309125A1 MARKERS RELATED TO AGE-RELATED MACULAR DEGENERATION AND USES THEREFOR 审中-公开
标题翻译：与年龄相关的玉米变性的标记及其用途
公开(公告)号：US20140309125A1
公开(公告)日：2014-10-16
申请号：US14101915
申请日：2013-12-10
申请人： Johanna M. Seddon , Mark Daly
发明人： Johanna M. Seddon , Mark Daly
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , G01N33/6893 , G01N2333/92 , G01N2800/164
摘要： Described herein are compositions, kits and methods for diagnosing and tracking the progression of AMD in a subject by detecting the presence or absence of particular lipid metabolism markers associated with AMD. Predictive computer models of disease risk are also disclosed.
摘要翻译：本文描述的是通过检测与AMD相关的特定脂质代谢标记的存在或不存在来诊断和跟踪受试者中AMD进展的组合物，试剂盒和方法。疾病风险预测计算机模型也被披露。

7. 发明申请

US20130040379A1 Method for Measuring Low-Density Lipoprotein (LDL) Cholesterol and Test Piece for Measuring LDL Cholesterol 审中-公开
标题翻译：用于测量低密度脂蛋白（LDL）胆固醇和测试用于测量低密度脂蛋白胆固醇的方法
公开(公告)号：US20130040379A1
公开(公告)日：2013-02-14
申请号：US13630532
申请日：2012-09-28
申请人： ARKRAY, Inc.
发明人： Takehiro Yamaguchi , Yuka Miyake
IPC分类号： C12M1/34
CPC分类号： G01N33/92 , C12Q1/26 , C12Q1/32 , C12Q1/44 , C12Q1/60 , G01N33/523 , G01N2333/904 , G01N2333/92
摘要： An LDL cholesterol measurement method that can be used with a test piece is provided. The LDL cholesterol measurement method for measuring LDL cholesterol in a sample has (A) a step of providing a total-cholesterol measurement portion and a non-LDL cholesterol measurement portion for measuring non-LDL cholesterol, which is cholesterol other than LDL cholesterol; (B) a step of measuring the total cholesterol in the sample in the total-cholesterol measurement portion; (C) a step of measuring the non-LDL cholesterol in the sample in the non-LDL cholesterol measurement portion; and (D) a step of obtaining the LDL cholesterol level in the sample by subtracting the non-LDL cholesterol value measured in the step (C) from the total-cholesterol value measured in the step (B).
摘要翻译：提供了可与试验片一起使用的低密度脂蛋白胆固醇测定方法。用于测定样品中的LDL胆固醇的低密度脂蛋白胆固醇测定方法具有（A）提供总胆固醇测定部位和非低密度脂蛋白胆固醇测定部，用于测定作为LDL胆固醇以外的胆固醇的非低密度脂蛋白胆固醇的步骤; （B）测定总胆固醇测定部中的样品中的总胆固醇的步骤; （C）测定非LDL胆固醇测定部中的样品中的非LDL胆固醇的步骤; 和（D）通过从步骤（B）中测量的总胆固醇值中减去步骤（C）中测量的非LDL胆固醇值，获得样品中的LDL胆固醇水平的步骤。

8. 发明申请

US20120230943A1 MODULATION OF ADIPOSE TRIGLYCERIDE LIPASE FOR PREVENTION AND TREATMENT OF CACHEXIA, LOSS OF WEIGHT AND MUSCLE ATROPHY AND METHODS OF SCREENING THEREFOR 有权
标题翻译： ADIPOSE TRIGLYCERIDE LIPASE的调控用于预防和治疗CACHEXIA，体重和肌肉损失及其筛选方法
公开(公告)号：US20120230943A1
公开(公告)日：2012-09-13
申请号：US13262094
申请日：2010-03-31
申请人： Robert Zimmerman , Rudolf Zechner , Günther Haemmerle , Gerald Höfler , Suman Das , Achim Lass
发明人： Robert Zimmerman , Rudolf Zechner , Günther Haemmerle , Gerald Höfler , Suman Das , Achim Lass
IPC分类号： A61K31/7088 , G01N33/573 , G01N21/75 , A61K31/713 , A61K38/20 , A61K31/4406 , A61K38/19 , A61P3/00 , A61K31/495 , A61K31/235 , A61K31/4152 , C12Q1/44 , A61K38/21
CPC分类号： C12Q1/44 , A61K31/41 , A61K31/495 , G01N2333/92 , G01N2500/02 , G01N2500/10 , G01N2500/20 , G01N2800/02 , G01N2800/042
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds are effective in the treatment, and more particularly, that inhibit cachexia, and its associated or related disorders and conditions. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by cachexia, and its associated or related disorders and conditions and/or cachexia, and its associated or related disorders and conditions, such as for example, cancer cachexia and cachexia associated with AIDS, autoimmune disorders, drug addiction, alcoholism, chronic inflammatory disorders, cirrhosis of the liver, anorexia and neurodegenerative disease. In particular, the diagnostic marker and drug target of the invention is the ATGL Lipase, which can be inhibited by e.g. siRNAs and compounds with any of the following structures (I).
摘要翻译：本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物在治疗中是有效的，更具体地，涉及抑制恶病质及其相关或相关的病症和病症。此外，本发明涉及用于治疗恶病质特征的病症的组合物和方法及其相关或相关的疾病和病症和/或恶病质及其相关或相关的病症和病症，例如，与艾滋病相关的癌症恶病质和恶病质，自身免疫性疾病，药物成瘾，酒精中毒，慢性炎性疾病，肝硬化，厌食和神经退行性疾病。特别地，本发明的诊断标记物和药物靶标是ATGL脂肪酶，其可被例如， siRNA和具有以下结构（I）的化合物。

9. 发明申请

US20100093009A1 ALTERNATIVE CRYSTAL FORM OF MONOACYLGLYCEROL LIPASE (MGLL) 有权
标题翻译：单糖醇脂（MGLL）的替代晶体形式
公开(公告)号：US20100093009A1
公开(公告)日：2010-04-15
申请号：US12576436
申请日：2009-10-09
申请人： Carsten Schubert , Bruce L. Grasberger , Celine Schalk-Hihi , Diane M. Maguire , Frank A. Lewandowski , Cynthia M. Milligan , Richard S. Alexander
发明人： Carsten Schubert , Bruce L. Grasberger , Celine Schalk-Hihi , Diane M. Maguire , Frank A. Lewandowski , Cynthia M. Milligan , Richard S. Alexander
IPC分类号： C12Q1/44 , C12N9/96 , G06G7/58 , C12N9/20 , C12N9/99
CPC分类号： C12N9/20 , C07K2299/00 , G01N2333/92 , G01N2500/04 , G06F19/16
摘要： A number of soluble engineered forms of MGLL that are suitable for high-throughput screening and protein crystallization, as well as a crystallized forms of monoacylglycerol lipase protein (MGLL) and descriptions of the X-ray diffraction patterns are disclosed. The engineered constructs of MGLL permit the expression and purification of protein suitable for crystallography or high-throughput screening and identification of ligands, which can function as active agents to MGLL. The X-ray diffraction patterns allow the three dimensional structure of MGLL to be determined at atomic resolution so that ligand binding sites on MGLL can be identified and the interactions of ligands with MGLL amino acid residues can be modeled. Models prepared using such maps permit the design of ligands which can function as active agents which include, but are not limited to, those that function as inhibitors of MGLL.
摘要翻译：公开了适用于高通量筛选和蛋白质结晶的多种可溶性工程化形式的MGLL，以及单酰基甘油脂肪酶蛋白质（MGLL）的结晶形式和X射线衍射图案的描述。 MGLL的工程化构建体允许蛋白质的表达和纯化适用于结晶学或高通量筛选和鉴定配体，其可以作为MGLL的活性剂。 X射线衍射图允许以原子分辨率确定MGLL的三维结构，使得可以鉴定MGLL上的配体结合位点，并且可以建模配体与MGLL氨基酸残基的相互作用。使用这种图谱制备的模型允许设计可用作活性剂的配体，其包括但不限于作为MGLL抑制剂的那些。

10. 发明申请

US20090181879A1 Methods for Monitoring Neuroinflammatory Destruction of Neurons and for Treating Diseases Having an Inflammatory component related to phospholipase A2 有权
标题翻译：监测神经炎症破坏神经元和治疗具有与磷脂酶A2相关的炎症成分的疾病的方法
公开(公告)号：US20090181879A1
公开(公告)日：2009-07-16
申请号：US11988253
申请日：2006-07-10
申请人： Timothy J. Cunningham , Lihua Yao , Jeffrey I. Greenstein
发明人： Timothy J. Cunningham , Lihua Yao , Jeffrey I. Greenstein
IPC分类号： A61K38/00 , G01N33/53 , C12Q1/00 , C12Q1/34
CPC分类号： G01N33/573 , G01N33/564 , G01N2333/918 , G01N2333/92 , G01N2800/285
摘要： The present invention relates to methods useful to monitor central and peripheral nervous system neuron/axon destruction resulting from an increase in acute phase inflammatory enzymes. The methods have applicability to monitoring the progress of neurological diseases, including multiple sclerosis and Alzheimer's disease, as well as neuroinflammatory damage that results from sports injuries, vigorous physical activity or any form of physical abuse. The invention further relates to methods of treating multiple sclerosis or other diseases with an inflammatory component related to phospholipase A2.
摘要翻译：本发明涉及用于监测由急性期炎症酶增加引起的中枢和周围神经系统神经元/轴突破坏的方法。该方法适用于监测包括多发性硬化和阿尔茨海默病在内的神经系统疾病的进展，以及运动损伤，体力活动或任何形式的身体虐待引起的神经炎症性损伤。本发明还涉及用与磷脂酶A2相关的炎性成分治疗多发性硬化症或其它疾病的方法。

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