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1. 发明申请

US20190219810A1 OBSERVATION APPARATUS 审中-公开
公开(公告)号：US20190219810A1
公开(公告)日：2019-07-18
申请号：US16364946
申请日：2019-03-26
申请人： OLYMPUS CORPORATION
发明人： Masaru MIZUNAKA , Shintaro TAKAHASHI , Akira MATSUSHITA , Yohei TANIKAWA , Tsuyoshi MOCHIZUKI , Shinichi TAKIMOTO
IPC分类号： G02B21/16 , G02B21/02 , G02B21/12 , G02B21/36 , G01N21/64
CPC分类号： G02B21/16 , G01N21/17 , G01N21/64 , G01N21/6458 , G01N2021/6478 , G02B21/02 , G02B21/06 , G02B21/10 , G02B21/12 , G02B21/125 , G02B21/24 , G02B21/33 , G02B21/36 , G02B21/367
摘要： An observation apparatus including: a light-source that emits illumination light and excitation light upward from below a specimen; and an image-capturing optical system having an objective lens that focuses, below the specimen, transmitted light, which is the illumination light that is emitted from the light-source, that is reflected above the specimen, and that has passed through the specimen, and fluorescence that is generated in the specimen that has been irradiated with the excitation light emitted from the light-source, wherein the light-source is disposed radially outside the objective lens.

2. 发明申请

US20170184832A1 SAMPLE OBSERVATION DEVICE AND SAMPLE OBSERVATION METHOD 审中-公开
公开(公告)号：US20170184832A1
公开(公告)日：2017-06-29
申请号：US15460743
申请日：2017-03-16
申请人： OLYMPUS CORPORATION
发明人： Yoshimasa SUZUKI
IPC分类号： G02B21/12 , G02B21/02
CPC分类号： G02B21/12 , G02B5/005 , G02B21/02 , G02B21/125 , G02B21/14
摘要： A sample observation device includes an illumination optical system and an observation optical system, and the illumination optical system includes a light source, a condenser lens, and an aperture member, and the observation optical system includes an objective lens and an imaging lens, and the aperture member has a light-shielding part or a darkening part, and a transmission part, and the transmission part is located outside of an outer edge of the light-shielding part or the darkening part, and an image of an inner edge of the transmission part is formed inside of an outer edge of a pupil of the objective lens, and an image of an outer edge of the transmission part is formed outside of the outer edge of the pupil of the objective lens, and the following conditional expression is satisfied. 0.005≦Ratio≦0.9.

3. 发明申请

US20170069455A1 Photocathode Including Silicon Substrate With Boron Layer 审中-公开
标题翻译：含有硅衬底的光电阴极
公开(公告)号：US20170069455A1
公开(公告)日：2017-03-09
申请号：US15353980
申请日：2016-11-17
申请人： KLA-TENCOR CORPORATION
发明人： YUNG-HO ALEX CHUANG , JOHN FIELDEN
IPC分类号： H01J29/38 , H01L27/148 , H01J31/50 , H01J1/34 , H01J31/26
CPC分类号： H01J29/385 , G01N21/9501 , G02B21/125 , H01J1/34 , H01J31/26 , H01J31/50 , H01L27/14643 , H01L27/148 , H01L27/14806 , H01L27/14893
摘要： A photocathode is formed on a monocrystalline silicon substrate having opposing illuminated (top) and output (bottom) surfaces. To prevent oxidation of the silicon, a thin (e.g., 1-5 nm) boron layer is disposed directly on the output surface using a process that minimizes oxidation and defects. An optional second boron layer is formed on the illuminated (top) surface, and an optional anti-reflective material layer is formed on the second boron layer to enhance entry of photons into the silicon substrate. An optional external potential is generated between the opposing illuminated (top) and output (bottom) surfaces. The photocathode forms part of novel electron-bombarded charge-coupled device (EBCCD) sensors and inspection systems.
摘要翻译：在具有相对的照明（顶部）和输出（底部）表面的单晶硅衬底上形成光电阴极。为了防止硅的氧化，使用最小化氧化和缺陷的工艺将薄（例如1-5nm）的硼层直接设置在输出表面上。在照明（顶部）表面上形成可选的第二硼层，并且在第二硼层上形成可选的抗反射材料层以增强光子进入硅衬底。在相对的照明（顶部）和输出（底部）表面之间产生可选的外部电位。光电阴极形成新型电子轰击电荷耦合器件（EBCCD）传感器和检测系统的一部分。

4. 发明授权

US09568722B2 Illumination device for an optical viewing apparatus 有权
标题翻译：用于光学观察装置的照明装置
公开(公告)号：US09568722B2
公开(公告)日：2017-02-14
申请号：US14752693
申请日：2015-06-26
申请人： Carl Zeiss Meditec AG
发明人： Peter Reimer , Daniel Kolster , Franz Merz , Stefan Meinkuss
IPC分类号： G02B21/06 , G02B21/08 , G02B21/12 , G02B21/00
CPC分类号： G02B21/06 , G02B21/0012 , G02B21/082 , G02B21/125
摘要： An illumination device for an optical viewing apparatus has a light source including a first individual light source and a second individual light source arranged in a plane. The first individual light source has a first midpoint and the second individual light source has a second midpoint. An axial direction is defined by a vector from the second midpoint to the first midpoint. An illumination optical unit defines an optical axis which is arranged perpendicularly to the plane and intersects the plane at an intersection point. The light source is imaged toward infinity by the illumination optical unit. The first individual light source has an extent along the axial direction. The midpoint is offset by an amount (Δ) in a positive direction along the axial direction relative to the intersection. The relationship 0.1*L1≦Δ≦1*L1 is satisfied for the offset.
摘要翻译：用于光学观察装置的照明装置具有包括布置在平面中的第一单独光源和第二单独光源的光源。第一单独光源具有第一中点，而第二单独光源具有第二中点。轴向方向由从第二中点到第一中点的矢量定义。照明光学单元限定垂直于该平面配置的光轴，并且在交叉点处与平面相交。光源通过照明光学单元向无穷远成像。第一单独的光源具有沿着轴向的程度。中点相对于交叉点沿轴向的正方向偏移量（Δ）。偏移量满足关系式为0.1 *L1≤Δ≤1* L1。

5. 发明授权

US09453995B2 Electronically variable illumination filter for microscopy 有权
标题翻译：用于显微镜的电子可变照明滤光片
公开(公告)号：US09453995B2
公开(公告)日：2016-09-27
申请号：US14542638
申请日：2014-11-16
申请人： Lloyd Douglas Clark , Brian A. Brown
发明人： Lloyd Douglas Clark , Brian A. Brown
IPC分类号： G02B21/06 , G02B21/08 , G02B21/12 , G02B21/14 , G02B21/00
CPC分类号： G02B21/08 , G02B21/0088 , G02B21/086 , G02B21/125 , G02B21/14
摘要： An illumination system for diascopic microscopy comprises a computer (610) with memory (625), a graphics program (605), a display driver (615), and graphical display (600). The display is positioned between a microscope's light source (105, 704) and condenser (110). When activated, the illumination system causes the display to display a predetermined pattern which the light source projects onto the condenser and is then focused by the condenser on a subject (125) to be examined. In conjunction with the microscope's light source, the illumination system emulates the illumination techniques of bright field, dark field, oblique, polarized, monochrome, modulation contrast and phase contrast illuminations.
摘要翻译：用于双相显微镜的照明系统包括具有存储器（625），图形程序（605），显示驱动器（615）和图形显示器（600）的计算机（610）。显示器位于显微镜的光源（105,704）和冷凝器（110）之间。当被激活时，照明系统使得显示器显示光源投射到冷凝器上的预定图案，然后由冷凝器聚焦在被检查对象（125）上。结合显微镜的光源，照明系统模拟明场，暗场，倾斜，偏振，单色，调制对比度和相位对比度照明的照明技术。

6. 发明申请

US20150300913A1 ON-TOOL WAVEFRONT ABERRATIONS MEASUREMENT SYSTEM AND METHOD 有权
标题翻译：工具波形测量系统和方法
公开(公告)号：US20150300913A1
公开(公告)日：2015-10-22
申请号：US14560932
申请日：2014-12-04
申请人： APPLIED MATERIALS ISRAEL LTD.
发明人： Boris Golberg , Amir Moshe Sagiv , Haim Feldman , Uriel Malul , Adam Baer
IPC分类号： G01M11/02
CPC分类号： G01M11/00 , G01N21/8806 , G01N21/9501 , G01N2021/95676 , G02B21/125
摘要： An on-tool measurement system and a method for measuring optical system's wavefront (WF) aberrations are disclosed. The on-tool measurement system includes an optical setup comprising a moveable deflection element further comprising a highly transparent region. The deflection element includes a first surface configured to project a first image of at least one object onto a sensor and the highly transparent region includes a second surface configured to project a second image of the at least one object onto the sensor. The on-tool measurement system includes a sensor configured to capture the first and second images and a controller configured to measure differential displacements between the first and second images at each deflection element position and to calculate the optical setup local WF gradients that depend on the measured differential displacements.
摘要翻译：公开了一种工具测量系统和用于测量光学系统的波前（WF）像差的方法。工具测量系统包括光学装置，其包括还包括高度透明区域的可移动偏转元件。偏转元件包括被配置为将至少一个物体的第一图像突出到传感器上的第一表面，并且高透明区域包括配置成将至少一个物体的第二图像投影到传感器上的第二表面。工具测量系统包括被配置为捕获第一和第二图像的传感器和被配置为测量在每个偏转元件位置处的第一和第二图像之间的差分位移的控制器，并且计算取决于被测量的光学设置局部WF梯度差分位移。

7. 发明授权

US08837042B2 Transillumination device for a microscope 有权
标题翻译：显微镜的透射装置
公开(公告)号：US08837042B2
公开(公告)日：2014-09-16
申请号：US13359226
申请日：2012-01-26
申请人： Robert Paulus , Harald Schnitzler , Didier Henry
发明人： Robert Paulus , Harald Schnitzler , Didier Henry
IPC分类号： G02B21/06 , G02B26/02 , G02B21/08 , G02B21/02 , G02B21/22 , G02B21/12
CPC分类号： G02B21/086 , G02B21/025 , G02B21/125 , G02B21/22 , G02B26/02
摘要： A transillumination device (150) for a microscope (100) comprises a flat panel light source (151), a diaphragm arrangement (152) arranged behind the flat panel light source (151) in the radiating direction (AR) that comprises two diaphragm elements movable relative to one another, at least one of the two diaphragm elements having a cutout, the two diaphragm elements defining, together with the at least one cutout, a diaphragm opening, wherein the dimensions of the diaphragm opening in two mutually perpendicular directions are determined by the position of the diaphragm elements relative to one another.
摘要翻译：用于显微镜（100）的透照装置（150）包括平板光源（151），在辐射方向（AR）后面布置在平板光源（151）之后的隔膜装置（152）），其包括两个隔膜元件所述两个隔膜元件中的至少一个具有切口，所述两个隔膜元件与所述至少一个切口一起限定了隔膜开口，其中所述隔膜开口在两个相互垂直的方向上的尺寸被确定通过隔膜元件相对于彼此的位置。

8. 发明申请

US20140061445A1 WIDEFIELD MICROSCOPE ILLUMINATION SYSTEM AND WIDEFIELD ILLUMINATION METHOD 有权
公开(公告)号：US20140061445A1
公开(公告)日：2014-03-06
申请号：US14111759
申请日：2012-04-11
申请人： Jonas Foelling
发明人： Jonas Foelling
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G01N21/6458 , G02B21/088 , G02B21/125 , G02B21/16 , G02B21/367
摘要： A widefield microscope illumination system and a method for illumination, the system having a microscope objective with an optical objective axis, an illumination light source sending widefield illumination light along illumination beam paths having corresponding illumination axes along which the illumination light penetrates into the microscope objective through illumination light entry sites located within a predetermined illumination light entry area, a spatially resolving light detector detecting detected light sent from an illuminated sample through the microscope objective along a detected light beam path, and an automatic illumination light beam path manipulation device, controlled by a control system, which is arranged in front of the microscope objective in relation to the direction of the illumination light beam path, and by which illumination light beam path manipulation device the illumination axes are automatically movable at time intervals to a plurality of illumination light entry sites.
摘要翻译：一种宽幅显微镜照明系统和一种照明方法，该系统具有具有光学物镜轴的显微镜物镜，照明光源沿着具有对应的照明轴的照明光束路径发送宽场照明光，照明光线沿着该照明轴照射到显微镜物镜中位于预定照明光入射区域内的照明光进入位置，沿着检测到的光束路径检测从被照射的样品通过显微镜物镜发送的检测光的空间分辨光检测器，以及自动照明光束路径操纵装置，控制系统，其布置在相对于照明光束路径的方向在显微镜物镜的前方，并且照明光束路径操纵装置的照明轴可以以时间间隔自动地移动到多个照明l 入境点。

9. 发明申请

US20140038206A1 IMAGE ANALYSIS AND MEASUREMENT OF BIOLOGICAL SAMPLES 有权
公开(公告)号：US20140038206A1
公开(公告)日：2014-02-06
申请号：US13951063
申请日：2013-07-25
申请人： Theranos, Inc.
发明人： Elizabeth A. Holmes , Chinmay Pangarkar , Timothy Smith , Karen Mohan , Semartha Anekal , Daniel L. Young , James R. Wasson
IPC分类号： G01N21/17
CPC分类号： G01N33/56972 , B01L3/502715 , G01N21/0303 , G01N21/05 , G01N21/17 , G01N21/27 , G01N21/6428 , G01N21/645 , G01N21/6458 , G01N21/6486 , G01N33/487 , G01N33/49 , G01N33/56966 , G01N2021/1738 , G01N2021/6439 , G01N2201/061 , G01N2201/12 , G01N2333/70589 , G01N2333/70596 , G02B7/09 , G02B21/0076 , G02B21/088 , G02B21/125 , G02B21/16 , G02B21/244 , G02B21/365
摘要： Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.

10. 发明申请

US20140030737A1 IMAGE ANALYSIS AND MEASUREMENT OF BIOLOGICAL SAMPLES 有权
公开(公告)号：US20140030737A1
公开(公告)日：2014-01-30
申请号：US13951449
申请日：2013-07-25
申请人： Theranos, Inc.
发明人： Elizabeth A. Holmes , Chinmay Pangarkar , Timothy Smith , Karan Mohan , Samartha Anekal , Daniel L. Young , James R. Wasson
IPC分类号： G01N33/569 , G02B7/09 , G01N21/64
CPC分类号： G01N33/56972 , B01L3/502715 , G01N21/0303 , G01N21/05 , G01N21/17 , G01N21/27 , G01N21/6428 , G01N21/645 , G01N21/6458 , G01N21/6486 , G01N33/487 , G01N33/49 , G01N33/56966 , G01N2021/1738 , G01N2021/6439 , G01N2201/061 , G01N2201/12 , G01N2333/70589 , G01N2333/70596 , G02B7/09 , G02B21/0076 , G02B21/088 , G02B21/125 , G02B21/16 , G02B21/244 , G02B21/365
摘要： Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.

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